Abstract
Hydrogels are three-dimensional insoluble networks able to imbibe large amount of water. They can be used in various fields including pharmaceutical and biomedical applications owing to their physical and chemical properties such as swelling behavior and chemical structure. Different methods used for the production of hydrogels as well as hydrogels based on several polymers such as chitosan, polyvinyl alcohol, and alginate have been reported. Moreover, the applications of hydrogels in transdermal drug delivery were described. In particular, the attention was focused on hydrogels as semisolid systems and film-based systems (matrix-type systems, membrane-coated systems, and film-forming solution) able to minimize skin irritation, promote adhesion properties, guarantee dosage flexibility, enhance patient acceptability, and improve ease of use.
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References
Ale I, Lachapelle JM, Maibach HI (2009) Skin tolerability associated with transdermal drug delivery systems: an overview. Adv Ther 26(10):920–935
Anderson JM, Shive MS (1997) Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 28:5–24
Berger J, Reist M, Mayer MJ, Felt O, Peppas NA, Gurny R (2004) Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm Biopharm 57:19–34
Brasch U, Burchard W (1996) Preparation and solution properties of microhydrogels from poly(vinyl alcohol). Macromol Chem Phys 197:223–235
Brown MB, Martin GP, Jones SA, Akomeah FK (2006) Dermal and transdermal drug delivery systems: current and future prospects. Drug Deliv 13(3):175–187
Cerchiara T, Luppi B, Bigucci F, Orienti I, Zecchi V (2002) Physically cross-linked chitosan hydrogels as topical vehicles for hydrophilic drugs. J Pharm Pharmacol 54:1453–1459
Chen L, Tian Z, Du Y (2004) Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices. Biomaterials 25(17):3725–3732
Damink LHHO, Dijkstra PJ, vanLuyn MJA, vanWachem PB, Nieuwenhuis P, Feijen J (1996) In vitro degradation of dermal sheep collagen cross-linked using a water-soluble carbodiimide. Biomaterials 17:679–684
Denet AR, Vanbever R, Préat V (2004) Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev 56:659–674
Draye JP, Delaey B, van de Voorde A, van den Bulcke A, Bogdanov B, Schacht E (1998) In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials 19:99–107
Eagland D, Crowther NJ, Butler CJ (1994) Complexation between polyoxyethylene and polymethacrylic acid – the importance of the molar mass of polyethylene. Eur Polym J 30:767–773
Eliaz RE, Kost J (2000) Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins. J Biomed Mater Res 50:388–396
Feldstein MM, Tohmakhchi VN, Malkhazov LB, Vasiliev AE, Plate NA (1996) Hydrophilic polymeric matrices for enhanced transdermal drug delivery. Int J Pharm 131:229–242
Grant G, Morris ER, Rees DA, Smith PJC, Thom D (1973) Biological interaction between polysaccharides and divalent cations: the egg-box model. FEBS Lett 32(1):195–198
Guo R, Du X, Zhang R, Deng L, Dong A, Zhang J (2011) Bioadhesive film formed from a novel organic-inorganic hybrid gel for transdermal drug delivery system. Eur J Pharm Biopharm 79(3):574–583
Guy RH (1996) Current status and future prospects of transdermal drug delivery. Pharm Res 13:1765–1769
He W, Guo X, Zhang M (2008) Transdermal permeation enhancement of N-trimethyl chitosan for testosterone. Int J Pharm 356(1–2):82–87
He W, Guo X, Xiao L, Feng M (2009) Study on the mechanisms of chitosan and its derivatives used as transdermal penetration enhancers. Int J Pharm 382(1–2):234–243
Hennink WE, van Nostrum CF (2002) Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 54(1):13–36
Henry S, McAllister DV, Allen MG, Prausnitz MR (1998) Microfabricated microneedles: a novel approach to transdermal drug. J Pharm Sci 87:922–925
Hickey AS, Peppas NA (1995) Mesh size and diffusive characteristics of semicrystalline poly(vinyl alcohol) membranes prepared by freezing/thawing techniques. J Membr Sci 107:229–237
