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Klinik des Morbus Crohn

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Chronisch-entzündliche Darmerkrankungen

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Die Diagnose eines Morbus Crohn wurde früher in vielen Fällen mit einer deutlichen Zeitverzögerung gestellt. Dieser allgemein verbreitete Eindruck ist heute so nicht mehr zutreffend. Die Möglichkeit des Vorliegens einer chronisch-entzündlichen Darmerkrankung wird bei entsprechender Symptomatik zumeist schnell in die differenzialdiagnostischen Überlegungen einbezogen und kann dann in der Regel auch zügig durch die sonografische, endoskopische und radiologische Diagnostik bestätigt werden (Pimentel et al. 2000).

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Literatur

  • Ananthakrishnan AN, Weber LR, Knox JF, Skaros S, Emmons J, Lundeen S, Issa M, Otterson MF, Binion DG (2008) Permanent work disability in Crohn’s disease. Am J Gastroenterol 103:154–161

    PubMed  Google Scholar 

  • Andersson P, Olaison G, Hallbook O, Sjodahl R (2002a) Segmental resection or subtotal colectomy in Crohn’s colitis? Dis Colon Rectum 45:47–53

    CAS  PubMed  Google Scholar 

  • Andersson P, Olaison G, Bodemar G, Nystrom PO, Sjodahl R (2002b) Surgery for Crohn colitis over a twenty-eight-year period: fewer stomas and the replacement of total colectomy by segmental resection. Scand J Gastroenterol 37:68–73

    CAS  PubMed  Google Scholar 

  • Ausfeld-Hafter B, Hoffmann S, Seibold F, Quattropani C, Heer P, Straumann A (2005) Status of alternative medicine in Crohn disease and ulcerative colitis patients: a questionnaire survey. Forsch Komplementarmed Klass Naturheilkd 12:134–138

    Google Scholar 

  • Baars JE et al (2017) Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: a systematic review. World J Gastroenterol 23:8073–8081

    PubMed  PubMed Central  Google Scholar 

  • Baird DD, Narendranathan M, Sandler RS (1990) Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology 99:987–994

    CAS  PubMed  Google Scholar 

  • Best WR, Becktel JM, Singleton JW, Kern F Jr (1976) Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study. Gastroenterology 70:439–444

    CAS  Google Scholar 

  • Borley NR, Mortensen NJ, Chaudry MA, Mohammed S, Warren BF, George BD, Clark T, Jewell DP, Kettlewell MG (2002) Recurrence after abdominal surgery for Crohn’s disease: relationship to disease site and surgical procedure. Dis Colon Rectum 45:377–383

    PubMed  Google Scholar 

  • Brandt LJ, Estabrook SG, Reinus JF (1995) Results of a survey to evaluate whether vaginal delivery and episiotomy lead to perineal involvement in women with Crohn’s disease. Am J Gastroenterol 90:1918–1922

    CAS  PubMed  Google Scholar 

  • Burr NE et al (2019) Decreasing risk of first and subsequent surgeries in patients with Crohn’s disease in England From 1994 through 2013. Clin Gastroenterol Hepatol (in press)

    Google Scholar 

  • Casellas F, Rodrigo L, Nino P, Pantiga C, Riestra S, Malagelada JR (2007) Sustained improvement of health-related quality of life in Crohn’s disease patients treated with infliximab and azathioprine for 4 years. Inflamm Bowel Dis 13:1395–1400

    PubMed  Google Scholar 

  • Cosnes J, Beaugerie L, Carbonnel F, Gendre JP (2001) Smoking cessation and the course of Crohn’s disease: an intervention study. Gastroenterology 120:1093–1099

    CAS  PubMed  Google Scholar 

  • Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, Gendre JP (2002) Long-term evolution of disease behavior of Crohn’s disease. Inflamm Bowel Dis 8:244–250

    PubMed  Google Scholar 

  • Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJ, Mascheretti S, Sanderson J, Forbes A, Mansfield J et al (2002) The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 122:867–874

    CAS  PubMed  Google Scholar 

  • Dietz DW, Laureti S, Strong SA, Hull TL, Church J, Remzi FH, Lavery IC, Fazio VW (2001) Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn’s disease. J Am Coll Surg 192:330–337, discussion 337–338

    CAS  PubMed  Google Scholar 

  • Ekbom A, Helmick C, Zack M, Adami HO (1990) Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement. Lancet 336:357–359

    CAS  PubMed  Google Scholar 

  • Ekbom A, Helmick C, Zack M, Adami HO (1991) Extracolonic malignancies in inflammatory bowel disease. Cancer 67:2015–2019

    CAS  PubMed  Google Scholar 

  • Elenkov IJ, Wilder RL, Bakalov VK, Link AA, Dimitrov MA, Fisher S, Crane M, Kanik KS, Chrousos GP (2001) IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab 86:4933–4938

    CAS  PubMed  Google Scholar 

  • Farmer RG, Hawk WA, Turnbull RB Jr (1975) Clinical patterns in Crohn’s disease: a statistical study of 615 cases. Gastroenterology 68:627–635

    CAS  PubMed  Google Scholar 

  • Faubion WA Jr, Loftus EV Jr, Harmsen WS, Zinsmeister AR, Sandborn WJ (2001) The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology 121:255–260

    CAS  PubMed  Google Scholar 

  • Fonager K, Sorensen HT, Olsen J, Dahlerup JF, Rasmussen SN (1998) Pregnancy outcome for women with Crohn’s disease: a follow-up study based on linkage between national registries. Am J Gastroenterol 93:2426–2430

    CAS  PubMed  Google Scholar 

  • Gasche C, Scholmerich J, Brynskov J, D’Haens G, Hanauer SB, Irvine EJ, Jewell DP, Rachmilewitz D, Sachar DB, Sandborn WJ et al (2000) A simple classification of Crohn’s disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 6:8–15

    CAS  PubMed  Google Scholar 

  • Goebell H (1988) Different activity indices in Crohnʼs disease and their possible role. In: Goebell H, Peskar BM, Malchow H (Hrsg) Inflammatory bowel disease: basic research and clinical implications. MTP Press, Lancaster, S 253–258

    Google Scholar 

  • Guassora AD, Kruuse C, Thomsen OO, Binder V (2000) Quality of life study in a regional group of patients with Crohn disease. A structured interview study. Scand J Gastroenterol 35:1068–1074

    CAS  PubMed  Google Scholar 

  • Hassan C, Zullo A, De Francesco V, Ierardi E, Giustini M, Pitidis A, Taggi F, Winn S, Morini S (2007) Systematic review: endoscopic dilatation in Crohn’s disease. Aliment Pharmacol Ther 26:1457–1464

    CAS  PubMed  Google Scholar 

  • Hutfless SM, Weng X, Liu L, Allison J, Herrinton LJ (2007) Mortality by medication use among patients with inflammatory bowel disease, 1996–2003. Gastroenterology 133:1779–1786

    PubMed  Google Scholar 

  • Irvine EJ, Feagan B, Rochon J, Archambault A, Fedorak RN, Groll A, Kinnear D, Saibil F, McDonald JW (1994) Quality of life: a valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease. Canadian Crohn’s Relapse Prevention Trial Study Group. Gastroenterology 106:287–296

    CAS  PubMed  Google Scholar 

  • Irvine EJ, Greenberg GR, Feagan BG, Martin F, Sutherland LR, Thomson AB, Nilsson LG, Persson T (2000) Quality of life rapidly improves with budesonide therapy for active Crohn’s disease. Canadian Inflammatory Bowel Disease Study Group. Inflamm Bowel Dis 6:181–187

    CAS  PubMed  Google Scholar 

  • Issa M, Vijayapal A, Graham MB, Beaulieu DB, Otterson MF, Lundeen S, Skaros S, Weber LR, Komorowski RA, Knox JF et al (2007) Impact of Clostridium difficile on inflammatory bowel disease. Clin Gastroenterol Hepatol 5:345–351

    PubMed  Google Scholar 

  • Jantschek G, Zeitz M, Pritsch M, Wirsching M, Klor HU, Studt HH, Rasenack J, Deter HC, Riecken EO, Feiereis H et al (1998) Effect of psychotherapy on the course of Crohn’s disease. Results of the German prospective multicenter psychotherapy treatment study on Crohn’s disease. German Study Group on Psychosocial Intervention in Crohn’s Disease. Scand J Gastroenterol 33:1289–1296

    CAS  PubMed  Google Scholar 

  • Jess T, Loftus EV Jr, Velayos FS, Harmsen WS, Zinsmeister AR, Smyrk TC, Schleck CD, Tremaine WJ, Melton LJ 3rd, Munkholm P et al (2006) Risk of intestinal cancer in inflammatory bowel disease: a population-based study from Olmsted County, Minnesota. Gastroenterology 130:1039–1046

    PubMed  Google Scholar 

  • Kane SV, Sable K, Hanauer SB (1998) The menstrual cycle and its effect on inflammatory bowel disease and irritable bowel syndrome: a prevalence study. Am J Gastroenterol 93:1867–1872

    CAS  PubMed  Google Scholar 

  • Khosla R, Willoughby CP, Jewell DP (1984) Crohn’s disease and pregnancy. Gut 25:52–56

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kratzer W, von Tirpitz C, Mason R, Reinshagen M, Adler G, Moller P, Rieber A, Kachele V (2002) Contrast-enhanced power Doppler sonography of the intestinal wall in the differentiation of hypervascularized and hypovascularized intestinal obstructions in patients with Crohn’s disease. J Ultrasound Med 21:149–157, quiz 158–149

    PubMed  Google Scholar 

  • Krupnick AS, Morris JB (2000) The long-term results of resection and multiple resections in Crohn’s disease. Semin Gastrointest Dis 11:41–51

    CAS  PubMed  Google Scholar 

  • Louis E, Collard A, Oger AF, Degroote E, Aboul Nasr El Yafi FA, Belaiche J (2001) Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut 49:777–782

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ma C et al (2017) Surgical rates for Crohn’s disease are decreasing: a population-based time trend analysis and validation study. Am J Gastroenterol 112:1840–1848

    PubMed  PubMed Central  Google Scholar 

  • Munkholm P, Langholz E, Davidsen M, Binder V (1994) Frequency of glucocorticoid resistance and dependency in Crohn’s disease. Gut 35:360–362

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nyhlin N, Bohr J, Eriksson S, Tysk C (2006) Systematic review: microscopic colitis. Aliment Pharmacol Ther 23:1525–1534

    CAS  PubMed  Google Scholar 

  • Panes J et al (2016) Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet 388:1281–1290

    PubMed  Google Scholar 

  • Park SH et al (2018) Computed tomography and magnetic resonance small bowel enterography: current status and future trends focusing on Crohn’s disease. Gastroenterol Clin North Am 47:475–499

    PubMed  Google Scholar 

  • Persson PG, Bernell O, Leijonmarck CE, Farahmand BY, Hellers G, Ahlbom A (1996) Survival and cause-specific mortality in inflammatory bowel disease: a population-based cohort study. Gastroenterology 110:1339–1345

    CAS  PubMed  Google Scholar 

  • Pimentel M, Chang M, Chow EJ, Tabibzadeh S, Kirit-Kiriak V, Targan SR, Lin HC (2000) Identification of a prodromal period in Crohn’s disease but not ulcerative colitis. Am J Gastroenterol 95:3458–3462

    CAS  PubMed  Google Scholar 

  • Rodemann JF, Dubberke ER, Reske KA, da Seo H, Stone CD (2007) Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol 5:339–344

    PubMed  Google Scholar 

  • Simillis C, Yamamoto T, Reese GE, Umegae S, Matsumoto K, Darzi AW, Tekkis PP (2008) A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn’s disease. Am J Gastroenterol 103:196–205

    PubMed  Google Scholar 

  • Sostegni R, Daperno M, Scaglione N et al (2003) Crohn’s disease: Monitoring disease activity. Aliment Pharmacol Ther 17:11–17

    Google Scholar 

  • von Wietersheim J, Overbeck A, Kiel K, Kohler T, Jantschek G, Feiereis H (1994) The significance of recurrence-inducing events for patients with chronic inflammatory bowel diseases. Results of a prospective longitudinal study over three years. Psychother Psychosom Med Psychol 44:58–64

    Google Scholar 

  • Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H (1993) Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet 341:1437–1439

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik I, Klinikum Braunschweig, Braunschweig, Deutschland

    Max Reinshagen

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  1. Max Reinshagen
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Correspondence to Max Reinshagen .

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Editors and Affiliations

  1. Medizinische Klinik I, St. Marien- und St. Annastiftskrankenhaus, Ludwigshafen, Germany

    Jörg C. Hoffmann

  2. Klinik für Innere Medizin, Medius-Klinik Ostfildern-Ruit, Ostfildern, Germany

    Bodo Klump

  3. Allg.-, Viszeral- & Unfallchirurgie, Krankenhaus Porz am Rhein, Köln, Germany

    Anton Kroesen

  4. Medizinische Klinik I, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Britta Siegmund

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Reinshagen, M. (2020). Klinik des Morbus Crohn. In: Hoffmann, J.C., Klump, B., Kroesen, A., Siegmund, B. (eds) Chronisch-entzündliche Darmerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59104-8_4

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  • DOI: https://doi.org/10.1007/978-3-662-59104-8_4

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