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Abstract

Mediastinoscopy and its technical variants, such as extended cervical mediastinoscopy, retrosternal mediastinoscopy and mediastino-thoracoscopy, have diagnostic, staging and therapeutic indications that have to be thoughtfully integrated with the available imaging, metabolic and endoscopic techniques. For lung cancer staging, mediastinoscopy has an average sensitivity and negative predictive values of 0.78 and 0.91, respectively. Video-mediastinoscopy has about the same staging values, but it has advantages over the standard procedure because of its teaching capability. Complication rate is about 3 %, but serious complications, such as bleeding from mediastinal vessels, are rare, and mortality rate is below 0.5 %.

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References

  1. Carlens E. Mediastinoscopy: a method for inspection and tissue biopsy in the superior mediastinum. Dis Chest. 1959;4:343–52.

    Article  Google Scholar 

  2. Krasnik M, Vilmann P, Larsen SS, Jacobsen GK. Preliminary experience with a new method of endoscopic transbronchial real time ultrasound guided biopsy for diagnosis of mediastinal and hilar lesions. Thorax. 2003;58:1083–6.

    Google Scholar 

  3. Wiersema MJ, Hawes RH, Tao LC, Wiersema LM, Kopecky KK, Rex DK, et al. Endoscopic ultrasonography as an adjunct to fine needle aspiration cytology of the upper and lower gastrointestinal tract. Gastrointest Endosc. 1992;38:35–9.

    Article  CAS  PubMed  Google Scholar 

  4. Vilmann P, Krasnik M, Larsen SS, Jacobsen GK, Clementsen P. Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy: a combined approach in the evaluation of mediastinal lesions. Endoscopy. 2005;37:833–9.

    Article  CAS  PubMed  Google Scholar 

  5. Hürtgen M, Friedel G, Toomes H, Fritz P. Radical video-assisted mediastinoscopic lymphadenectomy (VAMLA) – technique and first results. Eur J Cardiothorac Surg. 2002;21:348–51.

    Article  PubMed  Google Scholar 

  6. Leschber G, Holinka G, Linder A. Video-assisted mediastinoscopic lymphadenectomy (VAMLA) – a method for systematic mediastinal lymph node dissection. Eur J Cardiothorac Surg. 2003;24:192–5.

    Article  PubMed  Google Scholar 

  7. Kużdżał J, Zieliński M, Papla B, Szlubowski A, Hauer L, Nabialek T, et al. Transcervical extended mediastinal lymphadenectomy – the new operative technique and early results in lung cancer staging. Eur J Cardiothorac Surg. 2005;27:384–90.

    Article  PubMed  Google Scholar 

  8. Albanese AR. Biopsia por vía cervical, de ganglio o tumor del mediastino superior. Dia Med. 1942; Nov 23:1226.

    Google Scholar 

  9. Daniels AC. A method of biopsy useful in diagnosing certain intrathoracic diseases. Dis Chest. 1949;16:360–7.

    Article  CAS  PubMed  Google Scholar 

  10. Harken DE, Black H, Clauss R, Farrand RE. A simple cervicomediastinal exploration for tissue diagnosis of intrathoracic disease. N Engl J Med. 1954;251:1041–4.

    Article  CAS  PubMed  Google Scholar 

  11. Radner S. Suprasternal node biopsy in lymphaspreading intrathoracic disease. Acta Med Scand. 1955;152:413–5.

    Article  CAS  PubMed  Google Scholar 

  12. Palva T. Mediastinoscopy. Basel: S Karger; 1964.

    Google Scholar 

  13. Jepsen O. Mediastinoscopy. Copenhagen: Munksgaard; 1966.

    Google Scholar 

  14. Pearson FG. Mediastinoscopy: a method of biopsy in the superior mediastinum. Can J Surg. 1963;6:423–9.

    CAS  PubMed  Google Scholar 

  15. Pearson FG. Mediastinoscopy: a method of biopsy in the superior mediastinum. J Thorac Cardiovasc Surg. 1965;49:11–21.

    CAS  PubMed  Google Scholar 

  16. Pearson FG. An evaluation of mediastinoscopy in the treatment of presumably operable bronchial carcinoma. J Thorac Cardiovasc Surg. 1968;55:617–25.

    CAS  PubMed  Google Scholar 

  17. Pearson FG. Mediastinoscopy. Surg Annu. 1970;2:95–112.

    CAS  PubMed  Google Scholar 

  18. Pearson FG, Nelems JM, Henderson RD, Delarue NC. The role of mediastinoscopy in the selection of treatment for bronchial carcinoma with involvement of superior mediastinal lymph nodes. J Thorac Cardiovasc Surg. 1972;64:382–90.

    CAS  PubMed  Google Scholar 

  19. Coosemans W, Lerut T, Van Raemdonck D. Thoracoscopic surgery: the Belgian experience. Ann Thorac Surg. 1993;56:721–30.

    Article  CAS  PubMed  Google Scholar 

  20. Zakkar M, Tan C, Hunt I. Is video mediastinoscopy a safer and more effective procedure than conventional mediastinoscopy? Interact Cardiovasc Thorac Surg. 2012;14:81–4.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Walles T, Friedel G, Stegherr T, Steger V. Learning mediastinoscopy: the need for education, experience and modern techniques – interdependency of the applied technique and surgeon’s training level. Interact Cardiovasc Thorac Surg. 2013;16:450–4.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Chamberlain MH, Fareed K, Nakas A, Martin-Ucar AE, Waller DA. Video-assisted cervical thoracoscopy: a novel approach for diagnosis, staging and pleurodesis of malignant pleural mesothelioma. Eur J Cardiothorac Surg. 2008;34:200–3.

    Article  PubMed  Google Scholar 

  23. Fowkes L, Lau KK, Shah N, Black E. A cervical approach to investigate pleural disease. Ann Thorac Surg. 2009;88:315–7.

    Article  PubMed  Google Scholar 

  24. Azorin JF, Francisci MP, Tremblay B, Larmignat P, Carvaillo D. Closure of postpneumonectomy main bronchus fistula using video-assisted mediastinal surgery. Chest. 1996;109:1097–8.

    Article  CAS  PubMed  Google Scholar 

  25. Leschber G, Klemm W, Merk J. Video-mediastinoscopic resection of a long bronchial stump and reclosure of bronchial insufficiency after pneumonectomy. Eur J Cardiothorac Surg. 2009;35:1105–7.

    Article  PubMed  Google Scholar 

  26. Zieliński M, Pankowski J, Hauer L, Kużdżał J, Nabialek T. The right upper lobe pulmonary resection performed through the transcervical approach. Eur J Cardiothorac Surg. 2007;32:766–9.

    Article  PubMed  Google Scholar 

  27. Zieliński M, Kużdżał J, Szlubowski A, Soja J. Transcervical-subxiphoid-videothoracoscopic “maximal” thymectomy – operative technique and early results. Ann Thorac Surg. 2004;78:404–10.

    Article  PubMed  Google Scholar 

  28. Granato F, Luzzi L, Voltolini L, Gotti G. Video-assisted mediastinoscopic resection of two bronchogenic cysts: a novel approach. Interact Cardiovasc Thorac Surg. 2010;11:335–6.

    Article  PubMed  Google Scholar 

  29. Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, et al. Methods for staging non-small cell lung cancer. Diagnosis and management of lung cancer, 3rd edition: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(Suppl):e211S–50.

    Article  PubMed  Google Scholar 

  30. De Leyn P, Lardinois D, Van Schil PE, Rami-Porta R, Passlick B, Zielinski M, et al. ESTS guidelines for preoperative lymph node staging for non-small cell lung cancer. Eur J Cardiothorac Surg. 2007;32:1–8.

    Article  PubMed  Google Scholar 

  31. Gunluoglu MZ, Melek H, Medetoglu B, Demir A, Kara HV, Dincer SI. The validity of preoperative lymph node staging guidelines of European Society of Thoracic Surgeons in non-small-cell lung cancer patients. Eur J Cardiothorac Surg. 2011;40:287–90.

    PubMed  Google Scholar 

  32. Stahel RA, Weder W, Lievens Y, Felip E, ESMO Guidelines Working Group. Malignant pleural mesothelioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010;21 Suppl 5:v126–8.

    Article  PubMed  Google Scholar 

  33. Scherpereel A, Astoul P, Baas P, Berghmans T, Clayson H, de Vuyst P, et al. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J. 2010;35:479–95.

