Zusammenfassung
Dieses Kapitel widmet sich den verschiedenen Prophylaxemaßnahmen in der Intensivmedizin.
Die Pneumonieprophylaxe ist aufgrund deutlich erhöhter Morbiditäts- und Letalitätsraten und Therapiekosten von großer Bedeutung. Ziel dieses Kapitels ist es, einen Überblick über die empfohlenen allgemeinen und spezifischen Maßnahmen zu geben.
Die Notwendigkeit einer Thromboseprophylaxe bei allen intensivmedizinisch behandelten Patienten steht außer Frage und resultiert aus dem hohen Thromboserisiko durch dispositionelle und expositionelle Faktoren.
Die Stressulkusprophylaxe dient dem Schutz vor einer Schädigung der Magenschleimhaut.
Das Delir ist, insbesondere in der stillen bzw. hypoaktiven Form, ein oft unterschätztes (und nicht diagnostiziertes) Krankheitsbild auf Intensivstationen. Delirprophylaktische Maßnahmen umfassen zielgerichtetes Monitoring, die protokollgesteuerte Wahl von Substanzen für Sedierung, Analgesie und Delirium sowie nichtpharmakologische Ansätze.
Die Dekubitusprophylaxe wird als ein Qualitätsindikator der Pflege gewertet und stellt in der stationären Versorgung zunehmend älterer und multimorbider Patienten eine Herausforderung dar.
Literatur
Alexiou VG, Ierodiakonou V, Dimopoulos G, Falagas ME (2009) Impact of patient position on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. J Crit Care 24(4):515–522
Alhazzani W, Alenezi F, Jaeschke RZ, Moayyedi P, Cook DJ (2013a) Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 41(3):693–705 [Epub 16.01.2013]
Alhazzani W, Smith O, Muscedere J, Medd J, Cook D (2013b) Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med 41(2):646–655
Aly H, Badawy M, El-Kholy A, Nabil R, Mohamed A (2008) Randomized, controlled trial on tracheal colonization of ventilated infants: can gravity prevent ventilator-associated pneumonia? Pediatrics 122(4):770–774
Amaral MC, Favas C, Alves JD, Riso N, Riscado MV (2010) Stress-related mucosal disease: incidence of bleeding and the role of omeprazole in its prophylaxis. Eur J Intern Med 21(5):386–388 [Epub 08.09.2010]
Anders J et al (2010) Decubitus ulcers: pathophysiology and primary prevention. Dtsch Arztebl Int 107(21):371–382
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften AWMF (2010) S3-Leitlinie zu Analgesie, Sedierung und Delirmanagement in der Intensivmedizin – Kurzversion. AWMF ISSN 1612–3174. http://www.awmf.org/uploads/tx_szleitlinien/001-012_S3_Analgesie__Sedierung_und_Delirmanagement_in_der_Intensivmedizin_Kurz_12-2009_12-2014.pdf. Zugegriffen am 15.04.2013
Banerjee A et al (2011) The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unit. Curr Opin Anaesthesiol 24(2):195–201
Barkun AN, Bardou M, Pham CQ, Martel M (2012) Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta-analysis. Am J Gastroenterol 107(4):507–520; quiz 21 [Epub 01.02.2012]
Barletta JF, El-Ibiary SY, Davis LE, Nguyen B, Raney CR (2013) Proton pump inhibitors and the risk for hospital-acquired clostridium difficile infection. Mayo Clin Proc 88(10):1085–1090 [Epub 10.09.2013]
Bateman BT, Bykov K, Choudhry NK, Schneeweiss S, Gagne JJ, Polinski JM et al (2013) Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study. BMJ 347:f5416 [Epub 21.09.2013]
Bélanger L, Ducharme F (2011) patients`and nurse`experience of delirium: a review of qualitative studies. Nurs Crit Care 16(6):303–315
Black J, Boore JRP (2011) The effect of nurse-facilitated family participation in the psychological care of the critically ill patient. J Adv Nurs 67(5):1091–1101
Borkgren-Onkonek MJ (2008) Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and anti Xa activity. Surgery for obesity and related diseases. Expert Rev Cardiovasc Ther 4:625–631
Bosma KJ, Ranieri VM (2009) Filtering out the noise: evaluating the impact of noise and sound reduction strategies on sleep quality for ICU patients. Crit Care 13(3):151
