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Medikamentöse Tumortherapie

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Komplikationen in der Urologie
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Zusammenfassung

Erfreulicherweise stehen für die urologischen Tumorerkrankungen zahlreiche medikamentöse Therapieoptionen zur Verfügung. Die Vielzahl der auf unterschiedlichen Wirkmechanismen beruhenden Medikamente bedingen ein hohes Spektrum möglicher unerwünschter Nebenwirkungen. Die häufigsten und relevantesten Komplikationen werden hier besprochen und umfassen Paravasate von Zytostatika, Neutropenie, Anämie, Übelkeit und Erbrechen, Diarrhoe, Stomatitis, Hautveränderungen und immunvermittelte Nebenwirkungen. Diese Nebenwirkungen lassen sich meist durch adäquate Aufklärung der Patienten, Prophylaxe und spezifische Therapien gut kontrollieren.

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Literatur

  • Bellmunt J, Théodore C, Demkov T, Komyakov B, Sengelov L, Daugaard G, Caty A, Carles J, Jagiello-Gruszfeld A, Karyakin O, Delgado FM, Hurteloup P, Winquist E, Morsli N, Salhi Y, Culine S, von der Maase H (2010) Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J Clin Oncol 27(27):4454–4461

    Article  Google Scholar 

  • Bokemeyer C, Aapro MS, Courdi A, Foubert J, Link H, Osterborg A, Repetto L, Soubeyran P (2007) EORTC guidelines for the use of erythropoietic proteins in anaemic patients with cancer: 2006 update. European Organisation for Research and Treatment of Cancer (EORTC) taskforce for the elderly. Eur J Cancer 43(2):258–270

    Article  CAS  Google Scholar 

  • Cassagnol M, McBride A (2009) Management of chemotherapy extravasations. US Pharm 3(9 Oncol Suppl):311

    Google Scholar 

  • CTCAE v5.0 (2017) https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm

  • Fizazi K, Shore N, Tammela TL, Ulys A, Vjaters E, Polyakov S, Jievaltas M, Luz M, Alekseev B, Kuss I, Kappeler C, Snapir A, Sarapohja T, Smith MR, ARAMIS Investigators (2019) Darolutamide in nonmetastatic, castration-resistant prostate cancer. N Engl J Med 380(13):1235–1246

    Article  CAS  Google Scholar 

  • Ludwig H, van Belle S, Barrett-Lee P, Birgegard G, Bokemeyer C, Gascon P, Kosmidis P, Krzakowski M, Nortier J, Olmi P, Schneider M, Schrijvers D (2004) The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence and treatment of anemia in cancer patients. Eur J Cancer 40(15):2293–2306

    Article  Google Scholar 

  • Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J (2015) Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol 16(15):1473–1482

    Article  CAS  Google Scholar 

  • Schelenz S, Giles D, Abdallah S (2012) Epidemiology, management and economic impact of febrile neutropenia in oncology patients receiving routine care at a regional UK cancer centre. Ann Oncol 23(7):1889–1893

    Article  CAS  Google Scholar 

  • Schmoll HJ, Höffken K, Possinger K (2006) Kompendium internistische Onkologie, Standards in Diagnostik und Therapie. Springer Verlag, Berlin, Heidelberg

    Google Scholar 

  • Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, Olmos D, Mainwaring PN, Lee JY, Uemura H, Lopez-Gitlitz A, Trudel GC, Espina BM, Shu Y, Park YC, Rackoff WR, Yu MK, Small EJ (2018) SPARTAN investigators. Apalutamide treatment and metastasis-free survival in prostate cancer. N Engl J Med 378(15):1408–1418

    Article  CAS  Google Scholar 

  • Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, Langston AA, Nastoupil LJ, Rajotte M, Rolston K, Strasfeld L, Flowers CR (2018) Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice guideline update. JCO 36(14):1443–1453

    Article  Google Scholar 

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Correspondence to Martin Bögemann .

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Bögemann, M. (2021). Medikamentöse Tumortherapie. In: Kranz, J., Anheuser, P., Steffens, J.A. (eds) Komplikationen in der Urologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60625-4_10

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  • DOI: https://doi.org/10.1007/978-3-662-60625-4_10

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  • Online ISBN: 978-3-662-60625-4

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