    Article  CAS  PubMed  Google Scholar 

  34. Pfannschmidt J, Klode J, Muley T, Dienemann H, Hoffman H. Nodal involvement at the time of pulmonary metastasectomy: experience in 245 patients. Ann Thorac Surg. 2006;81:448–54.

    Article  PubMed  Google Scholar 

  35. Welter S, Jacobs J, Krbek T, Poettgen C, Stamatis G. Prognostic impact of lymph node involvement in pulmonary metastasis from colorectal cancer. Eur J Cardiothorac Surg. 2007;31:167–72.

    Article  PubMed  Google Scholar 

  36. García-Yuste M, Cassivi S, Paleru C. Thoracic lymphatic involvement in patients having pulmonary metastasectomy. Incidence and the effect on prognosis. J Thorac Oncol. 2010;5:s166–9.

    Article  PubMed  Google Scholar 

  37. Menon A, Milton R, Thorpe JA, Papagiannopoulos K. The value of video-assisted mediastinoscopy in pulmonary metastasectomy. Eur J Cardiothorac Surg. 2007;32:351–4.

    Article  PubMed  Google Scholar 

  38. Riquet M, Berna P, Brian E, Badia A, Vlas C, Bagan P, et al. Intrathoracic lymph node metastases from extrathoracic carcinoma: the place for surgery. Ann Thorac Surg. 2009;88:200–5.

    Article  PubMed  Google Scholar 

  39. Venissac N, Pop D, Mouroux J. Video-assisted mediastinoscopy as a therapeutic tool. Surg Endosc. 2009;23:2466–72.

    Article  PubMed  Google Scholar 

  40. Aslam MI, Abunasra H, Klimatsida M, Waller DA. Video-assisted mediastinoscopic drainage of a bronchogenic cysts presenting with cardiac dysfunction. Ann Thorac Surg. 2009;88:1010–2.

    Article  PubMed  Google Scholar 

  41. Makhija Z, Moir CR, Allen MS, Cassivi SD, Deschamps C, Nichols IV FC, et al. Surgical management of congenital cystic lung malformations in older patients. Ann Thorac Surg. 2011;91:1568–73.

    Article  PubMed  Google Scholar 

  42. Lesaffer J, Heremans B, De Leyn P, Van Raemdonck D. Video-assisted mediastinoscopic resection of a large symptomatic bronchogenic cyst. Interact Cardiovasc Thorac Surg. 2011;12:1071–3.

    Article  PubMed  Google Scholar 

  43. Pop D, Venissac N, Leo F, Mouroux J. Video-assisted mediastinoscopy: a useful technique for paratracheal mesothelial cysts. J Thorac Cardiovasc Surg. 2005;129:690–1.

    Article  PubMed  Google Scholar 

  44. Burjonrappa SC, Taddeucci R, Arcidi J. Mediastinoscopy in the treatment of mediastinal cysts. JSLS. 2005;9:142–8.

    PubMed Central  PubMed  Google Scholar 

  45. Tcherveniakov P, Menon A, Milton R, Papagiannopoulo K, Lansdown M, Thorpe JAC. Video-assisted mediastinoscopy (VAM) for surgical resection of ectopic parathyroid adenoma. J Cardiothorac Surg. 2007;2:41. doi:10.1186/1749-8090-2-41.

    Article  PubMed Central  PubMed  Google Scholar 

  46. Iacobone M, Mondi I, Viel G, Citton M, Tropea S, Frego M, et al. The results of surgery for mediastinal parathyroid tumours: a comparative study of 63 patients. Langenbecks Arch Surg. 2010;395:947–53.

    Article  PubMed  Google Scholar 

  47. Yu L, Ma S, Jing Y, Zhang Y, Li F, Krasna MJ. Combined unilateral-thoracoscopic and mediastinoscopic thymectomy. Ann Thorac Surg. 2010;90:2068–70.

    Article  PubMed  Google Scholar 

  48. Venissac N, Pop D, Mouroux J. Closure of left-sided bronchopleural fistula by video-assisted mediastinoscopy: is it always possible? J Thorac Cardiovasc Surg. 2006;132:1490–1.

