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Hirntumoren

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Kompendium Internistische Onkologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Im Kindesalter ist das Gehirn die häufigste Lokalisation solider Tumoren. Etwa die Hälfte der Fälle der Betroffenen hat ein Astrozytom niedriggradiger Malignität, das somit die häufigste von vielen, teils neu charakterisierten Entitäten ist. Der häufigste WHO-Grad-IV-Tumor ist das Medulloblastom, für das bislang die meisten Erkenntnisse vorliegen. Daher wird dieser Tumor ausführlicher dargestellt. Auf andere wichtige Hirntumoren beim Kind wird kurz vergleichend eingegangen. Neben der histologischen Diagnose wurden für die meisten Entitäten biologische Subgruppen identifiziert, deren Abgrenzung beim Medulloblastom bereits therapeutische Relevanz hat (z. B. WNT, SHH, Gruppe 3, Gruppe 4). Zudem gewinnt die Abklärung molekularer Parameter in Tumor und Keimbahn zunehmend an Bedeutung. Ebenso sind eine adäquate initiale Bildgebung und weitere Staging-Untersuchungen die Basis der postoperativen Versorgung und ggf. einer weiteren risikoadaptierten multimodalen Therapie (Radiotherapie, Chemotherapie).

Das Kapitel wurde in der 4. Auflage mitverfasst von Prof. Dr. med. Joachim Kühl, Universitätskinderklinik Würzburg.

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Author information

Authors and Affiliations

  1. Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Deutschland

    Stefan Rutkowski

  2. Department of Radiooncology, University of Leipzig Medical Center, Leipzig, Deutschland

    Rolf-Dieter Kortmann

Authors
  1. Stefan Rutkowski
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  2. Rolf-Dieter Kortmann
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Corresponding author

Correspondence to Stefan Rutkowski .

Editor information

Editors and Affiliations

  1. Abt. Hämatologie und Onkologie, Universitätsklinikum Halle-Wittenberg Klinik und Poliklinik Innere Medizin IV, Halle, Sachsen-Anhalt, Deutschland

    Hans-Joachim Schmoll

Section Editor information

  1. Pädiatrische Hämatologie/ Onkologie, Medizinische Hochschule Hannover, Hannover, Germany

    Ursula Creutzig

  2. Klinik für Pädiatrische Onkologie und Hämatologie, Universität des Saarlandes, Universitätsklinikum, Homburg/Saar, Deutschland

    Norbert Graf

  3. Klinische Studien in der Onkologie, Universitätsklinikum Halle (Saale), Halle, Deutschland

    Hans-Joachim Schmoll

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Rutkowski, S., Kortmann, RD. (2021). Hirntumoren. In: Schmoll, HJ. (eds) Kompendium Internistische Onkologie . Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46764-0_5-1

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  • DOI: https://doi.org/10.1007/978-3-662-46764-0_5-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-46764-0

  • Online ISBN: 978-3-662-46764-0

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