Zusammenfassung
Im epilepsiechirurgischen Krankengut finden sich ca. 30% Tumorpatienten. Patienten mit Epilepsie- bzw. langzeitepilepsieassoziierten Tumoren (LEAT) weisen klinisch meist (aber nicht immer) eine erstaunlich gute onkologische Prognose auf, sodass die Operationsindikation weniger onkologisch als vielmehr epileptologisch begründet ist. Histologisch finden sich am häufigsten glioneuronale Tumore, d. h. Gangliogliome (> 50%) und dysembryoplastische neuroepitheliale Tumoren (DNT), daneben diffuse Astrozytome und Oligodendrogliome/Astrozytome WHO-Grad II/III, pleomorphe Xanthoastrozytome (PXA), pilozytische Astrozytome und einige sehr seltene neuroepitheliale Tumorentitäten wie z. B. angiozentrische Gliome (ANET). Um postoperativ Anfallsfreiheit zu erreichen, muss man nicht nur den Tumor, sondern die gesamte „epileptogene Zone“ entfernen, die je nach Schweregrad der Epilepsie über die unmittelbare Tumor-Hirn-Grenze herausreichen kann.
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Simon, M., Delev, D., Grote, A. (2018). Epilepsieassoziierte glioneuronale und gliale Tumoren (LEAT). In: Simon, M. (eds) Gliomchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48694-8_26
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DOI: https://doi.org/10.1007/978-3-662-48694-8_26
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