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Zytokine in der pädiatrischen Rheumatologie

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Pädiatrische Rheumatologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Zytokine, „Zellbeweger“, sind lösliche Proteine oder Glykoproteine, Botenstoffe, die Signale zwischen Zellen vermitteln. Zu ihnen zählen Interferone, Interleukine, Tumor-Nekrose-Faktoren, Wachstumsfaktoren und Chemokine. Sie regulieren das Überleben der Zellen, Zellwachstum, Differenzierung und Aktivierung, Chemokine die Zellanlockung, die Chemotaxis. Daneben haben Zytokine systemische Effekte, wie Fieber, und einen vielfältigen Einfluss auf Gewebe. Zytokine regulieren die Immunantwort und sind sowohl an der erworbenen als auch der unspezifischen, angeborenen Immunität beteiligt. Den proinflammatorischen stehen antiinflammatorische Zytokine gegenüber. Ihre Wirkung vermitteln Zytokine durch Bindung an Zytokinrezeptoren, multimolekulare Komplexe, deren intrazelluläre Signalweiterleitung beispielsweise über Januskinasen oder Nuclear-factor-κB erfolgt. Die Bedeutung der Zytokine hat die Entwicklung von Anti-Zytokin- oder Anti-Rezeptor-Antikörpern und löslichen Rezeptoren beflügelt und die Behandlung unzähliger Erkrankungen revolutioniert. Auch die Hemmung der Signaltransduktion z. B. mit den Januskinase-Inhibitoren stellt ein erfolgreiches Therapieprinzip bei entzündlichen Erkrankungen dar

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Authors and Affiliations

  1. Zentrum Allgemeine Pädiatrie und Neonatologie, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Deutschland

    Gerd Horneff

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  1. Gerd Horneff
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Correspondence to Gerd Horneff .

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Editors and Affiliations

  1. Universitätsklinikum Aachen Klinik für Kinder- und Jugendmedizin, Aachen, Germany

    Norbert Wagner

  2. 15306 Seelow, Germany

    Günther Dannecker

  3. Kinderklinik, Charité Universitätsmedizin Berlin, Berlin, Berlin, Germany

    Tilmann Kallinich

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Horneff, G. (2021). Zytokine in der pädiatrischen Rheumatologie. In: Wagner, N., Dannecker, G., Kallinich, T. (eds) Pädiatrische Rheumatologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60411-3_6-1

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  • DOI: https://doi.org/10.1007/978-3-662-60411-3_6-1

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  • Print ISBN: 978-3-662-60411-3

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