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Diabetesnotfälle

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Weiterbildung Intensivmedizin und Notfallmedizin

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Zusammenfassung

Diabetesbedingte Notfälle sind häufig. Sie können sowohl hyperglykämische Zustände [dia-betische Ketoacidose (DKA) und hyperosmolares hyperglykämisches Syndrom (HHS)] als auch Hypoglykämien (hypoglykämisches Koma) oder nicht mit pathologischen Blutglucosewerten einhergehende Stoffwechselentgleisungen (z. B. Laktatacidose) betreffen. Die Kenntnis der entsprechenden Risikokonstellationen, Leitsymptome und Befunde sowie Früherkennung, Notfallmaßnahmen, intensivmedizinische Besonderheiten und Präventionsmaßnahmen bei den genannten Diabetesnotfällen müssen nicht nur dem intensivmedizinisch-tätigen Arzt, sondern auch dem ambulant-tätigen Diabetologen, Internisten und Hausarzt geläufig sein. Dies wird in diesem Beitrag in didaktisch klar aufbereiteter Form vermittelt.

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Literatur

  1. Scherbaum WA, Lobnlg BM (2012) Diabetes mellitus. In: Wolff H-R Weihrauch TR (Hrsg) Internistische Therapie 2012/2013,19. Auf], Elsevier Urban & Fischer, München, S 9731013

    Google Scholar 

  2. Scherbaum WA, Lobnig BM (2012) Hypoglykämien. In: Wolff H-P, Weihrauch TR (Hrsg) Internistische Therapie 2012/2013,19. Aufl. Elsevier Urban & Fischer, München, S1013–1019

    Google Scholar 

  3. Boehm BO, Dreyer M, Fritsche A et al (2013) Therapie desTyp-1 -Diabetes. Diabetologie 8(Suppl 2):133–143

    Google Scholar 

  4. Faich GA, Fishbeln HA, Ellis SE (1983) The epidemiology of diabetic acidosis. A population-based study. Am J Epidemiol 117:551–558

    CAS  PubMed  Google Scholar 

  5. Sillnk M (2011) Diabetic ketoacidosis in childhood and adolescence. In: Amiel SA, Davies MJ (Hrsg) Oxford textbook of endocrinology and diabetes. Oxford University Press, Oxford, S1888–1894

    Google Scholar 

  6. Rewers A, Chase HP, Mackenzie T et al (2002) Predictors of acute complications in children with type 1 diabetes. JAMA 287:2511–2518

    Article  PubMed  Google Scholar 

  7. Mallare JT, Cordice CC, Ryan BA et al (2003) Identifying risk factors for the development of diabetic ketoacidosis in new onset type 1 diabetes mellitus. Clin Pediatr (Phila) 42:591–597

    Article  Google Scholar 

  8. Kitabchi AE, Nyenwe E (2011) Hyperglycemic crisis in adult patients with diabetes mellitus. In: Amiel SA, Davies MJ (Hrsg) Oxford textbook of endocrinology and diabetes. Oxford University Press, Oxford, S1874- 1888

    Google Scholar 

  9. Centers for Disease Control and Prevention (2009) National Hospital Discharge Survey (NHDS). http://www.cdc.gov/nhcs/about/major/hdasd/nhds.htm

  10. Kitabchi AE, Umiperrez GE, Murphy MB et al (2006) Hyperglycemic crisis in adult patients with diabetes. A consensus statement of the American Diabetes Association. Diabetes Care 12:2739–2748

    Article  Google Scholar 

  11. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN (2009) Hyperglycemic crisis in adult patients with diabetes. Diabetes Care 7:1335–1343

    Article  Google Scholar 

  12. Neu A, Beyer P, Bürger-Büsing J et al (2013) Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Kindes- und Jugendalter. Diabetologie 8(Suppl 2):189–199

    Google Scholar 

  13. Edge JA, Roy Y, Bergomi A et al (2006) Conscious level in children with ketoacidosis is related to severity of acidosis and not to blood glucose concentration. Pediatr Diabetes 7:11–I5

    Article  PubMed  Google Scholar 

  14. Munro JF, Campbell IW, McCuish AC, Duncan U (1973) Euglycaemic diabetic ketoacidosis. BMJ 2:578–580

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. WaldhâusIW, Weinberger G, Korn A et al (1979) Severe hyperglycemia: effects of rehydration on endocrine derangements and blood glucose concentration. Diabetes 28:577–584

    Article  Google Scholar 

  16. Wolfsdorf J, Craig ME, Daneman D et al (2009) Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes 12(Suppl 10):118–133

    Article  Google Scholar 

  17. Rosenbloom AL, Hanas R (19%) Diabetic ketoacidosis (DKA): treatment guidelines. Clin Pediatr (Phila) 35:261–266

    Google Scholar 

  18. Ellis EN (1990) Concepts of fluid therapy in diabetic ketoacidosis and hyperosmolar hyperglycemic nonketotic coma. Pediatr Clin North Am 37:313–321

    CAS  PubMed  Google Scholar 

  19. Bureau MA, Bégin R, Berthiaume Y et aid 980) Cerebral hypoxia from bicarbonate infusion in diabetic acidosis. J Pediatr 96:968–973

    Google Scholar 

  20. Rosenbloom AL (1990) Intracerebral crisis during treatment of diabetic ketoacidosis. Diabetes Care 13:22–33

    Article  CAS  PubMed  Google Scholar 

  21. Hale PM, Rezvani I, Braunstein AW et al (1997) Factors predicting cerebral edema in young children with diabetic ketoacidosis and new onset type 1 diabetes. Acta Paediatr 86:626–631

    Article  CAS  PubMed  Google Scholar 

  22. Edge JA, Hawkins MM, Winter DL, Dunger DB (2001) The risk and outcome of cerebral oedema developing during diabetic ketoacidosis. Arch Dis Child 85:16–22

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Glaser N, Barnett P, McCaslin I et al (2001) Risk factors for cerebral edema in children with diabetic ketoacidosis. Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med 344:264–269

    Article  CAS  PubMed  Google Scholar 

  24. Tieder JS, McLeod L, Keren R et al (2013) Variation in resource use and readmission for diabetic ketoacidosis In children's hospitals. Pediatrics 132:229–236

    Article  PubMed  Google Scholar 

  25. Nationale Versorgungsleitlinie Therapie desTyp-2-Diabetes (2013) Letzte Bearbeitung/Version: 09/2013. http://www.versorgungsleitlinie/themen/diabetes2/dm2_therapie

  26. Arzneimittelkommlssion der deutschen Ärzteschaft (2013) Zunahme von Spontanberichten über Metformin -assoziierte Laktatazidosen (Aus 41. der UAW-Datenbank). Dtsch Arztebl 10

    Google Scholar 

  27. Kamber N, Davis WA, Bruce DG et al 42. (2008) Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study. Med J Aust 188:446-449

    Google Scholar 

  28. Schwabe U, Paffrath D (Hrsg) (2012) Arzneimittelverordnungs-Report 43. 2012. Springer, Berlin Heidelberg New York Tokio

    Google Scholar 

  29. Salpeter SR, Greyber E, Pasternak GA etal (2010) Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochra-. ne Database Syst Rev. 2006. Review update. (Published online: Cochrane. org/CD002967/risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus).

    Google Scholar 

  30. Lipska KJ, Bailey Cl, Inzucchl SE (2011) Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34:1431–1437.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. Cryer PE (2002) Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937-948

    Google Scholar 

  32. Goto A, ArahOW, Goto Metal (2013). Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis. BMJ 347:f4533. DOI 10.1136/bmj.f4533

    Google Scholar 

  33. Turchin A, Matheny ME, Shubina M et al (2009) Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward. Diabetes Care 32:1153–1157

    Article  PubMed Central  PubMed  Google Scholar 

  34. Kern W (2013) Hypoglykämien. Epidemiologie und Pathophysiologie. Diabetologe 9:14-18

    Google Scholar 

  35. Gais S, Born J, Peters A et al (2003) Hypoglycemia counterregulation 49. during sleep. Sleep 6:55–59

    Google Scholar 

  36. Inkster B, Riha RL, Van Look L et al (2013) Association between excessive daytime sleepiness and severe hypoglycemia in people with ty. pe 2 diabetes. The Edinburgh type 2 diabetes study. Diabetes Care. DOI 10:2337/dc13-0963

    Google Scholar 

  37. Schultes B, Jauch-Chara K, Gais S et al (2007) Defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus. PLoS Med 4:361–369.

