Zusammenfassung
Die Leber ist das zentrale Stoffwechselorgan des Körpers. Besprochen wird die Bedeutung der Leber für den Gesamtmetabolismus. Es werden die physiologischen und anatomischen Aspekte, die für das Verständnis der Pathophysiologie der nicht-alkoholischen Fettlebererkrankung wesentlich sind, dargestellt.
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Literatur
Häussinger D (1996) Physiological functions of the liver. In: Greger R, Windhorst U (Hrsg) Comprehensive human physiology. Springer, Berlin
Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275(4):2247–2250
Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115(2):209–218
Reeves HL, Friedman SL (2002) Activation of hepatic stellate cells–a key issue in liver fibrosis. Front Biosci 7:d808–d826
Nassir F et al (2015) Pathogenesis and prevention of hepatic steatosis. Gastroenterol Hepatol (N Y) 11(3):167–175
Donnelly KL et al (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115(5):1343–1351
Horn F (2015) Biochemie des Menschen. Thieme, Stuttgart
Ter Horst KW, Serlie MJ (2017) Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. Nutrients 9(9):981
Marra F, Svegliati-Baroni G (2018) Lipotoxicity and the gut-liver axis in NASH pathogenesis. J Hepatol 68(2):280–295
Utzschneider KM, Kahn SE (2006) Review: The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 91(12):4753–4761
Srikanthan P, Karlamangla AS (2011) Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 96(9):2898–2903
Pratesi A, Tarantini F, Di Bari M (2013) Skeletal muscle: an endocrine organ. Clin Cases Miner Bone Metab 10(1):11–14
Buechler C, Wanninger J, Neumeier M (2011) Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol 17(23):2801–2811
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© 2022 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature
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Reiter, F.P., Denk, G. (2022). Physiologie der Leber im Gesamtmetabolismus. In: Geier, A., Canbay, A., Lammert, F. (eds) Nicht-alkoholische Fettlebererkrankung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-62484-5_4
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DOI: https://doi.org/10.1007/978-3-662-62484-5_4
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