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Special Features of Psychopharmacological Therapy in Children and Adolescents

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Psychiatric Drugs in Children and Adolescents

Abstract

Therapy with psychopharmacological agents of particular symptoms and psychiatric disorders in children and adolescents is part of a multi-faceted therapeutic approach including complementary psycho- and socio-therapeutic measures. This applies in particular to the treatment of children and adolescents with attention deficit/hyperactivity disorder (ADHD), tics and Tourette’s syndrome, elimination disorders (enuresis, encopresis), psychoses, personality disorders, obsessions and compulsions, panic attacks, and anxiety disorders, as well as mood disorders (major depressive disorders and bipolar disorders).

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Literature

  • Akullu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M (1996) Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 278:441–446

    Google Scholar 

  • American Psychiatric Association (2002) Quality indicators, defining and measuring quality in psychiatric care for adults and children. American Psychiatric Association, Washington, DC

    Google Scholar 

  • Bertilsson L (1995) Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. Clin Pharmacokinet 29:192–209

    Article  CAS  PubMed  Google Scholar 

  • Correll CU (2008) Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J Am Acad Child Psychiatry 47:9–20

    Article  Google Scholar 

  • Egberts K, Mehler-Wex C, Gerlach M (2011) Therapeutic drug monitoring in child and adolescent psychiatry. Pharmacopsychiatry 44:249–253

    Article  CAS  PubMed  Google Scholar 

  • Federow H, Tribl F, Halliday G, Gerlach M, Riederer P, Double K (2005) Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson’s disease. Prog Neurobiol 75:109–124

    Article  Google Scholar 

  • Fegert JM (1999) Patienten- und Elternaufklärung beim Einsatz atypischer Neuroleptika in der Jugendpsychiatrie. In: Fegert JM, Häßler F, Rothärmel S (eds) Atypische Neuroleptika in der Jugendpsychiatrie. Schattauer, Stuttgart/New York, pp 195–206

    Google Scholar 

  • Findling RL, McNamara NK, Stansbrey RJ, Feeny NC, Young CM, Peric FV, Youngstrom EA (2006) The relevance of pharmacokinetic studies in designing efficacy trials in juvenile major depression. J Child Adolesc Psychopharmacol 16:131–145

    Article  PubMed  Google Scholar 

  • Gerlach M, Wewetzer C (2008) Entwicklungspsychopharmakologie. In: Herpertz-Dahlmann B, Resch F, Schulte-Markwort M, Warnke A (eds) Entwicklungspsychiatrie. Biopsychologische Grundlagen und die Entwicklung psychischer Störungen, 2nd edn. Schattauer, Stuttgart, pp 372–407

    Google Scholar 

  • Gerlach M, Hünnerkopf R, Rothenhöfer S, Libal G, Burger R, Clement H-W, Fegert JM, Wewetzer C, Mehler-Wex C (2007) Therapeutic drug monitoring of quetiapine in adolescents with psychotic disorders. Pharmacopsychiatry 40:72–76

    Article  CAS  PubMed  Google Scholar 

  • Gerlach M, Klampfl K, Warnke A, Mehler-Wex C (2010) Characteristics of psychopharmacological treatment in children and adults. Psychopharmakotherapie 17:118–124

    Google Scholar 

  • Giedd JN, Vaituzis C, Hamburger SD, Lange N, Rajapakse JC, Kaysen D, Vauss YC, Rapoport JL (1996) Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4–18 years. J Comp Neurol 366:223–230

    Article  CAS  PubMed  Google Scholar 

  • Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, Paus T, Evans C, Rapoport JL (1999) Brain development during childhood and adolescence: a longitudinal. MRI study. Nat Neurosci 2:861–863

    Article  CAS  PubMed  Google Scholar 

  • Hiemke C, Baumann P, Bergemann N, Conca A, Dietmaier O, Egberts K, Fric M, Gerlach M, Greiner C, Gründer G, Haen E, Havemann-Reinecke U, Jaquenoud Sirot E, Kirchherr H, Laux G, Lutz UC, Messer T, Müller MJ, Pfuhlmann B, Rambeck B, Riederer P, Schoppek B, Stingl J, Uhr M, Ulrich S, Waschgler R, Zernig G, The TDM group of the AGNP (2011) AGNP consensus guidelines for therapeutic drug monitoring in psychiatry – update 2011. Pharmacopsychiatry 44:195–235

    Article  Google Scholar 

  • Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology – drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167

    Article  CAS  PubMed  Google Scholar 

  • Kirchheiner J, Rodriguez-Antona C (2009) Cytochrome P450 2D6 genotyping. Potential role in improving treatment outcomes in psychiatric disorders. CNS Drugs 23:181–191

    Article  CAS  PubMed  Google Scholar 

  • Kölch M, Schnoor K, Fegert J (2007) The EU-regulation on medicinal products for paediatric use. Impacts on child and adolescent psychiatry and clinical research with minors. Eur Child Adolesc Psychiatry 16:229–235

    Article  PubMed  Google Scholar 

  • Kölch M, Schnoor K, Fegert JM (2008) Ethical issues in psychopharmacology of children and adolescents. Curr Opin Psychiatry 21:598–605

    Article  Google Scholar 

  • McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, Arnold LE, Lindsay R, Nash P, Hollway J, McDougle CJ, Posey D, Swiezy N, Kohn A, Scahill L, Martin A, Koenig K, Volkmar F, Carroll D, Lancor A, Tierney E, Ghuman J, Gonzalez NM, Grados M, Vitiello B, Ritz L, Davies M, Robinson J, McMahon G, for Research Units on Pediatric Psychopharmacology Autism Network (2002) Risperidone in children with autism and serious behavioral problems. N Engl J Med 347:314–321

    Article  CAS  PubMed  Google Scholar 

  • Mehler-Wex C, Kölch M, Kirchheimer J, Antony G, Fegert JM, Gerlach M (2009) Therapeutic drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacology. Child Adolesc Psychiatry Ment Health 3:14. doi:10.1186/1753-200-3-14

    Article  PubMed Central  PubMed  Google Scholar 

  • Morselli PL, Cuche H, Zarifian E (1978) Pharmacokinetics of psychotropic drugs in the pediatric patient. In: Mendlewicz J, van Praag HM (eds) Childhood psychopharmacology: current concepts. Advances in biological psychiatry. Karger, Basel, pp 70–86

    Google Scholar 

  • Remschmidt H, Schmidt M, Poustka F (2001) Multiaxiales Klassifikationsschema für psychische Störungen im Kindes- und Jugendalter, 4th edn. Huber-Verlag, Berne

    Google Scholar 

  • Retz W, Kornhuber J, Riederer P (1996) Neurotransmission and the ontology of human brain. J Neural Transm 103:403–419

    Article  CAS  PubMed  Google Scholar 

  • Rivera-Calimlin L, Griesbach PH, Perlmutter R (1979) Plasma chlorpromazine concentrations in children with behavioral disorders and mental illness. Clin Pharmacol Ther 26:114–121

    Google Scholar 

  • Rogers AS (1994) A research agenda for the study of therapeutic agents in adolescents. J Adolesc Health 15:672–678

    Article  CAS  PubMed  Google Scholar 

  • Schatzberg AF, Cole JO, DeBattista C (2003) Manual of clinical psychopharmacology, 4th edn. American Psychiatry Publishing, Washington, DC/London

    Google Scholar 

  • Seeman P, Bzowej NH, Guan H-C, Bergeron C, Becker LE, Reynolds GP, Bird ED, Riederer P, Jellinger K, Watanabe S, Tourtellotte W (1987) Human brain dopamine receptors in children and adolescents. Synapse 1:399–404

    Article  CAS  PubMed  Google Scholar 

  • Stoyanova-Beninska VV, Wohlfarth T, Isaac M, Kalverdijk LL, van den Berg H, Gispen-de Wied C (2011) The EU paediatric regulation. Effects on paediatric psychopharmacology in Europe. Eur Neuropsychopharmacol 21:565–570

    Article  CAS  PubMed  Google Scholar 

  • Thompson PM, Gieddi JN, Woods RP, MacDonald D, Evans AC, Toga AW (2000) Growth patterns in the developing brain detected by using continuum mechanical tensor maps. Nature 404:190–193

    Article  CAS  PubMed  Google Scholar 

  • Wedlund P (2000) The CYP2C19 enzyme polymorphism. Pharmacology 61:174–183

    Article  CAS  PubMed  Google Scholar 

  • Zito JM, Derivan AT, Kratochvil CJ, Safer DJ, Fegert JM, Greenhill L (2008) Off-label psychopharmacologic prescribing for children: history supports close clinical monitoring. Child Adolesc Psychiatry Ment Health 2:24. doi:10.1186/1753-2000-1182-1124

    Article  PubMed Central  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Laboratory for Clinical Neurobiology and Therapeutic Drug Monitoring, University of Würzburg, Füchsleinstr. 15, 97080, Würzburg, Germany

    Manfred Gerlach PhD

  2. NYS Psychiatric Institute, New York Presbyterian Hospital, Riverside Drive 1051, New York, NY, 10032, USA

    Laurence Greenhill MD

  3. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstr. 15, 97080, Würzburg, Germany

    Andreas Warnke MD

Authors
  1. Manfred Gerlach PhD
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  2. Laurence Greenhill MD
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  3. Andreas Warnke MD
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Corresponding author

Correspondence to Manfred Gerlach PhD .

Editor information

Editors and Affiliations

  1. Kinder- und Jugendpsychiatrie, Universitätsklinikum Würzburg Klinik und Poliklinik, Würzburg, Germany

    Manfred Gerlach

  2. Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Würzburg Klinik und Poliklinik für Kinder- und, Würzburg, Germany

    Andreas Warnke

  3. Child and Adolescent Psychiatry New York Presbyterian Hospital, New York, New York, USA

    Laurence Greenhill

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Gerlach, M., Greenhill, L., Warnke, A. (2014). Special Features of Psychopharmacological Therapy in Children and Adolescents. In: Gerlach, M., Warnke, A., Greenhill, L. (eds) Psychiatric Drugs in Children and Adolescents. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1501-5_2

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  • DOI: https://doi.org/10.1007/978-3-7091-1501-5_2

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1500-8

  • Online ISBN: 978-3-7091-1501-5

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