Skip to main content
SpringerLink
Log in

Established Crohn’s Disease

  • Chapter
  • First Online:
Video Capsule Endoscopy

  • 1541 Accesses

Abstract

Studies on the natural history of Crohn’s disease reveal that it is a progressive disease marked by spontaneous relapses; if left untreated, it can lead over time to severe, disabling bowel damage and dysfunction. Only 10 % of patients show prolonged clinical remission. Up to one third of patients have evidence of a stricturing or penetrating intestinal complication at diagnosis, and at least half have experienced an intestinal complication within 20 years after diagnosis. The annual incidence of hospitalizations is about 20 %. Half of patients require surgery within 10 years after diagnosis [1]. Young age, immediate need for corticosteroids, perianal disease, colonic resection, repeated small bowel resection, stricturing phenotype, substantial weight loss, and specific endoscopic lesions may predict a disabling disease course [2]. Considerable evidence is accumulating that achievement of mucosal healing will not only control symptoms but also will reduce the patient’s need for steroids, hospitalization, and surgery.

The work was first published in 2006 by Springer Medizin Verlag Heidelberg with the following title: Atlas of Video Capsule Endoscopy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Peyrin-Biroulet L, Loftus Jr EV, Colombel JF, Sandborn WJ. The natural history of adult Crohn’s disease in population-based cohorts. Am J Gastroenterol. 2010;105:289–97.

    Article  PubMed  Google Scholar 

  2. Baumgart DC, Sandborn WJ. Crohn’s disease. Lancet. 2012;380:1590–605.

    Article  PubMed  Google Scholar 

  3. Onali S, Calabrese E, Petruzziello C, et al. Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn’s disease. World J Gastroenterol. 2012;18:6088–95.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Hoffmann JC, Preiß JC, Autschbach F, et al. Clinical practice guideline on diagnosis and treatment of Crohn’s disease. Results of a German evidence-based consensus conference. Z Gastroenterol. 2008;46:1094–146.

    Article  CAS  PubMed  Google Scholar 

  5. Möschler O, May A, Müller MK, German EC, DBE. Study Group. Complications in and performance of double-balloon enteroscopy (DBE): results from a large prospective DBE database in Germany. Endoscopy. 2011;43:484–9.

    Article  PubMed  Google Scholar 

  6. Bourreille A, Ignjatovic A, Aabakken L, et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus. Endoscopy. 2009;41:618–37.

    Article  CAS  PubMed  Google Scholar 

  7. Liangpunsakul S, Chadalawada V, Rex DK, et al. Wireless capsule endoscopy detects small bowel ulcers in patients with normal results from state of the art enteroclysis. Am J Gastroenterol. 2003;98:1295–8.

    Article  PubMed  Google Scholar 

  8. Eliakim R, Fischer D, Suissa A, et al. Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease. Eur J Gastroenterol Hepatol. 2003;15:363–7.

    Article  PubMed  Google Scholar 

  9. Triester SL, Leighton JA, Leontiadis GI, et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol. 2006;101:954–64.

    Article  PubMed  Google Scholar 

  10. Voderholzer WA, Beinhoelzl J, Rogalla P, et al. Small bowel involvement in Crohn’s disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis. Gut. 2005;54:369–73.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Albert J. Small bowel imaging in managing Crohn’s disease patients. Gastroenterol Res Pract. 2012;2012:502198.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Goldstein JL, Eisen G, Lewis B, et al. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol. 2005;3:133–41.

    Article  PubMed  Google Scholar 

  13. Mitty R, Cave DR, Brighton MA. Focal villous denudation: a precursor to aphthoid ulcers in Crohn’s disease as detected by video capsule endoscopy. Gastroenterology. 2002;122(Suppl):A217.

    Google Scholar 

  14. Sidhu R, Sanders DS, Morris AJ, et al. Guidelines on small bowel enteroscopy and capsule endoscopy in adults. Gut. 2008;57:125–36.

    Article  CAS  PubMed  Google Scholar 

  15. Lorenzo-Zúñiga V, de Vega VM, Domènech E, Cabré E, Mañosa M, Boix J. Impact of capsule endoscopy findings in the management of Crohn’s Disease. Dig Dis Sci. 2010;55:411–4.

    Article  PubMed  Google Scholar 

  16. Mehdizadeh S, Chen GC, Barkodar L, Enayati PJ, Pirouz S, Yadegari M, et al. Capsule endoscopy in patients with Crohn’s disease: diagnostic yield and safety. Gastrointest Endosc. 2010;71:121–7.

    Article  PubMed  Google Scholar 

  17. Redondo-Cerezo E. Role of wireless capsule endoscopy in inflammatory bowel disease. World J Gastrointest Endosc. 2010;16:179–85.

    Google Scholar 

  18. Long M, Barnes E. The impact of capsule endoscopy on management of inflammatory bowel disease: a single tertiary care center experience. Inflamm Bowel Dis. 2011;17:1855–62.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Maunoury V, Savoye G, Bourreille A, Bouhnik Y, Jarry M, Sacher-Huvelin S, et al. Value of wireless capsule endoscopy in patients with indeterminate colitis (inflammatory bowel disease type unclassified). Inflamm Bowel Dis. 2007;13:152–5.

