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Febrile Neutropenia

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Supportive Care in Pediatric Oncology

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

Febrile neutropenia (FN) is a common, potentially life-threatening complication in pediatric oncology patients due to deficiencies in both innate and adaptive immunity usually secondary to treatment of the underlying malignancy. Although a majority of oncology patients experience FN, large randomized controlled trials to determine appropriate management strategies in pediatric FN are lacking and much of the decision-making process is based on extrapolation of adult guidelines, consensus pediatric guidelines, and institutional protocols. Here we review the relevant literature focusing on available models for risk stratification, appropriate diagnostic evaluations, applicable empiric therapies as well as proper location, timing, and duration of such therapies.

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Authors and Affiliations

  1. Center for Pediatric Infectious Diseases, Cleveland Clinic, Cleveland, OH, USA

    Blanca E. Gonzalez MD

  2. Pediatric Blood and Marrow Transplant Program, Rainbow Babies and Children’s Hospital, Cleveland, OH, USA

    Linda S. Cabral PAC

  3. Host Defense Program, Hematology/Oncology/BMT and Infectious Diseases, Nationwide Children’s Hospital, 700 Children’s Drive, ED557, Columbus, OH, 43205, USA

    Jeffery J. Auletta MD

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  1. Blanca E. Gonzalez MD
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  2. Linda S. Cabral PAC
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  3. Jeffery J. Auletta MD
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Correspondence to Jeffery J. Auletta MD .

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Editors and Affiliations

  1. Department of Hematology and Oncology, Childrens Hospital & Research Center Oak, Oakland, California, USA

    James H. Feusner

  2. Hematology/Oncology, Children's Hospital and Research Center, Oakland, California, USA

    Caroline A. Hastings

  3. Hematology/Oncology, Children's Hospital and Research Center, Oakland, California, USA

    Anurag K. Agrawal

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Gonzalez, B.E., Cabral, L.S., Auletta, J.J. (2015). Febrile Neutropenia. In: Feusner, J., Hastings, C., Agrawal, A. (eds) Supportive Care in Pediatric Oncology. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44317-0_1

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