Skip to main content
SpringerLink
Log in

Animal Models of Eating Disorders, Substance Use Disorders, and Addictions

  • Chapter
  • First Online:
Eating Disorders, Addictions and Substance Use Disorders

Abstract

Laboratory animal models are valuable in that they allow researchers to better understand the various biological and behavioral factors that may contribute to eating disorders and substance use disorders, as well as an opportunity to discover effective treatments for each. This chapter describes how animal models have been used to study features of anorexia nervosa, bulimia nervosa, and binge eating disorder, with a particular focus on the variables associated with the development of such behavior in animals. The second half of this chapter focuses on the various animal models that have been used to explore key characteristics of addiction. This chapter concludes with a brief discussion of the overlaps that exist between the two types of disorders and suggestions for future research directions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Ahmed, S. H., & Koob, G. F. (1999). Long-lasting increase in the set point for cocaine self-administration after escalation in rats. Psychopharmacology (Berl), 146(3), 303–312.

    Article  CAS  Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Publishing.

    Google Scholar 

  • Attia, E. (2010). Anorexia nervosa: Current status and future directions. Annual Review of Medicine, 61, 425–435. doi:10.1146/annurev.med.050208.200745.

    Article  CAS  PubMed  Google Scholar 

  • Avena, N. M., Carrillo, C. A., Needham, L., Leibowitz, S. F., & Hoebel, B. G. (2004). Sugar-dependent rats show enhanced intake of unsweetened ethanol. Alcohol, 34, 203–209.

    Article  CAS  PubMed  Google Scholar 

  • Avena, N. M., & Hoebel, B. G. (2003). A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Neuroscience, 122(1), 17–20.

    Article  CAS  PubMed  Google Scholar 

  • Avena, N., & Hoebel, B. (2012). Bingeing, withdrawal and craving: An animal model of sugar addiction. In K. Brownell & M. Gold (Eds.), Food and addiction: A comprehensive handbook. New York, NY: Oxford University Press.

    Google Scholar 

  • Avena, N. M., Long, K., & Hoebel, B. G. (2005). Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect. Physiology & Behavior, 84, 359–362.

    Article  CAS  Google Scholar 

  • Avena, N., Murray, S., Barbarich-Marsteller, N., & Rada, P. (September, 2013). Reward-related alterations in enkephalin gene expression and dopamine release in the accumbens as a result of activity-based anorexia in the rat [abstract]. In Eating Disorder Research Society, Bethesda, MD.

    Google Scholar 

  • Avena, N., Rada, P., & Hoebel, B. (2006). Sugar bingeing in rats. In J. Crawley, C. Gerfen, M. Rogawski, D. Sibley, P. Skolnick, & S. Wray (Eds.), Current protocols in neuroscience. New York, NY: Wiley and Sons, Inc.

    Google Scholar 

  • Avena, N. M., Rada, P., & Hoebel, B. G. (2008). Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake. Neuroscience & Biobehavioral Reviews, 32(1), 20–39. doi:10.1016/j.neubiorev.2007.04.019.

    Article  CAS  Google Scholar 

  • Barbarich-Marsteller, N. C., Foltin, R. W., & Walsh, B. T. (2011). Does anorexia nervosa resemble an addiction? Current Drug Abuse Reviews, 4(3), 197–200.

    Article  PubMed  Google Scholar 

  • Bartholome, L. T., Raymond, N. C., Lee, S. S., Peterson, C. B., & Warren, C. S. (2006). Detailed analysis of binges in obese women with binge eating disorder: Comparisons using multiple methods of data collection. International Journal of Eating Disorders, 39(8), 685–693. doi:10.1002/eat.20289.

    Article  PubMed  Google Scholar 

  • Belke, T., & Wagner, J. (1996). Investigating the reinforcing properties of running: Or, running is its own reward. In W. Epling & W. Pierce (Eds.), Activity anorexia: Theory, research, and treatment. Mahwah, NJ: Lawrence Erlbaum Associates.

    Google Scholar 

  • Boakes, R. A., & Dwyer, D. M. (1997). Weight loss in rats produced by running: Effects of prior experience and individual housing. Quarterly Journal of Experimental Psychology B, 50(2), 129–148. doi:10.1080/713932647.

    CAS  Google Scholar 

  • Boakes, R. A., Mills, K. J., & Single, J. P. (1999). Sex differences in the relationship between activity and weight loss in the rat. Behavioral Neuroscience, 113(5), 1080–1089.

    Article  CAS  PubMed  Google Scholar 

  • Bocarsly, M., & Avena, N. (2012). Animal models of binge eating palatable foods: Emergence of addiction-like behaviors and brain changes in the rat. In N. M. Avena (Ed.), Animal models of eating disorders. New York, NY: Humana.

    Google Scholar 

  • Brown, A. J., Avena, N. M., & Hoebel, B. G. (2008). A high-fat diet prevents and reverses the development of activity-based anorexia in rats. International Journal of Eating Disorders, 41(5), 383–389. doi:10.1002/eat.20510.

    Article  PubMed  Google Scholar 

  • Carr, K. D. (2002). Augmentation of drug reward by chronic food restriction: Behavioral evidence and underlying mechanisms. Physiology & Behavior, 76(3), 353–364.

    Article  CAS  Google Scholar 

  • Carrera, O., Cerrato, M., Sanchez, A., & Gutierrez, E. (2009). Long maternal separation has protective effects in rats exposed to activity-based anorexia. Developmental Psychobiology, 51(8), 616–624. doi:10.1002/dev.20396.

    Article  CAS  PubMed  Google Scholar 

  • Carrera, O., Gutierrez, E., & Boakes, R. A. (2006). Early handling reduces vulnerability of rats to activity-based anorexia. Developmental Psychobiology, 48(7), 520–527. doi:10.1002/dev.20175.

    Article  CAS  PubMed  Google Scholar 

  • Cifani, C., Polidori, C., Melotto, S., Ciccocioppo, R., & Massi, M. (2009). A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: Effect of sibutramine, fluoxetine, topiramate, and midazolam. Psychopharmacology (Berl), 204(1), 113–125. doi:10.1007/s00213-008-1442-y.

    Article  CAS  Google Scholar 

  • Cohen, L. R., Greenfield, S. F., Gordon, S., Killeen, T., Jiang, H., Zhang, Y., & Hien, D. (2010). Survey of eating disorder symptoms among women in treatment for substance abuse. American Journal on Addictions, 19(3), 245–251, doi:10.1111/j.1521-0391.2010.00038.x.

    Google Scholar 

  • Colantuoni, C., Rada, P., McCarthy, J., Patten, C., Avena, N. M., Chadeayne, A., & Hoebel, B. G. (2002). Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obesity Research, 10(6), 478–488.

    Google Scholar 

  • Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J. L., … & Hoebel, B. G. (2001). Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. Neuroreport, 12(16), 3549–3552.

    Google Scholar 

  • Corwin, R. L., Wojnicki, F. H., Fisher, J. O., Dimitriou, S. G., Rice, H. B., & Young, M. A. (1998). Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats. Physiology & Behavior, 65(3), 545–553.

    Article  CAS  Google Scholar 

  • Davis, J. D., & Campbell, C. S. (1973). Peripheral control of meal size in the rat. Effect of sham feeding on meal size and drinking rate. Journal of Comparative & Physiological Psychology, 83(3), 379–387.

    Article  CAS  Google Scholar 

  • Davis, C., & Claridge, G. (1998). The eating disorders as addiction: A psychobiological perspective. Addictive Behaviors, 23(4), 463–475.

    Article  CAS  PubMed  Google Scholar 

  • Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004). Evidence for addiction-like behavior in the rat. Science, 305(5686), 1014–1017. doi:10.1126/science.1099020.

    Article  CAS  PubMed  Google Scholar 

  • Dixon, D. P., Ackert, A. M., & Eckel, L. A. (2003). Development of, and recovery from, activity-based anorexia in female rats. Physiology & Behavior, 80(2–3), 273–279.

    Article  CAS  Google Scholar 

  • Doerries, L. E., Stanley, E. Z., & Aravich, P. F. (1991). Activity-based anorexia: Relationship to gender and activity-stress ulcers. Physiology & Behavior, 50(5), 945–949.

    Article  CAS  Google Scholar 

  • Duclos, M., Ouerdani, A., Mormede, P., & Konsman, J. P. (2012). Food restriction-induced hyperactivity: Addiction or adaptation to famine? Psychoneuroendocrinology, 38(6), 884–897. doi:10.1016/j.psyneuen.2012.09.012.

    Article  PubMed  Google Scholar 

  • Elbelt, U., Haas, V., Hofmann, T., Jeran, S., Pietz, H., Stengel, A., & Klapp, B.F. (2013). Energy expenditure and physical activity in patients with anorexia nervosa. Experimental and Clinical Endocrinology & Diabetes, 3, 121 - OP3_19, doi:10.1055/s-0033-1336627.

  • Emmett-Oglesby, M. W., Mathis, D. A., Moon, R. T., & Lal, H. (1990). Animal models of drug withdrawal symptoms. Psychopharmacology (Berl), 101(3), 292–309.

    Article  CAS  Google Scholar 

  • Epling, W., & Pierce, W. (1984). Activity-based anorexia in rats as a function of opportunity to run on an activity wheel. Nutrition & Behavior, 2, 37–49.

    Google Scholar 

  • Epling, W., & Pierce, W. (1988). Activity-based anorexia: A biobehavioral perspective. International Journal of Eating Disorders, 7(4), 475–485.

    Article  Google Scholar 

  • Garland, T., Jr., Schutz, H., Chappell, M. A., Keeney, B. K., Meek, T. H., Copes, L. E., … Eisenmann, J. C. (2011). The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: Human and rodent perspectives. Journal of Experimental Biology, 214(Pt 2), 206–229, doi:10.1242/jeb.048397.

    Google Scholar 

  • Gauvin, D., Briscoe, R., Baird, T., Vallett, M., Carl, K., & Holloway, F. (1996). Three-choice chlordiazepoxide, saline, and pentylenetetrazole discrimination in rats: Cross-generalization between drug and (olfactory) alarm substance stimuli. Experimental and Clinical Psychopharmacology, 4(4), 373–378.

    Article  CAS  Google Scholar 

  • Gearhardt, A. N., White, M. A., Masheb, R. M., & Grilo, C. M. (2013). An examination of food addiction in a racially diverse sample of obese patients with binge eating disorder in primary care settings. Comprehensive Psychiatry, 54(5), 500–505. doi:10.1016/j.comppsych.2012.12.009.

    Article  PubMed  Google Scholar 

  • Gibbs, J., & Falasco, J. D. (1978). Sham feeding in the rhesus monkey. Physiology & Behavior, 20(3), 245–249.

    Article  CAS  Google Scholar 

  • Gould, E., & Bres, M. (1986). Regurgitation in gorillas: Possible model for human eating disorders (rumination/bulimia). Journal of Developmental & Behavioral Pediatrics, 7(5), 314–319.

    Article  CAS  Google Scholar 

  • Gutierrez, E. (2013). A rat in the labyrinth of anorexia nervosa: Contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa. International Journal of Eating Disorders, 46(4), 289–301. doi:10.1002/eat.22095.

    Article  PubMed  Google Scholar 

  • Hagan, M. M., & Moss, D. E. (1991). An animal model of bulimia nervosa: Opioid sensitivity to fasting episodes. Pharmacology Biochemistry & Behavior, 39(2), 421–422.

    Article  CAS  Google Scholar 

  • Hagan, M. M., & Moss, D. E. (1997). Persistence of binge-eating patterns after a history of restriction with intermittent bouts of refeeding on palatable food in rats: Implications for bulimia nervosa. International Journal of Eating Disorders, 22(4), 411–420.

