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Ear and Temporal Bone

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Pathology of the Head and Neck

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Abstract

The ear and temporal bone have a unique function related to hearing and balance. The anatomy is complex and many different tissues are involved, making this a challenging area for the diagnostic pathologist. There are diseases that are unique to this part of the body and lesions may be small and relatively inaccessible. Biopsy tissue samples may be crushed, small in quantity and often associated with bone, which complicates processing. Diagnosis and treatment of tumours of the middle ear and inner ear usually take place in specialist centres. Correlation with imaging is essential and interpretation requires specialist expertise.

In this chapter the pathology of the ear is discussed in three main parts according to the anatomy: (i) conditions that affect the external ear, that is, the pinna and external ear canal, (ii) conditions that affect the middle ear and mastoid, (iii) conditions affecting the inner ear housed in the temporal bone.

Inflammatory and metabolic diseases are discussed including those benign lesions that mimic malignancy. Benign and malignant neoplasms are described with emphasis on morphological criteria and clinicopathological correlation to assist with the recognition and diagnosis of these rare and diverse entities.

The present chapter is the updated version of the previous edition that was written in his unparalleled style by Prof. Leslie Michaels

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References

  1. Michaels L, Hellquist. Ear, nose and throat histopathology. 2nd ed. London: Springer; 2001.

    Book  Google Scholar 

  2. Chandler J. Malignant external otitis. Laryngoscope. 1968;78:1257–94.

    Article  CAS  PubMed  Google Scholar 

  3. Shpitzer T, Stern Y, Cohen O, Levy R, Segal K, Feinmesser R. Malignant external otitis in nondiabetic patients. Ann Otol Rhinol Laryngol. 1993;102:870–2.

    Article  CAS  PubMed  Google Scholar 

  4. Wells M, Michaels L. “Malignant otitis externa”: a manifestation of chronic otitis media with complications? Clin Otolaryngol. 1984;9:131.

    Google Scholar 

  5. Ostfeld E, Segal M, Czernobilsky B. External otitis: early histopathologic changes and pathogenic mechanism. Laryngoscope. 1982;91:965–70.

    Google Scholar 

  6. Weinroth S, Schessel D, Tuazon CU. Malignant otitis externa in AIDS patients: case report and review of the literature. Ear Nose Throat J. 1992;73:772–4.

    Google Scholar 

  7. Heffner DK, Hyams VJ. Cystic chondromalacia (endochondral pseudocyst) of the auricle. Arch Pathol Lab Med. 1986;110(8):740–3.

    CAS  PubMed  Google Scholar 

  8. Chabra I, Singh R. Gouty tophi on the ear: a review. Cutis. 2013;92(4):190–2.

    Google Scholar 

  9. Devlin J, Harrison CJ, Whitby DJ, David TJ. Cartilaginous pseudocyst of the external auricle in children with atopic eczema. Br J Dermatol. 1990;122(5):699–704.

    Article  CAS  PubMed  Google Scholar 

  10. Bottomley WW, Goodfield MD. Chondrodermatitis nodularis helicis occurring with systemic sclerosis – an under-reported association? Clin Exp Dermatol. 1994;19(3):219–20.

    Article  CAS  PubMed  Google Scholar 

  11. Du Vivier A. Atlas of clinical dermatology. 4th ed. Saunders; Churchil Livingstone, London. 2003.

    Google Scholar 

  12. Corbridge R, Michaels L, Wright A. Epithelial migration in keratosis obturans. Am J Otolaryngol. 1996;17:411–4.

    Article  CAS  PubMed  Google Scholar 

  13. Soucek S, Michaels L. Keratosis of the tympanic membrane and deep external canal: a defect of auditory epithelial migration. Eur Arch Otorhinolaryngol. 1993;250:140–2.

    Article  CAS  PubMed  Google Scholar 

  14. Persaud RAP, Hajioff D, Thevasagayam MS, Wareing MJ, Wright A. Keratosis obturans and external ear canal cholesteatoma: how and why we should distinguish between these conditions. Clin Otolaryngol Allied Sci. 2004;29(6):577–81.

