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Systemischer Lupus erythematodes bei Kindern und Jugendlichen

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Pädiatrische Rheumatologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Der systemische Lupus erythematodes (SLE) ist eine Autoimmunerkrankung, die mit einer Immunkomplex-vermittelten Vaskulitis verschiedener Organe einhergeht. Für die Prognose entscheidend ist die Beteiligung der Nieren und des ZNS. Die Ursachen des SLE sind multifaktoriell: Genetische Suszeptibilität, exogene Einflüsse, wie z. B. Infektionen, humorale Faktoren und Störungen des angeborenen und des adaptiven Immunsystems. In der Immunpathogenese kommt den B-Zellen eine entscheidende Bedeutung zu. Charakteristisch für den SLE sind Autoantikörper, die gegen Zellkernbestandteile gerichtet sind (antinukleäre Antikörper, Anti-Doppelstrang-DNA-Antikörper). Klinisch imponieren ein Schmetterlingserythem, allgemeines Krankheitsgefühl und Fieber, Serositis der Pleura und des Perikards, Nephritis, ZNS-Symptome, Arthritiden und Myalgien. Die Prognose hat sich durch die intensive immunsuppressive Therapie unter anderem mit Glucocorticoiden, Cyclophosphamid und Biologika, z. B. Belimumab, deutlich gebessert.

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Authors and Affiliations

  1. Universitätsklinik Aachen, Klinik für Kinder- und Jugendmedizin, Aachen, Deutschland

    Norbert Wagner

  2. Klinik für Pädiatrische Nieren-, Leber- und Stoffwechselerkrankungen, Medizinische Hochschule Hannover, Hannover, Deutschland

    Dieter Haffner

  3. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Aachen, Aachen, Deutschland

    Klaus Tenbrock

  4. Pädiatrie, Sekt. Rheumatologie, Sozialpädiatrisches Zentrum, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Günther Dannecker

Authors
  1. Norbert Wagner
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  2. Dieter Haffner
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  3. Klaus Tenbrock
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  4. Günther Dannecker
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Correspondence to Norbert Wagner .

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Editors and Affiliations

  1. Universitätsklinikum Aachen Klinik für Kinder- und Jugendmedizin, Aachen, Germany

    Norbert Wagner

  2. 15306 Seelow, Germany

    Günther Dannecker

  3. Kinderklinik, Charité Universitätsmedizin Berlin, Berlin, Berlin, Germany

    Tilmann Kallinich

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Wagner, N., Haffner, D., Tenbrock, K., Dannecker, G. (2021). Systemischer Lupus erythematodes bei Kindern und Jugendlichen. In: Wagner, N., Dannecker, G., Kallinich, T. (eds) Pädiatrische Rheumatologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60411-3_38-1

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  • DOI: https://doi.org/10.1007/978-3-662-60411-3_38-1

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  • Print ISBN: 978-3-662-60411-3

  • Online ISBN: 978-3-662-60411-3

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