    Article  CAS  PubMed  Google Scholar 

  • Hagan, M. M., Wauford, P. K., Chandler, P. C., Jarrett, L. A., Rybak, R. J., & Blackburn, K. (2002). A new animal model of binge eating: Key synergistic role of past caloric restriction and stress. Physiology & Behavior, 77(1), 45–54.

    Article  CAS  Google Scholar 

  • Hancock, S., & Grant, V. (2009). Early maternal separation increases symptoms of activity-based anorexia in male and female rats. Journal of Experimental Psychology: Animal Behavior Processes, 35(3), 394–406. doi:10.1037/a0014736.

    PubMed  Google Scholar 

  • Hancock, S. D., Menard, J. L., & Olmstead, M. C. (2005). Variations in maternal care influence vulnerability to stress-induced binge eating in female rats. Physiology & Behavior, 85(4), 430–439. doi:10.1016/j.physbeh.2005.05.007.

    Article  CAS  Google Scholar 

  • Hargrave, S. L., & Kinzig, K. P. (2012). Repeated gastric distension alters food intake and neuroendocrine profiles in rats. Physiology & Behavior, 105(4), 975–981. doi:10.1016/j.physbeh.2011.11.006.

    Article  CAS  Google Scholar 

  • Hebebrand, J., Exner, C., Hebebrand, K., Holtkamp, C., Casper, R. C., Remschmidt, H., … & Klingenspor, M. (2003). Hyperactivity in patients with anorexia nervosa and in semistarved rats: Evidence for a pivotal role of hypoleptinemia. Physiology & Behavior, 79(1), 25–37.

    Google Scholar 

  • Hudson, J. I., Hiripi, E., Pope, H. G., Jr., & Kessler, R. C. (2007). The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biological Psychiatry, 61(3), 348–358. doi:10.1016/j.biopsych.2006.03.040.

    Article  PubMed Central  PubMed  Google Scholar 

  • Inoue, K., Kiriike, N., Okuno, M., Fujisaki, Y., Kurioka, M., Iwasaki, S., & Yamagami, S. (1998). Prefrontal and striatal dopamine metabolism during enhanced rebound hyperphagia induced by space restriction--a rat model of binge eating. Biological Psychiatry, 44(12), 1329–1336.

    Google Scholar 

  • Iwasaki, S., Inoue, K., Kiriike, N., & Hikiji, K. (2000). Effect of maternal separation on feeding behavior of rats in later life. Physiology & Behavior, 70(5), 551–556.

    Article  CAS  Google Scholar 

  • Kales, E. F. (1990). Macronutrient analysis of binge eating in bulimia. Physiology & Behavior, 48(6), 837–840.

    Article  CAS  Google Scholar 

  • Kanarek, R. B., & Collier, G. H. (1983). Self-starvation: A problem of overriding the satiety signal? Physiology & Behavior, 30(2), 307–311.

    Article  CAS  Google Scholar 

  • Kanarek, R. B., D’Anci, K. E., Jurdak, N., & Mathes, W. F. (2009). Running and addiction: Precipitated withdrawal in a rat model of activity-based anorexia. Behavioral Neuroscience, 123(4), 905–912. doi:10.1037/a0015896.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., Wagner, A., & Bischoff-Grethe, A. (2013). Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa? Biological Psychiatry, 73(9), 836–842. doi:10.1016/j.biopsych.2013.01.002.

    Article  PubMed  Google Scholar 

  • Koob, G. F. (2000). Animal models of craving for ethanol. Addiction, 95(Suppl 2), S73–S81.

    Article  PubMed  Google Scholar 

  • Krug, I., Pinheiro, A. P., Bulik, C., Jimenez-Murcia, S., Granero, R., Penelo, E., … & Fernandez-Aranda, F. (2009). Lifetime substance abuse, family history of alcohol abuse/dependence and novelty seeking in eating disorders: Comparison study of eating disorder subgroups. Psychiatry & Clinical Neurosciences, 63(1), 82–87, doi:10.1111/j.1440-1819.2008.01908.x.

