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Genetic Syndromes Associated with Neuroendocrine Tumours

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Neuroendocrine Tumours

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Abstract

Neuroendocrime tumors (NETs) represent a group of neoplasms arising from the neuroendocrine cells of the diffuse endocrine system. The majority of gastrointestinal, pancreatic, lung, and thymic NET are sporadic. However, some of the NET may occur as part of multisystem autosomal dominant inherited genetic disorders, such as the MEN-1 syndrome, VHL, NF-1, and TSC. Over the last three decades, the genetic basis of tumorigenesis in the context of these familial syndromes has been elucidated, thus providing clinicians with useful screening tools for affected families.

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Authors and Affiliations

  1. Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, Rotterdam, The Netherlands

    Wouter W. de Herder

  2. Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

    Gerlof D. Valk

Authors
  1. Wouter W. de Herder
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  2. Gerlof D. Valk
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Correspondence to Wouter W. de Herder .

Editor information

Editors and Affiliations

  1. Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey

    Suayib Yalcin

  2. Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden

    Kjell Öberg

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de Herder, W.W., Valk, G.D. (2015). Genetic Syndromes Associated with Neuroendocrine Tumours. In: Yalcin, S., Öberg, K. (eds) Neuroendocrine Tumours. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45215-8_5

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  • DOI: https://doi.org/10.1007/978-3-662-45215-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45214-1

  • Online ISBN: 978-3-662-45215-8

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