Abstract
Biological repair for degenerative disk diseases has right now a very slide attention in the field of treatment for this very common disorder with a high impact in the public health community. Therapeutic options for biological repair include the substitution of growth factors, transplantation of cells, tissue engineering, and gene modification. The aim of the repair and regenerative treatment is to prevent further progression of disk degeneration, supplement tissue loss, and stabilizing anatomy that might diminish disk degeneration-associated symptoms. Among cell-based therapies, transplantation of autologous intervertebral disk cells harvested from herniated disk material seems to be a promising option [1, 2]. Harvesting the disk cell material is a standard procedure by performing a microsurgical sequestrectomy in cases of disk herniation. Cell separation, culture, and expansion, although not simple, are possible and should be done with appropriate expertise under GMP (good manufacturing practice) conditions. The proceeding for the transplantation is comparable to the former routinely performed discography.
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Hohaus, C., Meisel, H.J. (2023). Biological Repair Options in Degenerative Disk Diseases. In: Vieweg, U., Grochulla, F. (eds) Manual of Spine Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64062-3_15
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DOI: https://doi.org/10.1007/978-3-662-64062-3_15
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