Skip to main content
SpringerLink
Log in

Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen

Die Intensivmedizin

Part of the book series: Springer Reference Medizin ((SRM))

  • 340 Accesses

Zusammenfassung

Kenntnisse in der Pharmakodynamik und Pharmakokinetik bilden die Grundlage für eine erfolgreiche Pharmakotherapie. Die Pharmakodynamik befasst sich mit der Art und Weise der biologischen Wirkungen eines Pharmakons und beinhaltet Überlegungen zu Wirkmechanismen, Rezeptortheorien, Dosis-Wirkungs-Beziehungen und Nebenwirkungen. Die Pharmakokinetik hingegen beschäftigt sich mit dem Weg des Pharmakons durch den Organismus und der zeitlichen Abfolge von Resorption, Verteilung und Elimination.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Literatur

  • Alexander JK, Dennis EW, Smith WG, Amad KH, Duncan WC, Austin RC (1962) Blood volume, cardiac output, and disposition of systemic blood flow in extreme obesity. Cardiovasc Res Cent Bull 1:39–44

    PubMed  Google Scholar 

  • Avasthi G, Sandhu JS, Mohindra K (2003) Acute renal failure in medical and surgical intensive care units a one year prospective study. Ren Fail 25:105–113

    Article  PubMed  Google Scholar 

  • Aveling W, Brandshaw AD, Crankshaw DP (1978) The effect of speed of injection on the potency of anaesthetic induction agents. Anaesth Intensive Care 6:116–119

    CAS  PubMed  Google Scholar 

  • Baylis C, Corman B (1998) The aging kidney: insights from experimental studies. J Am Soc Nephrol 9:699–709

    CAS  PubMed  Google Scholar 

  • Bovill JG (1997) Adverse drug interactions in anesthesia. J Clin Anesth 9:3–13

    Article  Google Scholar 

  • Bowman SL, Hudson SA, Simpson G, Munro JF, Clements JA (1986) A comparison of the pharmacokinetics of propanolol in obese and normal volunteers. Br J Clin Pharmacol 21:529–532

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Brivet FG, Kleinknecht DJ, Loirat P, Landais PJ (1996) Acute renal failure in intensive care units – causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure. Crit Care Med 24:192–198

    Article  CAS  PubMed  Google Scholar 

  • Cheymol G (1987) Comparative pharmacokinetics of intravenous propanolol in obese and normal volunteers. J Clin Pharmacol 27:874–879

    Article  CAS  PubMed  Google Scholar 

  • Derry CL, Kroboth PD, Pittenger AL, Kroboth FJ, Corey SE, Smith RB (1995) Pharmacokinetics and pharmacodynamics of triazolam after two intermittent doses in obese and normal-weight men. J Clin Psychopharmacol 15:197–205

    Article  CAS  PubMed  Google Scholar 

  • Dharnidharka VR, Kwon C, Stevens G (2002) Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 40:221–226

    Article  CAS  PubMed  Google Scholar 

  • Egan TD (1995) Remifentanil pharmacokinetics and pharmacodynamics. A preliminary appraisal. Clin Pharmacokinet 29:80–94

    Article  CAS  PubMed  Google Scholar 

  • Flechner SM, Kolbeinsson ME, Tam J, Lum B (1989) The impact of body weight on cyclosporine pharmacokinetics in renal transplant recipients. Transplantation 47:806–810

    Article  CAS  PubMed  Google Scholar 

  • Grandison MK, Boudinot FD (2000) Age related changes in protein binding of drugs: implications for therapy. Clin Pharmacokinet 38:271–290

    Article  CAS  PubMed  Google Scholar 

  • Green B, Duffull SB (2004) What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 58:119–133

    Article  PubMed Central  PubMed  Google Scholar 

  • Greenblatt DJ, Abernethy DR, Locniskar A, Harmatz JS, Limjuco RA, Shader RI (1984) Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 61:27–35

    Article  CAS  PubMed  Google Scholar 

  • Kennedy JM, van Rij AM, Spears GF et al (2000) Polypharmacy in a general surgical unit and consequences of drug withdrawal. Br J Clin Pharmacol 49:353–362

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kunin CM (1967) A guide to use of antibiotics in patients with renal disease. A table of recommended doses and factors governing serum levels. Ann Intern Med 67:151–158