    Article  CAS  Google Scholar 

  38. Bremer JP, Jauch-Chara K, Hall- schmid M et al (2009) Hypoglycemia unawareness in older compared with middle-aged patients with type 2 diabetes. Diabetes Care 32:1513–1517

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  39. Erbguth F (2013) Hypoglykämien und zentrales Nervensystem. Diabetologe 9:25–32

    Article  Google Scholar 

  40. Kulzer B, Klrchbaum M, Hermanns N (2013) Hypoglykämien und Psyche. Diabelologe 933–40

    Google Scholar 

  41. ScherbaumWA (2012) Individualisierte Medizin in der Oiabetoklgie. Diabelologe 8;94–97

    Google Scholar 

  42. Holstein A, PatzerOM, MachalkeKet al (2012) Substantial increase in Incidence of reliefe hypoglycemia betweeo 1997-2000and 2007-2010: a Germao loogitudinal populatlon·based ltudy. Diabetes Care 35:972–975

    Google Scholar 

  43. Feinkohl I, Aung PP, Keller M et al (2013) Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: the Edinburgh type 2 diabetes study. Diabetes Care. DOI 10:2337/dc13-1384

    Google Scholar 

  44. Holstein A, PlalChke A., Egbelll EH (2003) Cllnkal characterization of severe hypoglycaemla-a prospective populatlon-based study. Exp Clin Endocrinol Diabetes 111:364–369

    PubMed  Google Scholar 

  45. Robinson RT, Harris ND, Ireland RH et al (2003) Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia. Diabetes 52:1469–1474

    Google Scholar 

  46. Mitrakou A., Fanelli C, Venemanl et al (1 993) Reversibility of unawareness of hypoglyocemia in patlents with insulinomas. N Eng J Med 329:834–839

    Google Scholar 

  47. Cranston I, Lomas J, Maran A et al (1994) Restoration of hypoglyocaemia Awareness in palients with long-duration insulin-dependent diabetes. Lancet 344:283–287

    Google Scholar 

  48. Fanelli CG, Epifano L Rambotti AM et al (1993) Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short·term IDDM. Diabetes 42:1683–1689

    Google Scholar 

  49. U.K. Hypoglycaemia Study Group (2007) Risk of hypoglycaemia in type 1 and type 2diabetes: effects of treatment modalities and their duration. Diabetologia 50:1140–1147

    Google Scholar 

  50. Leelarathna L, Little SA, Walkinshaw E et al (2013) Restoration of self-awareness of hypoglycaemia in adults with long·standing type 1diabetes: hyperinsulinemic-hypogiycemic c1amp substudy results from the HypoCOMPaSS trial. Diabetes Care. DOI 10:2337/dc13-1004

    Google Scholar 

  51. Choudhary P, Ramasamy S, Green L et al (2013) Real-time continuous glucose monitoring significantly reduces severe hypoglycemia in hypoglycemia-unaware patients with type 1 diabetes. Diabetes Care. DOI 10:2337/dc 13–0939

    Google Scholar 

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Author information

Authors and Affiliations

  1. Universitätsklinikum, Heinrich-Heine-Universität, Düsseldorf

    W.A. Scherbaum & C.R. Scherbaum

Authors
  1. W.A. Scherbaum
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  2. C.R. Scherbaum
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Editor information

Editors and Affiliations

  1. Klinik für Innere Medizin, St. Antonius-Hospital, Dechant-Deckers-Str. 8, 52249, Eschweiler

    U. Janssens

  2. Univ.-Klinik für Innere Medizin I, Universitätsklinikum Innsbruck, Aichstr. 35, A-6020, Innsbruck

    M. Joannidis

  3. Med. Klinik und Poliklinik II, Universitätsklinikum Gießen, Klinikstr. 36, 35392, Gießen

    K. Mayer

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Scherbaum, W., Scherbaum, C. (2015). Diabetesnotfälle. In: Janssens, U., Joannidis, M., Mayer, K. (eds) Weiterbildung Intensivmedizin und Notfallmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46521-9_6

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  • DOI: https://doi.org/10.1007/978-3-662-46521-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-46520-2

  • Online ISBN: 978-3-662-46521-9

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