Bourdel-Marchasson I et al (2000) A multi-center trial of the effects of oral nutritional supplementation in critically ill older inpatients. Nutrition 16(1):1–5
Bourne RS, Mills GH (2004) Sleep disruption in critically ill patients – pharmacological considerations. Anaesthesia 59(4):374–384
Bours GJJ et al (2001) Prevalence, risk factors and prevention of pressure ulcers in Dutch intensive care units results of cross-sectional survey. J Intensive Care Med 27:1599–1605
Bowton DL, Hite RD, Martin RS, Sherertz R (2013) The impact of hospital-wide use of a tapered-cuff endotracheal tube on the incidence of ventilator-associated pneumonia. Respir Care 58(10):1582–1587
Braun JP, Kumpf O, Deja M, Brinkmann A, Marx G, Bloos F et al (2013) The German quality indicators in intensive care medicine 2013, 2. Aufl. Ger Med Sci 11:Doc09
Brea OR (2008) Anti Xa levels in bariatric surgery patients receiving prophylactic enoxaparin. Obes Surg 18:162–166
Cook DJ, Fuller HD, Guyatt GH, Marshall JC, Leasa D, Hall R et al (1994) Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 330(6):377–381 [Epub 10.02.1994]
Cook DJ, Reeve BK, Guyatt GH, Heyland DK, Griffith LE, Buckingham L et al (1996) Stress ulcer prophylaxis in critically ill patients. Resolving discordant meta-analyses. JAMA 275(4):308–314 [Epub 24.01.1996]
Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J (1999) Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27(12):2812–2817 [Epub 11.01.2000]
Cox J (2011) Predictors of pressure ulcer in adult critical care patients. Am J Crit Care 20(5):364–374
de Smet AM, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS et al (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360(1):20–31
Defloor T, Grypdonck MF (2005) Pressure ulcers: validation of two risk assessment scales. J Clin Nurs 14(3):378–382
Dennis CM et al (2010) Benefits of quiet time for neuro-intensive care patients. J Neurosci Nurs 42(4):217–224
Deutsches Netzwerk für Qualitätsentwicklung in der Pflege (DNQP) (Hrsg) Expertenstandard Dekubitusprophylaxe in der Pflege- 1. Aktualisierung 2010. Schriftenreihe des deutschen Netzwerkes für Qualitätsentwicklung in der Pflege. DNQP, Osnabrück
Dorner B et al (2009) The role of nutrition on pressure ulcer prevention and treatment: National Pressure Ulcer Advisory Panel white paper. Adv Skin Wound Care 22(5):212–221
Douketis J et al (2008) Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin. Arch Intern Med 168(16):1805–1812
Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M (1999) Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 354(9193):1851–1858
Dubois MJ et al (2001) Delirium in an intensive care unit: a study of risk factors. Intensive Care Med 27:1297–1304
Duplaga BA, Rivers CW, Nutescu E (2001) Dosing and monitoring of low-molecular-weight heparins in special populations. Pharmacotherapy 21(2):218–234
Eachempati SR et al (2001) Factors influencing the development of decubitus ulcers in critically ill surgical patients. J Crit Care Med 29:1678–1682
Ely EW et al (2004) Delirium as a predictor of mortality in mechanically ventilated patients. Crit Care Med 32(11):1753–1763
Encke A, Haas S (2009) S3-Leitlinien. Prophylaxe der venösen Thromboembolie (VTE). VASA 38:S/76
European Pressure Ulcer Advisory Panel and National Pressure Ulcer Advisory Panel (2009) Prevention and treatment of pressure ulcers. Quick reference guide. National Pressure Ulcer Advisory Panel, Washington, DC. Deutsche Übersetzung der Kurz-Version der internationalen Leitlinien des NPUAP/ EPUAP (2009). http://www.epuap.org/guidelines/QRG_Prevention_in_German.pdf. Zugegriffen am 15.04.2013
Fourrier F, Duvivier B, Boutigny H, Roussel-Delvallez M, Chopin C (1998) Colonization of dental plaque: a source of nosocomial infections in intensive care unit patients. Crit Care Med 26(2):301–308
Frankel H et al (2007) Risk factors for pressure ulcer development in a best practice surgical intensive care unit. Am Surg 73(12):1215–1217
Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ (2001) Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillaton. JAMA 285:2864–2870
Gamberini M et al (2009) Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery – a randomized controlled trial. Neurol Crit Care 37(5):1762–1768
Gastmeier P, Kampf G, Wischnewski N, Hauer T, Schulgen G, Schumacher M et al (1998) Prevalence of nosocomial infections in representative German hospitals. J Hosp Infect 38(1):37–49
Gastmeier P, Behnke M, Reichardt C, Geffers C (2011) Qualitatsmanagement zur Infektionspräavention im Krankenhaus. Die Bedeutung der Surveillance. Bundesgesundheitsbl 2: 207–212 (online publiziert: 27. Januar 2011)
Geerts WH et al (2008) Prevention of VTE: American College of Chest Physicians evidence based clinical practice guidelines, 8. Aufl, 133(6 Suppl):381–453. doi: 10.1378/chest.08-0656
Geffers C, Gastmeier P (2011) Nosocomial infections and multidrug-resistant organisms in Germany: epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int 108(6):87–93
Gilman G (1991) The pharmacological basis of therapeutics, 8. Aufl. McGraw-Hill, New York
Girard TD et al (2010a) Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 38(7):1513–1520
Girard TD et al (2010b) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38:428–437
Gould M, Garcia DA, Wren SM et al (2012) Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th edn. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e227S–e277S
Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T et al (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368(23):2159–2168
Hammerstingl C, Omran H (2009) Bridging of oral anticoagulation with low-molecular-weight heparin: experience in 373 patients with renal insufficiency undergoing invasive procedures. Thromb Haemost 101:1085–1090
Holt KM, Hollander D (1986) Acute gastric mucosal injury: pathogenesis and therapy. Annu Rev Med 37:107–124 [Epub 01.01.1986]
Hopkins RO, Spuhler VJ (2009) Strategies for promoting early activity in critically ill mechanically ventilated patients. AACN Adv Crit Care 20(3):277–289
Houwing RH et al (2003) A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin Nutr 22:401–405
Hu RF et al (2010) Effects of earplugs and eye masks on nocturnal sleep, melatonin and cortisol in a simulated intensive care unit environment. Crit Care 14(2):R66
Inouye SK (1999) Predisposing and precipitating factors for delirium in hospitalized older patients. Dement Geriatr Cogn Disord 10(5):393–400
Kahn R (2012) Prevention of VTE in nonsurgical patients antithrombotic therapy and prevention of thrombosis, 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e195S–e226S
Kalisvaart KJ (2005) Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc 53:1658–1666
Kirchheiner J, Glatt S, Fuhr U, Klotz U, Meineke I, Seufferlein T et al (2009) Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. Eur J Clin Pharmacol 65(1):19–31 [Epub 18.10.2008]
Klamroth R, Gottstein S, Essers E, Landgraf H (2010) Bridging with enoxaparin using a half-therapeutic dose regimen: safety and efficacy. Vasa 39:243–248
Klotz U (2005) Pharmakologie der Protonenpumpenhemmer. Pharmazie Unserer Zeit 34(3):200–204 [Epub 09.06.2005]
Kollef MH (2011) Prevention of nosocomial pneumonia in the intensive care unit: beyond the use of bundles. Surg Infect 11(3):211–220
Kottner J, Balzer K (2010) Do pressure ulcer risk assessment scales improve clinical practice? J Multidiscip Healthc 3:103–111
Kottner J et al (2009) Pressure ulcers: a critical review of definitions and classifications. Ostomy Wound Manage 55(9):22–2913
Krag M, Perner A, Wetterslev J, Wise MP, Hylander Moller M (2013) Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 40(1):11–22 [Epub 22.10.2013]
Kruse MW, Lee JJ (2004) Retrospective evaluation of a pharmacokinetic program for adjusting enoxaparin in renal impairment. Am Heart J 148(4):582–589
Lahmann NA et al (2009) Bundesweite Erhebung zu Pflegeproblemen 2009. Charité – Universitätsmedizin Berlin, Berlin
Lahmann NA et al (2012) Higher pressure ulcer risk on intensive care? Comparision between general wards and intensive care units. J Clin Nurs 21(3–4):354–361
Langer G et al (2003) Nutritional interventions for preventing and treating pressure ulcers. Cochrane Database Syst Rev 6, CD003216
Lin SM et al (2004) The impact of delirium on the survival of mechanically ventilated patients. Crit Care 32(11):2254–2259
Lindgren M et al (2004) Immobility- a major risk factor for development of pressure ulcers among adult hospitalized patients: a prospective study. Scand J Caring Sci 18:57–64
Mahmoodpoor A, Peyrovi-far A, Hamishehkar H, Bakhtyiari Z, Mirinezhad MM, Hamidi M et al (2013) Comparison of prophylactic effects of polyurethane cylindrical or tapered cuff and polyvinyl chloride cuff endotracheal tubes on ventilator-associated pneumonia. Acta Med Iran 51(7):461–466
Maldonado JR et al (2009) Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 50:206–217
Marcantonio ER et al (2000) Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 48(6):618–624
Marik PE, Vasu T, Hirani A, Pachinburavan M (2010) Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis. Crit Care Med 38(11):2222–2228 [Epub 17.08.2010]
Marsh PD (2010) Controlling the oral biofilm with antimicrobials. J Dent 38(Suppl 1):11–15
Matthews EE (2011) Sleep disturbances and fatigue in critically ill patients. AACN Adv Crit Care 22(30):204–224
Mauri T, Berra L, Kumwilaisak K, Pivi S, Ufberg JW, Kueppers F et al (2010) Lateral-horizontal patient position and horizontal orientation of the endotracheal tube to prevent aspiration in adult surgical intensive care unit patients: a feasibility study. Respir Care 55(3):294–302
McInnes E et al (2011) Support surfaces for pressure ulcer prevention. Cochrane Database Syst Rev 4, CD001735
Michaud L et al (2007) Delirium: guideline for general hospitals. J Psychosom Res 62:371–383
Mietto C, Pinciroli R, Patel N, Berra L (2013) Ventilator associated pneumonia: evolving definitions and preventive strategies. Respir Care 58(6):990–1007
Morris RJ, Woodcock JP (2010) Intermittent pneumatic compression of graduated compression stockings for deep vein thrombosis prophylaxis? A systematic review of direct clinical comparisons. Ann Surg 251:393–396
Muscedere J, Dodek P, Keenan S, Fowler R, Cook D, Heyland D (2008a) Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care 23(1):126–137
Muscedere JG, Martin CM, Heyland DK (2008b) The impact of ventilator-associated pneumonia on the Canadian health care system. J Crit Care 23(1):5–10
Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK (2011) Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 39(8):1985–1991
Nijs N et al (2009) Incidence and risk factors for pressure ulcers in the intensive care unit. J Clin Nurs 18(9):1258–1266
Nylund CM, Goudie A, Garza JM, Crouch G, Denson LA (2013) Venous thrombotic events in hospitalized children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 56(5):485–491
Pancorbo-Hidalgo PL et al (2006) Risk assessment scales for pressure ulcer prevention: a systematic review. J Adv Nurs 54(1):94–100
Pandharipande P, Ely EW (2006) Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill. Crit Care 22(2):313–327
Pandharipande P et al (2006) Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104(1):21–26
Pandharipande P et al (2010) Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care. Crit Care 14:157. http://ccforum.com/content/14/3/157. Zugegriffen am 20.05.2013
Pengo V, Cucchini U, Denas G, Davidson BL, Marzot F, Jose SP, Iliceto S (2010) Lower versus standard intensity oral anticoagulant therapy (OAT) in elderly warfarin-experienced patients with non-valvular atrial fibrillation. Thromb Haemost 103:442–449
Perme C, Chandrashekar R (2009) Early mobility and walking program for patients in intensive care units: creating a standard of care. Am J Crit Care 18(3):212–221
Peterson JF et al (2006) Delirium and its motoric subtypes: a study of 614 critically ill patients. Am Geriatr Soc 54(3):479–484
Poelaert J, Depuydt P, De Wolf A, Van de Velde S, Herck I, Blot S (2008) Polyurethane cuffed endotracheal tubes to prevent early postoperative pneumonia after cardiac surgery: a pilot study. J Thorac Cardiovasc Surg 135(4):771–776
Prakanrattana U, Prapaitrakool S (2007) Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care 35(5):714–719
Pun B, Ely EW (2007) The importance of diagnosing and managing ICU delirium. Chest 132:624–639
Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, Forst H et al (2010) Prävention, Diagnose, Therapie und Nachsorge der Sepsis. Erste Revision der S2k-Leitlinien der Deutschen Sepsis-Gesellschaft e. V. (DSG) und der Deutschen Interdisziplinaren Vereinigung für Intensiv- und Notfallmedizin (DIVI). Anaesthesist 59(4):347–370 [Epub 24.03.2010]
Rello J, Sonora R, Jubert P, Artigas A, Rue M, Valles J (1996) Pneumonia in intubated patients: role of respiratory airway care. Am J Respir Crit Care Med 154(1):111–115
Riker RR et al (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301:489–499
Robert Koch-Institut –RKI (2003) Gesundheitsberichterstattung des Bundes 12. Dekubitus. RKI, Berlin
Rocha AT (2006) Risk of venous thromboembolism and efficacy of thrombo-prophylaxis in hospitalised obese medical patients and in obese patients undergoing bariatric surgery. Obes Surg 16:1645–1655
Rondina MT, Wheeler M, Rodgers GM, Draper L, Pendleton RC (2010) Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-ill patients. Thromb Res 125(3):220–223
Rouze A, Nseir S (2013) Continuous control of tracheal cuff pressure for the prevention of ventilator-associated pneumonia in critically ill patients: where is the evidence? Curr Opin Crit Care 19(5):440–447
Rubino AS et al (2010) Impact of clonidine administration on delirium related respiratory weaning after surgical correction of acute type- A aortic dissection: results of a pilot study. Interact Cardiovasc Thorac Surg 10:58–62
Sayar S et al (2008) Incidence of pressure ulcers in intensive care unit patients at risk according to the waterlow scale and factors influencing the development of pressure ulcers. J Clin Nurs 18(5):765–774
Scannapieco FA, Stewart EM, Mylotte JM (1992) Colonization of dental plaque by respiratory pathogens in medical intensive care patients. Crit Care Med 20(6):740–745
Schiemann A et al (2011) Managing ICU delirium. Curr Opin Crit Care 17:131–140
Scholten DJ, Hoedema RM, Scholten SE (2002) A comparison of two different prophylactic dose regimens of low molecular weight heparin in bariatric surgery. Obes Surg 12(1):19–24
Schubert M et al (2010) Entwicklung eines interprofesionellen Behandlungskonzepts „Delir“ für eine medizinische und chirurgische Intensivstation. Intensiv 18:316–323
Schweickert WD et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882
Scottish Intercollegiate Guidelines Network –SIGN (2002) Prophylaxis of venous thromboembolism. A national clinical guideline (SIGN Pub. No. 62). Edinburgh: SIGN
Shahin ESM, Dassen T, Halfens RJG (2009) Incidence, prevention and treatment of pressure ulcers in intensive care patients: a longitudinal study. Int J Nurs Stud 46(4):413–421
Shehabi Y et al (2009) Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine Compared to Morphine-DEXCOM Study). Anesthesiology 111:1075–1084
Sherman RA, Hwang ER, Walker JA, Eisinger RP (1983) Reduction in serum phosphorus due to sucralfate. Am J Gastroenterol 78(4):210–211 [Epub 01.04.1983]
Shi Z, Xie H, Wang P, Zhang Q, Wu Y, Chen E et al (2013a) Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev 8, CD008367
Shi et al (2013b) Gesundheitsforsch. Gesundheitsschutz 54(2):207
Silvestri L, Gregori D, van Saene HK, Belli R, Blazic M (2010) Semirecumbent position to prevent ventilator-associated pneumonia is not evidence based. J Crit Care 25(1):152–153; author reply 3–4
Spronk PE et al (2009) Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med 35(7):1276–1280
Starlinger M, Schiessel R (1988) Bicarbonate (HCO3) delivery to the gastroduodenal mucosa by the blood: its importance for mucosal integrity. Gut 29(5):647–654 [Epub 01.05.1988]
Statistisches Bundesamt – DESTATIS (2011) Tiefgegliederte Diagnosedaten der Krankenhauspatientinnen und- patienten (Datensatzstruktur). https://www.destatis.de/DE/Publikationen/Thematisch/Gesundheit/Krankenhaeuser/TiefgegliederteDiagnosedaten.html. Zugegriffen am 18.04.2013
Statistisches Bundesamt – DESTATIS (2012) Gesundheit Grunddaten der Krankenhäuser Fachserie 12 Reihe 6.1.1. https://www.destatis.de/DE/Publikationen/Thematisch/Gesundheit/Krankenhaeuser/GrunddatenKrankenhaeuser.html. Zugegriffen am 18.04.2013
Stausberg J et al (2005) Häufigkeit des Dekubitus in einem Universitätsklinikum. Deutsch Med Wochensch 130:2311–2315
Tarnawski AS, Ahluwalia A, Jones MK (2012) The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem 19(1):4–15 [Epub 04.02.2012]
Terekeci H et al (2009) Risk assessment study of the pressure ulcers in intensive care unit patients. Eur J Intern Med 20:394–397
Theaker C et al (2000) Risk factors for pressure sores in the critically ill. Anaesthesia 55(3):221–224
Thomason J et al (2005) Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care 9:R375 (open access)
Trompeo AC et al (2011) Sleep disturbances in the critically ill patients: role of delirium and sedative agents. Minerva Anesthesiol 77:604–612
Van Eijk MM et al (2009) Comparison of delirium assessment tools in a mixed intensive care unit. Crit Care Med 37:1881–1885
Van Eijk MM et al (2010) Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet 376(9755):1829–1837
van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, Joore HC, van Schijndel RJ, van der Tweel I et al (2006) Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 34(2):396–402
Van Rompaey B et al (2009) Risk factors for delirium in intensive care patients. A prospective cohort study.Crit Care 13(3):R55. http://ccforum.com/content/13/3/R55. Zugegriffen am 20.05.2013
Van Rompaey B et al (2012) The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Crit Care 16:R73. http://ccforum.com/content/16/3/R73. Zugegriffen am 23.05.2012
Vanderwee K et al (2007) Effectiveness of turning with unequal time intervals on the incidence of pressure lesions. J Adv Nurs 57(1):59–68
Vasilevskis EE et al (2010) Reducing Iatrogenic risks. ICU-acquired delirium and weakness – crossing the quality chasm. Chest 138(5):1224–1233
Walder B et al (2000) Effects of guidelines implementation in a surgical intensive care unit to control nighttime light and noise levels. Crit Care Med 28(7):2242–2247
Wang W et al (2012) Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med 40(3):731–739
Weinhouse GL, Schwab RJ (2006) Sleep in the critically ill patient. Sleep 29(5):707–716
Weststrate JTM, Heule F (2001) Prevalence of PU, risk factors and use of pressure ulcer- relieving mattresses in UIU patients. Connect World Crit Care Nurs 1:77–82
Young T (2004) The 30° tilt position vs the 90° lateral and supine positions in reducing the incidence of non-blanching erythema in a hospital inpatient population: a randomized controlled trial. J Tissue Viabil 14(3):89–96
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Bingold, T.M., Hoffmann, M., Krotsetis, S., Muhl, E. (2015). Prophylaxen in der Intensivmedizin. In: Marx, G., Muhl, E., Zacharowski, K. (eds) Die Intensivmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54675-4_43-1
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