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The Extracellular Matrix Protein 1 (ECM1) in Molecular-Based Skin Biology

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Textbook of Aging Skin

Abstract

Extracellular matrix protein 1 (ECM1) is an 85-kDa secreted glycoprotein that plays a pivotal role in the structural and homeostatic biology of the skin, particularly in the proliferation and differentiation of epidermal keratinocytes, reconstitution of basement membrane, angiogenesis, malignant transformation, and aging. The multifocal interaction of ECM1 with various extracellular matrix and structural molecules is substantiated by loss-of-function mutations in the ECM1 gene in an autosomal recessive genodermatosis lipoid proteinosis and circulating IgG autoantibodies to this molecule in a humoral autoimmune condition lichen sclerosus, both of which are now recognized as an immunogenetic disease counterpart sharing comparable skin pathology. A series of underlying insights for the in vivo ECM1 biology, as a binding core and/or a scaffolding protein, arose not only for wide-ranged differentiation properties of the epidermal keratinocytes, acquisition of immune tolerance and allergic responses via particular T cell subsets such as CD4+ CD25+ regulatory T cells and Th2 cells, and various cancers but also from intrinsic and extrinsic aging of the skin.

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Authors and Affiliations

  1. Dermatology and Dermato-Allergology, Matsuda General Hospital, 1-13 Kanamecho, 912-0026, Ohno, Fukui, Japan

    Noritaka Oyama

  2. Department of Dermatology, Fukui University, Fukui, Japan

    Noritaka Oyama

  3. Laboratory of Molecular Biotechnology, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Antwerp, Belgium

    Joseph Merregaert

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  1. Noritaka Oyama
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  2. Joseph Merregaert
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Correspondence to Noritaka Oyama .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Oyama, N., Merregaert, J. (2017). The Extracellular Matrix Protein 1 (ECM1) in Molecular-Based Skin Biology. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_8

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_8

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

  • eBook Packages: MedicineReference Module Medicine

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