    Article  CAS  PubMed  Google Scholar 

  15. Hawke M, Jahn AF, Napthine D, MacKay A, Tam CS. Preparation of undecalcified temporal bone sections. Arch Otolaryngol. 1974;100(5):366–9.

    Article  CAS  PubMed  Google Scholar 

  16. Barnes L, Koss W, Nieland ML. Angiolymphoid hyperplasia with eosinophilia: a disease that may be confused with malignancy. Head Neck Surg. 1980;2(5):425–34.

    Article  CAS  PubMed  Google Scholar 

  17. Jansen T, Romiti R, Altmeyer P. Accessory tragus: report of two cases and review of the literature. Pediatr Dermatol. 2000;17(5):391–4.

    Article  CAS  PubMed  Google Scholar 

  18. Bendet E. A wattle (cervical accessory tragus). Otolaryngol Head Neck Surg. 1999;121(4):508–9.

    Article  CAS  PubMed  Google Scholar 

  19. Kim SW, Moon SE, Kim JA. Bilateral accessory tragi on the suprasternal region. J Dermatol. 1997;24(8):543–5.

    Article  CAS  PubMed  Google Scholar 

  20. De Sousa RF, Chakravarty B, Sharma A, Parwaz MA, Malik A. Efficacy of triple therapy in auricular keloids. J Cutan Aesthet Surg. 2014;7(2):98–102.

    Google Scholar 

  21. Cankar V, Crowley H. Tumors of ceruminous glands: a clinicopathological study of 7 cases. Cancer. 1964;17:67–75.

    Article  CAS  PubMed  Google Scholar 

  22. Wetli C, Pardo V, Millard M, Gersdon K. Tumors of ceruminous glands. Cancer. 1972;29:1169–78.

    Google Scholar 

  23. Megerian CA, Sofferman RA, McKenna MJ, Eavey RD, Nadol JB. Fibrous dysplasia of the temporal bone: ten new cases demonstrating the spectrum of otologic sequelae. Am J Otol. 1995;16(4):408–19.

    CAS  PubMed  Google Scholar 

  24. Nager GT, Kennedy DW, Kopstein E. Fibrous dysplasia: a review of the disease and its manifestations in the temporal bone. Ann Otol Rhinol Laryngol Suppl. 1982;92:1–52.

    CAS  PubMed  Google Scholar 

  25. Ramirez-Camacho R, Vicente J, Garcia Berrocal JR, Ramon y Cajal S. Fibro-osseous lesions of the external auditory canal. Laryngoscope. 1999;109(3):488–91.

    Article  CAS  PubMed  Google Scholar 

  26. Healy E, Angus B, Lawrence CM, Rees JL. Prognostic value of Ki67 antigen expression in basal cell carcinomas. Br J Dermatol. 1995;133(5):737–41.

    Article  CAS  PubMed  Google Scholar 

  27. Staibano S, Boscaino A, Salvatore G, Orabona P, Palombini L, De Rosa G. The prognostic significance of tumor angiogenesis in nonaggressive and aggressive basal cell carcinoma of the human skin. Hum Pathol. 1996;27(7):695–700.

    Article  CAS  PubMed  Google Scholar 

  28. Stafford ND, Frootko NJ. Verrucous carcinoma in the external auditory canal. Am J Otol. 1986;7(6):443–5.

    CAS  PubMed  Google Scholar 

  29. Clark RR, Soutar DS, Hunter KD. A retrospective analysis of histological prognostic factors for the development of lymph node metastases from auricular squamous cell carcinoma. Histopathology. 2010;57(1):138–46.

    Google Scholar 

  30. Nyrop M, Grantved A. Cancer of the external auditory canal. Arch Otolaryngol Head Neck Surg. 2002;128:834–7.

    Article  PubMed  Google Scholar 

  31. Milbrath MM, Campbell BH, Madiedo G, Janjan NA. Malignant melanoma of the external auditory canal. Am J Clin Oncol. 1998;21(1):28–30.

    Article  CAS  PubMed  Google Scholar 

  32. Davidsson A, Hellquist HB, Villman K, Westman G. Malignant melanoma of the ear. J Laryngol Otol. 1993;107(9):798–802.

    Article  CAS  PubMed  Google Scholar 

  33. Shah JP, Kraus DH, Dubner S, Sarkar S. Patterns of regional lymph node metastases from cutaneous melanomas of the head and neck. Am J Surg. 1991;162(4):320–3.

    Article  CAS  PubMed  Google Scholar 

  34. Ravin AG, Pickett N, Johnson JL, Fisher SR, Levin LS, Seigler HF. Melanoma of the ear: treatment and survival probabilities based on 199 patients. Ann Plast Surg. 2006;57(1):70–6.

    Article  CAS  PubMed  Google Scholar 

  35. Juhn SK, Jung MK, Hoffman MD, Drew BR, Preciado DA, Sausen NJ, et al. The role of inflammatory mediators in the pathogenesis of otitis media and sequelae. Clin Exp Otorhinolaryngol. 2008;1(3):117–38.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Schuknecht H. Pathology of the ear. 2nd ed. Philadelphia: Lea & Febiger; 1993.

    Google Scholar 

  37. Liang J, Michaels L, Wright A. Immunohistochemical characterization of the epidermoid formation in the middle ear. Laryngoscope. 2003;113(6):1007–14.

    Article  PubMed  Google Scholar 

  38. McGill TJ, Merchant S, Healy GB, Friedman EM. Congenital cholesteatoma of the middle ear in children: a clinical and histopathological report. Laryngoscope. 1991;101(6 Pt 1):606–13.

    CAS  PubMed  Google Scholar 

  39. Grundfast KM, Ahuja GS, Parisier SC, Culver SM. Delayed diagnosis and fate of congenital cholesteatoma (keratoma). Arch Otolaryngol Head Neck Surg. 1995;121(8):903–7.

    Article  CAS  PubMed  Google Scholar 

  40. Cohen D. Locations of primary cholesteatoma. Am J Otol. 1987;8(1):61–5.

    CAS  PubMed  Google Scholar 

  41. Kronenburg J, Ben-Shoshan J, Modam M, Leventon G. Blast injury and cholesteatoma. Am J Otol. 1988;9:127–30.

    Article  Google Scholar 

  42. Wells MD, Michaels L. Role of retraction pockets in cholesteatoma formation. Clin Otolaryngol Allied Sci. 1983;8(1):39–45.

    Article  CAS  PubMed  Google Scholar 

  43. Masaki M, Wright CG, Lee DH, Meyerhoff WL. Experimental cholesteatoma. Epidermal ingrowth through tympanic membrane following middle ear application of propylene glycol. Acta Otolaryngol. 1989;108(1–2):113–21.

    Article  CAS  PubMed  Google Scholar 

  44. Wright C, Meyerhoff WL, Burns DK. Middle ear cholesteatoma: an animal model. Am J Otolaryngol. 1985;6:327–41.

    Article  CAS  PubMed  Google Scholar 

  45. Broekaert DCP, Leperque S. Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. Ann Otol Rhinol Laryngol. 1992;101:931–8.

    Article  CAS  PubMed  Google Scholar 

  46. Sudhoff H, Bujia J, Fisselereckhoff A, Holly A, Schuflake C, Hildmann H. Expression of a cell-cycle-associated nuclear antigen (MIB1) in cholesteatoma and auditory meatal skin. Laryngoscope. 1995;105:1227–31.

    Article  CAS  PubMed  Google Scholar 

  47. Sudhoff H, Fisseler-Eckhoff A, Stark T, Borkowski G, Luckhaupt H, Cooper J, et al. Argyrophilic nucleolar organizer regions in auditory meatal skin and middle ear cholesteatoma. Clin Otolaryngol Allied Sci. 1997;22(6):545–8.

    Article  CAS  PubMed  Google Scholar 

  48. Sudhoff H, Bujia J, Holly A, Kim C, Fisseler-Eckhoff A. Functional characterization of middle ear mucosa residues in cholesteatoma samples. Am J Otol. 1994;15(2):217–21.

    CAS  PubMed  Google Scholar 

  49. Jindal M, Riskalla A, Jiang D, Connor S, O’Connor AF. A systematic review of diffusion-weighted magnetic resonance imaging in the assessment of postoperative cholesteatoma. Otol Neurotol. 2011;32(8):1243–9.

