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Patient Blood Management

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Perioperative Hemostasis

Abstract

Blood transfusions have been shown to be associated with a significant increase of mortality and morbidity in a dose dependent relationship in all surgical specialties. Side effects such as increased infections rates, transfusion related acute lung injury and renal dysfunction lead to increased length of hospital stay and thereby increased costs. Because of the facts that blood transfusions have serious complications and are more costly than previously assumed, new approaches in the treatment of anemia and bleeding management are required. Patient Blood Management (PBM) allows for transfusion rates to be dramatically reduced by (1) correcting preoperative existing anemia by stimulating erythropoiesis up to 4 weeks before surgery, (2) minimization of perioperative blood loss by improved surgical techniques, and (3) optimizing the physiological tolerance of anemia.

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References

  • Abraham I, Sun D (2012) The cost of blood transfusion in Western Europe as estimated from six studies. Transfusion 52:1983–1988

    PubMed  Google Scholar 

  • Achneck HE, Sileshi B et al (2010) A comprehensive review of topical hemostatic agents: efficacy and recommendations for use. Ann Surg 251(2):217–228

    PubMed  Google Scholar 

  • Addeo R, Caraglia M et al (2009) Two faces for Janus: recombinant human erythropoiesis-stimulating agents and cancer mortality. Expert Rev Hematol 2(5):513–515

    PubMed  CAS  Google Scholar 

  • Amato A, Pescatori M (2006) Perioperative blood transfusions for the recurrence of colorectal cancer. Cochrane Database Syst Rev 25;(1):CD005033.

    Google Scholar 

  • Auerbach M, Rodgers GM (2007) Intravenous iron. N Engl J Med 357(1):93–94

    PubMed  CAS  Google Scholar 

  • Australian Patient Blood Management Guidelines. http://www.nba.gov.au/guidelines/module2/po-mod2.pdf

  • Belizaire RM, Prakash PS et al (2012) Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation. J Am Coll Surg 214(4):648–655

    PubMed  PubMed Central  Google Scholar 

  • Bernard AC, Davenport DL et al (2009) Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg 208(5):931–937, 937 e931–932; discussion 938–939

    PubMed  Google Scholar 

  • Bierbaum BE, Callaghan JJ et al (1999) An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 81(1):2–10

    PubMed  CAS  Google Scholar 

  • Blasi B, D’Alessandro A et al (2012) Red blood cell storage and cell morphology. Transfus Med 22(2):90–96

    PubMed  CAS  Google Scholar 

  • Borkent-Raven BA, Janssen MP et al (2010) The PROTON study: profiles of blood product transfusion recipients in the Netherlands. Vox Sang 99(1):54–64

    PubMed  CAS  Google Scholar 

  • Brookhart MA, Schneeweiss S et al (2010) Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA 303(9):857–864

    PubMed  CAS  Google Scholar 

  • Buddeberg F, Schimmer BB et al (2008) Transfusion-transmissible infections and transfusion-related immunomodulation. Best Pract Res Clin Anaesthesiol 22(3):503–517

    PubMed  Google Scholar 

  • Carless PA, Henry DA et al (2010) Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev (10):CD002042

    Google Scholar 

  • Carson JL, Terrin ML et al (2011) Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 365(26):2453–2462

    PubMed  CAS  PubMed Central  Google Scholar 

  • Carson JL, Carless PA et al (2012a) Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 4, CD002042

    PubMed  Google Scholar 

  • Carson JL, Grossman BJ et al (2012b) Red blood cell transfusion: a clinical practice guideline from the AABB. Ann Intern Med 157:49–58

    PubMed  Google Scholar 

  • Castillo JJ, Dalia S et al (2010) Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies. Blood 116(16):2897–2907

    PubMed  CAS  Google Scholar 

  • Chaiwat O, Lang JD et al (2009) Early packed red blood cell transfusion and acute respiratory distress syndrome after trauma. Anesthesiology 110(2):351–360

    PubMed  Google Scholar 

  • Chang CH, Chang CC et al (2002) Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients. Clin Nephrol 57(2):136–141

    PubMed  CAS  Google Scholar 

  • Chin-Yee I, Arya N et al (1997) The red cell storage lesion and its implication for transfusion. Transfus Sci 18(3):447–458

