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Gentianae radix

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The Gentianaceae - Volume 2: Biotechnology and Applications

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Abstract

Gentian root (Gentianae radix) consists of the dried rhizomes and roots of Gentiana lutea L. (Gentianaceae). It occurs as single or branched subcylindrical pieces of various lengths and usually 10–40 mm in thickness. The smooth, transversely cut surface shows a bark, occupying about one-third of the radius, separated by the well-marked cambium from an indistinctly radiate and parenchymatous xylem. Powdered gentian roots show specific diagnostic characters, namely fragments of the subero-phellodermic layer, cortical and ligneous parenchymatous cells, and lignified vessels . The raw material contains gentiopicroside (also known as gentiopicrin), swertiamarin and sweroside, and a very small amount of amarogentin, which causes the bitter taste. Also present are xanthones (gentisin , isogentisin, gentioside), phytosterols, phenolic acid, trisaccharides (gentianose), polysaccharides (pectin), and essential oil. The bitterness of the raw material stimulates secretions in the gastrointestinal tract, especially of gastric juice. Traditionally, Gentianae radix is used to increase the appetite during recovery from acute atonic dyspepsia. Its antihepatotoxic, adaptogenic, and anti-inflammatory activities are also postulated from many experiments. Possible effects on the central nervous system of Gentianae radix have been investigated such as antidepressant and analgesic activities in mice. Extract of G. lutea showed radioprotective activity, probably due to its antioxidant activity.

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References

  • Amin A (2008) Ketoconazole-induced testicular damage in rats reduced by Gentiana extract. Exp Toxicol Pathol 59:377–384

    Article  CAS  PubMed  Google Scholar 

  • Antunes MB, Tamashiro E, Cohen NA (2008) Chapter 9: Complementary and alternative medicine in rhinology. In: Thaler ER, Kennedy DW (eds) Rhinosinusitis. Springer Science + Business Media, LLC, New York, pp 133–143. doi:10.1007/978-0-387-73062-29

  • Arino A, Arberas I, Leiton MJ, de Renobales M, Dominguez JB (1997) The extraction of yellow gentian root (Gentiana lutea L.). Z Lebensm Unters Forsch A 205:295–299

    Article  CAS  Google Scholar 

  • Blanco E, Macia MJ, Morales R (1999) Medicinal and veterinary plants of El Caurel (Galicia, northwest Spain). J Ethnopharmacol 65:113–124

    Article  CAS  PubMed  Google Scholar 

  • Blumberger W, Glatzel H (1968) The action of customary spices on the lysozyme activity of the saliva (in German). Dtsch Zahnarztl Z 23:666–674

    CAS  PubMed  Google Scholar 

  • Blumenthal M, Goldberg A, Brinckmann J (2000) Herbal medicine: expanded commission E monographs. American Botanical Council, Austin

    Google Scholar 

  • Botion LM, Ferreira AVM, Cortes SF, Lemos VS, Braga FC (2005) Effects of the Brazilian phytopharmaceutical product Ierobina® on lipid metabolism and intestinal tonus. J Ethnopharmacol 102:137–142

    Article  CAS  PubMed  Google Scholar 

  • British Herbal Pharmacopoeia (1996) British Herbal Medicine Association, Exeter

    Google Scholar 

  • Brown SM, Tabaee A, Anand VK (2009) Chapter 30: Evidence-based medicine in rhinosinusitis. In: Stucker FJ, de Souza C, Kenyon GS, Lian TS, Draf W, Schick B (eds) Rhinology and facial plastic surgery. Springer, Berlin, pp 345–353

    Chapter  Google Scholar 

  • Brunton LL, Chabner BA, Knollmann BC (2011) Chapter 15: Goodman & Gilman’s the pharmacological basis of therapeutics, 12th edn. Drug therapy of depression and anxiety disorders. McGraw-Hill Companies Inc, New York, pp 397-415

    Google Scholar 

  • Chen L, Liu JC, Zhang XN, Guo YY, Xu ZH, Cao W, Sun XL, Sun WJ, Zhao MG (2008) Down-regulation of NR2B receptors partially contributes to analgesic effects of gentiopicroside in persistent inflammatory pain. Neuropharmacology 54:1175–1181

    Article  CAS  PubMed  Google Scholar 

  • Cheng H-Y, Huang H-H, Yang Ch-M, Lin L-T, Lin Ch-Ch (2008) The in vitro anti-Herpes simplex virus type-1 and type-2 activity of Long Dan Xie Gan Tan, a prescription of traditional Chinese medicine. Chemotherapy 54:77–83