    Google Scholar 

  50. Kamerer DB, Caparosa RJ. Temporal bone encephalocele – diagnosis and treatment. Laryngoscope. 1982;92(8 Pt 1):878–82.

    CAS  PubMed  Google Scholar 

  51. McGregor DH, Cherian R, Kepes JJ, Kepes M. Case reports: heterotopic brain tissue of middle ear associated with cholesteatoma. Am J Med Sci. 1994;308(3):180–3.

    Article  CAS  PubMed  Google Scholar 

  52. Iurato S, Bux G, Colucci S, Davidson C, Ettorre GC, Mazzarella L, et al. Histopathology of spontaneous brain herniations into the middle ear. Acta Otolaryngol. 1992;112(2):328–33.

    Article  CAS  PubMed  Google Scholar 

  53. Hinni ML, Beatty CW. Salivary gland choristoma of the middle ear: report of a case and review of the literature. Ear Nose Throat J. 1996;75(7):422–4.

    CAS  PubMed  Google Scholar 

  54. Nelson EG, Kratz RC. Sebaceous choristoma of the middle ear. Otolaryngol Head Neck Surg. 1993;108(4):372–3.

    Article  CAS  PubMed  Google Scholar 

  55. Crain N, Nelson BL, Barnes EL, Thompson LD. Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases. Head Neck Pathol. 2009;3(1):1–17.

    Article  PubMed  Google Scholar 

  56. Derlacki EL, Barney PL. Adenomatous tumors of the middle ear and mastoid. Laryngoscope. 1976;86(8):1123–35.

    Article  CAS  PubMed  Google Scholar 

  57. Hyams VJ, Michaels L. Benign adenomatous neoplasm (adenoma) of the middle ear. Clin Otolaryngol Allied Sci. 1976;1(1):17–26.

    Article  CAS  PubMed  Google Scholar 

  58. Murphy G, Pilch BZ, Dickersin GR, Goodman MC, Nadol JB. Carcinoid tumor of the middle ear. Am J CLin Pathol. 1980;73:816–23.

    Google Scholar 

  59. Stanley MW, Horwitz CA, Levinson RM, Sibley RK. Carcinoid tumors of the middle ear. Am J Clin Pathol. 1987;87(5):592–600.

    Article  CAS  PubMed  Google Scholar 

  60. Wassef M, Kanavaros P, Polivka M, Nemeth J, Monteil JP, Frachet B, et al. Middle ear adenoma. A tumor displaying mucinous and neuroendocrine differentiation. Am J Surg Pathol. 1989;13(10):838–47.

    Article  CAS  PubMed  Google Scholar 

  61. Ribe A, Fernandez PL, Ostertarg H, Claros P, Bombi JA, Palacin A, et al. Middle-ear adenoma (MEA): a report of two cases, one with predominant “plasmacytoid” features. Histopathology. 1997;30(4):359–64.

    Article  CAS  PubMed  Google Scholar 

  62. Torske KR, Thompson LD. Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol. 2002;15(5):543–55.

    Article  PubMed  Google Scholar 

  63. Gaffey MJ, Mills SE, Boyd JC. Aggressive papillary tumor of middle ear/temporal bone and adnexal papillary cystadenoma. Manifestations of von Hippel-Lindau disease. Am J Surg Pathol. 1994;18(12):1254–60.

    Article  CAS  PubMed  Google Scholar 

  64. Heffner DK. Low-grade adenocarcinoma of probable endolymphatic sac origin A clinicopathologic study of 20 cases. Cancer. 1989;64(11):2292–302.

    Article  CAS  PubMed  Google Scholar 

  65. Adam W, Johnson JC, Paul DJ, Clausen K, Schuller DE. Primary adenocarcinoma of the middle ear. AJNR Am J Neuroradiol. 1982;3(6):674–6.

    CAS  PubMed  Google Scholar 

  66. Benecke JE, Noel FL, Carberry JN, House JW, Patterson M. Adenomatous tumors of the middle ear and mastoid. Am J Otol. 1990;11(1):20–6.

    PubMed  Google Scholar 

  67. Blamires TL, Friedmann I, Moffat DA. Von Hippel-Lindau disease associated with an invasive choroid plexus tumor presenting as a middle ear mass. J Laryngol Otol. 1992;106(5):429–35.

    Google Scholar 

  68. Dadas B, Alkan S, Turgut S, Basak T. Primary papillary adenocarcinoma confined to the middle ear and mastoid. Eur Arch Otorhinolaryngol. 2001;258(2):93–5.

    Article  CAS  PubMed  Google Scholar 

  69. Gaffey MJ, Mills SE, Fechner RE, Intemann SR, Wick MR. Aggressive papillary middle-ear tumor. A clinicopathologic entity distinct from middle-ear adenoma. Am J Surg Pathol. 1988;12(10):790–7.

    Article  CAS  PubMed  Google Scholar 

  70. Goebel JA, Smith PG, Kemink JL, Graham MD. Primary adenocarcinoma of the temporal bone mimicking paragangliomas: radiographic and clinical recognition. Otolaryngol Head Neck Surg. 1987;96(3):231–8.

    CAS  PubMed  Google Scholar 

  71. Gulya AJ, Glasscock ME, Pensak ML. Primary adenocarcinoma of the temporal bone with posterior fossa extension: case report. Laryngoscope. 1986;96(6):675–7.

    Article  CAS  PubMed  Google Scholar 

  72. Hassard AD, Boudreau SF, Cron CC. Adenoma of the endolymphatic sac. J Otolaryngol. 1984;13(4):213–6.

    CAS  PubMed  Google Scholar 

  73. Jefferson G, Whitehead R. Papilliferous cystoma of petrous bone associated with hypernephroma and cystic pancreas. Br J Surg. 1931;19:55–62.

    Article  Google Scholar 

  74. Palmer JM, Coker NJ, Harper RL. Papillary adenoma of the temporal bone in von Hippel-Lindau disease. Otolaryngol Head Neck Surg. 1989;100(1):64–8.

    Article  CAS  PubMed  Google Scholar 

  75. Polinsky M, Brumberg J, McKeever P, Sandler H, Telian S, Ross D. Aggressive papillary middle ear tumors: a report of two cases with review of the literature. Neurosurgery. 1994;35:493–7. (discussion Robertson JH):497.

    Google Scholar 

  76. Stendel R, Suess O, Prosenc N, Funk T, Brock M. Neoplasm of endolymphatic sac origin: clinical, radiological and pathological features. Acta Neurochir (Wien). 1998;140(10):1083–7.

    Article  CAS  Google Scholar 

  77. Stone HE, Lipa M, Bell RD. Primary adenocarcinoma of the middle ear. Arch Otolaryngol. 1975;101(11):702–5.

    Article  CAS  PubMed  Google Scholar 

  78. Tysome JR, Harcourt J, Patel MC, Sandison A, Michaels L. Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm? Ear Nose Throat J. 2008;87(7):378–93.

    PubMed  Google Scholar 

  79. Siedentop KH, Jeantet C. Primary adenocarcinoma of the middle ear. Report of three cases. Ann Otol Rhinol Laryngol. 1961;70:719–33.

    Article  CAS  PubMed  Google Scholar 

  80. Muller M, Zammit-Maempel I, Hill J, Wilkins B. An unusual middle-ear mass. J Laryngol Otol. 2010;124(1):108–10.

    Google Scholar 

  81. Mills S, Gaffey M, Frierson HJ. Tumors of the upper aerodigestive tract and ear. Atlas of tumor pathology, Third series, Fascicle 26; 2000.

    Google Scholar 

  82. Ophir D. Familial multicentric paragangliomas in a child. J Laryngol Otol. 1991;105(5):376–80.

    Article  CAS  PubMed  Google Scholar 

  83. Schwaber MK, Glasscock ME, Nissen AJ, Jackson CG, Smith PG. Diagnosis and management of catecholamine secreting glomus tumors. Laryngoscope. 1984;94(8):1008–15.

    Article  CAS  PubMed  Google Scholar 

  84. Kliewer K, Duan-Ren W, Pasquale A, Cochrane AJ. Paragangliomas: assessment of prognosis by histologic, immunohistochemical and ultrastructural techniques. Hum Pathol. 1989;20:29–39.