Hoffman AS (1991) Environmentally sensitive polymers and hydrogels – “smart” biomaterials. MRS Bull XVI:42–46
Hoffman AS (2002) Hydrogels for biomedical applications. Adv Drug Deliv Rev 54:3–12
Hu Q, Liang W, Bao J, Ping Q (2000) Enhanced transdermal delivery of tetracaine by electroporation. Int J Pharm 202:121–124
Iordanskii AL, Feldstein MM, Markin VS, Hadgraft J, Plate NA (2000) Modeling of the drug delivery from a hydrophilic transdermal therapeutic system across polymer membrane. Eur J Pharm Biopharm 49:287–293
Ishii Y, Nakae T, Sakamoto F, Matsuo K, Quan YS, Kamiyama F et al (2008) A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection. J Control Release 131(2):113–120
Jatav VS, Singh H, Singh SK (2011) Recent trends on hydrogels in human body. IJRPBS 2:442–447
Kabanov VY (1998) Preparation of polymeric biomaterials with the aid of radiation-chemical methods. Russ Chem Rev 67:783–816
Khare AR, Peppas NA, Massimo G, Colombo P (1992) Measurement of the swelling force in ionic polymeric networks. I. Effect of pH and ionic content. J Control Release 22:239–244
Kim J, Shin SC (2004) Controlled release of atenolol from the ethylene-vinyl acetate matrix. Int J Pharm 273:23–27
Kim SW, Bae YH, Okano T (1992) Hydrogels: swelling, drug loading and release. Pharm Res 9:283–290
Kopeceka J (2007) Hydrogel biomaterials: a smart future? Biomaterials 28:5185–5192
Kurihara-Bergstrom T, Good WR, Feisulin S, Signur C (1991) Skin compatibility of transdermal drug delivery systems. J Control Release 15:271–278
Langer R (2004) Transdermal drug delivery: past progress, current status and future prospects. Adv Drug Deliv Rev 56:557–558
Lee KY, Bouhadir KH, Mooney DJ (2004) Controlled degradation of hydrogels using multi-functional cross-linking molecules. Biomaterials 25(13):2461–2466
Luo Y, Kirker RK, Prestwich GD (2000) Crosslinked hyaluronic acid hydrogels films: new biomaterials for drug delivery. J Control Release 69:169–184
Luppi B, Cerchiara T, Bigucci F, Di Pietra AM, Orienti I, Zecchi V (2003) Crosslinked poly(methyl vinyl ether-co-maleic anhydride) as topical vehicles for hydrophilic and lipophilic drugs. Drug Deliv 10:239–244
Luppi B, Bigucci F, Cerchiara T, Zecchi V (2010a) Chitosan-based hydrogels for nasal drug delivery: from inserts to nanoparticles. Expert Opin Drug Deliv 7:811–828
Luppi B, Bigucci F, Baldini M, Abruzzo A, Cerchiara T, Corace G et al (2010b) Hydroxypropylmethylcellulose films for prolonged delivery of the antipsychotic drug chlorpromazine. J Pharm Pharmacol 62:305–309
Mengatto LN, Helbling IM, Luna JA (2012) Recent advances in chitosan films for controlled release of drugs. Recent Pat Drug Deliv Formul 6(2):156–170
Miyata T, Uragami T, Nakamae K (2002) Biomolecule-sensitive hydrogels. Adv Drug Deliv Rev 54(1):79–98
Murdan S (2003) Electro-responsive drug delivery from hydrogels. J Control Release 92(1–2):1–17
Murphy M, Carmichael AJ (2000) Transdermal drug delivery systems and skin sensitivity reactions: incidence and management. Am J Clin Dermatol 1(6):361–368
Muzzarelli R, Baldassarre V, Conti F, Ferrara P, Biagini G, Gazzanelli G et al (1988) Biological activity of chitosan: ultrastructural study. Biomaterials 9:247–252
Nedkov E, Tsvetkova S (1994) Effect of γ-irradiation on the crystalline structure of ultra high molecular weight poly(ethylene oxide). Radiat Phys Chem 43:397–401
Noble L, Gray AL, Sadiq L, Uchegbu IF (1999) A non-covalently cross-linked chitosan based hydrogel. Int J Pharm 192(2):173–182
Orienti I, Di Pietra A, Luppi B, Zecchi V (2000) Crosslinked polyvinylalcohol hydrogels as vehicles for hydrophilic drugs. Arch Pharm Pharm Med Chem 333:421–424
Padula C, Colombo G, Nicoli S, Catellani PL, Massimo G, Santi P (2003) Bioadhesive film for the transdermal delivery of lidocaine: in vitro and in vivo behaviour. J Control Release 88(2):277–285
Peppas NA, Mikos AG (1986) Preparation methods and structure of hydrogels. In: Peppas NA (ed) Hydrogels in medicine and pharmacy. CRC press, Boca Raton, pp 1–25
Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27–46
Peppas NA, Hilt JZ, Khademhosseini A, Langer R (2006) Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater 18:1345–1360
Pikal MJ (2001) The role of electroosmotic flow in transdermal iontophoresis. Adv Drug Deliv Rev 46:281–305
Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26(11):1261–1268
Qu X, Wirsen A, Albertson AC (1999) Synthesis and characterization of pH-sensitive hydrogels based on chitosan and D. L-lactic acid. J Appl Polym Sci 74:3186–3192
Rosiak JM (1991) Hydrogel dressings. In: Clough RL, Shalaby SW (eds) Radiation effects on polymers. ACS symposium series 475. American Chemical Society, Washington, DC. pp 271–299
Safrany A (1997) Radiation processing: synthesis and modification of biomaterials for medical use. Nucl Inst Methods Phys Res B 131(1–4):376–381
Sahin S, Selek H, Ponchel G, Ercan MT, Sargon M, Hincal AA et al (2002) Preparation, characterization and in vivo distribution of terbutaline sulfate loaded albumin microspheres. J Control Release 82(2–3):345–358
Schroeder IZ, Franke P, Schaefer UF, Lehr C (2007) Development and characterization of film forming polymeric solutions for skin drug delivery. Eur J Pharm Biopharm 65(1):111–121
Silva CL, Pereira JC, Ramalho A, Pais AACC, Sousa JJS (2008) Films based on chitosan polyelectrolyte complexes for skin drug delivery: development and characterization. J Membr Sci 320:268–279
Sintov AC, Krimberk I, Daniel D, Hannan T, Sohn Z, Levin G (2003) Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs. J Control Release 89:311–320
Sludden J, Uchegbu IF, Schatzlein AG (2000) The encapsulation of bleomycin within chitosan based polymeric vesicles does not alter its biodistribution. J Pharm Pharmacol 52:377–382
Stauffer SR, Peppas NA (1992) Poly(vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing. Polymers 33(18):3932–3936
Taveira SF, Nomizo A, Lopez RFV (2009) Effect of the iontophoresis of a chitosan gel on doxorubicin skin penetration and cytotoxicity. J Control Release 134:35–40
Thacharodi D, Rao KP (1995) Development and in vitro evaluation of chitosan-based transdermal drug delivery systems for the controlled delivery of propranolol hydrochloride. Biomaterials 16:145–148
Thong HY, Zhai H, Maibach HI (2007) Percutaneous penetration enhancers: an overview. Skin Pharmacol Physiol 20(6):272–282
Timmer MD, Jo S, Wang C, Ambrose CG, Mikos AG (2002) Characterization of the cross-linked structure of fumarate-based degradable polymer networks. Macromolecules 35:4373–4379
Uchegbu IF, Schatzlein AG, Tetley L, Gray AI, Sludden J, Siddique S, Mosha E (1998) Polymeric chitosan-based vesicles for drug deliver. J Pharm Pharmacol 50:453–458
Wang C, Steward RJ, Kopecek J (1999) Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. Nature 397:417–420
Watanabe T, Ohtsuka A, Murase N, Barth P, Gersonde K (1996) NMR studies on water and polymer diffusion in dextran gels. Influence of potassium ions on microstructure formation and gelation mechanism. Magn Reson Med 35:697
Wichterle O, Lim D (1960) Hydrophilic gels for biological use. Nature 185:117–118
Wohlrab J, Kreft B, Tamke B (2011) Skin tolerability of transdermal patches. Expert Opin Drug Deliv 8(7):939–948
Xiao C, Zhou G (2003) Synthesis and properties of degradable poly(vinyl alcohol) hydrogel. Polym Degrad Stab 81(2):297–301
Zu Y, Zhang Y, Zhao X, Shan C, Zu S, Wang K et al (2012) Preparation and characterization of chitosan–polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin. Int J Biol Macromol 50:82–87
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Cerchiara, T., Bigucci, F., Luppi, B. (2015). Hydrogel Vehicles for Hydrophilic Compounds. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45013-0_20
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DOI: https://doi.org/10.1007/978-3-662-45013-0_20
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