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Grundlagen der Tumorimmunologie

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Kompendium Internistische Onkologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Das Immunsystem ist die effektivste Waffe des Körpers, um Krankheitserreger, aber auch Krebszellen abzuwehren. Trotzdem entkommen manche Tumorzellen dieser Immunüberwachung. Grundlegende Voraussetzungen für das Verständnis von zielgerichteten Strategien zur Beeinflussung des Immunsystems bei der Bekämpfung von Krebs sind, die Prinzipien der Entstehung, Aktivierung und Regulation von Immunzellen sowie die molekularen Strukturen und Interaktionen zu kennen. In diesem Kapitel werden daher zunächst die wesentlichen Mechanismen vorgestellt, mit denen Immunzellen des angeborenen und adaptiven Immunsystems ihre Abwehrfunktion ausüben. Weiterhin werden bisher identifizierte Immune-Escape-Strategien von Tumorzellen beschrieben, die zu einer Tumorentwicklung und -progression führen können. Auf der Basis dieser grundlegenden immunologischen Erkenntnisse konnten in den vergangenen Jahren mehrere sehr erfolgreiche immunonkologische Therapiestrategien entwickelt und in die klinische Anwendung gebracht werden.

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Authors and Affiliations

  1. III. Medizinische Klinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland

    Matthias Theobald

  2. Universitätsklinikum Bonn, Medizinische Klinik III für Onkologie, Hämatologie, Immunonkologie und Rheumatologie, Universitätsklinikum Bonn, Bonn, Deutschland

    Peter Brossart

  3. Institut für Medizinische Immunologie, Universitätsklinikum Halle (Saale), Martin- Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland

    Barbara Seliger

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  1. Matthias Theobald
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  2. Peter Brossart
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  3. Barbara Seliger
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Correspondence to Matthias Theobald .

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  1. Abt. Hämatologie und Onkologie, Universitätsklinikum Halle-Wittenberg Klinik und Poliklinik Innere Medizin IV, Halle, Sachsen-Anhalt, Deutschland

    Hans-Joachim Schmoll

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  1. Translational Medical Oncology, NCT Heidelberg, Heidelberg, Deutschland

    Peter Horak

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Theobald, M., Brossart, P., Seliger, B. (2022). Grundlagen der Tumorimmunologie. In: Schmoll, HJ. (eds) Kompendium Internistische Onkologie . Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46764-0_265-1

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