    Article  CAS  PubMed  Google Scholar 

  85. van Baars FM, Cremers CW, van den Broek P, Veldman JE. Familiar non-chromaffinic paragangliomas (glomus tumors). Clinical and genetic aspects (abridged). Acta Otolaryngol. 1981;91(5–6):589–93.

    Article  PubMed  Google Scholar 

  86. Mariman EC, van Beersum SE, Cremers CW, van Baars FM, Ropers HH. Analysis of a second family with hereditary non-chromaffin paragangliomas locates the underlying gene at the proximal region of chromosome 11q. Hum Genet. 1993;91(4):357–61.

    Article  CAS  PubMed  Google Scholar 

  87. Nager GT. Meningiomas involving the temporal bone. Springfield: Charles C Thomas; 1963.

    Google Scholar 

  88. Thompson LDR, Bouffard J-P, Sandberg GD, Mena H. Primary ear and temporal bone meningiomas: a clinicopathologic study of 36 cases with a review of the literature. Mod Pathol. 2003;16(3):236–45.

    Article  PubMed  Google Scholar 

  89. Rushing EJ, Bouffard JP, McCall S, Olsen C, Mena H, Sandberg GD, et al. Primary extracranial meningiomas: an analysis of 146 cases. Head Neck Pathol. 2009;3(2):116–30.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Michaels L, Wells M. Squamous cell carcinoma of the middle ear. Clin Otolaryngol Allied Sci. 1980;5(4):235–48.

    Article  CAS  PubMed  Google Scholar 

  91. Nakhelh R, Swanson PE, Dehner LP. Juvenile (embryonal and alveolar) rhabdomyosarcoma of the head and neck in adults. A clinical, pathologic, and immunohistochemical study of 12 cases. Cancer. 1991;15(67):1019–24.

    Article  Google Scholar 

  92. Durve DV, Kanegaonkar RG, Albert D, Levitt G. Paediatric rhabdomyosarcoma of the ear and temporal bone. Clin Otolaryngol Allied Sci. 2004;29(1):32–7.

    Article  CAS  PubMed  Google Scholar 

  93. Hill BA, Kohut RI. Metastatic adenocarcinoma of the temporal bone. Arch Otolaryngol. 1976;102(9):568–71.

    Article  CAS  PubMed  Google Scholar 

  94. Jahn AF, Farkashidy J, Berman JM. Metastatic tumors in the temporal bone – a pathophysiologic study. J Otolaryngol. 1979;8(1):85–95.

    CAS  PubMed  Google Scholar 

  95. Michaels L, Soucek S. Atypical mature bone in the otosclerotic otic capsule as the differentiated zone of an invasive osseous neoplasm. Acta Otolaryngol. 2014;134(2):118–23.

    Google Scholar 

  96. Bahmad Jr F, Merchant SN. Paget disease of the temporal bone. Otol Neurotol. 2007;28(8):1157–8.

    PubMed  PubMed Central  Google Scholar 

  97. Davies DG. Paget’s disease of the temporal bone. A clinical and histopathological survey. Acta Otolaryngol. 1968;Suppl 242:3+.

    Google Scholar 

  98. Nager GT. Paget’s disease of the temporal bone. Ann Otol Rhinol Laryngol. 1975;84(4 Pt 3 Suppl 22):1–31.

    Google Scholar 

  99. Pillion JP, Vernick D, Shapiro J. Hearing loss in osteogenesis imperfecta: characteristics and treatment considerations. Genet Res Int. 2011;2011:983942.

    PubMed  PubMed Central  Google Scholar 

  100. Igarashi M, King AI, Schwenzfeier CW, Watanabe T, Alford BR. Inner ear pathology in osteogenesis imperfecta congenita. J Laryngol Otol. 1980;94(7):697–705.

    Article  CAS  PubMed  Google Scholar 

  101. Dieler R, Muller J, Helms J. Stapes surgery in osteogenesis imperfecta patients. Eur Arch Otorhinolaryngol. 1997;254(3):120–7.

    Article  CAS  PubMed  Google Scholar 

  102. Arslan M, Ricci V. Histochemical investigations of otosclerosis with special regard to collagen disease. J Laryngol Otol. 1963;77:365–73.

    Article  Google Scholar 

  103. McKenna MJ, Kristiansen AG, Bartley ML, Rogus JJ, Haines JL. Association of COL1A1 and otosclerosis: evidence for a shared genetic etiology with mild osteogenesis imperfecta. Am J Otol. 1998;19(5):604–10.

    CAS  PubMed  Google Scholar 

  104. Hamersma H. Osteopetrosis (marble bone disease) of the temporal bone. Laryngoscope. 1970;80(10):1518–39.

    Article  CAS  PubMed  Google Scholar 

  105. Milroy CM, Michaels L. Temporal bone pathology of adult-type osteopetrosis. Arch Otolaryngol Head Neck Surg. 1990;116(1):79–84.

    Article  CAS  PubMed  Google Scholar 

  106. Myers EN, Stool S. The temporal bone in osteopetrosis. Arch Otolaryngol. 1969;89(3):460–9.

    Article  CAS  PubMed  Google Scholar 

  107. Stagno S, Reynolds DW, Amos CS, Dahle AJ, McCollister FP, Mohindra I, et al. Auditory and visual defects resulting from symptomatic and subclinical congenital cytomegaloviral and toxoplasma infections. Pediatrics. 1977;59(5):669–78.

    CAS  PubMed  Google Scholar 

  108. Davis GL. Cytomegalovirus in the inner ear. Case report and electron microscopic study. Ann Otol Rhinol Laryngol. 1969;78(6):1179–88.

    Article  CAS  PubMed  Google Scholar 

  109. Davis LE, Johnsson LG, Kornfeld M. Cytomegalovirus labyrinthitis in an infant: morphological, virological, and immunofluorescent studies. J Neuropathol Exp Neurol. 1981;40(1):9–19.

    Article  CAS  PubMed  Google Scholar 

  110. Hanshaw JB, Scheiner AP, Moxley AW, Gaev L, Abel V, Scheiner B. School failure and deafness after “silent” congenital cytomegalovirus infection. N Engl J Med. 1976;295(9):468–70.

    Article  CAS  PubMed  Google Scholar 

  111. Myers EN, Stool S. Cytomegalic inclusion disease of the inner ear. Laryngoscope. 1968;78(11):1904–15.

    Article  CAS  PubMed  Google Scholar 

  112. Strauss M. Human cytomegalovirus labyrinthitis. Am J Otolaryngol. 1990;11(5):292–8.

    Article  CAS  PubMed  Google Scholar 

  113. Soucek S, Michaels L. The ear in the acquired immunodeficiency syndrome: II. Clinical and audiologic investigation. Am J Otol. 1996;17(1):35–9.

    CAS  PubMed  Google Scholar 

  114. Michaels L, Soucek S, Liang J. The ear in the acquired immunodeficiency syndrome: I. Temporal bone histopathologic study. Am J Otol. 1994;15(4):515–22.

    CAS  PubMed  Google Scholar 

  115. Friedmann I, Wright MI. Histopathological changes in the foetal and infantile inner ear caused by maternal rubella. Br Med J. 1966;2(5504):20–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Fujiwara Y, Yanagihara N, Kurata T. Middle ear mucosa in Ramsay Hunt syndrome. Ann Otol Rhinol Laryngol. 1990;99(5 Pt 1):359–62.

    Article  CAS  PubMed  Google Scholar 

  117. Wackym PA. Molecular temporal bone pathology: II. Ramsay Hunt syndrome (herpes zoster oticus). Laryngoscope. 1997;107(9):1165–75.

    Article  CAS  PubMed  Google Scholar 

  118. Burgess RC, Michaels L, Bale JF, Smith RJ. Polymerase chain reaction amplification of herpes simplex viral DNA from the geniculate ganglion of a patient with Bell’s palsy. Ann Otol Rhinol Laryngol. 1994;103(10):775–9.

    Article  CAS  PubMed  Google Scholar 

  119. Turgeon RD, Wilby KJ, Ensom MH. Antiviral treatment of Bell’s palsy based on baseline severity: a systematic review and meta-analysis. Am J Med 2015;128(6):617–28.

    Google Scholar 

  120. Merchant SN, Gopen Q. A human temporal bone study of acute bacterial meningogenic labyrinthitis. Am J Otol. 1996;17(3):375–85.

    CAS  PubMed  Google Scholar 

  121. Schuknecht H. Cupolithiasis. Arch Otolaryngol. 1969;90:765–78.

    Article  CAS  PubMed  Google Scholar 

  122. Xenellis JE, Linthicum FH. On the myth of the glial/schwann junction (Obersteiner-Redlich zone): origin of vestibular nerve schwannomas. Otol Neurotol. 2003;24(1):1.

    Article  PubMed  Google Scholar 

  123. Leonard JR, Talbot ML. Asymptomatic acoustic neurilemoma. Arch Otolaryngol. 1970;91(2):117–24.

    Article  CAS  PubMed  Google Scholar 

  124. Tosaka M, Hirato J, Miyagishima T, Saito N, Nakazato Y, Sasaki T. Calcified vestibular schwannoma with unusual histological characteristics – positive immunoreactivity for CD-34 antigen. Acta Neurochir (Wien). 2002;144(4):395–9.

    Article  CAS  Google Scholar 

  125. Bedavanija A, Brieger J, Lehr H-A, Maurer J, Mann WJ. Association of proliferative activity and size in acoustic neuroma: implications for timing of surgery. J Neurosurg. 2003;98(4):807–11.

    Article  PubMed  Google Scholar 

  126. Nevoux J, Nowak C, Vellin JF, Lepajolec C, Sterkers O, Richard S, et al. Management of endolymphatic sac tumors: sporadic cases and von Hippel-Lindau disease. Otol Neurotol. 2014;35(5):899–904.

    Google Scholar 

  127. Aguiar PH, Tatagiba M, Samii M, Dankoweit-Timpe E, Ostertag H. The comparison between the growth fraction of bilateral vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibular schwannomas using the monoclonal antibody MIB 1. Acta Neurochir (Wien). 1995;134(1–2):40–5.

    Article  CAS  Google Scholar 

  128. Singh S, Cottingham SL, Slone W, Boesel CP, Welling DB, Yates AJ. Lipomas of the internal auditory canal. Archiv Pathol Lab Med. 1996;120:681–3.

    CAS  Google Scholar 

  129. Megerian CA, Haynes DS, Poe DS, Choo DI, Keriakas TJ, Glasscock ME. Hearing preservation surgery for small endolymphatic sac tumors in patients with von Hippel-Lindau syndrome. Otol Neurotol. 2002;23(3):378–87.

    Article  PubMed  Google Scholar 

  130. Pollak A, Bohmer A, Spycher M, Fisch U. Are papillary adenomas endolymphatic sac tumors? Ann Otol Rhinol Laryngol. 1995;104(8):613–9.

    Article  CAS  PubMed  Google Scholar 

  131. Amedee RG, Marks HW, Lyons GD. Cholesterol granuloma of the petrous apex. Am J Otol. 1987;8(1):48–55.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Histopathology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, W68RF, UK

    Ann Sandison BSc(Hons), MPhil, MBCHB, FRCPath

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  1. Ann Sandison BSc(Hons), MPhil, MBCHB, FRCPath
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Correspondence to Ann Sandison BSc(Hons), MPhil, MBCHB, FRCPath .

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Editors and Affiliations

  1. University of Barcelona, Anatomic Pathology Hospital Clínic University of Barcelona, Barcelona, Spain

    Antonio Cardesa

  2. Radboud Univ Nijmegen Medical Center, Pathology Radboud Univ Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter J. Slootweg

  3. University of Ljubljana,, Institute of Pathology, Faculty of Medic University of Ljubljana,, Ljublijana, Slovenia

    Nina Gale

  4. University of Florence, Dept of Surg & Translational Medicine University of Florence, Florence, Italy

    Alessandro Franchi

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Sandison, A. (2016). Ear and Temporal Bone. In: Cardesa, A., Slootweg, P., Gale, N., Franchi, A. (eds) Pathology of the Head and Neck. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49672-5_8

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  • DOI: https://doi.org/10.1007/978-3-662-49672-5_8

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