    Google Scholar 

  • Leigh, A. J., Stock, M. J., Lacey, J. H., & Wilson, C. A. (1998). Diet-induced loss of cyclic ovarian function at normal body weight in a rodent model for bulimia nervosa. Journal of Reproduction & Fertility, 112(2), 217–223.

    Article  CAS  Google Scholar 

  • Lynch, W. J., Nicholson, K. L., Dance, M. E., Morgan, R. W., & Foley, P. L. (2010). Animal models of substance abuse and addiction: Implications for science, animal welfare, and society. Comparative Medicine, 60(3), 177–188.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Manwaring, J. L., Hilbert, A., Wilfley, D. E., Pike, K. M., Fairburn, C. G., Dohm, F. A., & Striegel-Moore, R. H. (2006). Risk factors and patterns of onset in binge eating disorder. International Journal of Eating Disorders, 39(2), 101–107, doi:10.1002/eat.20208.

    Google Scholar 

  • Markou, A., Weiss, F., Gold, L. H., Caine, S. B., Schulteis, G., & Koob, G. F. (1993). Animal models of drug craving. Psychopharmacology (Berl), 112(2–3), 163–182.

    Article  CAS  Google Scholar 

  • Marrazzi, M., & Luby, E. (1986). An auto-addiction opioid model of chronic anorexia nervosa. International Journal of Eating Disorders, 5(2), 191–208.

    Article  Google Scholar 

  • Martinsen, M., Bratland-Sanda, S., Eriksson, A. K., & Sundgot-Borgen, J. (2010). Dieting to win or to be thin? A study of dieting and disordered eating among adolescent elite athletes and non-athlete controls. British Journal of Sports Medicine, 44(1), 70–76. doi:10.1136/bjsm.2009.068668.

    Article  CAS  PubMed  Google Scholar 

  • Martinsen, M., & Sundgot-Borgen, J. (2012). Higher prevalence of eating disorders among adolescent elite athletes than controls. Medicine and Science in Sports and Exercise, 45(6), 188–1197. doi:10.1249/MSS.0b013e318281a939.

    Google Scholar 

  • Masheb, R., & White, M. A. (2012). Bulimia nervosa in overweight and normal-weight women. Comprehensive Psychiatry, 53(2), 181–186. doi:10.1016/j.comppsych.2011.03.005.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ness, J. W., Marshall, T. R., & Aravich, P. F. (1995). Effects of rearing condition on activity-induced weight loss. Developmental Psychobiology, 28(3), 165–173. doi:10.1002/dev.420280304.

    Article  CAS  PubMed  Google Scholar 

  • Nikander, P., & Pekkanen, L. (1977). An inborn alcohol tolerance in alcohol-preferring rats. The lack of relationship between tolerance to ethanol and the brain microsomal (Na+ K+) ATPase activity. Psychopharmacology (Berl), 51(3), 219–223.

    Article  CAS  Google Scholar 

  • Oliver, G., Wardle, J., & Gibson, E. L. (2000). Stress and food choice: A laboratory study. Psychosomatic Medicine, 62(6), 853–865.

    CAS  PubMed  Google Scholar 

  • Oswald, K. D., Murdaugh, D. L., King, V. L., & Boggiano, M. M. (2011). Motivation for palatable food despite consequences in an animal model of binge eating. International Journal of Eating Disorders, 44(3), 203–211. doi:10.1002/eat.20808.

    Article  PubMed Central  PubMed  Google Scholar 

  • Pare, W. P., Vincent, G. P., Isom, K. E., & Reeves, J. M. (1978). Sex differences and incidence of activity-stress ulcers in the rat. Psychological Reports, 43(2), 591–594.

    Article  CAS  PubMed  Google Scholar 

  • Pieper, W. A., Skeen, M. J., McClure, H. M., & Bourne, P. G. (1972). The chimpanzee as an animal model for investigating alcoholism. Science, 176(4030), 71–73.

    Article  CAS  PubMed  Google Scholar 

  • Pierce, W. D., Epling, W. F., & Boer, D. P. (1986). Deprivation and satiation: The interrelations between food and wheel running. Journal of the Experimental Analysis of Behavior, 46(2), 199–210.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Pjetri, E., de Haas, R., de Jong, S., Gelegen, C., Oppelaar, H., Verhagen, L. A., … & Kas, M. J. (2012). Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations. PLoS One, 7(11), e50453, doi:10.1371/journal.pone.0050453.

    Google Scholar 

  • Rada, P., Avena, N. M., & Hoebel, B. G. (2005). Daily bingeing on sucrose repeatedly releases dopamine in the accumbens shell. Neuroscience, 134, 737–744.

    Article  CAS  PubMed  Google Scholar 

  • Rasmussen, K., Beitner-Johnson, D. B., Krystal, J. H., Aghajanian, G. K., & Nestler, E. J. (1990). Opiate withdrawal and the rat locus coeruleus: Behavioral, electrophysiological, and biochemical correlates. Journal of Neuroscience, 10(7), 2308–2317.

    CAS  PubMed  Google Scholar 

  • Raymond, N. C., Bartholome, L. T., Lee, S. S., Peterson, R. E., & Raatz, S. K. (2007). A comparison of energy intake and food selection during laboratory binge eating episodes in obese women with and without a binge eating disorder diagnosis. International Journal of Eating Disorders, 40(1), 67–71. doi:10.1002/eat.20312.

    Article  PubMed  Google Scholar 

  • Reinking, M. F., & Alexander, L. E. (2005). Prevalence of disordered-eating behaviors in undergraduate female collegiate athletes and nonathletes. Journal of Athletic Training, 40(1), 47–51.

    PubMed Central  PubMed  Google Scholar 

  • Root, T. L., Pisetsky, E. M., Thornton, L., Lichtenstein, P., Pedersen, N. L., & Bulik, C. M. (2010). Patterns of co-morbidity of eating disorders and substance use in Swedish females. Psychological Medicine, 40(1), 105–115. doi:10.1017/S0033291709005662.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rosen, J., Leitenberg, H., Fisher, C., & Khazam, C. (1986). Binge‐eating episodes in bulimia nervosa: The amount and type of food consumed. International Journal of Eating Disorders, 5(2), 255–267.

    Article  Google Scholar 

  • Routtenberg, A., & Kuznesof, A. W. (1967). Self-starvation of rats living in activity wheels on a restricted feeding schedule. Journal of Comparative & Physiological Psychology, 64(3), 414–421.

    Article  CAS  Google Scholar 

  • Ryu, V., Lee, J. H., Yoo, S. B., Gu, X. F., Moon, Y. W., & Jahng, J. W. (2008). Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation. International Journal of Obesity (Lond), 32(9), 1355–1362. doi:10.1038/ijo.2008.108.

    Article  CAS  Google Scholar 

  • Scheurink, A. J., Boersma, G. J., Nergardh, R., & Sodersten, P. (2010). Neurobiology of hyperactivity and reward: Agreeable restlessness in anorexia nervosa. Physiology & Behavior, 100(5), 490–495. doi:10.1016/j.physbeh.2010.03.016.

    Article  CAS  Google Scholar 

  • Schulz, S., & Laessle, R. G. (2012). Stress-induced laboratory eating behavior in obese women with binge eating disorder. Appetite, 58(2), 457–461. doi:10.1016/j.appet.2011.12.007.

    Article  CAS  PubMed  Google Scholar 

  • Spangler, R., Wittkowski, K. M., Goddard, N. L., Avena, N. M., Hoebel, B. G., & Leibowitz, S. F. (2004). Opiate-like effects of sugar on gene expression in reward areas of the rat brain. Molecular Brain Research, 124, 134–142.

    Article  CAS  PubMed  Google Scholar 

  • Spurrell, E. B., Wilfley, D. E., Tanofsky, M. B., & Brownell, K. D. (1997). Age of onset for binge eating: Are there different pathways to binge eating? International Journal of Eating Disorders, 21(1), 55–65.

    Article  CAS  PubMed  Google Scholar 

  • Tiffany, S. T., & Maude-Griffin, P. M. (1988). Tolerance to morphine in the rat: Associative and nonassociative effects. Behavioral Neuroscience, 102(4), 534–543.

    Article  CAS  PubMed  Google Scholar 

  • Van Vort, W., & Smith, G. P. (1987). Sham feeding experience produces a conditioned increase of meal size. Appetite, 9(1), 21–29.

    Article  PubMed  Google Scholar 

  • Vanderschuren, L. J., & Ahmed, S. H. (2013). Animal studies of addictive behavior. Cold Spring Harbor Perspectives in Medicine, 3(4), a011932. doi:10.1101/cshperspect.a011932.

    Article  PubMed  Google Scholar 

  • Vanderschuren, L. J., & Everitt, B. J. (2004). Drug seeking becomes compulsive after prolonged cocaine self-administration. Science, 305(5686), 1017–1019. doi:10.1126/science.1098975.

    Article  CAS  PubMed  Google Scholar 

  • Vaswani, K., Tejwani, G. A., & Mousa, S. (1983). Stress induced differential intake of various diets and water by rat: The role of the opiate system. Life Sciences, 32(17), 1983–1996.

    Article  CAS  PubMed  Google Scholar 

  • Volkow, N. D., & Wise, R. A. (2005). How can drug addiction help us understand obesity? Nature Neuroscience, 8(5), 555–560. doi:10.1038/nn1452.

    Article  CAS  PubMed  Google Scholar 

  • Watanabe, K., Hara, C., & Ogawa, N. (1992). Feeding conditions and estrous cycle of female rats under the activity-stress procedure from aspects of anorexia nervosa. Physiology & Behavior, 51(4), 827–832.

    Article  CAS  Google Scholar 

  • Wilson, G. T. (2010). Eating disorders, obesity and addiction. European Eating Disorders Review, 18(5), 341–351. doi:10.1002/erv.1048.

    Article  PubMed  Google Scholar 

  • Wilson, J. F., & Cantor, M. B. (1987). An animal model of excessive eating: Schedule-induced hyperphagia in food-satiated rats. Journal of the Experimental Analysis of Behavior, 47(3), 335–346. doi:10.1901/jeab.1987.47-335.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wolffgramm, J., Galli, G., Thimm, F., & Heyne, A. (2000). Animal models of addiction: Models for therapeutic strategies? Journal of Neural Transmission, 107(6), 649–668.

    Article  CAS  PubMed  Google Scholar 

  • Yanovski, S. Z., Leet, M., Yanovski, J. A., Flood, M., Gold, P. W., Kissileff, H. R., & Walsh, B. T. (1992). Food selection and intake of obese women with binge-eating disorder. American Journal of Clinical Nutrition, 56(6), 975–980.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL, USA

    Susan Murray & Nicole M. Avena

  2. Department of Psychology, Princeton University, Princeton, NJ, USA

    Susan Murray, Monica Gordillo & Nicole M. Avena

Authors
  1. Susan Murray
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Monica Gordillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nicole M. Avena
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nicole M. Avena .

Editor information

Editors and Affiliations

  1. Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA

    Timothy D. Brewerton

  2. Psychiatry and Behavioral Neurosciences, University of South Florida, Bloomfield Hills, Michigan, USA

    Amy Baker Dennis

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Murray, S., Gordillo, M., Avena, N.M. (2014). Animal Models of Eating Disorders, Substance Use Disorders, and Addictions. In: Brewerton, T., Baker Dennis, A. (eds) Eating Disorders, Addictions and Substance Use Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45378-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-45378-6_1

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45377-9

  • Online ISBN: 978-3-642-45378-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation