Zusammenfassung
Die multimodale Therapie, bestehend aus zytoreduktiver Chirurgie (CRS) in Kombination mit hyperthermer intraperitonealer Chemotherapie (HIPEC) und systemischer Therapie, ist eine Therapieoption für Patienten mit primär peritonealen Neoplasien und Patienten mit sekundärer peritonealer Metastasierung.
Entscheidend für die Prognose ist neben der Qualität der operativen Therapie vor allem eine sorgfältige Patientenselektion. Durch die Auswahl geeigneter Patienten und die Anwendung standardisierter Operationstechniken kann das Gesamtüberleben im Vergleich zur alleinigen systemischen Therapie signifikant verlängert werden. Nach mehr als 3 Jahrzehnten klinischer Anwendung sind die Selektionskriterien für die einzelnen Tumorentitäten inzwischen gut definiert, das Therapieverfahren standardisiert und Komplikationsraten niedrig.
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Leebmann, H., Piso, P. (2023). Peritonealkarzinose und Erkrankungen des Peritoneums. In: Kreis, M., Bartsch, D.K., Lang, H. (eds) Viszeral- und Allgemeinchirurgie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-61724-3_61-1
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