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Aging of Human Mesenchymal Stem Cells

  • Chapter
Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Abstract

Mesenchymal stem cells (MSCs) are multipotent precursors with osteogenic, chondrogenic, and adipogenic yet also anti-inflammatory and tissue-protective properties. Due to organism aging, the controlled perpetuation and continuance of developmental principles comprising cellular, interstitial, and systemic cues, stem cell proliferation, as well as progenitor differentiation appears to become constricted. Over the recent years, during which abundant information regarding MSC biology has been gathered, also a plethora of information regarding age-associated changes and molecular mechanisms has been collected, which are comprehended in this contribution, in particular regarding insights derived from both in vitro and in vivo analyses which cover alterations in DNA and chromatin modifications, as well as changes in regulatory elements such as miRNAs.

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Acknowledgments

Our work was previously funded by the Austrian Science Fund and the Jubilee Fund of the Austrian National Bank. Currently our research is supported by grants gifted by the EC (FP7 – Health VascuBone, Marie Curie Re-integration HyalStemAge), the Austrian Research Agency (Laura Bassi Centre for Excellence – DIALIFE), and the Tyrolean Future Fund (Translational Project – Smart Implants).

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Authors and Affiliations

  1. Department of Cell Biology and Physiology, Stem Cell and Healthy Longevity Research, University Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria

    Günter Lepperdinger

  2. Department of Extracellular Matrix Research, Institute for Biomedical Aging Research, Universität Innsbruck, Rennweg 10, A-6020, Innsbruck, Austria

    Günter Lepperdinger & Stephan Reitinger

  3. Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria

    Günter Lepperdinger & Stephan Reitinger

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  1. Günter Lepperdinger
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  2. Stephan Reitinger
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Correspondence to Günter Lepperdinger .

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Editors and Affiliations

  1. Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Hartmut Geiger

  2. Department of Biology, University of Rochester, Rochester, New York, USA

    Heinrich Jasper

  3. Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Maria Carolina Florian

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Lepperdinger, G., Reitinger, S. (2015). Aging of Human Mesenchymal Stem Cells. In: Geiger, H., Jasper, H., Florian, M. (eds) Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1232-8_11

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