Abstract
Infectious microecology is a branch of microecology that uses microecological theory and methods to investigate the appearance, development and outcome of infection. The main purpose of this chapter is to investigate the pathogenesis of infection and its clinical manifestations, preventions and therapies. Under normal conditions, the gut microflora exists in a state of equilibrium with the host that has been described as a separate “organ” adapted to human physiology. From the moment of birth, the neonatal intestine is confronted with potent immunostimulatory substances while the body surfaces are protected from environmental and microbial exposure during fetal life [1]. Microbial antigenic challenge is required for maturation of several physiological and anatomical functions of the intestinal epithelial barrier (IEB) [2]. Commensal bacteria regulate intestinal innate and adaptive immunity and provide stimuli for ongoing repair and restitution of IEB [3]. Colonization by pathogenic bacteria and (or) dysmature response to microbial antigen may result in flagrant inflammatory response [4].
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Diao, H., Cui, G., Chen, J., Wei, Y. (2014). Infectious Microecology and Immunology. In: Li, L. (eds) Infectious Microecology. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43883-1_3
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