Zusammenfassung
Nach der Entdeckung des Grundprinzips 1917, nachdem Laser bis heute funktionieren, bedurfte es einiger Zeit, bis erste klinische Anwendungen Eingang in die Dermatologie gefunden haben. Die speziellen Eigenschaften von Laserlicht ermöglichen vielfältige Applikationen von der Abtragung, der Koagulation, der selektiven Fotothermolyse bis hin zur Kombination von fraktionalen Lasern und anderen Lichtquellen, die neue Therapieformen für die Behandlung der Feldkanzerisierung und der chronisch lichtgealterten Haut bieten. Die photodynamische Therapie erlebte so einen neuen Aufschwung in ihrer Weiterentwicklung als Tageslicht-PDT, laserassistierte PDT und laserassistierte artifizielle Tageslicht-PDT. Die antiinfektiöse PDT ist aufgrund der oxidativen Wirkung unabhängig vom antibiotischen Resistenzmuster oder des Typs der Bakterien wahrscheinlich ebenso zukunftsträchtig.
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Literatur
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Erstbeschreiber
Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220:524–527
Goldman L et al (1963) Pathology of the effect of the laser beam on the skin. Nature 197:912–914
Kennedy JC, Pottier RH, Pross DC (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B 6:143–148
Maiman T (1960) Stimulated optical radiation in ruby. Nature 187:493–494
Manstein D, Herron GS, Sink RK et al (2004) Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 34:426–438
Wiegell SR, Haedersdal M, Philipsen PA, Eriksen P, Enk CD, Wulf HC (2008) Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study. Br J Dermatol 158:740–746
Zaret MM, Breinin GM, Schmidt H et al (1961) Ocular lesions produced by an optical maser (laser). Science 134:1525–1526
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Bäumler, W., Landthaler, M., Paasch, U. (2018). Laser, hochenergetische Blitzlampen und photodynamische Therapie. In: Plewig, G., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco’s Dermatologie, Venerologie und Allergologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49544-5_119
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