Abstract
Autologous fat grafting is a reconstructive and cosmetic procedure used to restore form and function in many areas of the body. It can restore the natural tissue volume and fill up soft tissue defects by sequential injection of lipoaspirate, using dedicated instrumentation. The authors discuss fat retrieval and volume restoration and regenerative potential of fat grafting in the face. Patient selection, donor site selection, time schedule, and surgical technique are described. Five representative cases are presented to show the results.
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References
Del Vecchio D, Rohrich RJ. A classification of clinical fat grafting: different problems, different solutions. Plast Reconstr Surg. 2012;130(3):511–22.
Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg. 2006;118(3 Suppl):108S–20.
Fisher C, Grahovac TL, Schafer ME, Shippert RD, Marra KG, Rubin JP. Comparison of harvest and processing techniques for fat grafting and adipose stem cell isolation. Plast Reconstr Surg. 2013;132(2):351–61.
Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg. 1997;24(2):347–67.
Shiffman MA, Mirrafati S. Fat transfer techniques: the effect of harvest and transfer methods on adipocyte viability and review of the literature. Dermatol Surg. 2001;27(9):819–26.
Kaufman MR, Miller TA, Huang C, Roostaeian J, Roostaien J, Wasson KL, Ashley RK, Bradley JP. Autologous fat transfer for facial recontouring: is there science behind the art? Plast Reconstr Surg. 2007;119(7):2287–96.
Smith P, Adams WP, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA. Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg. 2006;117(6):1836–44.
Coleman SR. Structural fat grafts: the ideal filler? Clin Plast Surg. 2001;28(1):111–9.
Allen RJ, Canizares O, Scharf C, Nguyen PD, Thanik V, Saadeh PB, Coleman SR, Hazen A. Grading lipoaspirate: is there an optimal density for fat grafting? Plast Reconstr Surg. 2013;131(1):38–45.
Zhu M, Zhou Z, Chen Y, Schreiber R, Ransom JT, Fraser JK, Hedrick MH, Pinkernell K, Kuo HC. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg. 2010;64(2):222–8.
Butala P, Hazen A, Szpalski C, Sultan SM, Coleman SR, Warren SM. Endogenous stem cell therapy enhances fat graft survival. Plast Reconstr Surg. 2012;130(2):293–306.
Mazzola RF, Cantarella G, Torretta S, Sbarbati A, Lazzari L, Pignataro L. Autologous fat injection to face and neck: from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital. 2011;31(2):59–69.
Rigotti G, Marchi A, Galie M, Baroni G, Benati D, Krampera M, Pasini A, Sbarbati A. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409–22.
Tabit CJ, Slack GC, Fan K, Wan DC, Bradley JP. Fat grafting versus adipose-derived stem cell therapy: distinguishing indications, techniques, and outcomes. Aesthetic Plast Surg. 2012;36(3):704–13.
Nguyen PSA, Desouches C, Gay AM, Hautier A, Magalon G. Development of micro-injection as an innovative autologous fat graft technique: the use of adipose tissue as dermal filler. J Plast Reconstr Aesthet Surg. 2012;65(12):1692–9.
Alharbi Z, Opländer C, Almakadi S, Fritz A, Vogt M, Pallua N. Conventional vs. Micro-fat harvesting: how fat harvesting technique affects tissue-engineering approaches using adipose tissue-derived stem/stromal cells. J Plast Reconstr Aesthet Surg. 2013;66(9):1271–8.
Barret JP, Sarobe N, Grande N, Vila D, Palacin JM. Maximizing results for lipofilling in facial reconstruction. Clin Plast Surg. 2009;36(3):487–92.
Kantanen DJ, Closmann JJ, Rowshan HH. Abdominal fat harvest technique and its uses in maxillofacial surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(3):367–71.
Genden EM. Reconstruction of the mandible and the maxilla: the evolution of surgical technique. Arch Facial Plast Surg. 2010;12(2):87–90.
Seruya M, Fisher M, Rodriguez ED. Computer-assisted versus conventional free fibula flap technique for craniofacial reconstruction: an outcomes comparison. Plast Reconstr Surg. 2013;132:1219–28.
Ciocca L, Mazzoni S, Fantini M, Persiani F, Baldissara P, Marchetti C, Scotti R. A CAD/cam-prototyped anatomical condylar prosthesis connected to a custom-made bone plate to support a fibula free flap. Med Biol Eng Comput. 2012;50(7):743–9.
Sink J, Hamlar D, Kademani D, Khariwala SS. Computer-aided stereolithography for presurgical planning in fibula free tissue reconstruction of the mandible. J Reconstr Microsurg. 2012;28(6):395–403.
Antony AK, Chen WF, Kolokythas A, Weimer KA, Cohen MN. Use of virtual surgery and stereolithography-guided osteotomy for mandibular reconstruction with the free fibula. Plast Reconstr Surg. 2011;128(5):1080–4.
Vissink A, Jansma J, Spijkervet FKL, Burlage FR, Coppes RP. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003;14(3):199–212.
Epstein JB, Thariat J, Bensadoun R-J, Barasch A, Murphy BA, Kolnick L, et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin. 2012;62(6):400–22.
Bourget A, Chang JTC, Wu DB-S, Chang CJ, Wei FC. Free flap reconstruction in the head and neck region following radiotherapy: a cohort study identifying negative outcome predictors. Plast Reconstr Surg. 2011;127(5):1901–8.
Wetterau M, Szpalski C, Hazen A, Warren SM. Autologous fat grafting and facial reconstruction. J Craniofac Surg. 2012;23(1):315–8.
Phulpin B, Gangloff P, Tran N, Bravetti P, Merlin J-L, Dolivet G. Rehabilitation of irradiated head and neck tissues by autologous fat transplantation. Plast Reconstr Surg. 2009;123(4):1187–97.
Navach V, Calabrese LS, Zurlo V, Alterio D, Funicelli L, Giugliano G. Functional base of tongue fat injection in a patient with severe postradiation dysphagia. Dysphagia. 2011;26(2):196–9.
Tarallo M, Rizzo MI, Monarca C, Fanelli B, Parisi P, Scuderi N. Optimal care for eyelid contraction after radiotherapy: case report and literature review. J Oral Maxillofac Surg. 2012;70(10):2459–65.
Mazzola IC, Cantarella G, Mazzola RF. Management of tracheostomy scar by autologous fat transplantation: a minimally invasive new approach. J Craniofac Surg. 2013;24(4):1361–4.
Cantarella G, Mazzola RF, Domenichini E, Arnone F, Maraschi B. Vocal fold augmentation by autologous fat injection with lipostructure procedure. Otolaryngol Head Neck Surg. 2005;132(2):239–43.
De Santis G, Nocini PF, Chiarini L, Bedogni A. Functional rehabilitation of the atrophic mandible and maxilla with fibula flaps and implant-supported prosthesis. Plast Reconstr Surg. 2004;113(1):88–98.
Coleman SR. Facial augmentation with structural fat grafting. Clin Plast Surg. 2006;33(4):567–77.
Condé-Green A, de Amorim NFG, Pitanguy I. Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study. J Plast Reconstr Aesthet Surg. 2010;63(8):1375–81.
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Bedogni, A., Bettini, G., Fior, A., Saia, G. (2014). Secondary Correction of Facial Deformities Following Major Resection and Reconstruction: Fat Stem Cell for Restoration of Facial Asymmetries. In: Shiffman, M., Di Giuseppe, A., Bassetto, F. (eds) Stem Cells in Aesthetic Procedures. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45207-9_32
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DOI: https://doi.org/10.1007/978-3-642-45207-9_32
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