    Article  CAS  PubMed  Google Scholar 

  • Laterza OF, Price CP, Scott MG (2002) Cystatin C: an improved estimator of glomerular filtration rate. Clin Chem 48:699–707

    CAS  PubMed  Google Scholar 

  • Lazarou J, Pomeranz BH, Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients. JAMA 279:1200–1205

    Article  CAS  PubMed  Google Scholar 

  • Maddox A, Horowitz M, Wishart J, Collins P (1989) Gastric and oesophageal emptying in obesity. Scand J Gastroenterol 24:593–598

    Article  CAS  PubMed  Google Scholar 

  • Newman DJ, Thakkar H, Edwards RG et al (1995) Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine for glomerular filtration rate. Kidney Int 47:312–318

    Article  CAS  PubMed  Google Scholar 

  • Olkkola KT, Ahonen J (2001) Drug interactions. Curr Opin Anesth 14:411–416

    Article  CAS  Google Scholar 

  • Osborne R, Joel S, Slevin M (1986) Morphine intoxication in renal failure; the role of morphine-6-glucuronide. Br Med J 293:1101

    Article  CAS  Google Scholar 

  • Paar WD, Spengler U, Muller A, Hirner A, Sauerbruch T (1996) Diagnostik des akuten Leberversagens. Dtsch Med Wochenschr 121:305–309

    Article  CAS  PubMed  Google Scholar 

  • Papp-Jámbor C, Jaschinksi U, Forst H (2002) Cytochrom-P450-Enzyme und ihre Bedeutung für Medikamenteninteraktionen. Anaesthesist 51:2–15

    Article  PubMed  Google Scholar 

  • Rowe JW, Shock NW, DeFronzo RA (1976) The influence of age on the renal response to water deprivation in man. Nephron 17:270–278

    Article  CAS  PubMed  Google Scholar 

  • Schaeffner ES, Eber N, Delanaye P et al (2012) Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med 157:471–481

    Article  PubMed  Google Scholar 

  • Schuster HP (2001) Update – Akutes Nierenversagen in der Intensivmedizin Intensivmed. Intensivmed Notfallmed 38:179–186

    Article  Google Scholar 

  • Schwilk B, Wiedeck H, Stein B, Reinelt H, Treiber H, Bothner U (1997) Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care. Intensive Care Med 23:1204–1211

    Article  CAS  PubMed  Google Scholar 

  • Stanski DR, Mihm FG, Rosenthal MH, Kalman SM (1983) Pharmacokinetics of high-dose thiopental used in cerebral resuscitation. Anesthesiology 53:169–171

    Article  Google Scholar 

  • Syberth HW, Schwab M (2007) Besonderheiten der Arzneimitteltherapie im Kindesalter. In: Pharmakotherapie Klinische Pharmakologie, 13. Aufl. Springer, Berlin/Heidelberg/New York

    Google Scholar 

  • Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Magedo E, Gibney N, Tolwani A, Ronco C (2005) Beginning and ending supportive therapy for the kidney (best kidney) investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813–818

    Article  CAS  PubMed  Google Scholar 

  • Wood M (1991) Pharmacokinetic drug interactions in anaesthetic practice. Clin Pharmacokinet 21:285–307

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland

    Julia Langgartner

Authors
  1. Julia Langgartner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Julia Langgartner .

Editor information

Editors and Affiliations

  1. Klinik für Anästhesiologie, RWTH Aachen Universitätsklinikum Aachen, Aachen, Germany

    Gernot Marx

  2. Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Lübeck, Germany

    Elke Muhl

  3. Dir. der Klinik fuer Anaesthesie Intensivmed. und Schmerzther., Frankfurt, Hessen, Germany

    Kai Zacharowski

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Berlin Heidelberg

About this entry

Cite this entry

Langgartner, J. (2015). Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen. In: Marx, G., Muhl, E., Zacharowski, K. (eds) Die Intensivmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54675-4_37-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54675-4_37-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-54675-4

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen
    Published:
    06 April 2023

    DOI: https://doi.org/10.1007/978-3-642-54675-4_37-2

  2. Original

    Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen
    Published:
    15 August 2015

    DOI: https://doi.org/10.1007/978-3-642-54675-4_37-1

Search

Navigation