Skip to main content
SpringerLink
Log in

Retinoblastoma: Focal Therapy – Laser Treatment, Cryotherapy, and Brachytherapy

  • Chapter
  • First Online:
Clinical Ophthalmic Oncology

  • 1062 Accesses

Abstract

In the management of intraocular retinoblastoma, the term “focal therapy” refers to focal modalities such as laser treatment, cryotherapy, and brachytherapy. They can be used as primary treatment for small tumors or in conjunction with intravenous chemotherapy for larger tumors (i.e., chemoreduction). Focal therapies have the inherent advantage of eradicating focal areas of tumor formation in the retina without any risk of regional or systemic side effects. In this chapter, general guidelines on the use of focal therapies are provided to assist an ophthalmic surgeon who is relatively new to the treatment of retinoblastoma. This chapter might also be of help to those ophthalmologists who would like to compare their current approach with principles and techniques used by other surgeons.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Meyer Schwickerath G, Vogel MH. Malignant melanoma of the choroid treated with photocoagulation. A 10 year follow up. Mod Probl Ophthalmol. 1974;12:544–9.

    PubMed  CAS  Google Scholar 

  2. Oosterhuis JA, Journée-de Korver HG, Kakebeeke-Kemme HM, Bleeker JC. Transpupillary thermotherapy in choroidal melanomas. Arch Ophthalmol. 1995;113(3):315–21.

    Article  PubMed  CAS  Google Scholar 

  3. Abramson D, Schefler AC. Transpupillary thermotherapy as initial treatment for small intraocular retinoblastoma: technique and predictors of success. Ophthalmology. 2004;111(5):984–91.

    Article  PubMed  Google Scholar 

  4. Shields CL, Santos MC, Diniz W, et al. Thermotherapy for retinoblastoma. Arch Ophthalmol. 1999;117(7):885–93.

    Article  PubMed  CAS  Google Scholar 

  5. Francis JH, Abramson DH, Brodie SE, Marr BP. Indocyanine green enhanced transpupillary thermotherapy in combination with ophthalmic artery chemosurgery for retinoblastoma. Br J Ophthalmol. 2013;97(2):164–8.

    Article  PubMed  Google Scholar 

  6. Lincoff H, McLean J, Long R. The cryosurgical treatment of intraocular tumors. Am J Ophthalmol. 1967;63(3):389–99.

    Article  PubMed  CAS  Google Scholar 

  7. Abramson DH, Ellsworth RM, Rozakis GW. Cryotherapy for retinoblastoma. Arch Ophthalmol. 1982;100(8):1253–6.

    Article  PubMed  CAS  Google Scholar 

  8. Anagnoste SR, Scott IU, Murray TG, et al. Rhegmatogenous retinal detachment in retinoblastoma patients undergoing chemoreduction and cryotherapy. Am J Ophthalmol. 2000;129(6):817–9.

    Article  PubMed  CAS  Google Scholar 

  9. Moore RF. Choroidal sarcoma treated by the intraocular insertion of radon seeds. Br J Ophthalmol. 1930;14(4):145–52.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  10. Stallard HB. Radiotherapy of malignant intra-ocular neoplasms. Br J Ophthalmol. 1948;32(9):618–39.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. Stallard HB. The conservative treatment of retinoblastoma. Trans Ophthalmol Soc UK. 1962;82:473–534.

    PubMed  CAS  Google Scholar 

  12. Schueler AO, Jurklies C, Heimann H, et al. Thermochemotherapy in hereditary retinoblastoma. Br J Ophthalmol. 2003;87(1):90–5.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  13. Hernandez JC, Brady LW, Shields CL, et al. Conservative treatment of retinoblastoma. The use of plaque brachytherapy. Am J Clin Oncol. 1993;16(5):397–401.

    Article  PubMed  CAS  Google Scholar 

  14. Sealy R, le Roux PL, Rapley F, et al. The treatment of ophthalmic tumours with low-energy sources. Br J Radiol. 1976;49(582):551–4.

    Article  PubMed  CAS  Google Scholar 

  15. Lommatzsch P. Treatment of choroidal melanomas with 106Ru/106Rh beta-ray applicators. Surv Ophthalmol. 1974;19(2):85–100.

    PubMed  CAS  Google Scholar 

  16. Schueler AO, Flühs D, Anastassiou G, et al. Beta-ray brachytherapy with 106Ru plaques for retinoblastoma. Int J Radiat Oncol Biol Phys. 2006;65(4):1212–21.

    Article  PubMed  Google Scholar 

  17. Astrahan MA, Luxton G, Pu Q, Petrovich Z. Conformal episcleral plaque therapy. Int J Radiat Oncol Biol Phys. 1997;39(2):505–19.

    Article  PubMed  CAS  Google Scholar 

  18. Shields CL, Shields JA, Cater J, et al. Plaque radiotherapy for retinoblastoma: long-term tumor control and treatment complications in 208 tumors. Ophthalmology. 2001;108(11):2116–21.

    Article  PubMed  CAS  Google Scholar 

  19. Buys RJ, Abramson DH, Ellsworth RM, Haik B. Radiation regression patterns after cobalt plaque insertion for retinoblastoma. Arch Ophthalmol. 1983;101(8):1206–8.

    Article  PubMed  CAS  Google Scholar 

  20. Merchant TE, Gould CJ, Wilson MW, et al. Episcleral plaque brachytherapy for retinoblastoma. Pediatr Blood Cancer. 2004;43(2):134–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, The Vision Center, Children’s Hospital Los Angeles/University of Southern California, 4650 Sunset Blvd, #88, Los Angeles, CA, USA

    A. Linn Murphree MD

  2. Department of Ophthalmology, Retinoblastoma Service, The Vision Center, Children’s Hospital Los Angeles/University of Southern California, 4650 Sunset Blvd, #88, Los Angeles, CA, USA

    Jonathan W. Kim MD

Authors
  1. A. Linn Murphree MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jonathan W. Kim MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Linn Murphree MD .

Editor information

Editors and Affiliations

  1. Dept. of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

  2. Department of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, USA

    A. Linn Murphree

  3. University of California, San Francisco, California, USA

    Bertil E. Damato

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Murphree, A.L., Kim, J.W. (2015). Retinoblastoma: Focal Therapy – Laser Treatment, Cryotherapy, and Brachytherapy. In: Singh, A., Murphree, A., Damato, B. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43451-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-43451-2_10

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43450-5

  • Online ISBN: 978-3-662-43451-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation