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Molekularbiologische Aspekte bei der Entstehung und Behandlung von Keimzelltumoren

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Uroonkologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Die Therapieerfolge bei der zytostatischen Behandlung von Keimzelltumoren sind unter den soliden Tumoren des Erwachsenen einzigartig. Die Therapieempfindlichkeit wird ihren biologischen Eigenschaften zugeschrieben, die in Teilen denen von embryonalen Stammzellen entsprechen. Als ausschlaggebend werden einerseits die niedrige Schwelle zur Einleitung eines programmierten Zelltodes und andererseits die beschränkte Kapazität zur Reparatur von DNA-Schäden betrachtet. Bislang leiten sich aus dem wachsenden Verständnis der biologischen Zusammenhänge jedoch noch keine klinischen Konsequenzen ab.

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Author information

Authors and Affiliations

  1. Praxis und Tagesklinik, Friedrichshafen, Deutschland

    Frank Mayer

  2. Klinik für Urologie, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Lübeck, Deutschland

    Axel S. Merseburger

  3. Klinik und Poliklinik für Urologie und Urologische Onkologie, Medizinischen Hochschule Hannover, Hannover, Deutschland

    Markus Kuczyk

  4. Klinik für Hämatologie, Onkologie und Immunologie, Franziskus Hospital, Bielefeld, Deutschland

    Jörg T. Hartmann

Authors
  1. Frank Mayer
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  2. Axel S. Merseburger
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  3. Markus Kuczyk
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  4. Jörg T. Hartmann
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Corresponding author

Correspondence to Frank Mayer .

Editor information

Editors and Affiliations

  1. Helios Marien Klinikum Duisburg, Duisburg, Nordrhein-Westfalen, Germany

    Herbert Rübben

  2. Urologische Klinik/Poliklinik, Universitätsklinikum Rostock, Rostock, Mecklenburg-Vorpommern, Germany

    Oliver Hakenberg

  3. Klinik und Poliklinik für Urologie, Universitätsklinikum Jena, Jena, Thüringen, Germany

    Marc-Oliver Grimm

  4. Caritaskrankenhaus St. Josef, Regensburg, Germany

    Maximilian Burger

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Mayer, F., Merseburger, A.S., Kuczyk, M., Hartmann, J.T. (2020). Molekularbiologische Aspekte bei der Entstehung und Behandlung von Keimzelltumoren. In: Rübben, H., Hakenberg, O., Grimm, MO., Burger, M. (eds) Uroonkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54652-9_62-2

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  • DOI: https://doi.org/10.1007/978-3-662-54652-9_62-2

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