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Hormone bei therapieresistenten affektiven Störungen

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Therapieresistenz bei Depressionen und bipolaren Störungen

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Zusammenfassung

Die Bedeutung von Hormonen für affektive Störungen wird seit langem erforscht. Das Vorkommen psychiatrischer Symptome bei primären Schilddrüsenerkrankungen ist häufig, aber unspezifisch. Schilddrüsenhormone scheinen die Wirksamkeit von Antidepressiva beschleunigen zu können. Dies gilt für uni- und bipolare affektive Störungen und in besonderem Maße für das Rapid Cycling.

Die Auswirkungen von Sexualhormonen auf verschiedene Neurotransmittersysteme im zentralen Nervensystem gelten als wichtigste definierende Variable dafür, dass Frauen innerhalb ihres reproduktionsfähigen Alters doppelt so häufig unter einer unipolaren Major Depression leiden wie Männer. So kann die alleinige oder augmentative Gabe von Estrogen eine wirksame Behandlung depressiver, vor allem peri- und postmenopausaler Frauen darstellen. Hypogonadale Männer, die an einer Dysthymie leiden, können von einer Testosteronbehandlung profitieren. Eine alleinige Gabe von Testosteron stellt jedoch keine effektive Behandlung der Major Depression bei Männern dar.

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Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland

    Hannelore Findeis & Michael Bauer

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  1. Hannelore Findeis
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  2. Michael Bauer
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Correspondence to Michael Bauer .

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Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland

    Michael Bauer

  2. Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Anne Berghöfer

  3. Klinische Psychologie und Psychotherapie, Zentrum für Psychologische Psychotherapie, Universität Greifswald, Greifswald, Deutschland

    Eva-Lotta Brakemeier

  4. Fliedner Klinik Berlin und Klinik für Psychiatrie und Psychotherapie, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Deutschland

    Mazda Adli

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Findeis, H., Bauer, M. (2022). Hormone bei therapieresistenten affektiven Störungen. In: Bauer, M., Berghöfer, A., Brakemeier, EL., Adli, M. (eds) Therapieresistenz bei Depressionen und bipolaren Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65734-8_9

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