    PubMed  CAS  Google Scholar 

  • Claridge JA, Sawyer RG et al (2002) Blood transfusions correlate with infections in trauma patients in a dose-dependent manner. Am Surg 68(7):566–572

    PubMed  Google Scholar 

  • Cobain TJ, Vamvakas EC et al (2007) A survey of the demographics of blood use. Transfus Med 17(1):1–15

    PubMed  CAS  Google Scholar 

  • Corwin HL, Gettinger A et al (2004) The CRIT study: anemia and blood transfusion in the critically ill–current clinical practice in the United States. Crit Care Med 32(1):39–52

    PubMed  Google Scholar 

  • Cosgrove DM, Loop FD et al (1985) Determinants of blood utilization during myocardial revascularization. Ann Thorac Surg 40(4):380–384

    PubMed  CAS  Google Scholar 

  • Cuenca J, Garcia-Erce JA et al (2004) Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: a pilot study. Transfusion 44(10):1447–1452

    PubMed  CAS  Google Scholar 

  • Dara SI, Rana R et al (2005) Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med 33(11):2667–2671

    PubMed  Google Scholar 

  • de Calignon A, Polydoro M et al (2012) Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron 73(4):685–697

    PubMed  PubMed Central  Google Scholar 

  • Emmert MY, Salzberg SP et al (2011) How good patient blood management leads to excellent outcomes in Jehovah’s witness patients undergoing cardiac surgery. Interact Cardiovasc Thorac Surg 12(2):183–188

    PubMed  Google Scholar 

  • Endres HG, Wedding U et al (2009) Prevalence of anemia in elderly patients in primary care: impact on 5-year mortality risk and differences between men and women. Curr Med Res Opin 25(5):1143–1158

    PubMed  Google Scholar 

  • Epstein JS, Holmberg JA (2010) Progress in monitoring blood safety. Transfusion 50(7):1408–1412

    PubMed  Google Scholar 

  • Etchason J, Petz L et al (1995) The cost effectiveness of preoperative autologous blood donations. N Engl J Med 332(11):719–724

    PubMed  CAS  Google Scholar 

  • Farrugia A (2011) Falsification or paradigm shift? Toward a revision of the common sense of transfusion. Transfusion 51(1):216–224

    PubMed  Google Scholar 

  • Ferraris VA, Ferraris SP et al (2007) Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg 83(5 Suppl):S27–S86

    PubMed  Google Scholar 

  • Ferraris VA, Brown JR et al (2011) 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg 91(3):944–982

    PubMed  Google Scholar 

  • Ferraris VA, Davenport DL et al (2012) Surgical outcomes and transfusion of minimal amounts of blood in the operating room. Arch Surg 147(1):49–55

    PubMed  Google Scholar 

  • Filicori F, Di Saverio S et al (2010) Packing for damage control of nontraumatic intra-abdominal massive hemorrhages. World J Surg 34(9):2064–2068

    PubMed  Google Scholar 

  • Freedman J, Luke K et al (2005) A provincial program of blood conservation: the Ontario Transfusion Coordinators (ONTraC). Transfus Apher Sci 33(3):343–349

    PubMed  CAS  Google Scholar 

  • Freischlag JA (2004) Intraoperative blood salvage in vascular surgery – worth the effort? Crit Care 8(Suppl 2):S53–S56

    PubMed  PubMed Central  Google Scholar 

  • Fukusaki M, Sumikawa K (2000) The combination of hemodilution and controlled hypotension: physiology and clinical application. J Anesth 14(4):194–203

    PubMed  CAS  Google Scholar 

  • Fukusaki M, Maekawa T et al (1997) Acute haemodilution and prostaglandin E1-induced hypotension: effects on the coagulation-fibrinolysis system. Eur J Anaesthesiol 14(4):443–449

    PubMed  CAS  Google Scholar 

  • Gajic O, Dzik WH et al (2006) Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm? Crit Care Med 34(5 Suppl):S170–S173

    PubMed  Google Scholar 

  • Ganter MT, Hofer CK (2008) Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg 106(5):1366–1375

    PubMed  Google Scholar 

  • Ganter MT, Spahn DR (2010) Active, personalized, and balanced coagulation management saves lives in patients with massive bleeding. Anesthesiology 113(5):1016–1018

    PubMed  Google Scholar 

  • Glance LG, Dick AW et al (2011) Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology 114(2):283–292

    PubMed  Google Scholar 

  • Gombotz H (2011) Patient blood management is key before elective surgery. Lancet 378(9800):1362–1363

    PubMed  Google Scholar 

  • Gombotz H, Rehak PH et al (2007) Blood use in elective surgery: the Austrian benchmark study. Transfusion 47(8):1468–1480

    PubMed  Google Scholar 

  • Gombotz H, Hofman A et al (2011a) Patient blood management (part 2). Practice: the 3 pillars. Anasthesiol Intensivmed Notfallmed Schmerzther 46(7–8):466–474

    PubMed  Google Scholar 

  • Gombotz H, Hofmann A et al (2011b) Patient blood management (part 1) – patient-specific concept to reduce and avoid anemia, blood loss and transfusion. Anasthesiol Intensivmed Notfallmed Schmerzther 46(6):396–401

    PubMed  Google Scholar 

  • Goodnough LT (2005) Risks of blood transfusion. Anesthesiol Clin North America 23(2):241–252, v

    PubMed  Google Scholar 

  • Goodnough LT (2007) Erythropoietin and iron-restricted erythropoiesis. Exp Hematol 35(4 Suppl 1):167–172

    PubMed  CAS  Google Scholar 

  • Goodnough LT, Shander A (2007) Blood management. Arch Pathol Lab Med 131(5):695–701

    PubMed  Google Scholar 

  • Goodnough LT, Nemeth E et al (2010) Detection, evaluation, and management of iron-restricted erythropoiesis. Blood 116(23):4754–4761

    PubMed  CAS  Google Scholar 

  • Goodnough LT, Maniatis A et al (2011) Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J Anaesth 106(1):13–22

    PubMed  CAS  PubMed Central  Google Scholar 

  • Gorlinger K, Dirkmann D et al (2011) First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 115(6):1179–1191

    PubMed  Google Scholar 

  • Grover K, McManus P (2006) Randomized clinical trial of the effect of quilting latissimus dorsi flap donor site on seroma formation (Br J Surg) 2006; 93; 825–830. Br J Surg 93(12):1563; author reply 1563–1564

    PubMed  CAS  Google Scholar 

  • Gude D (2012) TRALI: a volley of caution. Ann Card Anaesth 15(1):86–87

    PubMed  Google Scholar 

  • Hess JR, Brohi K et al (2008) The coagulopathy of trauma: a review of mechanisms. J Trauma 65(4):748–754

    PubMed  CAS  Google Scholar 

  • Hill GE, Frawley WH et al (2003) Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma 54(5):908–914

    PubMed  Google Scholar 

  • Ho AM, Karmakar MK et al (2005) Are we giving enough coagulation factors during major trauma resuscitation? Am J Surg 190(3):479–484

    PubMed  Google Scholar 

  • Holcomb JB (2004) Methods for improved hemorrhage control. Crit Care 8(Suppl 2):S57–S60

    PubMed  PubMed Central  Google Scholar 

  • Isbister JP, Shander A et al (2011) Adverse blood transfusion outcomes: establishing causation. Transfus Med Rev 25(2):89–101

    PubMed  Google Scholar 

  • Jakobsen CJ, Ryhammer PK et al (2012) Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients. Eur J Cardiothorac Surg 42:114–120

    PubMed  Google Scholar 

  • Jans O, Kehlet H et al (2012) Transfusion-related mortality after primary hip arthroplasty – an analysis of mechanisms and confounders. Vox Sang 103:301–308

    PubMed  CAS  Google Scholar 

  • Kamper-Jorgensen M, Hjalgrim H et al (2010) Expensive blood safety initiatives may offer less benefit than we think. Transfusion 50(1):240–242

    PubMed  Google Scholar 

  • Khan H, Belsher J et al (2007) Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 131(5):1308–1314

    PubMed  Google Scholar 

  • Khanna MP, Hebert PC et al (2003) Review of the clinical practice literature on patient characteristics associated with perioperative allogeneic red blood cell transfusion. Transfus Med Rev 17(2):110–119

    PubMed  Google Scholar 

  • Klein HG, Spahn DR et al (2007) Red blood cell transfusion in clinical practice. Lancet 370(9585):415–426

    PubMed  Google Scholar 

  • Koch CG, Li L et al (2006) Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med 34(6):1608–1616

    PubMed  Google Scholar 

  • Koch CG, Li L et al (2008) Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 358(12):1229–1239

    PubMed  CAS  Google Scholar 

  • Kotze A, Carter LA et al (2012) Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle. Br J Anaesth 108(6):943–952

    PubMed  CAS  Google Scholar 

  • Lauscher P, Mirakaj V, Rosenberger P, Meier J (2012) Practical guidelines for blood transfusions in Germany. Anasthesiol Intensivmed Notfallmed Schmerzther 47(6):410–417

    Google Scholar 

  • Leichtle SW, Mouawad NJ et al (2011) Does preoperative anemia adversely affect colon and rectal surgery outcomes? J Am Coll Surg 212(2):187–194

    PubMed  Google Scholar 

  • Lier H, Krep H et al (2008) Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 65(4):951–960

    PubMed  Google Scholar 

  • Liumbruno G, Bennardello F et al (2009) Recommendations for the transfusion of red blood cells. Blood Transfus 7(1):49–64

    PubMed  PubMed Central  Google Scholar 

  • Liumbruno GM, Bennardello F et al (2011) Recommendations for the transfusion management of patients in the peri-operative period. III. The post-operative period. Blood Transfus 9(3):320–335

    PubMed  PubMed Central  Google Scholar 

  • Madjdpour C, Spahn DR (2005) Allogeneic red blood cell transfusions: efficacy, risks, alternatives and indications. Br J Anaesth 95(1):33–42

    PubMed  CAS  Google Scholar 

  • Malone DL, Dunne J et al (2003) Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 54(5):898–905

    PubMed  Google Scholar 

  • Martini WZ, Dubick MA et al (2006) Does bicarbonate correct coagulation function impaired by acidosis in swine? J Trauma 61(1):99–106

    PubMed  CAS  Google Scholar 

  • Meier J, Kemming GI et al (2004) Hyperoxic ventilation reduces six-hour mortality after partial fluid resuscitation from hemorrhagic shock. Shock 22(3):240–247

    PubMed  Google Scholar 

  • Mircescu G, Garneata L et al (2006) Intravenous iron supplementation for the treatment of anaemia in pre-dialyzed chronic renal failure patients. Nephrol Dial Transplant 21(1):120–124

    PubMed  CAS  Google Scholar 

  • Moore FA, Moore EE et al (1997) Blood transfusion. An independent risk factor for postinjury multiple organ failure. Arch Surg 132(6):620–624, discussion 624–625

    PubMed  CAS  Google Scholar 

  • Morales R, Duran-Aniotz C et al (2011) De novo induction of amyloid-beta deposition in vivo. Mol Psychiatry 17:1347–1353

    PubMed  Google Scholar 

  • Morton J, Anastassopoulos KP et al (2010) Frequency and outcomes of blood products transfusion across procedures and clinical conditions warranting inpatient care: an analysis of the 2004 healthcare cost and utilization project nationwide inpatient sample database. Am J Med Qual 25(4):289–296

    PubMed  Google Scholar 

  • Moskowitz DM, McCullough JN et al (2010) The impact of blood conservation on outcomes in cardiac surgery: is it safe and effective? Ann Thorac Surg 90(2):451–458

    PubMed  Google Scholar 

  • Munoz M, Bisbe E et al (2005) Allogeneic blood transfusion and wound healing disturbance after orthopaedic surgery. Anesth Analg 101(6):1889–1890, author reply 1890

    PubMed  Google Scholar 

  • Murphy GJ, Reeves BC et al (2007) Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 116(22):2544–2552

    PubMed  Google Scholar 

  • Musallam KM, Tamim HM et al (2011) Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 378(9800):1396–1407

    PubMed  Google Scholar 

  • Na HS, Shin SY et al (2011) Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty. Transfusion 51(1):118–124

    PubMed  CAS  Google Scholar 

  • Ness PM (2011) Does transfusion of stored red blood cells cause clinically important adverse effects? A critical question in search of an answer and a plan. Transfusion 51(4):666–667

    PubMed  Google Scholar 

  • Nguyen XD, Dengler T et al (2011) A novel tool for high-throughput screening of granulocyte-specific antibodies using the automated flow cytometric granulocyte immunofluorescence test (Flow-GIFT). ScientificWorldJournal 11:302–309

    PubMed  CAS  Google Scholar 

  • Norda R, Tynell E et al (2006) Cumulative risks of early fresh frozen plasma, cryoprecipitate and platelet transfusion in Europe. J Trauma 60(6 Suppl):S41–S45

    PubMed  Google Scholar 

  • Nunez TC, Cotton BA (2009) Transfusion therapy in hemorrhagic shock. Curr Opin Crit Care 15(6):536–541

    PubMed  PubMed Central  Google Scholar 

  • Offner PJ (2004) Age of blood: does it make a difference? Crit Care 8(Suppl 2):S24–S26

    PubMed  PubMed Central  Google Scholar 

  • Patel MS, Carson JL (2009) Anemia in the preoperative patient. Med Clin North Am 93(5):1095–1104

    PubMed  CAS  PubMed Central  Google Scholar 

  • Pati S, Matijevic N et al (2010) Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. J Trauma 69(Suppl 1):S55–S63

    PubMed  PubMed Central  Google Scholar 

  • Pfanner G, Koscielny J et al (2007) Preoperative evaluation of the bleeding history. Recommendations of the working group on perioperative coagulation of the Austrian Society for Anaesthesia, Resuscitation and Intensive Care. Anaesthesist 56(6):604–611

    PubMed  CAS  Google Scholar 

  • Pomper GJ, Wu Y et al (2003) Risks of transfusion-transmitted infections: 2003. Curr Opin Hematol 10(6):412–418

    PubMed  Google Scholar 

  • Popovsky MA, Chaplin HC Jr et al (1992) Transfusion-related acute lung injury: a neglected, serious complication of hemotherapy. Transfusion 32(6):589–592

    PubMed  CAS  Google Scholar 

  • Raat NJ, Berends F et al (2005) The age of stored red blood cell concentrates at the time of transfusion. Transfus Med 15(5):419–423

    PubMed  CAS  Google Scholar 

  • Rachoin JS, Daher R et al (2009) Microbiology, time course and clinical characteristics of infection in critically ill patients receiving packed red blood cell transfusion. Vox Sang 97(4):294–302

    PubMed  Google Scholar 

  • Rana R, Fernandez-Perez ER et al (2006) Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study. Transfusion 46(9):1478–1483

    PubMed  Google Scholar 

  • Reeves BC, Murphy GJ (2008a) Increased mortality, morbidity, and cost associated with red blood cell transfusion after cardiac surgery. Curr Opin Anaesthesiol 21(5):669–673

    PubMed  Google Scholar 

  • Reeves BC, Murphy GJ (2008b) Increased mortality, morbidity, and cost associated with red blood cell transfusion after cardiac surgery. Curr Opin Cardiol 23(6):607–612

    PubMed  Google Scholar 

  • Rogers MA, Blumberg N et al (2006) Allogeneic blood transfusions explain increased mortality in women after coronary artery bypass graft surgery. Am Heart J 152(6):1028–1034

    PubMed  Google Scholar 

  • Rossaint R, Cerny V et al (2006) Key issues in advanced bleeding care in trauma. Shock 26(4):322–331

    PubMed  Google Scholar 

  • Rossaint R, Bouillon B et al (2010) Management of bleeding following major trauma: an updated European guideline. Crit Care 14(2):R52

    PubMed  PubMed Central  Google Scholar 

  • Shander A, Knight K et al (2004) Prevalence and outcomes of anemia in surgery: a systematic review of the literature. Am J Med 116(Suppl 7A):58S–69S

    PubMed  Google Scholar 

  • Shander A, Hofmann A et al (2007) Estimating the cost of blood: past, present, and future directions. Best Pract Res Clin Anaesthesiol 21(2):271–289

    PubMed  Google Scholar 

  • Shander A, Hofmann A et al (2010) Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 50(4):753–765

    PubMed  Google Scholar 

  • Shorr AF, Duh MS et al (2004) Red blood cell transfusion and ventilator-associated pneumonia: a potential link? Crit Care Med 32(3):666–674

    PubMed  Google Scholar 

  • Spahn DR (2010) Anemia and patient blood management in hip and knee surgery: a systematic review of the literature. Anesthesiology 113(2):482–495

    PubMed  Google Scholar 

  • Spahn DR, Madjdpour C (2006) Physiologic transfusion triggers: do we have to use (our) brain? Anesthesiology 104(5):905–906

    PubMed  Google Scholar 

  • Spahn DR, Rossaint R (2005) Coagulopathy and blood component transfusion in trauma. Br J Anaesth 95(2):130–139

    PubMed  CAS  Google Scholar 

  • Spahn DR, Zollinger A et al (1996) Hemodilution tolerance in elderly patients without known cardiac disease. Anesth Analg 82(4):681–686

    PubMed  CAS  Google Scholar 

  • Spahn DR, Cerny V et al (2007) Management of bleeding following major trauma: a European guideline. Crit Care 11(1):R17

    PubMed  PubMed Central  Google Scholar 

  • Spahn DR, Moch H et al (2008) Patient blood management: the pragmatic solution for the problems with blood transfusions. Anesthesiology 109(6):951–953

    PubMed  Google Scholar 

  • Spahn DR, Theusinger OM et al (2012) Patient blood management is a win-win: a wake-up call. Br J Anaesth 108(6):889–892

    PubMed  CAS  Google Scholar 

  • Spinella PC, Carroll CL et al (2009) Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Crit Care 13(5):R151

    PubMed  PubMed Central  Google Scholar 

  • Stanworth SJ, Brunskill SJ et al (2004) Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials. Br J Haematol 126(1):139–152

    PubMed  CAS  Google Scholar 

  • Surgenor SD, DeFoe GR et al (2006) Intraoperative red blood cell transfusion during coronary artery bypass graft surgery increases the risk of postoperative low-output heart failure. Circulation 114(1 Suppl):I43–I48

    PubMed  Google Scholar 

  • Surgenor SD, Kramer RS et al (2009) The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgery. Anesth Analg 108(6):1741–1746

    PubMed  Google Scholar 

  • Taylor RW, O’Brien J et al (2006) Red blood cell transfusions and nosocomial infections in critically ill patients. Crit Care Med 34(9):2302–2308, quiz 2309

    PubMed  Google Scholar 

  • Theusinger OM, Leyvraz PF et al (2007) Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. Anesthesiology 107(6):923–927

    PubMed  CAS  Google Scholar 

  • Theusinger OM, Spahn DR et al (2009) Transfusion in trauma: why and how should we change our current practice? Curr Opin Anaesthesiol 22(2):305–312

    PubMed  Google Scholar 

  • Theusinger OM, Nurnberg J et al (2010) Rotation thromboelastometry (ROTEM) stability and reproducibility over time. Eur J Cardiothorac Surg 37(3):677–683

    PubMed  Google Scholar 

  • Theusinger OM, Felix C et al (2012) Strategies to reduce the use of blood products: a European perspective. Curr Opin Anaesthesiol 25(1):59–65

    PubMed  CAS  Google Scholar 

  • Theusinger OM, Stein P et al (2014) Applying ‘Patient Blood Management’ in the trauma center. Curr Opin Anaesthesiol 27(2):225–232

    PubMed  Google Scholar 

  • Tokuno O, Hayakawa I et al (2012) Evaluation with the BacT/ALERT microbial detection system of bacterial contamination in autologous blood donation and transfusion. Transfus Med 22(1):73–74

    PubMed  CAS  Google Scholar 

  • Toy P, Popovsky MA et al (2005) Transfusion-related acute lung injury: definition and review. Crit Care Med 33(4):721–726

    PubMed  Google Scholar 

  • Tung JP, Fraser JF et al (2012) Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Crit Care 16(1):R19

    PubMed  PubMed Central  Google Scholar 

  • Upile T, Jerjes W et al (2009) Blood product transfusion and cancer prognosis. Clin Adv Hematol Oncol 7(10):656–661

    PubMed  Google Scholar 

  • Urner M, Herrmann IK et al (2012) Effects of blood products on inflammatory response in endothelial cells in vitro. PLoS One 7(3):e33403

    PubMed  CAS  PubMed Central  Google Scholar 

  • Vamvakas EC, Blajchman MA (2010) Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortality. Transfus Med Rev 24(2):77–124

    PubMed  Google Scholar 

  • Vincent JL, Baron JF et al (2002) Anemia and blood transfusion in critically ill patients. JAMA 288(12):1499–1507

    PubMed  Google Scholar 

  • Vivien B, Langeron O et al (2005) Early hypocalcemia in severe trauma. Crit Care Med 33(9):1946–1952

    PubMed  CAS  Google Scholar 

  • Vuille-Lessard E, Boudreault D et al (2012) Postoperative anemia does not impede functional outcome and quality of life early after hip and knee arthroplasties. Transfusion 52(2):261–270

    PubMed  CAS  Google Scholar 

  • Weber CF, Gorlinger K et al (2012) Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 117(3):531–547

    PubMed  Google Scholar 

  • Weiskopf RB (2010) Emergency transfusion for acute severe anemia: a calculated risk. Anesth Analg 111(5):1088–1092

    PubMed  Google Scholar 

  • Wells AW, Mounter PJ et al (2002) Where does blood go? Prospective observational study of red cell transfusion in north England. BMJ 325(7368):803

    PubMed  CAS  PubMed Central  Google Scholar 

  • Weltert L, D’Alessandro S et al (2010) Preoperative very short-term, high-dose erythropoietin administration diminishes blood transfusion rate in off-pump coronary artery bypass: a randomized blind controlled study. J Thorac Cardiovasc Surg 139(3):621–626, discussion 626–627

    PubMed  CAS  Google Scholar 

  • Westenbrink BD, Kleijn L et al (2011) Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial. Heart 97(19):1590–1596

    PubMed  CAS  Google Scholar 

  • Williams D, McCarthy R (2003) Identifying patients for blood conservation strategies (Br J Surg 2002; 89: 1176–1182). Br J Surg 90(3):368

    PubMed  CAS  Google Scholar 

  • Yang L, Stanworth S et al (2012) Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials. Transfusion 52(8):1673–1686

    PubMed  CAS  Google Scholar 

  • Yoo YC, Shim JK et al (2011) Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. Anesthesiology 115(5):929–937

    PubMed  CAS  Google Scholar 

  • Young PP, Cotton BA et al (2011) Massive transfusion protocols for patients with substantial hemorrhage. Transfus Med Rev 25(4):293–303

    PubMed  PubMed Central  Google Scholar 

  • Zufferey P, Merquiol F et al (2006) Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 105(5):1034–1046

    PubMed  Google Scholar 

  • Zwart JJ, Dijk PD et al (2010) Peripartum hysterectomy and arterial embolization for major obstetric hemorrhage: a 2-year nationwide cohort study in the Netherlands. Am J Obstet Gynecol 202(2):150, e151–157

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Anesthesiology, University Hospital Zurich, Raemistrasse 100, CH - 8091, Zurich, Switzerland

    Oliver M. Theusinger MD, Stephanie L. Kind MD & Donat R. Spahn MD, FRCA

  2. Medical Section Anesthesiology, Intensive Care Medicine, OR-Management University, Zurich, Switzerland

    Donat R. Spahn MD, FRCA

Authors
  1. Oliver M. Theusinger MD
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  2. Stephanie L. Kind MD
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  3. Donat R. Spahn MD, FRCA
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Corresponding author

Correspondence to Oliver M. Theusinger MD .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, University Hospital of Lausanne, Lausanne, Switzerland

    Carlo Enrique Marcucci

  2. Department of Anesthesiology, University Hospital of Lausanne, Lausanne, Switzerland

    Patrick Schoettker

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Theusinger, O.M., Kind, S.L., Spahn, D.R. (2015). Patient Blood Management. In: Marcucci, C., Schoettker, P. (eds) Perioperative Hemostasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55004-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-55004-1_13

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