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Intraoperative Brain Mapping

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Abstract

The main objective of brain surgery is complete tumor resection with maximal preservation of neurological function. Identification of eloquent areas before tumor excision is essential to surgical approach planning. Preoperatively, functional magnetic resonance imaging and diffusion tensor imaging can identify cortical and subcortical structures corresponding to motor and language areas. Direct intraoperative electrical, cortical and subcortical, stimulation is a reliable, accurate, and safe technique to map essential neurological networks during brain tumor surgery. Using this approach, targeted resection boundaries can be executed with greater precision, decreasing postoperative neurological deficits and hence improving patient quality of life.

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References

  1. Bai HM, Wang WM, Li TD, He H, et al. Three core techniques in surgery of neuroepithelial tumors in eloquent areas: awake anaesthesia, intraoperative direct electrical stimulation and ultrasonography. Chin Med J (Engl). 2011;124(19):3035–41.

    Google Scholar 

  2. Bello L, Castellano A, Fava E, Casacelli G, et al. Intraoperative use of diffusion tensor imaging fiber tractography and subcortical mapping for resection of gliomas: technical considerations. Neurosurg Focus. 2010;28(2):E6.

    Article  PubMed  Google Scholar 

  3. Berger MS, Deliganis AV, Dobbins J, Keles GE. The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas. Cancer. 1994;74:1784–91.

    Article  CAS  PubMed  Google Scholar 

  4. Berman J, Berger MS, Mukherjee P, Henry RG. Diffusion-tensor imaging-guided tracking of fibers of the pyramidal tract combined with intraoperative cortical stimulation mapping in patients with gliomas. J Neurosurg. 2004;101:66–72.

    Article  PubMed  Google Scholar 

  5. Bertani G, Fava E, Casaceli G, et al. Intraoperative mapping and monitoring of brain functions for the resection of low-grade gliomas: technical considerations. Neurosurg Focus. 2009;27(4):E4.

    Article  PubMed  Google Scholar 

  6. Brown PD, Maurer MJ, Rummans TA, Pollock BE, et al. A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: the impact of the extent of resection on quality of life and survival. Neurosurgery. 2005;57(3):495–504.

    Article  PubMed  Google Scholar 

  7. Carrabba G, Fava E, Giussani C, Acerbi F, et al. Cortical and subcortical motor mapping in rolandic and perirolandic glioma surgery: impact on postoperative morbidity and extent of Resection. J Neurosurg Sci. 2007;51(2):45–51.

    CAS  PubMed  Google Scholar 

  8. Chang EF, Clark A, Smith JS, Pollley MY, et al. Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain. Improvement of long-term survival. J Neurosurg. 2011;114:566–73.

    Article  PubMed  Google Scholar 

  9. Choi BD, Mehta AI, Batich KA, Friedman AH, et al. The use of motor mapping to aid resection of eloquent gliomas. Neurosurg Clin N Am. 2012;23(2):215–25.

    Article  PubMed  Google Scholar 

  10. D’Andrea G, Angelini A, Romano A, Di Lauro A, et al. Intraoperative DTI and brain mapping for surgery of neoplasm of the motor cortex and the corticospinal tract: our protocol and series in Brain Suite. Neurosurg Rev. 2012;35:401–12.

    Article  PubMed  Google Scholar 

  11. de Benedictis A, Moritz-Gasser S, Duffau H. Awake mapping optimizes the extent of resection for low-grade gliomas in eloquent area. Neurosurgery. 2010;66(6):1078–84.

    Article  Google Scholar 

  12. De Witt Hammer PC, Robles SG, Zwinderman AH, Duffau H, et al. Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol. 2012;30(20):2559–65.

    Article  Google Scholar 

  13. Duffau H. Contribution of cortical and subcortical electrostimulation in brain glioma surgery: methodological and functional considerations. Clin Neurophysiol. 2007;37:373–82.

    Article  CAS  Google Scholar 

  14. Duffau H. The challenge to remove diffuse low-grade gliomas while preserving brain functions. Acta Neurochir. 2012;154:569–74.

    Article  PubMed  Google Scholar 

  15. Duffau H. Awake surgery for incidental WHO grade II gliomas involving eloquent areas. Acta Neurochir. 2012;154:575–84.

