Skip to main content
SpringerLink
Log in

Arteriosklerose: Ätiologie und Pathogenese

  • Chapter
  • First Online:
Operative und interventionelle Gefäßmedizin

Part of the book series: Springer Reference Medizin ((SRM))

  • 857 Accesses

Zusammenfassung

Eine Schlüsselrolle in der Arteriosklerose-Entwicklung nimmt die arterielle Endothelzelle ein. In den letzten Jahren hat unser Wissen über die Endothelzellen beachtlich zugenommen, und insbesondere hat sich über die Endothelzellen eine kausale Verbindung zur Entzündung und zum metabolischen Syndrom ergeben. Die Arteriosklerose wird deswegen häufig als entzündliche Erkrankung der Endothelzellen verstanden. Dieses Verständnis hat die alte Zweiteilung in „Schädigungstheorie“ und „Fett-Theorie“ der Arteriosklerose durch ein umfassenderes Verständnis abgelöst. Endothelzellen, Entzündung und Blutgerinnung sind, wie wir heute wissen, verschiedene Bestandteile eines Systems. Am besten wird die große klinische Bedeutung dieses Systems durch die großen Erfolge derjenigen Bereiche der Pharmakotherapie der Arteriosklerose dokumentiert, die eine Hemmung der proinflammatorischen Reaktionen des Endothels und eine Hemmung der Blutgerinnung zum Ziel haben.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 399.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Agarwal S (2009) The association of active and passive smoking with peripheral arterial disease: results from NHANES 1999–2004. Angiology 60:335–345 [Epub vor Druck]

    Article  PubMed  Google Scholar 

  • Archer SL, Huang JM, Hampl V et al (1994) Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A 91:7583–7587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bapat SP, Myoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y (2015) Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528:137–141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beasley JM, Ange BA, Anderson CA, Miller ER 3rd, Erlinger TP, Holbrook JT, Sacks FM, Appel LJ (2009) Associations between macronutrient intake and self-reported appetite and fasting levels of appetite hormones: results from the optimal macronutrient intake trial to prevent heart disease. Am J Epidemiol 169:893–900

    Article  PubMed  PubMed Central  Google Scholar 

  • Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13:587–596

    Article  CAS  PubMed  Google Scholar 

  • Boon RA, Horrevoets AJ (2009) Key transcriptional regulators of the vasoprotective effects of shear stress. Hamostaseologie 29:39–40

    Article  CAS  PubMed  Google Scholar 

  • Cerwinka WH, Cooper D, Krieglstein CF et al (2002) Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. Am J Physiol Heart Circ Physiol 282:H1111–H1117

    Article  CAS  PubMed  Google Scholar 

  • Chelland Campbell S, Moffatt RJ, Stamford BA (2008) Smoking and smoking cessation – the relationship between cardiovascular disease and lipoprotein metabolism: a review. Atherosclerosis 201:225–235

    Article  PubMed  CAS  Google Scholar 

  • Chen HW, Lii CK, Ku HJ, Wang TS (2009) Cigarette smoke extract induces expression of cell adhesion molecules in HUVEC via actin filament reorganization. Environ Mol Mutagen 50:96–104

    Article  CAS  PubMed  Google Scholar 

  • Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA Jr (2004) Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A 101:14871–14876

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA Jr (2007) Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res 101:723–733

    Article  CAS  PubMed  Google Scholar 

  • Deguchi J et al (2009) Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Lab Invest 89:315–326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dimmeler S, Zeiher AM (1999) Nitric oxide-an endothelial cell survival factor. Cell Death Differ 6:964–968

    Article  CAS  PubMed  Google Scholar 

  • Elkind MS (2009) Inflammatory markers and stroke. Curr Cardiol Rep 11:12–20

    Article  PubMed  Google Scholar 

  • Faggioli G, Ferri M, Rapezzi C, Tonon C, Manzoli L, Stella A (2009) Atherosclerotic aortic lesions increase the risk of cerebral embolism during carotid stenting in patients with complex aortic arch anatomy. J Vasc Surg 49:80–85

    Article  PubMed  Google Scholar 

  • Foresta C, Caretta N, Corona G, Fabbri A, Francavilla S, Jannini E, Maggi M, Bettocchi C, Lenzi A (2009) Clinical and metabolic evaluation of subjects with erectile dysfunction: a review with a proposal flowchart. Int J Androl 32(3):198–211

    Article  CAS  PubMed  Google Scholar 

  • Gambaryan S, Kobsar A, Hartmann S et al (2008) NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity. J Thromb Haemost 6:1376–1384

    Article  CAS  PubMed  Google Scholar 

  • Geerts CC, Bots ML, Grobbee DE, Uiterwaal CS (2008) Parental smoking and vascular damage in young adult offspring: is early life exposure critical? The atherosclerosis risk in young adults study. Arterioscler Thromb Vasc Biol 28:2296–2302

    Article  CAS  PubMed  Google Scholar 

  • Hellenthal FA, Geenen IL, Teijink JA, Heeneman S, Schurink GW (2008) Histological features of human abdominal aortic aneurysm are not related to clinical characteristics. Cardiovasc Pathol 18(5):286–293

    Article  PubMed  Google Scholar 

  • Homme JL, Aubry MC, Edwards WD, Bagniewski SM, Shane Pankratz V, Kral CA, Tazelaar HD (2008) Surgical pathology of the ascending aorta: a clinicopathologic study of 513 cases. Am J Surg Pathol 30(9):1159–1168

    Google Scholar 

  • Kallio K et al (2009) Decreased aortic elasticity in healthy 11-year-old children exposed to tobacco smoke. Pediatrics 123(2):e267–e273

    Article  PubMed  Google Scholar 

  • Kasashima S, Zen Y, Kawashima A, Konishi K, Sasaki H, Endo M, Matsumoto Y, Kawakami K, Kasashima F, Moriya M, Kimura K, Ohtake H, Nakanuma Y (2008) Inflammatory abdominal aortic aneurysm: close relationship to IgG4-related periaortitis. Am J Surg Pathol 32:197–204

    Article  PubMed  Google Scholar 

  • Kasashima S, Zen Y, Kawashima A, Endo M, Matsumoto Y, Kasashima F (2009) A new clinicopathological entity of IgG4-related inflammatory abdominal aortic aneurysm. J Vasc Surg 49:1264–1271 [Epub vor Druck]

    Article  PubMed  Google Scholar 

  • Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348:101–108

    Article  PubMed  Google Scholar 

  • Kimmelstiel P, Wilson C (1936) Benign and malignant hypertension and nephrosclerosis. A clinical and pathological study. Am J Pathol 12:45–48

    CAS  PubMed  PubMed Central  Google Scholar 

  • Knoflach M et al (2009) Cardiovascular risk factors and atherosclerosis in young women. Atherosclerosis risk factors in female youngsters (ARFY study). Stroke 40:1063–1069 [Epub vor Druck]

    Article  CAS  PubMed  Google Scholar 

  • Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn EA, Sarabi A, Kramp BK, Piccinini AM, Paludan SR, Kowalska MA, Kungl AJ, Hackeng TM, Mayo KH, Weber C (2009) Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat Med 15:97–103

    Article  CAS  PubMed  Google Scholar 

  • Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88:4651–4655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA Jr, Balasubramanian V, García-Cardeña G, Jain MK (2005) Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res 96:e48–e57

    Article  CAS  PubMed  Google Scholar 

  • Ljungberg LU, Persson K (2008) Effect of nicotine and nicotine metabolites on angiotensin-converting enzyme in human endothelial cells. Endothelium 15:239–245

    Article  CAS  PubMed  Google Scholar 

  • Ni M, Wang Y, Zhang M, Zhang PF, Ding SF, Liu CX, Liu XL, Zhao YX, Zhang Y (2009) Atherosclerotic plaque disruption induced by stress and lipopolysaccharide in apolipoprotein E knockout mice. Am J Physiol Heart Circ Physiol 296(5):H1598–H1606

    Article  CAS  PubMed  Google Scholar 

  • Nishio E, Fukushima K, Shiozaki M et al (1996) Nitric oxide donor SNAP induces apoptosis in smooth muscle cells through cGMP-independent mechanism. Biochem Biophys Res Commun 221:163–168

    Article  CAS  PubMed  Google Scholar 

  • Ohman MK, Shen Y, Obimba CI, Wright AP, Warnock M, Lawrence DA, Eitzman DT (2008) Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 117:798–805

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Otsuka F, Byrne RA, Yahagi K, Mori H, Ladich E, Fowler DR, Kutys R, Xhepa E, Kastrati A, Virmani R, Joner M (2015) Neoatherosclerosis: overview of histopathologic findings and implications for intravascular imaging assessment. Eur Heart J 36(32):2147–2159. https://doi.org/10.1093/eurheartj/ehv205, Epub 2015 May 20

    Article  PubMed  Google Scholar 

  • Pacifico L et al (2008) Nonalcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr Res 63:423–427

    Article  CAS  PubMed  Google Scholar 

  • Park YM, Febbraio M, Silverstein RL (2009) CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest 119:136–145

