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Pharmacology of Psychiatric Drugs and Their Effects on Sleep

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Sleep Disorders in Psychiatric Patients
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Abstract

This chapter provides an overview of psychotropic drugs encountered in psychiatry and includes the effects on sleep of those frequently prescribed for depression, anxiety, psychosis, dementia and ADHD, with a small section about recreational drugs. Drugs which treat, exacerbate or provoke sleep disorders are covered in the last section.

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References

  • Bell C, Vanderlinden H, Hiersemenzel R, Otoul C, Nutt D, Wilson S. The effects of levetiracetam on objective and subjective sleep parameters in healthy volunteers and patients with partial epilepsy. J Sleep Res. 2002;11:255–63.

    Article  PubMed  Google Scholar 

  • Benkert O, Szegedi A, Philipp M, Kohnen R, Heinrich C, Heukels A, van der Vegte-Senden M, Baker RA, Simmons JH, Schutte AJ. Mirtazapine orally disintegrating tablets versus venlafaxine extended release: a double-blind, randomized multicenter trial comparing the onset of antidepressant response inpatients with major depressive disorder. J Clin Psychopharmacol. 2006;26:75–8.

    Article  CAS  PubMed  Google Scholar 

  • Carhart-Harris RL, Nutt DJ, Munafo M, Wilson SJ. Current and former ecstasy users report different sleep to matched controls: a web-based questionnaire study. J Psychopharmacol. 2009;23:249–57.

    Article  CAS  PubMed  Google Scholar 

  • Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, Amato D, Roth T. Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006;59:1052–60.

    Article  CAS  PubMed  Google Scholar 

  • Feige B, Voderholzer U, Riemann D, Dittmann R, Hohagen F, Berger M. Fluoxetine and sleep EEG: effects of a single dose, subchronic treatment, and discontinuation in healthy subjects. Neuropsychopharmacology. 2002;26:246–58.

    Article  CAS  PubMed  Google Scholar 

  • Feige B, Gann H, Brueck R, Hornyak M, Litsch S, Hohagen F, Riemann D. Effects of alcohol on polysomnographically recorded sleep in healthy subjects. Alcohol Clin Exp Res. 2006;30:1527–37.

    Article  PubMed  Google Scholar 

  • Friston KJ, Sharpley AL, Solomon RA, Cowen PJ. Lithium increases slow wave sleep: possible mediation by brain 5-HT-2 receptors. Psychopharmacology. 1989;98:139–40.

    Article  CAS  PubMed  Google Scholar 

  • Gann H, Riemann D, Hohagen F, Muller WE, Berger M. The influence of carbamazepine on sleep-EEG and the clonidine test in healthy subjects: results of a preliminary study. Soc Biol Psychiatry. 1994;35:893–6.

    Article  CAS  Google Scholar 

  • Garcia-Borreguero D, Patrick J, DuBrava S, Becker PM, Lankford A, Chen C, Miceli J, Knapp L, Allen RP. Pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome. Sleep. 2014;37:635–43.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gossop M, Bradley B. Insomnia among addicts during supervised withdrawal from opiates: a comparison of oral methadone and electrostimulation. Drug Alcohol Dep. 1984;13:191–8.

    Article  CAS  Google Scholar 

  • Gouzoulis E, Steiger A, Ensslin M, Kovar A, Hermle L. Sleep EEG effects of 3,4-methylenedioxyethamphetamine (MDE; “eve”) in healthy volunteers. Biol Psychiatry. 1992;32:1108–17.

    Article  CAS  PubMed  Google Scholar 

  • Harding GFA, Alford CA, Powell TE. The effects of sodium valproate on sleep, reaction times, and visual evoked potential in normal subjects. Epilepsia. 1985;26:597–601.

    Article  CAS  PubMed  Google Scholar 

  • Jain SV, Glauser TA. Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia. 2014;55:26–37.

    Article  CAS  PubMed  Google Scholar 

  • Kaynak H, Kaynak D, Gozukirmizi E, et al. The effects of trazodone on sleep in patients treated with stimulant antidepressants. Sleep Med. 2004;5:15–20.

    Article  PubMed  Google Scholar 

  • Landolt HP, Raimo EB, Schnierow BJ, Kelsoe JR, Rapaport MH, Gillin JC. Sleep and sleep electroencephalogram in depressed patients treated with phenelzine. Arch Gen Psychiatry. 2001;58:268–76.

    Article  CAS  PubMed  Google Scholar 

  • Landolt HP, Kelsoe JR, Rapaport MH, Gillin JC. Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. J Sleep Res. 2003;12:13–8.

    Article  PubMed  Google Scholar 

  • Larrosa O, de la Llave Y, Bario S, Granizo JJ, Garcia-Borreguero D. Stimulant and anticataplectic effects of reboxetine in patients with narcolepsy: a pilot study. Sleep. 2001;24:282–5.

    Article  CAS  PubMed  Google Scholar 

  • Larsson V, Aarsland D, Ballard C, Minthon L, Londos E. The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson’s disease dementia. Int J Geriatr Psychiatry. 2010;25:1030–8.

    Article  PubMed  Google Scholar 

  • Moldofsky H, Inhaber NH, Guinta DR, Alvarez-Horine SB. Effects of sodium oxybate on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled study. J Rheumatol. 2010;37:2156–66.

    Article  CAS  PubMed  Google Scholar 

  • Monaca C, Boutrel B, Hen R, Hamon M, Adrien J. 5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice. Neuropsychopharmacology. 2003;28:850–6.

    Article  CAS  PubMed  Google Scholar 

  • Monti JM, Monti D. Sleep in schizophrenia patients and the effects of antipsychotic drugs. Sleep Med Rev. 2004;8:133–48.

    Article  PubMed  Google Scholar 

  • Mouret J, Lemoine P, Minuit MP, Benkalfat C, Renardet M. Effects of trazodone on the sleep of depressed patients. Psychopharmacology. 1988;95:S37–43.

    Article  PubMed  Google Scholar 

  • Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24:305–13.

    Article  CAS  PubMed  Google Scholar 

  • Nutt DJ. Death by tricyclic: the real antidepressant scandal? J Psychopharmacol. 2005;19(2):123–4.

    Article  PubMed  Google Scholar 

  • Paterson LM, Wilson SJ, Nutt DJ, Hutson PH, Wilson SJ. A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers. Psychopharmacology. 2007;191:943–50.

    Article  CAS  PubMed  Google Scholar 

  • Paterson LM, Nutt DJ, Durant C, Wilson SJ. Efficacy of trazodone in primary insomnia: a double-blind randomised placebo-controlled polysomnographic study. J Psychopharmacol. 2009;23:A32.

    Google Scholar 

  • Plazzi G, Pizza F, Vandi S, Arico D, Bruni O, Dauvilliers Y, Ferri R. Impact of acute administration of sodium oxybate on nocturnal sleep polysomnography and on multiple sleep latency test in narcolepsy with cataplexy. Sleep Med. 2014;15:1046–54.

    Article  PubMed  Google Scholar 

  • Riemann D, Gann H, Dressing H, Muller WE, Aldenhoff JB. Influence of the cholinesterase inhibitor galanthamine hydrobromide on normal sleep. Psychiatry Res. 1994;51:253–67.

    Article  CAS  PubMed  Google Scholar 

  • Riemann D, Voderholzer U, Cohrs S, Rodenbeck A, Hajak G, Ruther E, Wiegand MH, Laakmann G, Baghai T, Fischer W, Hoffmann M, Hohagen F, Mayer G, Berger M. Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. Pharmacopsychiatry. 2002;35:165–74.

    Article  CAS  PubMed  Google Scholar 

  • Russo EB, Guy GW, Robson PJ, Baghai T, Fischer W, Hoffmann M, Hohagen F, Mayer G, Berger M. Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. Chem Biodivers. 2007;4:1729–43.

    Article  CAS  PubMed  Google Scholar 

  • Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437:1257–63.

    Article  CAS  PubMed  Google Scholar 

  • Schredl M, Weber B, Braus D, et al. The effect of rivastigmine on sleep in elderly healthy subjects. Exp Gerontol. 2000;35:243–9.

    Article  CAS  PubMed  Google Scholar 

  • Schredl M, Hornung O, Regen F, et al. The effect of donepezil on sleep in elderly, healthy persons: a double-blind placebo-controlled study. Pharmacopsychiatry. 2006;39:205–8.

    Article  CAS  PubMed  Google Scholar 

  • Sharpley AL, Rawlings NB, Brain S, McTavish SF, Cowen PJ. Does agomelatine block 5-HT2C receptors in humans? Psychopharmacology. 2011;213:653–5.

    Article  CAS  PubMed  Google Scholar 

  • Wilson S, Argyropoulos S. Antidepressants and sleep: a qualitative review of the literature. Drugs. 2005;65:927–47.

    Article  CAS  PubMed  Google Scholar 

  • Wilson SJ, Bailey JE, Rich AS, et al. The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. J Psychopharmacol. 2005;19:609–13.

    Article  CAS  PubMed  Google Scholar 

  • Wilson SJ, Nutt DJ, Alford C, et al. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol. 2010;24:1577–601.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Sue Wilson .

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Wilson, S. (2018). Pharmacology of Psychiatric Drugs and Their Effects on Sleep. In: Selsick, H. (eds) Sleep Disorders in Psychiatric Patients. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54836-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-54836-9_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54835-2

  • Online ISBN: 978-3-642-54836-9

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