    Article  PubMed  Google Scholar 

  16. Duffau H, Capelle L, Denvil D, Sichez N, et al. Usefulness of intraoperative electrical subcortical mapping during surgery for low-grade gliomas located within eloquent brain regions: functional results in a consecutive series of 103 patients. J Neurosurg. 2003;98:764–78.

    Article  PubMed  Google Scholar 

  17. Duffau H, Lopes M, Arthuis F, Bitar A, et al. Contribution of intraoperative electrical stimulations in surgery of low-grade gliomas: a comparative study between two series without (1985–96) and with (1996–2003) functional mapping in the same institution. J Neurol Neurosurg Psychiatry. 2005;76(6):845–51.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Duffau H, Gatignol P, Mandonnet E, Capelle L, et al. Intraoperative subcortical stimulation mapping of language pathways in a consecutive series of 115 patients with grade II glioma in the left dominant hemisphere. J Neurosurg. 2008;109:461–71.

    Article  PubMed  Google Scholar 

  19. Gil Robles S, Duffau H. Surgical management of World Health Organization grade II gliomas in eloquent areas: the necessity of preserving a margin around functional structures. Neurosurg Focus. 2010;28:E8.

    Article  PubMed  Google Scholar 

  20. GonzĂ¡lez-Darder JM, GonzĂ¡lez-LĂ³pez P, Talamantes F, Quilis V, et al. Multimodal navigation in the functional microsurgical resection of intrinsic brain tumors located in eloquent motor areas: role of tractography. Neurosurg Focus. 2010;28(2):E5.

    Article  PubMed  Google Scholar 

  21. Guyotat J, Signorelli F, Bret P. Usefulness of direct cortical stimulations during surgery for gliomas located within eloquent brain regions. Neurochirurgie. 2005;51:368–78.

    Article  CAS  PubMed  Google Scholar 

  22. Kamada K, Todo T, Masutani Y, Aoki S, et al. Combined use of tractography-integrated functional neuronavigation and direct fiber stimulation. J Neurosurg. 2005;102:661–72.

    Article  Google Scholar 

  23. Kekhia H, Rigolo L, Norton I, Golby A. Special surgical considerations for functional brain mapping. Neurosurg Clin N Am. 2011;22(2):111–32.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Keles GE, Lamborn KR, Berger MS. Low-grade hemispheric gliomas in adults: a critical review of extent of resection as a factor influencing outcome. J Neurosurg. 2001;95:735–45.

    Article  CAS  PubMed  Google Scholar 

  25. Keles GE, Lundin DA, Lamborn KR, Chang EF, et al. Intraoperative subcortical stimulation mapping for hemispheric perirolandic gliomas located within or adjacent to the descending motor pathways: evaluation of morbidity and assessment of functional outcome in 294 patients. J Neurosurg. 2004;100:369–75.

    Article  PubMed  Google Scholar 

  26. Kim SS, McCutcheon IE, Suki D, Weinberg JS, et al. Awake craniotomy for brain tumors near eloquent cortex: correlations of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery. 2009;64:836–46.

    Article  PubMed  Google Scholar 

  27. Krishnan R, Raabe A, Hattingen E, Szelenyi A, et al. Functional magnetic resonance imaging-integrated neuronavigation: correlation between lesion-to-motor cortex distance and outcome. Neurosurgery. 2004;55:904–15.

    Article  PubMed  Google Scholar 

  28. Lang FF, Olansen NE, DeMonte F, et al. Surgical resection of intrinsic insular tumors: complication avoidance. J Neurosurg. 2001;95:638–50.

    Article  CAS  PubMed  Google Scholar 

  29. Mandonnet E, Winkler PA, Duffau H. Direct electrical stimulation as an input gate into brain functional networks: principles, advantages and limitations. Acta Neurochir. 2010;152:185–93.

    Article  PubMed  Google Scholar 

  30. Mikuni N, Okada T, Enatsu R, Miki Y, et al. Clinical impact of integrated functional neuronavigation and subcortical electrical stimulation to preserve motor function during resection of brain tumors. J Neurosurg. 2007;106:593–8.

    Article  PubMed  Google Scholar 

  31. Mikuni N, Okada T, Nishida N, Taki J, et al. Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain tumors. J Neurosurg. 2007;106:128–33.

    Article  PubMed  Google Scholar 

  32. Nimsky C, Ganslandt O, Buchfelder M, Fahlbusch R. Intraoperative visualization for resection of gliomas: the role of functional neuronavigation and intraoperative 1.5 T MRI. Neurol Res. 2006;28(5):482–7.

