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Stem Cells in Joint Repair

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Bio-orthopaedics

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Abstract

Autologous cellular therapies have been introduced in the treatment of articular cartilage defects in 1994 by Brittberg et al. [1] Indeed, autologous chondrocyte implantation (ACI) has been proven to restore hyaline-like articular surface, which is mechanically and functionally stable even in athletes at long-term follow-up. However, despite the breakthrough merit of the original procedure, it showed some issues such as local morbidity for periosteal harvest, complications related to the use of periosteum as a cover, and uncertain distribution of the cell suspension. In particular, the possible periosteal patch hypertrophy and the potential degenerative changes of chondrocyte that have been extensively passaged in vitro [2] prompted the development of improved and alternative techniques to overcome these limitations [3].

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Author information

Authors and Affiliations

  1. Musculoskeletal Translational Medicine, Novartis Institutes for Biomedical Research Basel, Novartis Pharma AG, CH-4056, Basel, Switzerland

    Celeste Scotti M.D., Ph.D.

  2. Medicine for Sports and Performing Arts, Department of Health and Sport Sciences, Osaka University Graduate School of Medicine, Osaka, Japan

    Kota Koizumi

  3. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Kota Koizumi

  4. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura M.D., Ph.D.

  5. Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan

    Norimasa Nakamura M.D., Ph.D.

Authors
  1. Celeste Scotti M.D., Ph.D.
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  2. Kota Koizumi
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  3. Norimasa Nakamura M.D., Ph.D.
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Corresponding author

Correspondence to Celeste Scotti M.D., Ph.D. .

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Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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Scotti, C., Koizumi, K., Nakamura, N. (2017). Stem Cells in Joint Repair. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_17

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  • DOI: https://doi.org/10.1007/978-3-662-54181-4_17

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  • Online ISBN: 978-3-662-54181-4

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