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Nilotinib

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Small Molecules in Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 201))

Abstract

Targeted therapy of Philadelphia chromosome-positive chronic myeloid leukemia (CML) using the tyrosine kinase inhibitor imatinib mesylate has been one of the most striking achievements in modern cancer medicine. However, while imatinib can establish long-term remission in many cases, resistance to or intolerance of imatinib is eventually experienced by a substantial number of patients. Subsequent advances have led to the development of novel tyrosine kinase inhibitors (TKIs). One such inhibitor, nilotinib, was rationally designed to increase its affinity and specificity for the oncogenic tyrosine kinase Bcr-Abl compared with imatinib and has been shown to be effective after imatinib failure. Recently, nilotinib has been shown to be more effective when used as first-line therapy of chronic phase CML.

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Authors and Affiliations

  1. Campus Virchow-Klinikum, Medical Department, Division of Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Benjamin N. Ostendorf, Philipp le Coutre & Theo D. Kim

  2. Department of Leukemia, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA

    Alfonso Quintás-Cardama

Authors
  1. Benjamin N. Ostendorf
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  2. Philipp le Coutre
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  3. Theo D. Kim
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  4. Alfonso Quintás-Cardama
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Corresponding author

Correspondence to Benjamin N. Ostendorf .

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Editors and Affiliations

  1. Cancer Center Heilbronn-Franken, SLK-Kliniken Heilbronn GmbH Medizinische Klinik III, Heilbronn, Germany

    Uwe M. Martens

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Ostendorf, B.N., le Coutre, P., Kim, T.D., Quintás-Cardama, A. (2014). Nilotinib. In: Martens, U. (eds) Small Molecules in Oncology. Recent Results in Cancer Research, vol 201. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54490-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-54490-3_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54489-7

  • Online ISBN: 978-3-642-54490-3

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