Abstract
Traumatic brain injuries demonstrate various symptoms, including the disturbance of higher brain function, which is not visualized as a morphological lesion on magnetic resonance (MR) imaging. We examined the use of iomazenil single photon emission computed tomography (SPECT) for patients with traumatic brain injury and evaluated its diagnostic value. The study population included patients who were admitted to our hospital for traumatic brain injuries. All patients survived and were discharged from our hospital. MR imaging and iomazenil SPECT were examined during the acute and/or chronic phases. MR images were acquired using a 1.5-T clinical instrument. The T1- and T2-weighted and fluid-attenuated inversion recovery (FLAIR) axial images were evaluated. SPECT images were acquired using a multi-detector SPECT machine 3 h after the intravenous injection of 740 MBq of iomazenil. Axial, statistically analyzed images and stereotactic extraction estimation images were reconstructed and evaluated statistically based on the Z-score for each cerebral cortex. Iomazenil SPECT showed various lesions that were not demonstrated by MR imaging. Some clinical symptoms correlated with the iomazenil SPECT findings. Iomazenil SPECT is thus considered to be valuable for evaluating both brain lesions and the brain function after traumatic brain injury.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Abi-Dargham A, Laruelle M, Seibyl J, Rattner Z, Baldwin RM, Zoghbi SS et al (1994) SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms. J Nucl Med 35:228–238
Gowda NK, Agrawal D, Bal C, Chandrashekar N, Tripati M, Bandopadhyaya GP et al (2006) Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. AJNR Am J Neuroradiol 27:447–451
Hashimoto K, Abo M (2009) Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with mild traumatic brain injury. J Rehabil Med 41:661–665
Hatazawa J, Satoh T, Shimosegawa E, Okudera T, Inugami A, Ogawa T et al (1995) Evaluation of cerebral infarction with iodine 123-iomazenil SPECT. J Nucl Med 36:2154–2161
Hatazawa J, Shimosegawa E, Satoh T, Kanno I, Uemura K (1995) Central benzodiazepine receptor distribution after subcortical hemorrhage evaluated by means of [123I]iomazenil and SPECT. Stroke 26:2267–2271
Koizumi H, Fujisawa H, Kurokawa T, Suehiro E, Iwanaga H, Nakagawara J et al (2010) Recovered neuronal viability revealed by iodine-123-iomazenil SPECT following traumatic brain injury. J Cereb Blood Flow Metab 30:1673–1681
Nakagawara J, Sperling B, Lassen NA (1997) Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil. Stroke 28:124–132
Savic I, Roland P, Sedvall GR, Persson A, Pauli S, Widen L (1988) In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. Lancet 332:863–866
Conflict of Interest
This study was partially supported by a Research Grant for the authors from ZENKYOREN (National Mutual Insurance Federation of Agricultural Cooperatives).
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Wien
About this paper
Cite this paper
Shibata, Y., Endo, K. (2013). Evaluation of Cerebral Function Using Iomazenil SPECT for Patients with Traumatic Brain Injury. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_48
Download citation
DOI: https://doi.org/10.1007/978-3-7091-1434-6_48
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-1433-9
Online ISBN: 978-3-7091-1434-6
eBook Packages: MedicineMedicine (R0)