    Article  PubMed  Google Scholar 

  49. Pop D, Venissac N, Mouroux J. Video-assisted mediastinoscopy improved radical resection for cancer in transhiatal esophagectomy. J Thorac Cardiovasc Surg. 2007;133:267–8.

    Article  PubMed  Google Scholar 

  50. Callejas MA, Rami R, Catalán M, Mainer A, Sánchez-Lloret J. Mediastinoscopy as an emergency diagnostic procedure in superior vena cava syndrome. Scand J Thorac Cardiovasc Surg. 1991;25:137–9.

    Google Scholar 

  51. Jahangiri M, Goldstraw P. The role of mediastinoscopy in superior vena caval obstruction. Ann Thorac Surg. 1995;59:453–5.

    Article  CAS  PubMed  Google Scholar 

  52. Dosios T, Theakos N, Chatziantoniou C. Cervical mediastinoscopy and anterior mediastinotomy in superior vena cava obstruction. Chest. 2005;128:1551–6.

    Article  PubMed  Google Scholar 

  53. Yamada K, Kumar P, Goldstraw P. Cervical mediastinoscopy after total laryngectomy and radiotherapy: its feasibility. Eur J Cardiothorac Surg. 2002;21:71–3.

    Article  PubMed  Google Scholar 

  54. Douketis JD, Berger PB, Dunn AS, Jaffer AK, Spyropoulos AC, Becker RC, et al. American College of Chest Physicians. The perioperative management of antithrombotic therapy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133(6 suppl):299s–339s.

    Google Scholar 

  55. Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R, Goldstraw P. The IASLC lung cancer staging project. A proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4:568–77.

    Article  PubMed  Google Scholar 

  56. De Leyn P, Doomes C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, et al. Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small cell lung cancer. Eur J Cardiothorac Surg. 2014. doi:10.1093/ejcts/ezu028.

  57. Rami-Porta R. Quantification of regional lymph node involvement in lung cancer. Thorax. 2011;66:271–2.

    Article  PubMed  Google Scholar 

  58. Bonadies J, D’Agostino RS, Ruskis AF, Ponn RB. Outpatient mediastinoscopy. J Thorac Cardiovasc Surg. 1993;106:686–8.

    CAS  PubMed  Google Scholar 

  59. Cybulsky IJ, Bennet WF. Mediastinoscopy as a routine outpatient procedure. Ann Thorac Surg. 1994;58:176–8.

    Article  CAS  PubMed  Google Scholar 

  60. Venuta F, Rendina EA, Pescarmona EO, de Giacomo T, Flaishman I, Guarino E, et al. Ambulatory mediastinal biopsy for hematologic malignancies. Eur J Cardiothorac Surg. 1997;11:218–21.

    Article  CAS  PubMed  Google Scholar 

  61. Molins L, Fibla JJ, Pérez J, Sierra A, Vidal G, Simón C. Outpatient thoracic surgical programme in 300 patients: clinical results and economic impact. Eur J Cardiothorac Surg. 2006;29:271–5.

    Article  PubMed  Google Scholar 

  62. Lee JD, Ginsberg RJ. Lung cancer staging: the value of ipsilateral scalene lymph node biopsy performed at mediastinoscopy. Ann Thorac Surg. 1996;62:338–41.

    Article  CAS  PubMed  Google Scholar 

  63. Ginsberg RJ, Rice TW, Goldberg M, Waters PF, Schmocker BJ. Extended cervical mediastinoscopy: a single staging procedure for bronchogenic carcinoma of the left upper lobe. J Thorac Cardiovasc Surg. 1987;94:673–8.

    CAS  PubMed  Google Scholar 

  64. Stemmer EA, Calvin JW, Chandor SB, Connolly E. Mediastinal biopsy for indeterminate pulmonary and mediastinal lesions. J Thorac Cardiovasc Surg. 1965;49:405–11.

    CAS  PubMed  Google Scholar 

  65. McNeil TM, Chamberlain JM. Diagnostic anterior mediastinoscopy. Ann Thorac Surg. 1966;2:532–9.

    Article  Google Scholar 

  66. Deslauriers J, Beaulieu M, Dufour C, Michaud P, Despres JP, Lemieux M. Mediastinopleuroscopy: a new approach to the diagnosis of intrathoracic diseases. Ann Thorac Surg. 1976;22:265–9.