    Article  CAS  PubMed  Google Scholar 

  • Chibanguza G, Marz R, Sterner W (1984) Zur Wirksamkeit und Toxizität eines pflanzlichen Sekretolytikums und seiner Einzeldrogen. Arzneimittelforschung 34:32–36

    CAS  PubMed  Google Scholar 

  • Ciuman RR (2012) Phytotherapeutic and naturopathic adjuvant therapies in otorhinolaryngology. Eur Arch Otorhinolaryngol 269:389–397

    Article  PubMed Central  PubMed  Google Scholar 

  • Dopico E, San Fabian JL, Garcia-Vazquez E (2008) Traditional medicine in twenty-first Spain. Hum Ecol 36:125–129

    Article  Google Scholar 

  • Dziegielewski J, Goetz W, Baulch JE (2010) Heavy ions, radioprotectors and genomic instability: implications for human space exploration. Radiat Environ Biophys 49:303–316

    Article  CAS  PubMed  Google Scholar 

  • Egyptian Pharmacopoeia (1953) Fouad I. University Press, Cairo

    Google Scholar 

  • EMEA (2010) Assessment report on Gentiana lutea L. radix. European Medicines Agency, London, pp 1–19

    Google Scholar 

  • Ernst E, Marz RW, Sieder C (1997) Acute bronchitis—Benefits of Sinupret. Comparative post-marketing surveillance study involving 3,187 patients. Fortschr Med 115:3–7

    Google Scholar 

  • European Pharmacopoeia (2010) 7th edn. European Directorate for the Quality of Medicines and Health Care, Strasbourg

    Google Scholar 

  • Farmacopea Chilena (1941–1951) Tercera edn. Ministerio de Salubridad, Prevision y Asistencia Social, Santiago de Chile

    Google Scholar 

  • Farmakopea Polska (2008) 8 edn. Minister Zdrowia, Warszawa

    Google Scholar 

  • Gebhardt R (1997) Stimulation of acid secretion by extracts of Gentiana lutea L. in cultured cells from rat gastric mucosa. Pharmaceut Pharmacol Lett 7:106–108

    CAS  Google Scholar 

  • Ghedira K, Goetz P, Le Jeune R, Faivre C (2009) Gentiana lutea L. (Gentianaceae). Phytothérapie 7:172–176

    Article  Google Scholar 

  • Glatzel H, Hackenberg K (1967) Roentgenological studies of the effect of bitters on digestive organs (in German). Planta Med 15:223–232

    Article  CAS  PubMed  Google Scholar 

  • Goetz P (2010) Phytotherapie de la depression. Phytothrapie 8:245–248

    Google Scholar 

  • Guo R, Canter PH, Ernst E (2006) Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol Head Neck Surg 135:496–506

    Article  PubMed  Google Scholar 

  • Haraguchi H, Tanaka Y, Kabbash A, Fujioka T, Ishizu T, Yagi A (2004) Monoamine oxidase inhibitors from Gentiana lutea. Phytochemistry 65:2255–2260

    Article  CAS  PubMed  Google Scholar 

  • Hostettmann K, Wagner H (1977) Xanthone glycosides. Phytochemistry 16:821–829

    Article  CAS  Google Scholar 

  • Jensen SR, Schripsema J (2002) Chemotaxonomy and pharmacology of Gentianaceae. In: Struwe L, Albert VA (eds) Gentianaceae—Systematics and natural history. Cambridge University Press, Cambridge, pp 573–631

    Google Scholar 

  • Jiang RW, Wong KL, Chan YM, Xu HX, But PP, Shaw PC (2005) Isolation of iridoid and secoiridoid glycosides and comparative study on Radix gentianae and related adulterants by HPLC analysis. Phytochem 66:2674–2680

    Article  CAS  Google Scholar 

  • Kondo Y, Takano F, Hojo H (1994) Suppression of chemically and immunologically induced hepatic injuries by gentiopicroside in mice. Planta Med 60:414–416

    Article  CAS  PubMed  Google Scholar 

  • Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P (2007) Ethno-pharmacological approaches to wound healing—Exploring medicinal plants of India. J Ethnopharmacol 114:103–113

    Article  CAS  PubMed  Google Scholar 

  • Kumarasamy Y, Nahar L, Sarker SD (2003) Bioactivity of gentiopicroside from the aerial parts of Centaurium erythraea. Fitoterapia 74:151–154

    Article  CAS  PubMed  Google Scholar 

  • Kusar A, Zupancic A, Sentjurc M, Baricevic D (2006) Free radical scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin resonance. Hum Exp Toxicol 25:599–604

    Article  CAS  PubMed  Google Scholar 

  • Lans C, Turner N, Khan T, Brauer G (2007) Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada. Vet Parasitol 148:325–340

    Article  PubMed  Google Scholar 

  • Lazarević-Pašti M, Čolović J, Savić T, Vasić V, Momić V (2011) Oxidation of diazinon and malathion by myeloperoxidase. Pestic Biochem Physiol 100:140–144

    Article  Google Scholar 

  • Leslie GB (1978) A pharmacometric evaluation of nine Bio-Strath herbal remedies. Medita 8:31–47

    Google Scholar 

  • Lian L-H, Wu Y-L, Wan Y, Li X, Xie W-X, Nan J-X (2010) Anti-apoptotic activity of gentiopicroside in d-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. Chem Biol Interact 188:127–133

    Article  CAS  PubMed  Google Scholar 

  • Liao JF, Jan YM, Huang SY, Wang HH, Yu LL, Chen CF (1995) Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs. In: Proceedings of the national science council, Republic of China—Part B, Life Sciences 19:151–158

    Google Scholar 

  • Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR (2005) In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res 19:988–991

    Article  PubMed  Google Scholar 

  • Martin M, Mathias E, McCorkle CM (2001) Ethnoveterinary medicine: An annotated bibliography of community. Animal Healthcare ITDG Publishing, London

    Book  Google Scholar 

  • Mathew A, Taranalli AD, Torgal SS (2004) Evaluation of anti-inflammatory and wound healing activity of Gentiana lutea rhizome extracts in animals. Pharm Biol 42:8–12

    Article  Google Scholar 

  • Melzer J, Saller R, Schapowal A, Brignoli R (2006) Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch Komplementärmed 13:78–87

    Article  Google Scholar 

  • Menković N, Juranić Z, Stanojković T, Raonić-Stevanović T, Savikin K, Zdunić G, Borojević N (2010) Radioprotective activity of Gentiana lutea extract and mangiferin. Phytother Res 24:1693–1696

    Article  PubMed  Google Scholar 

  • Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529–540

    Article  CAS  PubMed  Google Scholar 

  • Nastasijević B, Lazarević-Pašti T, Dimitrijević-Branković S, Pašti I, Vujačić A, Joksić G, Vasić V (2012) Inhibition of myeloperoxidase and antioxidative activity of Gentiana lutea extracts. J Pharm Biomed Anal 66:191–196

    Article  PubMed  Google Scholar 

  • Neubauer N, März RW (1994) Placebo-controlled, randomized double-blind clinical trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1:177–181

    Article  CAS  PubMed  Google Scholar 

  • Niiho Y, Takayanagi K, Takagi K (1977) Effects of a combined stomachic and its ingredients on rabbit stomach motility in situ. Jpn J Pharmacol 27:177–179

    Article  CAS  PubMed  Google Scholar 

  • Niiho Y, Yamazaki T, Nakajima Y, Yamamoto T, Ando H, Hirai Y, Toriizuka K, Ida Y (2006) Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats. J Nat Med 60:82–88

    Article  CAS  Google Scholar 

  • Okabe S, Takeuchi K, Ikenishi H, Ohmi F, Takaoka A (1983) Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats (in Japanese). Nippon Yakurigaku Zasshi (Jpn J Pharmacol) 81:285–294

    Article  CAS  Google Scholar 

  • Öztürk N, Herekman-Demir T, Öztürk Y, Bozan B, Base KHC (1998) Choleretic activity of Gentiana lutea ssp. Symphyandra in rats. Phytomedicine 5:283–288

    Article  PubMed  Google Scholar 

  • Öztürk N, Can Başer KH, Aydin S, Öztürk Y, Caliş I (2002) Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice. Phytother Res 16:627–631

    Article  PubMed  Google Scholar 

  • Öztürk N, Korkmaz S, Öztürk Y, Can Başer KH (2006) Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from Gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Planta Med 72:289–294

    Article  PubMed  Google Scholar 

  • Pharmacopée Belge (1962–1966) 5me édition. Ministere des Affaires Sociales, de la Sante Publique et de l’Environnment, Bruxelles

    Google Scholar 

  • Pharmacopoea Bohemoslovenica (1970–1976) Editio tertio et Addendum. Avicenum-Zdravotnickié nakladatelstvi, Praha

    Google Scholar 

  • Pharmacopoea Nordica (1963–1973) Editio Norvegica. Universitets forlaget, Oslo

    Google Scholar 

  • Pharmacopoée Française (1974) 9e édition. Commission Nationale de la Pharmacopée, Paris

    Google Scholar 

  • Pharmacopoeia of Japan (1976) 9th edn. Ministry of Health and Welfare, Tokyo

    Google Scholar 

  • Richstein A, Mann W (1980) Treatment of chronic sinusitis with Sinupret. Ther Gegenwart 119:1055–1060

    CAS  PubMed  Google Scholar 

  • Šavikin K, Menković N, Zdunić G, Stević T, Radanović D, Janković T (2009) Antimicrobial activity of Gentiana lutea L. extracts. Z Naturforsch 64c:339–342

    Google Scholar 

  • Schmieder A, Schwaiger S, Csordas A, Backovic A, Messner B, Wick G, Stuppner H, Bernhard D (2007) Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury. Atherosclerosis 194:317–325

    Article  CAS  PubMed  Google Scholar 

  • Severino L, Ambrosio L (2012) Chapter 12: Herbal drugs used for domestic animals. In: Rai M, Cordell GA, Martinez JL, Marinoff M, Rastrelli L (eds) Medicinal plants. Biodiversity and drugs. CRC Press, Taylor & Francis Group, Boca Raton, London, pp 334–354. doi:10.1201/b12527-13

  • Suzuki O, Katsumata Y, Oya M (1978) Inhibition of monoamine oxidase by isogentisin and its 3-O-glucoside. Biochem Pharmacol 27:2075–2078

    Article  CAS  PubMed  Google Scholar 

  • Tang ZM, Peng M, Zhan CJ (2003) Screening 20 Chinese herbs often used for clearing heat and dissipating toxin with nude mice model of hepatitis C viral infection. Zhongguo Zhong Xi Yi Jie He Za Zhi 23:447–448

    PubMed  Google Scholar 

  • Trease GD (1949) A text-book of pharmacognosy. Baillière, Tindall and Cox, London

    Google Scholar 

  • Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, Kosslyn SM, Rose RM, Cohen JD (2004) Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 303:1162–1167

    Article  CAS  PubMed  Google Scholar 

  • Weckessera S, Engela K, Simon-Haarhausa B, Wittmerb A, Pelzb K, Schempp CM (2007) Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. Phytomedicine 14:508–516

    Article  Google Scholar 

  • Wegner T (1997) Anwendung eines Trockenextraktes aus Gentianae luteae radix bei dyspeptischem Symptomkomplex. Z Phytotherapie 19:163–164

    Google Scholar 

  • WHO (2007) WHO monographs on selected medicinal plants, vol 3. World Health Organization, Geneva, pp 150–159

    Google Scholar 

  • Wong RWK, Hagg U, Samaranayake L, Yuen MKZ, Seneviratne CJ, Kao R (2010) Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study. Int J Oral Maxillofac Surg 39:599–605

    Article  CAS  PubMed  Google Scholar 

  • Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M (2005) Up-regulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci 25:11107–11116

    Article  CAS  PubMed  Google Scholar 

  • Wynn SG, Fougere BJ (2007) Veterinary herbal medicine: a systems-based approach. In: Wynn SG, Fougere BJ (eds) Veterinary herbal medicine. Mosby, Elsevier, St. Louis, pp 291–409

    Chapter  Google Scholar 

  • Yamahara J, Konoshima T, Sawada T, Fujimura H (1978) Biologically active principles of crude drugs: pharmacological actions of Swertia japonica extracts, swertiamarin and gentianine (in Japanese). Yakugaku Zasshi 98:1446–1451

    CAS  PubMed  Google Scholar 

  • Zimmermann W, Gaisbauer G, Gaisbauer M (1986) Wirkung von Bitterstoff-Drogen auf das darmassoziierte Immunsystem. Z Phytother 7:59–56

    Google Scholar 

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Acknowledgments

Authors express thanks to Drs. Rybczyński and Mikuła for their help to have macro- and microscopic figures of G. lutea roots.

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Authors and Affiliations

  1. Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego Str. 71B, 60-630, Poznań, Poland

    Waldemar Buchwald & Przemysław Ł. Mikołajczak

  2. Department of Pharmacology, Poznań University of Medical Sciences, Rokietnicka Str. 5A, 60-806, Poznań, Poland

    Przemysław Ł. Mikołajczak

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  1. Waldemar Buchwald
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Correspondence to Waldemar Buchwald .

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Editors and Affiliations

  1. Botanical Garden-Center for Biological Diversity Conservation, Polish Academy of Sciences, Warsaw, Poland

    Jan J. Rybczyński

  2. Plant and Crop Sciences Division, University of Nottingham School of Biosciences, Loughborough, United Kingdom

    Michael R. Davey

  3. Botanical Garden-Center for Biological Diversity Conservation, Polish Academy of Sciences, Warsaw, Poland

    Anna Mikuła

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Buchwald, W., Mikołajczak, P.Ł. (2015). Gentianae radix . In: Rybczyński, J., Davey, M., Mikuła, A. (eds) The Gentianaceae - Volume 2: Biotechnology and Applications. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54102-5_17

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