Abstract
Peroxisomes are multifunctional organelles that play an important role in the metabolism of lipids and reactive oxygen species. As many cellular signaling functions are regulated via lipids, lipid second messengers, and oxidative stress-related factors, it is not surprising to see that these organelles are increasingly recognized as critical regulators of cellular signaling events. To fulfill these signaling functions, peroxisomes physically and functionally interact with other cell organelles, including mitochondria. Recent progress in the development of tools to visualize and modulate molecular processes at the subcellular level has made it possible to gain a better insight into the potential mechanisms governing peroxisomal signaling. This chapter is intended to provide a comprehensive overview of the tools and strategies that are currently available to study peroxisome-mediated signaling pathways in living cells. To provide the reader with relevant background information, we also highlight key studies that have contributed to our understanding of how peroxisomes may function as important sites of redox-, lipid-, inflammatory-, and viral-mediated signal transduction.
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Acknowledgments
MF is supported by grants from the “Fonds voor Wetenschappelijk Onderzoek- Vlaanderen (Onderzoeksproject G.0754.09)” and the “Bijzonder Onderzoeksfonds van de KU Leuven (OT/09/045).” MN is supported by a FLOF fellowship from the Department of Cellular and Molecular Medicine, KU Leuven. BW is a recipient of a DBOF fellowship (DBOF/10/059) from the KU Leuven.
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Wang, B., Apanasets, O., Nordgren, M., Fransen, M. (2014). Dissecting Peroxisome-Mediated Signaling Pathways: A New and Exciting Research Field. In: Brocard, C., Hartig, A. (eds) Molecular Machines Involved in Peroxisome Biogenesis and Maintenance. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1788-0_11
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DOI: https://doi.org/10.1007/978-3-7091-1788-0_11
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