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The Value of 11C-Methionine PET in the Differential Diagnosis Between Brain Tumor Recurrence and Radionecrosis

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PET and SPECT in Neurology

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Abstract

11C-methionine (MET) positron emission tomography (PET) is one of the most used nuclear imaging modalities in brain tumors. Because of its characteristics, MET-PET should be able to provide us a high detection rate of brain tumors and good lesion delineation. This book chapter provides a clinical overview of important issues in primary brain tumors, recurrent brain tumors, and brain metastases. The role and dilemmas in neuroimaging are discussed. The working mechanism, scan interpretation, and quantification possibilities of MET-PET are explained. An overview is given of the role of MET-PET in gliomas (diagnostic accuracy, grading, prognosis, and assessment of tumor extent) with special focus on available literature in the role of MET-PET to differentiate between tumor progression/recurrent tumor and radiation necrosis.

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Acknowledgment

The authors want to thank Dr. Annemiek M. R. Walenkamp for her help in writing this book chapter.

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Authors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands

    Andor W. J. M. Glaudemans MD, Ronald W. J. van Rheenen & Riemer H. J. A. Slart

  2. Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands

    Roelien H. Enting

  3. Department of Radiotherapy, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands

    Mart A. A. M. Heesters

  4. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Rudi A. J. O. Dierckx

  5. Department of Radiology and Nuclear Medicine, Ghent University, De Pintelaan 185 K12, Ghent, 9000, Belgium

    Rudi A. J. O. Dierckx

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  1. Andor W. J. M. Glaudemans MD
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  3. Mart A. A. M. Heesters
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Correspondence to Andor W. J. M. Glaudemans MD .

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Editors and Affiliations

  1. Dept. of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Neurology, University Medical Center Groningen, Groningen, The Netherlands

    Klaus L. Leenders

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Glaudemans, A.W.J.M., Enting, R.H., Heesters, M.A.A.M., van Rheenen, R.W.J., Dierckx, R.A.J.O., Slart, R.H.J.A. (2014). The Value of 11C-Methionine PET in the Differential Diagnosis Between Brain Tumor Recurrence and Radionecrosis. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Leenders, K. (eds) PET and SPECT in Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54307-4_43

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