Zusammenfassung
Die systemische medikamentöse Therapie neuroorthopädischer Erkrankungen bezieht sich vor allem auf die drei Symptome Spastik, Dystonie und Ataxie (hier vor allem Tremor). Während die Spastik mit den klassischen Antispastika wie Baclofen oder Tizanidin häufig auch in Ergänzung mit einer fokalen Botulinumtoxin-Therapie gut behandelt werden kann, sind die Möglichkeiten bei der Dystonie oder Ataxie meist deutlich begrenzt. In diesem Kapitel soll auf die einzelnen Substanzen, die Wirkmechanismen, die Limitationen und typische Nebenwirkungen eingegangen werden.
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Literatur
Albanese A, Barnes MP, Bhatia KP, Fernandez-Alvarez E, Filippini G, Gasser T, Krauss JK, Newton A, Rektor I, Savoiardo M, Valls-Sole J (2006) A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. Eur J Neurol 13:433–444
Carranza-del Rio J, Clegg NJ, Moore A, Delgado MR (2011) Use of trihexyphenidyl in children with cerebral palsy. Pediatr Neurol 44:202–206
Cutter NC, Scott DD, Johnson JC, Whiteneck G (2000) Gabapentin effect on spasticity in multiple sclerosis: a placebo-controlled, randomized trial. Arch Phys Med Rehabil 81:164–169
Ertzgaard P, Campo C, Calabrese A (2017) Efficacy and safety of oral baclofen in the management of spasticity: a rationale for intrathecal baclofen. J Rehabil Med 49:193–203
Harvey AR, Baker LB, Reddihough DS, Scheinberg A, Williams K (2018) Trihexyphenidyl for dystonia in cerebral palsy. Cochrane Database Syst Rev 5:CD012430
Hwang WJ, Calne DB, Tsui JK, de la Fuente-Fernandez R (2001) The long-term response to levodopa in dopa-responsive dystonia. Parkinsonism Relat Disord 8:1–5
Meythaler JM, Guin-Renfroe S, Johnson A, Brunner RM (2001) Prospective assessment of tizanidine for spasticity due to acquired brain injury. Arch Phys Med Rehabil 82:1155–1163
Pinder RM, Brogden RN, Speight TM, Avery GS (1977) Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity. Drugs 13:3–23
Platz T, Vuadens P, Eickhof C, Arnold P, Van Kaick S, Heise K (2008) REPAS, a summary rating scale for resistance to passive movement: item selection, reliability and validity. Disabil Rehabil 30:44–53
Sechi GP, Zuddas M, Piredda M, Agnetti V, Sau G, Piras ML, Tanca S, Rosati G (1989) Treatment of cerebellar tremors with carbamazepine: a controlled trial with long-term follow-up. Neurology 39:1113–1115
Yadav V, Bever C Jr, Bowen J, Bowling A, Weinstock-Guttman B, Cameron M, Bourdette D, Gronseth GS, Narayanaswami P (2014) Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology. Neurology 82:1083–1092
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Kerling, F. (2021). Systemische medikamentöse Therapie. In: Strobl, W.M., Schikora, N., Pitz, E., Abel, C. (eds) Neuroorthopädie - Disability Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-61330-6_29
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DOI: https://doi.org/10.1007/978-3-662-61330-6_29
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