Zusammenfassung
Angesichts der demografischen Bevölkerungsentwicklung ist die Kardiologie immer häufiger aufgefordert, sich mit Therapieentscheidungen bei hochbetagten Menschen zu beschäftigen. Dabei sind neben Komorbiditäten stets auch Patientenwünsche besonders zu berücksichtigen. Therapieziele verlagern sich mit zunehmendem Alter regelmäßig von Morbiditäts- bzw. Mortalitätsreduktion hin zu Verbesserung der Lebensqualität . Diese komplexen Anforderungen an kardiologische Behandlungsstrategien implizieren die Intensivierung eines interdisziplinären Vorgehens bei verschiedenen Krankheitsentitäten. Folgendes Kapitel setzt sich vorwiegend mit den verschiedenen Manifestationsformen der koronaren Herzkrankheit auseinander, da diese die häufigste Ursache kardiologischer Notfälle in einem geriatrischen Patientenkollektiv ist. Diverse andere Erkrankungen des Herzens sind im fortgeschrittenen Alter natürlich ebenfalls von großer Bedeutung, bedürfen aber seltener einer Notfallversorgung, sondern erfordern eher ein elektives oder zumindest semi-elektives Patientenmanagement. Aus diesem Grund werden sie in diesem Kapitel nicht im Detail beleuchtet, weshalb dieser Beitrag keinesfalls einen Anspruch auf Gesamtheit stellen kann. Zu den hier nicht ausführlich behandelten Erkrankungen gehören z. B. die im Folgenden aufgeführten.
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Literatur
Camm AJ, Lip GY, De Caterina R et al (2012) 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: An update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart 33(21):2719–2747
Murabito JM, Evans JC, Larson MG, Levy D (1993) Prognosis after the onset of coronary heart disease. An investigation of differences in outcome between the sexes according to initial coronary disease presentation. Circulation 88(6):2548–2555
Granger CB et al (2003) Predictors of hospital mortality in the Global Registry of Acute Coronary Events. Arch Intern Med 163:2345–2353
Alexander KP et al (2007) Acute coronary care in the elderly, part I. Circulation 115:2549–2569
Capodanno D et al (2010) Antithrombotic therapy in the elderly. JACC 56:1683–1692
Alexander KP et al (2005) Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. JAMA 294:3108–3116
Fox K et al (2006) The Task Force on the management of stable angina pectoris. Guidelines on the management of stable angina pectoris: executive summary. European Heart Journal 27:1341–1381
van de Werf F et al (2008) The Task Force on the management of ST-segment elevation acute myocardial infarction. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation. European Heart Journal 29:2909–2945
Hamm CW et al (2011) Task Force for the management of ACS in patients presenting without persistent ST-segment elevation. ESC guidelines for the management of ACS in patients presenting without persistent ST-segment elevation. European Heart Journal 32:2999–3054
Wiviott SD et al (2007) TRITON-TIMI 38 Investigators. Prasugrel versus Clopidogrel in patients with acute coronary syndromes. NEJM 357:2001–2015
Wallentin L et al (2009) PLATO Investigators. Ticagrelor versus Copidogrel in patients with acute coronary syndromes. NEJM 361:1–13
Dagenais et al (2006) Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials. Lancet 368(9538):581–588
Freemantle N et al (1999) Beta Blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 318:1730–1737
The Cardiac Insufficiency Bisoprolol Study II (CIBIS II): a randomised trial (1999) Lancet 353: 9–13
Flather MD et al (2005) Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). European Heart Journal 26(3):215–225
Perk J, De Backer G, Gohlke H et al (2012) European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 33(13):1635–1701 (for the Fifth Joint Task Force et al)
Reiner Z et al (2011) The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) ESC/EAS Guidelines for the management of dyslipidaemias. European Heart Journal 32:1769–1818
Yusuf S et al (2006) Comparison of fondaparinux and enoxaparin in acute coronary syndromes. NEJM 354:1464–1476
Lincoff AM et al (2004) Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial. JAMA 292:696–703
Cannon CP et al (2001) Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. NEJM 344:1879–1887 (for the TACTICS (Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy) – Thrombolysis in Myocardial Infarction, 18 Investigators)
de Winter RJ et al (2005) Early invasive versus selectively invasive management for acute coronary syndromes. NEJM 353:1095–1104 (for the Invasive versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS) Investigators)
Bhatt DL et al (2004) Utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative. JAMA 292:2096–2104
Krumholz HM et al (2003) Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 Study. Am Heart J 146:839–847
Alexander KP et al (2007) Acute coronary care in the elderly, part II. Circulation 115:2570–2589
Mehta RH et al (2001) Acute myocardial infarction in the elderly: differences by age. J Am Coll Cardiol 38:736–741
Goldberg RJ et al (2000) Decade-long trends and factors associated with time to hospital presentation in patients with acute myocardial infarction: the Worcester Heart Attack Study. Arch Intern Med 160:3217–3223
Berger AK et al (2000) Thrombolytic therapy in older patients. JACC 36:366–374
Eagle EA et al (2002) Practice variation and missed opportunities for reperfusion in ST segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE). Lancet 359:373–377
Armstrong PW, Gershlick AH, Goldstein P et al (2013) Fibrinolysis on Primary PCI in ST-Segment Elevation Myocordial Infarctions. N Engl J Med 368:1379–1387
Wallentin L et al (2003) Efficacy and safety of tenecteplase in combination with the low-molecular-weight heparin enoxaparin or unfractionated heparin in the prehospital setting: the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 PLUS Randomized Trial in Acute Myocardial Infarction. Circulation 108:135–142
Antman EM et al (2006) Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. NEJM 354:1477–1488 (for the ExTRACT-TIMI 25 Investigators)
Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group (1994) Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 343:311–322
Steg PG et al (2012) ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J : doi:10.1093/eurheartj/ehs215
Antman EM et al (2004) ACC/AHA Guidelines for the management of patients with ST-elevation myocardial infarction – executive summary. Circulation 110:588–636
Boersma E (2006) Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27:779–788 (for the Primary Coronary Angioplasty vs. Thrombolysis Group)
Boden WE et al (2007) Optimal medical therapy with or without PCI for stable coronary disease. NEJM 356:1503–1516 (for the COURAGE Trial Research Group)
TIME Investigators (2001) Trial of invasive versus medical therapy in elderly patients with chronic symptomatic coronary-artery disease (TIME): a randomized trial. Lancet 358:951–957
Pfisterer M et al (2003) Outcome of elderly patients with chronic symptomatic coronary artery disease with an invasive vs optimized medical treatment strategy. One-year results of the randomized TIME trial. JAMA 289:1117–1123 (for the TIME Investigators)
Pfisterer M et al (2004) Long-term outcome in elderly patients with chronic angina managed invasively versus by optimized medical therapy. Four-year follow-up of the randomized trial of invasive versus medical therapy in elderly patients (TIME). Circulation 110:1213–1218 (for the TIME Investigators)
Wijns W et al (2010) European Association for Percutaneous Cardiovascular Interventions (EAPCI) (2010) Guidelines on myocardial revascularisation. Eur Heart J 31(20):2501–2555 (for the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS); Epub 2010 Aug 29)
Farkouh ME, Domanski M, Sleeper LA et al for the FREEDOM Trial Investigators (2012) Strategies for multivessel revascularization in patients with diabetes. N Engl J Med Nov 4 [Epub ahead of print]
Ramanathan KB et al (2005) Percutaneous intervention versus coronary bypass surgery for patients older than 70 years of age with high-risk unstable angina. Ann Thorac Surg 80:1340–1346
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Alber, H., Pachinger , O. (2013). Kardiologische Therapie bei Hochbetagten. In: Pinter, G., Likar, R., Schippinger, W., Janig, H., Kada, O., Cernic, K. (eds) Geriatrische Notfallversorgung. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1581-7_27
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