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Interleukin-10-Producing B Cells and the Regulation of Immunity

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Interleukin-10 in Health and Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 380))

Abstract

B cells are usually considered primarily for their unique capacity to produce antibodies after differentiation into plasma cells. In addition to their roles as antibody-producing cells, it has become apparent during the last 10 years that B cells also perform important functions in immunity through the production of cytokines. In particular, it was shown that B cells could negatively regulate immunity through provision of interleukin (IL)-10 during autoimmune and infectious diseases in mice. Here, we review data on the suppressive functions of B cells in mice with particular emphasis on the signals controlling the acquisition of such suppressive functions by B cells, the phenotype of the B cells involved in the negative regulation of immunity, and the processes targeted by this inhibitory circuit. Finally, we discuss the possibility that human B cells might also perform similar inhibitory functions through the provision of IL-10, and review data suggesting that such B cell-mediated regulatory activities might be impaired in patients with autoimmune diseases.

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Authors and Affiliations

  1. Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Chariteplatz 1, 10117, Berlin, Germany

    Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa & Simon Fillatreau

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  1. Ellen Hilgenberg
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  2. Ping Shen
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  3. Van Duc Dang
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  4. Stefanie Ries
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  5. Imme Sakwa
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  6. Simon Fillatreau
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Correspondence to Simon Fillatreau .

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Editors and Affiliations

  1. Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany

    Simon Fillatreau

  2. Div. of Immunoregulation, The MRC National Institute for Medical Research, London, United Kingdom

    Anne O'Garra

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Hilgenberg, E., Shen, P., Dang, V.D., Ries, S., Sakwa, I., Fillatreau, S. (2014). Interleukin-10-Producing B Cells and the Regulation of Immunity. In: Fillatreau, S., O'Garra, A. (eds) Interleukin-10 in Health and Disease. Current Topics in Microbiology and Immunology, vol 380. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43492-5_4

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