Zusammenfassung
In der Therapie des Schocks und bei der Therapie kritisch kranker Patienten ist der Wert einer schnellen und effektiven Volumentherapie in der Intensivmedizin unumstritten. Durch Erhalt und Wiederherstellung des notwendigen Plasmavolumens verbessert man die Organperfusion und erhält die notwendige Mikrozirkulation. Im Schock besteht sowohl ein absoluter als auch ein relativer Flüssigkeitsmangel mit Abnahme der kardialen Vorlast, konsekutiver Verminderung des Herzzeitvolumens, Reduktion der Mikrozirkulation und somit einer Reduktion der Gewebeoxygenierung. Es muss ein ausreichend zirkulierendes Blutvolumen erreicht werden. Durch diese z. T. sehr umfassende Volumentherapie soll eine Steigerung der Pumpleistung des Herzens und dadurch eine verbesserte Gewebeoxygenierung und Gewebeperfusion sowie eine bessere Organfunktion insgesamt erreicht werden.
Literatur
Alderson P, Bunn F, Lefebvre C, Li WP, Li L, Roberts I et al (2004) Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev [Meta-Analysis Review] (4):CD001208
Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declère AD et al (2013) Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA 310(17):1809–1817
Blasco V, Leone M, Antonini F, Geissler A, Albanese J, Martin C (2008) Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation. Br J Anaesth 100(4):504–508
Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N et al (2008) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358(2):125–139
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM et al (2012) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock. Intensive Care Med 39(2):165–228
Dubin A, Pozo MO, Casabella CA, Murias G, Palizas F Jr, Moseinco MC et al (2010) Comparison of 6 % hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients. J Crit Care 25(4):659 e1–659 e8
Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350(22):2247–2256
Friedman G, Jankowski S, Shahla M, Gomez J, Vincent JL (2008) Hemodynamic effects of 6 % and 10 % hydroxyethyl starch solutions versus 4 % albumin solution in septic patients. J Clin Anesth 20(7):528–533 [Comparative Study Randomized Controlled Trial]
Godet G, Lehot JJ, Janvier G, Steib A, De Castro V, Coriat P (2008) Safety of HES 130/0.4 (Voluven (R)) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial. Eur J Anaesthesiol 25(12):986–994
Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M et al (2013) Hydroxyethyl starch 130/0.38–0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis. BMJ 346:f839
Lehmann G, Marx G, Forster H (2007a) Bioequivalence comparison between hydroxyethyl starch 130/0.42/6: 1 and hydroxyethyl starch 130/0.4/9: 1. Drugs RD 8(4):229–240
Lehmann GB, Asskali F, Boll M, Burmeister MA, Marx G, Hilgers R et al (2007b) HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly. Br J Anästh 98(5):635–644
Monnet X, Rienzo M, Osman D, Anguel N, Richard C, Pinsky MR et al (2006) Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med 34(5):1402–1407
Myburgh J, Cooper DJ, Finfer S, Bellomo R, Norton R, Bishop N et al (2007) Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med 357(9):874–884
Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D et al (2012) Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 367(20):1901–1911
Palumbo D, Servillo G, D’Amato L, Volpe ML, Capogrosso G, De Robertis E et al (2006) The effects of hydroxyethyl starch solution in critically ill patients. Minerva Anestesiol 72(7–8):655–664
Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A et al (2012) Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 367(2):124–134
Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1(8009):466–469
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19):1368–1377
Sakr Y, Payen D, Reinhart K, Sipmann FS, Zavala E, Bewley J et al (2007) Effects of hydroxyethyl starch administration on renal function in critically ill patients. Br J Anaesth 98(2):216–224
Saw MM, Chandler B, Ho KM (2012) Benefits and risks of using gelatin solution as a plasma expander for perioperative and critically ill patients: a meta-analysis. Anaesth Intensive Care 40(1):17–32
Shaw AD, Bagshaw SM, Goldstein SL, Scherer LA, Duan M, Schermer CR et al (2012) Major complications, mortality, and resource utilization after open abdominal surgery: 0.9 % saline compared to Plasma-Lyte. Ann Surg 255(5):821–829
Smith SH, Perner A (2012) Higher vs. lower fluid volume for septic shock: clinical characteristics and outcome in unselected patients in a prospective, multicenter cohort. Crit Care 16(3):R76
Sumpelmann R, Witt L, Brutt M, Osterkorn D, Koppert W, Osthaus WA (2010) Changes in acid–base, electrolyte and hemoglobin concentrations during infusion of hydroxyethyl starch 130/0.42/6: 1 in normal saline or in balanced electrolyte solution in children. Paediatr Anaesth 20(1):100–104
Surviving Sepsis Campaign (SSC) (2012) International Guidelines for Management of Severe Sepsis and Septic Shock http://www.survivingsepsis.org/Guidelines/Pages/default.aspx. Zugegriffen im Juni 14
Trof RJ, Sukul SP, Twisk JW, Girbes AR, Groeneveld AB (2010) Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia. Intensive Care Med 36(4):697–701
Wiesen P, Canivet JL, Ledoux D, Roediger L, Damas P (2005) Effect of hydroxyethylstarch on renal function in cardiac surgery: a large scale retrospective study. Acta Anaesthesiol Belg 56(3):257–263
Wilkes MM, Navickis RJ (2001) Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials. Ann Intern Med 135(3):149–164
Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M (2012) Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 308(15):1566–1572
Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC et al (2013) Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA 309(7):678–688 [Meta-Analysis Review]
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Simon, TP., Zacharowski, K., Marx, G. (2015). Volumentherapie. In: Marx, G., Muhl, E., Zacharowski, K. (eds) Die Intensivmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54675-4_39-1
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DOI: https://doi.org/10.1007/978-3-642-54675-4_39-1
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DOI: https://doi.org/10.1007/978-3-642-54675-4_39-2
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DOI: https://doi.org/10.1007/978-3-642-54675-4_39-1