Abstract
Purpose: Vasogenic edema on glioblastoma multiforme (GBM) or a metastatic brain tumor (METS) may have different T2 relaxation time values because it involves an increased water component. In this study, we assessed the diagnostic utility of T2 mapping techniques in distinguishing GBM from METS.
Materials and Methods: We studied a glioblastoma (GBM) patient and a metastatic brain tumor (METS) patient who had not undergone previous surgery or treatment. All MR imaging was carried out using a 3.0-T whole-body unit, and axial T2 maps were generated with five TEs (TE = 20, 40, 60, 80, and 100 ms). Data were analyzed by using image processing and analysis software.
Results: The T2 map of a GBM case showed that the peritumoral area at a T2 relaxation time of 120–160 ms is prominent compared with the area at 210–240 ms. In contrast, the peritumoral area at 210–240 ms was prominent compared with the area at 120–160 ms in a METS case.
Conclusion: The distribution of T2 relaxation time in the peritumoral area shows different patterns in glioblastomas and metastatic brain tumors.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Soffietti R, Ruda R, Mutani R (2002) Management of brain metastases. J Neurol 249:1357–1369. doi:10.1007/s00415-002-0870-6
Prather JL, Long JM, van Heertum R, Hardman J (1975) Multicentric and isolated multifocal glioblastoma multiforme simulating metastatic disease. Br J Radiol 48:10–15
Kurki T, Lundbom N, Valtonen S (1995) Tissue characterisation of intracranial tumours: the value of magnetisation transfer and conventional MRI. Neuroradiology 37:515–521
Laakso MP, Partanen K, Soininen H, Lehtovirta M, Hallikainen M, Hanninen T, Helkala EL, Vainio P, Riekkinen PJ Sr (1996) MR T2 relaxometry in Alzheimer’s disease and age-associated memory impairment. Neurobiol Aging 17:535–540
Jacobs MA, Mitsias P, Soltanian-Zadeh H, Santhakumar S, Ghanei A, Hammond R, Peck DJ, Chopp M, Patel S (2001) Multiparametric MRI tissue characterization in clinical stroke with correlation to clinical outcome: part 2. Stroke 32:950–957
Yanagawa Y, Tsushima Y, Tokumaru A, Un-no Y, Sakamoto T, Okada Y, Nawashiro H, Shima K (2000) A quantitative analysis of head injury using T2*-weighted gradient-echo imaging. J Trauma 49:272–277
Thurnher MM, Thurnher SA, Fleischmann D, Steuer A, Rieger A, Helbich T, Trattnig S, Schindler E, Hittmair K (1997) Comparison of T2-weighted and fluid-attenuated inversion-recovery fast spin-echo MR sequences in intracerebral AIDS-associated disease. AJNR Am J Neuroradiol 18:1601–1609
Stevenson VL, Parker GJ, Barker GJ, Birnie K, Tofts PS, Miller DH, Thompson AJ (2000) Variations in T1 and T2 relaxation times of normal appearing white matter and lesions in multiple sclerosis. J Neurol Sci 178:81–87
Opstad KS, Murphy MM, Wilkins PR, Bell BA, Griffiths JR, Howe FA (2004) Differentiation of metastases from high-grade gliomas using short echo time 1H spectroscopy. J Magn Reson Imaging 20:187–192. doi:10.1002/jmri.20093
Ishimaru H, Morikawa M, Iwanaga S, Kaminogo M, Ochi M, Hayashi K (2001) Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy. Eur Radiol 11:1784–1791
Tsuchiya K, Fujikawa A, Nakajima M, Honya K (2005) Differentiation between solitary brain metastasis and high-grade glioma by diffusion tensor imaging. Br J Radiol 78:533–537. doi:10.1259/bjr/68749637
Lu S, Ahn D, Johnson G, Cha S (2003) Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors. AJNR Am J Neuroradiol 24:937–941
Tang YM, Ngai S, Stuckey S (2006) The solitary enhancing cerebral lesion: can FLAIR aid the differentiation between glioma and metastasis? AJNR Am J Neuroradiol 27:609–611. doi: 27/3/609[pii]
Kelly PJ, Daumas-Duport C, Kispert DB, Kall BA, Scheithauer BW, Illig JJ (1987) Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms. J Neurosurg 66:865–874. doi:10.3171/jns.1987.66.6.0865
Stuckey SL, Wijedeera R (2008) Multicentric/multifocal cerebral lesions: can fluid-attenuated inversion recovery aid the differentiation between glioma and metastases? J Med Imaging Radiat Oncol 52:134–139. doi: ARA1931[pii]10.1111/j.1440-1673.2008.01931.x
Conflict of Interest
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Wien
About this paper
Cite this paper
Nakai, K., Nawashiro, H., Shima, K., Kaji, T. (2013). An Analysis of T2 Mapping on Brain Tumors. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_36
Download citation
DOI: https://doi.org/10.1007/978-3-7091-1434-6_36
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-1433-9
Online ISBN: 978-3-7091-1434-6
eBook Packages: MedicineMedicine (R0)