    Article  PubMed  Google Scholar 

  20. Lopes S, Figueiredo P, Portela F, Freire P, Almeida N, Lerias C, et al. Capsule endoscopy in inflammatory bowel disease type unclassified and indeterminate colitis serologically negative. Inflamm Bowel Dis. 2010;16:1663–8.

    Article  PubMed  Google Scholar 

  21. Mehdizadeh S, Chen G, Enayati PJ, Cheng DW, Han NJ, Shaye OA, et al. Diagnostic yield of capsule endoscopy in ulcerative colitis and inflammatory bowel disease of unclassified type (IBDU). Endoscopy. 2008;40:30–5.

    Article  CAS  PubMed  Google Scholar 

  22. Pons Beltrán V, Nos P, Bastida G, Beltrán B, Argüello L, Aguas M, et al. Evaluation of postsurgical recurrence in Crohn’s disease: a new indication for capsule endoscopy? Gastrointest Endosc. 2007;66:533–40.

    Article  PubMed  Google Scholar 

  23. Bourreille A, Jarry M, D’Halluin PN, Ben-Soussan E, Maunoury V, Bulois P, et al. Wireless capsule endoscopy versus ileocolonoscopy for the diagnosis of postoperative recurrence of Crohn’s disease: a prospective study. Gut. 2006;55:978–83.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Björkesten CG, Nieminen U, Turunen U, Arkkila PE, Sipponen T, Färkkilä MA. Endoscopic monitoring of infliximab therapy in Crohn’s disease. Inflamm Bowel Dis. 2011;17:947–53.

    Article  Google Scholar 

  25. Akhtar RY, Lewis BS, Ullman T. Mucosal healing of Crohn’s disease demonstrated by capsule endoscopy in a woman with obscure gastrointestinal bleeding. Am J Gastroenterol. 2009;104:1065–6.

    Article  CAS  PubMed  Google Scholar 

  26. Efthymiou A, Viazis N, Mantzaris G, et al. Does clinical response correlate with mucosal healing in patients with Crohn’s disease of the small bowel? A prospective, case-series study using wireless capsule endoscopy. Inflamm Bowel Dis. 2008;14:1542–7.

    Article  PubMed  Google Scholar 

  27. Gralnek IM, Defranchis R, Seidman E, Leighton JA, Legnani P, Lewis BS. Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther. 2008;27:146–54.

    Article  CAS  PubMed  Google Scholar 

  28. Gal E, Geller A, Fraser G, Levi Z, Niv Y. Assessment and validation of the new capsule endoscopy Crohn’s disease activity index (CECDAI). Dig Dis Sci. 2008;53:1933–7.

    Article  PubMed  Google Scholar 

  29. Niv Y, Ilani S, Levi Z, Hershkowitz M, Niv E, Fireman Z, et al. Validation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective study. Endoscopy. 2012;44:21–6.

    Article  CAS  PubMed  Google Scholar 

  30. Swaminath A, Legnani P, Kornbluth A. Video capsule endoscopy in inflammatory bowel disease: past, present, and future. Inflamm Bowel Dis. 2012;16:1254–62.

    Article  Google Scholar 

  31. Cheifetz AS, Kornbluth AA, Legnani P, Schmelkin I, Brown A, Lichtiger S, Lewis BS. The risk of retention of the capsule endoscope in patients with known or suspected Crohn’s disease. Am J Gastroenterol. 2006;101:2218–22.

    Article  PubMed  Google Scholar 

  32. Parikh DA, Parikh JA, Albers GC, Chandler CF. Acute small bowel perforation after wireless capsule endoscopy in a patient with Crohn’s disease: a case report. Cases J. 2009;2:7607.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Herrerias JM, Leighton JA, Costamagna G, et al. Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy. Gastrointest Endosc. 2008;67:902–9.

    Article  PubMed  Google Scholar 

  34. Boivin ML, Lochs H, Voderholzer W. Does passage of the patency capsule indicate small bowel patency? A prospective clinical evaluation. Endoscopy. 2005;37:808–15.

    Article  CAS  PubMed  Google Scholar 

  35. Saunders BP, Brown GJ, Lemann M, Rutgeerts P. Balloon dilation of ileocolonic strictures in Crohn’s disease. Endoscopy. 2004;36:1001–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gastroenterology Practice, Berlin, Germany

    Winfried A. Voderholzer

  2. Mount Sinai Hospital, New York, NY, USA

    Asher Kornbluth & Peter E. Legnani

Authors
  1. Winfried A. Voderholzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Asher Kornbluth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter E. Legnani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Winfried A. Voderholzer .

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Bethesda Krankenhaus Bergedorf, Academic Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Martin Keuchel

  2. 1st Medical Department, Asklepios Klinik Altona, Academic Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Friedrich Hagenmüller

  3. Dept. Internal Medicine, Division of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan

    Hisao Tajiri

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Voderholzer, W.A., Kornbluth, A., Legnani, P.E. (2014). Established Crohn’s Disease. In: Keuchel, M., Hagenmüller, F., Tajiri, H. (eds) Video Capsule Endoscopy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44062-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-44062-9_25

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-44061-2

  • Online ISBN: 978-3-662-44062-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation