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Preparation of Functional Vincristine Liposomes for Treatment of Invasive Breast Cancer

Liposome-Based Drug Delivery Systems

Part of the book series: Biomaterial Engineering ((BIOENG))

  • 164 Accesses

Abstract

Clinical treatment of cancers usually adopts a comprehensive strategy, which consists of surgical treatment, radiotherapy, chemotherapy, and biotherapy. Among which, chemotherapy plays a crucial role. However, conventional chemotherapy fails to obtain a satisfactory efficacy, including unfavorable pharmacokinetic properties and systemic toxicities, which are caused by the direct delivery of free drugs into the circulatory system. This chapter focuses on the liposomal formulations of encapsulated vinca alkaloid and mainly introduces the preparation and characterization of functional vincristine liposomes, which were designed to treat the invasive breast cancer along with eliminating the vasculogenic mimicry channels. In this liposomal drug delivery system, vincristine was used as an anticancer agent, dasatinib was used as a promising regulator, and the targeting molecular c(RGDyK) was modified on the surface of the liposomes. The functional liposomes were round in shape and displayed a smooth surface with approximately 100 nm in diameter. The investigations were performed on invasive breast cancer MDA-MB-231 cells and MDA-MB-231 xenografts in nude mice. The functional vincristine plus dasatinib liposomes displayed a prolonged circulation time in blood system and an increased accumulation in tumor tissue, resulting in a robust overall anticancer efficacy.

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Authors and Affiliations

  1. Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

    Fan Zeng

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  1. Fan Zeng
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Correspondence to Fan Zeng .

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Editors and Affiliations

  1. Department of Pharmaceutics, Peking University Department of Pharmaceutics, Beijing, China

    Wan-Liang Lu

  2. Department of Pharmaceutics, Peking University Department of Pharmaceutics, Beijing, China

    Xiang-Rong Qi

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Zeng, F. (2018). Preparation of Functional Vincristine Liposomes for Treatment of Invasive Breast Cancer. In: Lu, WL., Qi, XR. (eds) Liposome-Based Drug Delivery Systems. Biomaterial Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49231-4_10-1

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  • DOI: https://doi.org/10.1007/978-3-662-49231-4_10-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-49231-4

  • Online ISBN: 978-3-662-49231-4

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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Chapter history

  1. Latest

    Preparation of Functional Vincristine Liposomes for Treatment of Invasive Breast Cancer
    Published:
    28 July 2018

    DOI: https://doi.org/10.1007/978-3-662-49231-4_10-2

  2. Original

    Preparation of Functional Vincristine Liposomes for Treatment of Invasive Breast Cancer
    Published:
    30 November 2017

    DOI: https://doi.org/10.1007/978-3-662-49231-4_10-1

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