    Article  PubMed  Google Scholar 

  33. Ojemann G, Ojemann G, Lettich E, et al. Cortical language localization in left, dominant hemisphere. An electrical stimulation mapping investigation in 117 patients. J Neurosurg. 1989;71:316–26.

    Article  CAS  PubMed  Google Scholar 

  34. Pamir MN, Ozduman K, Dincer A, Yildiz E, et al. First intraoperative, shared-resource, ultrahigh-field 3-Tesla magnetic resonance imaging system and its application in low-grade glioma Resection. J Neurosurg. 2010;112(1):57–69.

    Article  PubMed  Google Scholar 

  35. Prabhu SS, Gasco J, Tummala S, Weinberg JS, et al. Intraoperative magnetic resonance imaging-guided tractography with integrated monopolar subcortical functional mapping for resection of brain tumors. J Neurosurg. 2011;114:719–26.

    Article  PubMed  Google Scholar 

  36. Piepmeier J, Christopher S, Spencer D, Byrne T, et al. Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas. Neurosurgery. 1996;38:872–9.

    Article  CAS  PubMed  Google Scholar 

  37. Pinsker MO, Navabi A, Mehdorn HM. Neuronavigation and resections of lesions located in eloquent brain areas under local anesthesia and neuropsychological-neurophysiological monitoring. Minim Invasive Neurosurg. 2007;50(5):281–4.

    Article  CAS  PubMed  Google Scholar 

  38. Pouratian N, Bookheimer SY. The reliability of neuroanatomy as a predictor of eloquence: a review. Neurosurg Focus. 2010;28(2):E3.

    Article  PubMed  Google Scholar 

  39. Ramina R, Coelho Neto M, Giacomelli A, Barros E, et al. Optimizing costs of intraoperative magnetic resonance imaging. A series of 29 gliomas cases. Acta Neurochir (Wien). 2010;152(1):27–33.

    Article  Google Scholar 

  40. Sanai N, Berger MS. Intraoperative stimulation techniques for functional pathway preservation and glioma resection. Neurosurg Focus. 2010;28(2):E1.

    Article  PubMed  Google Scholar 

  41. Sakurada K, Matsuda K, Funiu H, Kuge A, et al. Usefulness of multimodal examination and intraoperative magnetic resonance imaging system in glioma surgery. Neurol Med Chir (Tokyo). 2012;52:553–7.

    Article  Google Scholar 

  42. Schiffbauer H, Ferrari P, Rowley HA, Berger MS, et al. Functional activity within brain tumors: a magnetic source imaging study. Neurosurgery. 2001;49:1313–21.

    Article  CAS  PubMed  Google Scholar 

  43. Smith JS, Chang EF, Lamborn KR, Chang SM, et al. Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 2008;26:1338–45.

    Article  PubMed  Google Scholar 

  44. SuĂ¡rez-FernĂ¡ndez D, VĂ¡zquez-Barquero A, GĂ³mez E, Marco de Lucas E, et al. Efficacy and safety of intraoperative electrical stimulation mapping for resection of WHO grade ii and iii gliomas within eloquent areas. Med Clin (Barc). 2012;139(8):331–40.

    Article  Google Scholar 

  45. Szelényi A, Bello L, Duffau H, Fava E, et al. Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice. Neurosurg Focus. 2010;28(2):E7.

    Article  PubMed  Google Scholar 

  46. Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, et al. Supratentorial low-grade gliomas respectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology. 2006;239:506–13.

    Article  PubMed Central  PubMed  Google Scholar 

  47. Yamaguchi S, Kobayashi H, Terasaka S, Ishii N, et al. The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas. Jpn J Clin Oncol. 2012;42(4):270–7.

    Article  PubMed  Google Scholar 

  48. Yingling CD. Intraoperative mapping and monitoring of motor cortex-A new paradigm. US Neurol. 2011;7(1):64–7.

    Google Scholar 

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Acknowledgment

The authors would like to thank Gabriela De Pino (BSc) of the FLENI Department of Neuroradiology for her valuable help with the figures.

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Correspondence to Andrés Cervio .

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The author reports no conflict of interest concerning the materials or methods used in this study or the findings specified in this chapter.

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Cervio, A. (2014). Intraoperative Brain Mapping. In: Ramina, R., de Aguiar, P., Tatagiba, M. (eds) Samii's Essentials in Neurosurgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54115-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-54115-5_9

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