    CAS  PubMed  Google Scholar 

  • Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA Jr, García-Cardeña G (2005) Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem 280:26714–26719

    Article  CAS  PubMed  Google Scholar 

  • Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA Jr, García-Cardeña G (2006) Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest 116:49–58

    Article  CAS  PubMed  Google Scholar 

  • Ponnuswamy P, Ostermeier E, Schroettle A, Chen J, Huang PL, Ertl G, Nieswandt B, Kuhlencordt PJ (2009) Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174:2400–2410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Radomski MW, Palmer RM, Moncada S (1987) The anti-aggregating properties of vascular endothelium: interactions between prostacyclin. Br J Pharmacol 92(3):639–646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rapp JH, Pan XM, Neumann M, Hong M, Hollenbeck K, Liu J (2008) Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition. Stroke 39:2354–2361

    Article  CAS  PubMed  Google Scholar 

  • Sakata N, Tashiro T, Uesugi N, Kawara T, Furuya K, Hirata Y, Iwasaki H, Kojima M (2008) IgG4-positive plasma cells in inflammatory abdominal aortic aneurysm: the possibility of an aortic manifestation of IgG4-related sclerosing disease. Am J Surg Pathol 32:553–559

    Article  PubMed  Google Scholar 

  • Sato Y, Hatakeyama K, Marutsuka K, Asada Y (2008) Incidence of asymptomatic coronary thrombosis and plaque disruption: comparison of non-cardiac and cardiac deaths among autopsy cases. Thromb Res 124(1):19–23

    Article  PubMed  CAS  Google Scholar 

  • SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA Jr, García-Cardeña G, Jain MK (2004) KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med 199:1305–1315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shah PK (2009) Inflammation and plaque vulnerability. Cardiovasc Drugs Ther 23:31–40

    Article  CAS  PubMed  Google Scholar 

  • Sommer G et al (2009) Secretory products form human adiocytes stimulate proinflammatory cytokine secretion from human endothelial cells. J Cell Biochem 106:729–737

    Article  CAS  PubMed  Google Scholar 

  • Spalding KL et al (2008) Dynamics of fat cell turnover in humans. Nature 453:783–787

    Article  CAS  PubMed  Google Scholar 

  • Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, Mietus-Snyder ML, American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular Nursing, Council on Nutrition, Physical Activity, and Metabolism (2009) Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 119:628–647

    Article  PubMed  Google Scholar 

  • Tabas I (2009) Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress. Antioxid Redox Signal 11(9):2333–2339

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C (2008) Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes. Trends Mol Med 14:441–449

    Article  CAS  PubMed  Google Scholar 

  • Vaglio A, Greco P, Corradi D, Palmisano A, Martorana D, Ronda N, Buzio C (2006) Autoimmune aspects of chronic periaortitis. Autoimmun Rev 5:458–464

    Article  PubMed  Google Scholar 

  • Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B (2015) Interactions between adipose tissue and the immune system in health and malnutrition. Semin Immunol. https://doi.org/10.1016/j.smim.2015.10.006, pii: S1044-5323(15)00070-6

    Article  PubMed  Google Scholar 

  • Wilson AM, Cooke P (2007) L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 116:188–195

    Article  CAS  PubMed  Google Scholar 

  • Yusuf K, Murat B, Unal A, Ulku K, Taylan K, Ozerdem O, Erdal Y, Tahsin Y (2007) Inflammatory abdominal aortic aneurysm: predictors of long-term outcome in a case-control study. Surgery 142:123 (Kommentar in Surgery 143: 300)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathologisches Institut der Universität, Luitpoldkrankenhaus, Würzburg, Deutschland

    Justus G. Müller

  2. Angiologie, Asklepios Klinik Altona, Hamburg, Deutschland

    Peter Kuhlencordt

Authors
  1. Justus G. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter Kuhlencordt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Justus G. Müller .

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Gefäßmedizin Gefäßchirurgie – Angiologie – endovaskuläre Therapie, Universitätsklinikum Hamburg-Eppendorf Universitäres Herz- und Gefäßzentrum, Hamburg, Germany

    Eike Sebastian Debus

  2. Abteilung für Diagnostische und Interventionelle Radiologie, Asklepios Klinikum Harburg, Hamburg, Germany

    Walter Gross-Fengels

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Müller, J.G., Kuhlencordt, P. (2020). Arteriosklerose: Ätiologie und Pathogenese. In: Debus, E., Gross-Fengels, W. (eds) Operative und interventionelle Gefäßmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53380-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-53380-2_12

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53378-9

  • Online ISBN: 978-3-662-53380-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation