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Nichtinvasive Hirnstimulationsverfahren

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Therapieresistenz bei Depressionen und bipolaren Störungen

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Zusammenfassung

Nichtinvasive Hirnstimulationsverfahren wie beispielsweise die transkranielle Magnetstimulation und die transkranielle Gleichstromstimulation haben sich in zahlreichen Studien und einigen Metaanalysen als vielversprechende Behandlungsmöglichkeiten von depressiven Symptomen bei unipolarer und teilweise auch bipolarer Störung erwiesen. In diesem Kapitel gehen wir auf die theoretischen Grundlagen der verschiedenen Hirnstimulationsverfahren und auf die zugrunde liegenden pathophysiologischen Prozesse affektiver Erkrankungen ein. Zudem bieten wir eine Zusammenfassung der wichtigsten klinischen Studien zu diesem Thema und schlagen vor, wie man nichtinvasive Gehirnstimulationsverfahren in die klinische Praxis integrieren kann.

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Literatur

  • Alexander ML, Alagapan S, Lugo CE, Mellin JM, Lustenberger C, Rubinow DR et al (2019) Double-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (tACS) for the treatment of major depressive disorder (MDD). Transl Psychiatry 9:106

    Article  PubMed  PubMed Central  Google Scholar 

  • Alonzo A, Fong J, Ball N, Martin D, Chand N, Loo C (2019) Pilot trial of home-administered transcranial direct current stimulation for the treatment of depression. J Affect Disord 252:475–483

    Article  PubMed  Google Scholar 

  • Antal A, Alekseichuk I, Bikson M, Brockmöller J, Brunoni AR, Chen R et al (2017) Low intensity transcranial electric stimulation: safety, ethical, legal regulatory and application guidelines. Clin Neurophysiol 128:1774–1809

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arns M, Drinkenburg WH, Fitzgerald PB, Kenemans JL (2012) Neurophysiological predictors of non-response to rTMS in depression. Brain Stimul 5:569–576

    Article  PubMed  Google Scholar 

  • Baeken C, De Raedt R, Bossuyt A, Van Hove C, Mertens J, Dobbeleir A et al (2011) The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression. Brain Stimul 4:104–111. https://doi.org/10.1016/j.brs.2010.09.002

    Article  PubMed  Google Scholar 

  • Baeken C, De Raedt R, Leyman L, Schiettecatte J, Kaufman L, Poppe K et al (2009a) The impact of one HF-rTMS session on mood and salivary cortisol in treatment resistant unipolar melancholic depressed patients. J Affect Disord 113:100–108

    Article  CAS  PubMed  Google Scholar 

  • Baeken C, De Raedt R, Van Hove C, Clerinx P, De Mey J, Bossuyt A (2009b) HF-rTMS treatment in medication-resistant melancholic depression: results from 18FDG-PET brain imaging. CNS Spectr 14:439–448

    Article  PubMed  Google Scholar 

  • Baeken C, Marinazzo D, Wu G-R, Van Schuerbeek P, De Mey J, Marchetti I et al (2014) Accelerated HF-rTMS in treatment-resistant unipolar depression: insights from subgenual anterior cingulate functional connectivity. World J Biol Psychiatry 15:286–297

    Article  PubMed  Google Scholar 

  • Bajbouj M, Brakemeier E-L, Schubert F, Lang UE, Neu P, Schindowski C et al (2005) Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex and cortical excitability in patients with major depressive disorder. Exp Neurol 196:332–338

    Article  PubMed  Google Scholar 

  • Barker AT, Jalinous R, Freeston IL (1985) Non-invasive magnetic stimulation of human motor cortex. Lancet 325:1106–1107

    Article  Google Scholar 

  • Beam W, Borckardt JJ, Reeves ST, George MS (2009) An efficient and accurate new method for locating the F3 position for prefrontal TMS applications. Brain Stimul 2:50–54

    Article  PubMed  PubMed Central  Google Scholar 

  • Bikson M, Grossman P, Thomas C, Zannou AL, Jiang J, Adnan T et al (2016) Safety of transcranial direct current stimulation: evidence based update 2016. Brain Stimul 9:641–661

    Article  PubMed  PubMed Central  Google Scholar 

  • Blumberger DM, Mulsant BH, Fitzgerald PB, Rajji TK, Ravindran AV, Young LT et al (2012) A randomized double-blind sham-controlled comparison of unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant major depression. World J Biol Psychiatry 13:423–435

    Article  PubMed  Google Scholar 

  • Blumberger DM, Vila-Rodriguez F, Thorpe KE, Feffer K, Noda Y, Giacobbe P et al (2018) Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial. Lancet 391:1683–1692

    Article  PubMed  Google Scholar 

  • Blumberger DM, Vila-Rodriguez F, Wang W, Knyahnytska Y, Butterfield M, Noda Y et al (2021) A randomized sham controlled comparison of once vs twice-daily intermittent theta burst stimulation in depression: A Canadian rTMS treatment and biomarker network in depression (CARTBIND) study. Brain Stimul 14:1447–1455

    Article  PubMed  Google Scholar 

  • Brunoni AR, Machado-Vieira R, Zarate CA Jr, Vieira ELM, Vanderhasselt M-A, Nitsche MA et al (2014) BDNF plasma levels after antidepressant treatment with sertraline and transcranial direct current stimulation: results from a factorial, randomized, sham-controlled trial. Eur Neuropsychopharmacol 24:1144–1151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunoni AR, Moffa AH, Fregni F, Palm U, Padberg F, Blumberger DM et al (2016) Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data. Br J Psychiatry 208:522–531

    Article  PubMed  PubMed Central  Google Scholar 

  • Brunoni AR, Chaimani A, Moffa AH, Razza LB, Gattaz WF, Daskalakis ZJ et al (2017a) Repetitive transcranial magnetic stimulation for the acute treatment of major depressive episodes: a systematic review With network meta-analysis. JAMA Psychiat 74:143–152

    Google Scholar 

  • Brunoni AR, Moffa AH, Sampaio-Junior B, Borrione L, Moreno ML, Fernandes RA et al (2017b) Trial of electrical direct-current therapy versus escitalopram for depression. N Engl J Med 376:2523–2533

    Google Scholar 

  • Brunoni AR, Valiengo L, Baccaro A, Zanão TA, de Oliveira JF, Goulart A, et al (2013a) The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry ;70:383–91

    Google Scholar 

  • Brunoni AR, Vanderhasselt M-A, Boggio PS, Fregni F, Dantas EM, Mill JG et al (2013b) Polarity- and valence-dependent effects of prefrontal transcranial direct current stimulation on heart rate variability and salivary cortisol. Psychoneuroendocrinology 38:58–66

    Google Scholar 

  • Bulubas L, Padberg F, Bueno PV, Duran F, Busatto G, Amaro E Jr et al (2019) Antidepressant effects of tDCS are associated with prefrontal gray matter volumes at baseline: evidence from the ELECT-TDCS trial. Brain Stimul 12:1197–1204

    Article  PubMed  Google Scholar 

  • Chen M, Yang X, Liu C, Li J, Wang X, Yang C, et al (2021) Comparative efficacy and cognitive function of magnetic seizure therapy vs. electroconvulsive therapy for major depressive disorder: a systematic review and meta-analysis. Transl Psychiatry ;11:437

    Google Scholar 

  • Cho SS, Strafella AP (2009) rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex. PLoS ONE 4:e6725

    Article  PubMed  PubMed Central  Google Scholar 

  • Chou Y-H, Ton That V, Chen AY-C, Sundman M, Huang Y-Z. TMS-induced seizure cases stratified by population, stimulation protocol, and stimulation site: A systematic literature search. Clin Neurophysiol 2020;131:1019–20

    Google Scholar 

  • Cogné M, Gil-Jardiné C, Joseph P-A, Guehl D, Glize B (2017) Seizure induced by repetitive transcranial magnetic stimulation for central pain: adapted guidelines for post-stroke patients. Brain Stimul 10:862–864

    Article  PubMed  Google Scholar 

  • Cole EJ, Stimpson KH, Bentzley BS, Gulser M, Cherian K, Tischler C et al (2020) Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression. Am J Psychiatry 177:716–726

    Google Scholar 

  • Deng Z-D, Lisanby SH, Peterchev AV (2011) Electric field strength and focality in electroconvulsive therapy and magnetic seizure therapy: a finite element simulation study. J Neural Eng 8:016007

    Article  PubMed  PubMed Central  Google Scholar 

  • Dondé C, Amad A, Nieto I, Brunoni AR, Neufeld NH, Bellivier F, Poulet E, Geoffroy PA (August 2017) Transcranial direct-current stimulation (tDCS) for bipolar depression: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 1(78):123–131

    Google Scholar 

  • Downar J, Daskalakis ZJ (2013) New targets for rTMS in depression: a review of convergent evidence. Brain Stimul 6:231–240

    Article  PubMed  Google Scholar 

  • Drysdale AT, Grosenick L, Downar J, Dunlop K, Mansouri F, Meng Y et al (2017) Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nat Med 23:28–38. https://doi.org/10.1038/nm.4246

    Article  CAS  PubMed  Google Scholar 

  • Ekici B (2015) Transcranial direct current stimulation-induced seizure: analysis of a case. Clin EEG Neurosci 46:169

    Article  PubMed  Google Scholar 

  • Elyamany O, Leicht G, Herrmann CS, Mulert C (2021) Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry. Eur Arch Psychiatry Clin Neurosci 271:135–156

    Article  PubMed  Google Scholar 

  • Fitzgerald PB, Brown TL, Marston NAU, Daskalakis ZJ, De Castella A, Kulkarni J (2003) Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry 60:1002–1008

    Article  PubMed  Google Scholar 

  • Fitzgerald PB, Hoy KE, Elliot D, McQueen S, Wambeek LE, Chen L et al (2018) A pilot study of the comparative efficacy of 100 Hz magnetic seizure therapy and electroconvulsive therapy in persistent depression. Depress Anxiety 35:393–401

    Article  PubMed  Google Scholar 

  • Fonteneau C, Mondino M, Arns M, Baeken C, Bikson M, Brunoni AR et al (2019) Sham tDCS: a hidden source of variability? Reflections for further blinded, controlled trials. Brain Stimul 12:668–673

    Article  PubMed  Google Scholar 

  • Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A (2006) Treatment of major depression with transcranial direct current stimulation. Bipolar Disord 8:203–204

    Article  PubMed  Google Scholar 

  • Fregni F, El-Hagrassy MM, Pacheco-Barrios K, Carvalho S, Leite J, Simis M et al (2021) Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation in neurological and psychiatric disorders. Int J Neuropsychopharmacol 24:256–313

    Article  PubMed  Google Scholar 

  • Fried PJ, Santarnecchi E, Antal A, Bartres-Faz D, Bestmann S, Carpenter LL et al (2021) Training in the practice of noninvasive brain stimulation: recommendations from an IFCN committee. Clin Neurophysiol 132:819–837

    Article  PubMed  Google Scholar 

  • Gaede G, Tiede M, Lorenz I, Brandt AU, Pfueller C, Dörr J et al (2018) Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue. Neurol Neuroimmunol Neuroinflamm 5:e423

    Article  PubMed  Google Scholar 

  • George MS, Ketter TA, Post RM (1994) Prefrontal cortex dysfunction in clinical depression. Depression 2:59–72

    Article  Google Scholar 

  • George MS, Wassermann EM, Williams WA, Callahan A, Ketter TA, Basser P et al (1995) Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. NeuroReport 6:1853–1856

    Article  CAS  PubMed  Google Scholar 

  • George MS, Wassermann EM, Williams WA, Steppel J, Pascual-Leone A, Basser P et al (1996) Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation (rTMS) of the prefrontal cortex. J Neuropsychiatry Clin Neurosci 8:172–180

    Article  CAS  PubMed  Google Scholar 

  • Goerigk SA, Padberg F, Bühner M, Sarubin N, Kaster TS, Daskalakis ZJ et al (2021a) Distinct trajectories of response to prefrontal tDCS in major depression: results from a 3-arm randomized controlled trial. Neuropsychopharmacology 46:774–782

    Article  CAS  PubMed  Google Scholar 

  • Goerigk SA, Padberg F, Chekroud A, Kambeitz J, Bühner M, Brunoni AR (2021b) Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: a symptom clustering approach on ELECT-TDCS. Brain Stimul 14:906–912

    Article  PubMed  Google Scholar 

  • Groiss SJ, Trenado C, Sabel M, Schnitzler A, Wojtecki L (2017) Focal seizure induced by preoperative navigated transcranial magnetic stimulation in a patient with anaplastic oligoastrocytoma. Brain Stimul 10:331–332

    Article  PubMed  Google Scholar 

  • Hesdorffer DC, Ishihara L, Mynepalli L, Webb DJ, Weil J, Hauser WA (2012) Epilepsy, suicidality, and psychiatric disorders: a bidirectional association. Ann Neurol 72:184–191

    Article  PubMed  Google Scholar 

  • Höflich G, Kasper S, Hufnagel A, Ruhrmann S, Möller H-J (1993) Application of transcranial magnetic stimulation in treatment of drug-resistant major depression-a report of two cases. Hum Psychopharmacol 8:361–365

    Article  Google Scholar 

  • Hone-Blanchet A, Edden RA, Fecteau S (2016) Online effects of transcranial direct current stimulation in real time on human prefrontal and striatal metabolites. Biol Psychiatry 80:432–438

    Google Scholar 

  • Huang Y-Z, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron 45:201–206

    Article  CAS  PubMed  Google Scholar 

  • Kambeitz J, Goerigk S, Gattaz W, Falkai P, Benseñor IM, Lotufo PA et al (2020) Clinical patterns differentially predict response to transcranial direct current stimulation (tDCS) and escitalopram in major depression: a machine learning analysis of the ELECT-TDCS study. J Affect Disord 265:460–467

    Article  PubMed  Google Scholar 

  • Kedzior KK, Gellersen HM, Brachetti AK, Berlim MT (2015) Deep transcranial magnetic stimulation (DTMS) in the treatment of major depression: an exploratory systematic review and meta-analysis. J Affect Disord 187:73–83

    Article  PubMed  Google Scholar 

  • Kito S, Hasegawa T, Fujita K, Koga Y (2010) Changes in hypothalamic-pituitary-thyroid axis following successful treatment with low-frequency right prefrontal transcranial magnetic stimulation in treatment-resistant depression. Psychiatry Res 175:74–77

    Article  CAS  PubMed  Google Scholar 

  • Lefaucheur J-P, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V et al (2020) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014–2018). Clin Neurophysiol 131:474–528

    Article  PubMed  Google Scholar 

  • Lefaucheur J-P, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH et al (2014) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol 125:2150–2206

    Article  PubMed  Google Scholar 

  • Lefaucheur J-P, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F et al (2017) Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol 128:56–92

    Article  PubMed  Google Scholar 

  • Lefaucheur JP, Lucas B, Andraud F, Hogrel JY, Bellivier F, Del Cul A et al (2008) Inter-hemispheric asymmetry of motor corticospinal excitability in major depression studied by transcranial magnetic stimulation. J Psychiatr Res 42:389–398

    Article  CAS  PubMed  Google Scholar 

  • Levkovitz Y, Isserles M, Padberg F, Lisanby SH, Bystritsky A, Xia G et al (2015) Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial. World Psychiatry 14:64–73

    Article  PubMed  PubMed Central  Google Scholar 

  • Li B-J, Friston K, Mody M, Wang H-N, Lu H-B, Hu D-W (2018) A brain network model for depression: from symptom understanding to disease intervention. CNS Neurosci Ther 24:1004–1019

    Article  PubMed  PubMed Central  Google Scholar 

  • Lisanby SH, Luber B, Schlaepfer TE, Sackeim HA (2003) Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy. Neuropsychopharmacology 28:1852–1865

    Article  PubMed  Google Scholar 

  • Liston C, Chen AC, Zebley BD, Drysdale AT, Gordon R, Leuchter B et al (2014) Default mode network mechanisms of transcranial magnetic stimulation in depression. Biol Psychiatry 76:517–526

    Article  PubMed  PubMed Central  Google Scholar 

  • Loo CK, Alonzo A, Martin D, Mitchell PB, Galvez V, Sachdev P (2012) Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. Br J Psychiatry 200:52–59

    Article  PubMed  Google Scholar 

  • Loo CK, Husain MM, McDonald WM, Aaronson S, O’Reardon JP, Alonzo A et al (2018) International randomized-controlled trial of transcranial direct current stimulation in depression. Brain Stimul 11:125–133

    Article  PubMed  Google Scholar 

  • Luborzewski A, Schubert F, Seifert F, Danker-Hopfe H, Brakemeier E-L, Schlattmann P et al (2007) Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression. J Psychiatr Res 41:606–615

    Article  PubMed  Google Scholar 

  • Merzagora AC, Foffani G, Panyavin I, Mordillo-Mateos L, Aguilar J, Onaral B et al (2010) Prefrontal hemodynamic changes produced by anodal direct current stimulation. Neuroimage 49:2304–2310

    Article  CAS  PubMed  Google Scholar 

  • Nguyen TD, Hieronymus F, Lorentzen R, McGirr A, Østergaard SD (Januar 2021) The efficacy of repetitive transcranial magnetic stimulation (rTMS) for bipolar depression: a systematic review and meta-analysis. J Affect Disord 15(279):250–255

    Google Scholar 

  • Nitsche MA, Kuo M-F, Karrasch R, Wächter B, Liebetanz D, Paulus W (2009) Serotonin affects transcranial direct current-induced neuroplasticity in humans. Biol Psychiatry 66:503–508

    Article  CAS  PubMed  Google Scholar 

  • Nitsche MA, Paulus W (2000) Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 527(Pt 3):633–639

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ontario Health (Quality) (2021) Repetitive transcranial magnetic stimulation for people with treatment-resistant depression: a health technology assessment. Ont Health Technol Assess Ser 21:1–232

    Google Scholar 

  • Opitz A, Paulus W, Will S, Antunes A, Thielscher A (2015) Determinants of the electric field during transcranial direct current stimulation. Neuroimage 109:140–150

    Article  PubMed  Google Scholar 

  • O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z et al (2007) Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 62:1208–1216

    Article  PubMed  Google Scholar 

  • Padberg F, Bulubas L, Mizutani-Tiebel Y, Burkhardt G, Kranz GS, Koutsouleris N, Kambeitz J, Hasan A, Takahashi S, Keeser D, Goerigk S, Brunoni AR (2021) The intervention, the patient and the illness – Personalizing non-invasive brain stimulation in psychiatry. Exp Neurol 341:113713. https://doi.org/10.1016/j.expneurol.2021.113713

    Article  PubMed  Google Scholar 

  • Palm U, Feichtner KB, Hasan A, Gauglitz G, Langguth B, Nitsche MA et al (2014) The role of contact media at the skin-electrode interface during transcranial direct current stimulation (tDCS). Brain Stimul 7:762–764

    Article  PubMed  Google Scholar 

  • Palm U, Kumpf U, Behler N, Wulf L, Kirsch B, Wörsching J et al (2018) Home use, remotely supervised, and remotely controlled transcranial direct current stimulation: a systematic review of the available evidence. Neuromodulation 21:323–333

    Article  PubMed  Google Scholar 

  • Pascual-Leone A, Valls-Solé J, Wassermann EM, Hallett M (1994) Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 117(Pt 4):847–858

    Article  PubMed  Google Scholar 

  • Pogarell O, Koch W, Pöpperl G, Tatsch K, Jakob F, Zwanzger P et al (2006) Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study. J Psychiatr Res 40:307–314

    Article  PubMed  Google Scholar 

  • Razza LB, Afonso Dos Santos L, Borrione L, Bellini H, Branco LC, Cretaz E, et al (2021a) Appraising the effectiveness of electrical and magnetic brain stimulation techniques in acute major depressive episodes: an umbrella review of meta-analyses of randomized controlled trials. Braz J Psychiatry 43:514–24

    Google Scholar 

  • Rossi S, Antal A, Bestmann S, Bikson M, Brewer C, Brockmöller J et al (2021) Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines. Clin Neurophysiol 132:269–306

    Article  PubMed  Google Scholar 

  • Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D et al (2006) Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 163:1905–1917

    Article  PubMed  Google Scholar 

  • Schecklmann M, Nejati V, Poeppl TB, Peytard J, Rupprecht R, Wetter TC et al (2021) Bifrontal high-frequency transcranial random noise stimulation is not effective as an add-on treatment in depression. J Psychiatr Res 132:116–122

    Article  PubMed  Google Scholar 

  • Smart OL, Tiruvadi VR, Mayberg HS (2015) Multimodal approaches to define network oscillations in depression. Biol Psychiatry 77:1061–1070

    Article  PubMed  PubMed Central  Google Scholar 

  • Szuba MP, O’Reardon JP, Rai AS, Snyder-Kastenberg J, Amsterdam JD, Gettes DR et al (2001) Acute mood and thyroid stimulating hormone effects of transcranial magnetic stimulation in major depression. Biol Psychiatry 50:22–27

    Article  CAS  PubMed  Google Scholar 

  • Tarapore PE, Picht T, Bulubas L, Shin Y, Kulchytska N, Meyer B et al (2016) Safety and tolerability of navigated TMS for preoperative mapping in neurosurgical patients. Clin Neurophysiol 127:1895–1900

    Article  PubMed  Google Scholar 

  • Tavares DF, Myczkowski ML, Alberto RL, Valiengo L, Rios RM, Gordon P et al (2017) Treatment of bipolar depression with deep TMS: results from a double-blind, randomized, parallel group. Sham-controlled glinical trial. Neuropsychopharmacology 42:2593–2601

    Google Scholar 

  • Theleritis C, Sakkas P, Paparrigopoulos T, Vitoratou S, Tzavara C, Bonaccorso S et al (2017) Two versus one high-frequency repetitive transcranial magnetic stimulation session per day for treatment-resistant depression: a randomized sham-controlled trial. J ECT 33:190–197

    Article  PubMed  Google Scholar 

  • Thielscher A, Kammer T (2004) Electric field properties of two commercial figure-8 coils in TMS calculation of focality and efficiency. Clin Neurophysiol 115:1697–1708

    Google Scholar 

  • Trapp NT, Bruss J, King Johnson M, Uitermarkt BD, Garrett L, Heinzerling A, et al (2020) Reliability of targeting methods in TMS for depression: Beam F3 vs. 5.5 cm. Brain Stimul 13:578–81

    Google Scholar 

  • Trevizol AP, Downar J, Vila-Rodriguez F, Thorpe KE, Daskalakis ZJ, Blumberger DM (2020) Predictors of remission after repetitive transcranial magnetic stimulation for the treatment of major depressive disorder: An analysis from the randomised non-inferiority THREE-D trial. EClin Med 22:100349

    Article  PubMed  PubMed Central  Google Scholar 

  • Voigt JD, Leuchter AF, Carpenter LL (2021) Theta burst stimulation for the acute treatment of major depressive disorder: a systematic review and meta-analysis. Transl Psychiatry 11:330

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang HX, Wang K, Sun ZC, Peng M, Xue Q, Li N, et al (2020) A pilot study of transcranial alternating current stimulation in the treatment of drug-naive adult patients with major depressive disorder. Zhonghua Yi Xue Za Zhi 100:197–201

    Google Scholar 

  • Weigand A, Horn A, Caballero R, Cooke D, Stern AP, Taylor SF et al (2018) Prospective validation that subgenual connectivity predicts antidepressant efficacy of transcranial magnetic stimulation sites. Biol Psychiatry 84:28–37

    Article  CAS  PubMed  Google Scholar 

  • Westin GG, Bassi BD, Lisanby SH, Luber B (2014) Determination of motor threshold using visual observation overestimates transcranial magnetic stimulation dosage: safety implications. Clin Neurophysiol 125:142–147

    Article  PubMed  Google Scholar 

  • Woods AJ, Antal A, Bikson M, Boggio PS, Brunoni AR, Celnik P et al (2016) A technical guide to tDCS and related non-invasive brain stimulation tools. Clin Neurophysiol 127:1031–1048

    Article  CAS  PubMed  Google Scholar 

  • Zanardini R, Gazzoli A, Ventriglia M, Perez J, Bignotti S, Rossini PM et al (2006) Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. J Affect Disord 91:83–86

    Article  CAS  PubMed  Google Scholar 

  • Zhang R, Lam CLM, Peng X, Zhang D, Zhang C, Huang R et al (2021) Efficacy and acceptability of transcranial direct current stimulation for treating depression: a meta-analysis of randomized controlled trials. Neurosci Biobehav Rev 126:481–490

    Article  PubMed  Google Scholar 

  • Ziemann U (2004) TMS induced plasticity in human cortex. Rev Neurosci 15:253–266

    Article  PubMed  Google Scholar 

  • Zwanzger P, Baghai TC, Padberg F, Ella R, Minov C, Mikhaiel P et al (2003) The combined dexamethasone-CRH test before and after repetitive transcranial magnetic stimulation (rTMS) in major depression. Psychoneuroendocrinology 28:376–385

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. LMU Klinikum München, Klinik für Psychiatrie und Psychotherapie, München, Deutschland

    Lucia Bulubas, Ulrike Kumpf & Frank Padberg

  2. Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Klinik für Psychiatrie und Psychotherapie, Berlin, Deutschland

    Malek Bajbouj

Authors
  1. Lucia Bulubas
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  2. Ulrike Kumpf
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  3. Malek Bajbouj
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  4. Frank Padberg
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Correspondence to Frank Padberg .

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Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland

    Michael Bauer

  2. Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Anne Berghöfer

  3. Klinische Psychologie und Psychotherapie, Zentrum für Psychologische Psychotherapie, Universität Greifswald, Greifswald, Deutschland

    Eva-Lotta Brakemeier

  4. Fliedner Klinik Berlin und Klinik für Psychiatrie und Psychotherapie, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Deutschland

    Mazda Adli

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Bulubas, L., Kumpf, U., Bajbouj, M., Padberg, F. (2022). Nichtinvasive Hirnstimulationsverfahren. In: Bauer, M., Berghöfer, A., Brakemeier, EL., Adli, M. (eds) Therapieresistenz bei Depressionen und bipolaren Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65734-8_18

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