    Article  CAS  PubMed  Google Scholar 

  67. Mavridou P, Papadopoulou M, Igropolou O, Manataki A. Unexpected endotracheal tube cuff perforation during video mediastinoscopy. J Cardiothorac Vasc Anesth. 2007;21:723.

    Article  PubMed  Google Scholar 

  68. Hoyer ER, Leonard CE, Hazuka MB, Wechsler-Jentzsch K. Mediastinoscopy incisional metastasis: a radiotherapeutic approach. Cancer. 1992;70:1612–5.

    Article  CAS  PubMed  Google Scholar 

  69. Schubach SL, Landreneau RJ. Mediastinoscopic injury to the bronchus: use of in-continuity bronchial flap repair. Ann Thorac Surg. 1992;53:1100–3.

    Article  CAS  PubMed  Google Scholar 

  70. Le Pimpec Barthes F, D’Attellis N, Assouad J, Badia A, Souilamas R, Riquet M. Chylous leak after cervical mediastinoscopy. J Thorac Cardiovasc Surg. 2003;126:1199–200.

    Article  PubMed  Google Scholar 

  71. Pereszlenyi Jr A, Niks M, Danko J, Radulov S, Zernovicky F, Harustiak S. Complications of video-mediastinoscopy: successful management in four cases. Bratisl Lek Listy. 2003;104:201–4.

    PubMed  Google Scholar 

  72. Saumench-Perramon R, Rami-Porta R, Call-Caja S, Iglesias-Sentis M, Serra-Mitjans M, Bidegain-Pavón C, et al. Mediastinoscopic injuries to the right main bronchus and their mediastinoscopic repair. J Bronchol. 2008;15:191–3.

    Article  Google Scholar 

  73. Benouaich V, Marcheix B, Carfagna L, Brouchet L, Guitard J. Anatomical bases of left recurrent nerve lesions during mediastinoscopy. Surg Radiol Anat. 2009;31:295–9.

    Article  PubMed  Google Scholar 

  74. Pop D, Nadeemy AS, Venissac N, Guiraudet P, Mouroux J. Late mediastinal hematoma followed by incisional metastasis after video-assisted mediastinoscopy. J Thorac Oncol. 2010;5:919–20.

    Article  PubMed  Google Scholar 

  75. Elsayed H. Haemothorax after mediastinoscopy: a word of caution. Eur J Cardiothorac Surg. 2012;41:138–9.

    PubMed Central  PubMed  Google Scholar 

  76. Park BJ, Flores R, Downey RJ, Bains MS, Rusch VW. Management of major hemorrhage during mediastinoscopy. J Thorac Cardiovasc Surg. 2003;126:726–31.

    Article  PubMed  Google Scholar 

  77. Hammoud ZT, Anderson RC, Meyers BF, Guthrie TJ, Roper CL, Cooper JD, et al. The current role of mediastinoscopy in the evaluation of thoracic diseases. J Thorac Cardiovasc Surg. 1999;118:894–9.

    Article  CAS  PubMed  Google Scholar 

  78. Kliems G, Savic B. Complications of mediastinoscopy. Endoscopy. 1979;1:9–12.

    Article  Google Scholar 

  79. Kirschner PA. Cervical mediastinoscopy. Chest Surg Clin N Am. 1996;6:1–20.

    CAS  PubMed  Google Scholar 

  80. Urschel JD. Conservative management (packing) of hemorrhage complicating mediastinoscopy. Ann Thorac Cardiovasc Surg. 2000;6:9–12.

    CAS  PubMed  Google Scholar 

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Acknowledgement

We are most thankful to Dr. Mario Jorge Branda, thoracic surgeon and historian, from the Cetrángalo Hospital, in Buenos Aires, Argentina, for calling our attention to the procedure described by Dr. Alfonso R. Albanese and for providing copies of his original publications.

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Correspondence to Ramón Rami-Porta MD, PhD, FETCS .

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Rami-Porta, R., Call, S., Serra-Mitjans, M. (2014). Mediastinoscopy. In: Zieliński, M., Rami-Porta, R. (eds) The Transcervical Approach in Thoracic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54565-8_2

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