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Secondary Correction of Facial Deformities Following Major Resection and Reconstruction: Fat Stem Cell for Restoration of Facial Asymmetries

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Stem Cells in Aesthetic Procedures

Abstract

Autologous fat grafting is a reconstructive and cosmetic procedure used to restore form and function in many areas of the body. It can restore the natural tissue volume and fill up soft tissue defects by sequential injection of lipoaspirate, using dedicated instrumentation. The authors discuss fat retrieval and volume restoration and regenerative potential of fat grafting in the face. Patient selection, donor site selection, time schedule, and surgical technique are described. Five representative cases are presented to show the results.

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References

  1. Del Vecchio D, Rohrich RJ. A classification of clinical fat grafting: different problems, different solutions. Plast Reconstr Surg. 2012;130(3):511–22.

    Article  PubMed  Google Scholar 

  2. Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg. 2006;118(3 Suppl):108S–20.

    Article  CAS  PubMed  Google Scholar 

  3. Fisher C, Grahovac TL, Schafer ME, Shippert RD, Marra KG, Rubin JP. Comparison of harvest and processing techniques for fat grafting and adipose stem cell isolation. Plast Reconstr Surg. 2013;132(2):351–61.

    Article  CAS  PubMed  Google Scholar 

  4. Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg. 1997;24(2):347–67.

    CAS  PubMed  Google Scholar 

  5. Shiffman MA, Mirrafati S. Fat transfer techniques: the effect of harvest and transfer methods on adipocyte viability and review of the literature. Dermatol Surg. 2001;27(9):819–26.

    CAS  PubMed  Google Scholar 

  6. Kaufman MR, Miller TA, Huang C, Roostaeian J, Roostaien J, Wasson KL, Ashley RK, Bradley JP. Autologous fat transfer for facial recontouring: is there science behind the art? Plast Reconstr Surg. 2007;119(7):2287–96.

    Article  CAS  PubMed  Google Scholar 

  7. Smith P, Adams WP, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA. Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg. 2006;117(6):1836–44.

    Article  CAS  PubMed  Google Scholar 

  8. Coleman SR. Structural fat grafts: the ideal filler? Clin Plast Surg. 2001;28(1):111–9.

    CAS  PubMed  Google Scholar 

  9. Allen RJ, Canizares O, Scharf C, Nguyen PD, Thanik V, Saadeh PB, Coleman SR, Hazen A. Grading lipoaspirate: is there an optimal density for fat grafting? Plast Reconstr Surg. 2013;131(1):38–45.

    Article  CAS  PubMed  Google Scholar 

  10. Zhu M, Zhou Z, Chen Y, Schreiber R, Ransom JT, Fraser JK, Hedrick MH, Pinkernell K, Kuo HC. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg. 2010;64(2):222–8.

    Article  CAS  PubMed  Google Scholar 

  11. Butala P, Hazen A, Szpalski C, Sultan SM, Coleman SR, Warren SM. Endogenous stem cell therapy enhances fat graft survival. Plast Reconstr Surg. 2012;130(2):293–306.

    Article  CAS  PubMed  Google Scholar 

  12. Mazzola RF, Cantarella G, Torretta S, Sbarbati A, Lazzari L, Pignataro L. Autologous fat injection to face and neck: from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital. 2011;31(2):59–69.

    CAS  PubMed Central  PubMed  Google Scholar 

  13. Rigotti G, Marchi A, Galie M, Baroni G, Benati D, Krampera M, Pasini A, Sbarbati A. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409–22.

    Article  CAS  PubMed  Google Scholar 

  14. Tabit CJ, Slack GC, Fan K, Wan DC, Bradley JP. Fat grafting versus adipose-derived stem cell therapy: distinguishing indications, techniques, and outcomes. Aesthetic Plast Surg. 2012;36(3):704–13.

    Article  PubMed  Google Scholar 

  15. Nguyen PSA, Desouches C, Gay AM, Hautier A, Magalon G. Development of micro-injection as an innovative autologous fat graft technique: the use of adipose tissue as dermal filler. J Plast Reconstr Aesthet Surg. 2012;65(12):1692–9.

    Article  CAS  PubMed  Google Scholar 

  16. Alharbi Z, Opländer C, Almakadi S, Fritz A, Vogt M, Pallua N. Conventional vs. Micro-fat harvesting: how fat harvesting technique affects tissue-engineering approaches using adipose tissue-derived stem/stromal cells. J Plast Reconstr Aesthet Surg. 2013;66(9):1271–8.

    Article  PubMed  Google Scholar 

  17. Barret JP, Sarobe N, Grande N, Vila D, Palacin JM. Maximizing results for lipofilling in facial reconstruction. Clin Plast Surg. 2009;36(3):487–92.

    Article  PubMed  Google Scholar 

  18. Kantanen DJ, Closmann JJ, Rowshan HH. Abdominal fat harvest technique and its uses in maxillofacial surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(3):367–71.

    Article  PubMed  Google Scholar 

  19. Genden EM. Reconstruction of the mandible and the maxilla: the evolution of surgical technique. Arch Facial Plast Surg. 2010;12(2):87–90.

    Article  PubMed  Google Scholar 

  20. Seruya M, Fisher M, Rodriguez ED. Computer-assisted versus conventional free fibula flap technique for craniofacial reconstruction: an outcomes comparison. Plast Reconstr Surg. 2013;132:1219–28.

    Article  CAS  PubMed  Google Scholar 

  21. Ciocca L, Mazzoni S, Fantini M, Persiani F, Baldissara P, Marchetti C, Scotti R. A CAD/cam-prototyped anatomical condylar prosthesis connected to a custom-made bone plate to support a fibula free flap. Med Biol Eng Comput. 2012;50(7):743–9.

    Article  CAS  PubMed  Google Scholar 

  22. Sink J, Hamlar D, Kademani D, Khariwala SS. Computer-aided stereolithography for presurgical planning in fibula free tissue reconstruction of the mandible. J Reconstr Microsurg. 2012;28(6):395–403.

    PubMed  Google Scholar 

  23. Antony AK, Chen WF, Kolokythas A, Weimer KA, Cohen MN. Use of virtual surgery and stereolithography-guided osteotomy for mandibular reconstruction with the free fibula. Plast Reconstr Surg. 2011;128(5):1080–4.

    Article  CAS  PubMed  Google Scholar 

  24. Vissink A, Jansma J, Spijkervet FKL, Burlage FR, Coppes RP. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003;14(3):199–212.

    Article  CAS  PubMed  Google Scholar 

  25. Epstein JB, Thariat J, Bensadoun R-J, Barasch A, Murphy BA, Kolnick L, et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin. 2012;62(6):400–22.

    Article  PubMed  Google Scholar 

  26. Bourget A, Chang JTC, Wu DB-S, Chang CJ, Wei FC. Free flap reconstruction in the head and neck region following radiotherapy: a cohort study identifying negative outcome predictors. Plast Reconstr Surg. 2011;127(5):1901–8.

    Article  CAS  PubMed  Google Scholar 

  27. Wetterau M, Szpalski C, Hazen A, Warren SM. Autologous fat grafting and facial reconstruction. J Craniofac Surg. 2012;23(1):315–8.

    Article  PubMed  Google Scholar 

  28. Phulpin B, Gangloff P, Tran N, Bravetti P, Merlin J-L, Dolivet G. Rehabilitation of irradiated head and neck tissues by autologous fat transplantation. Plast Reconstr Surg. 2009;123(4):1187–97.

    Article  CAS  PubMed  Google Scholar 

  29. Navach V, Calabrese LS, Zurlo V, Alterio D, Funicelli L, Giugliano G. Functional base of tongue fat injection in a patient with severe postradiation dysphagia. Dysphagia. 2011;26(2):196–9.

    Article  PubMed  Google Scholar 

  30. Tarallo M, Rizzo MI, Monarca C, Fanelli B, Parisi P, Scuderi N. Optimal care for eyelid contraction after radiotherapy: case report and literature review. J Oral Maxillofac Surg. 2012;70(10):2459–65.

    Article  PubMed  Google Scholar 

  31. Mazzola IC, Cantarella G, Mazzola RF. Management of tracheostomy scar by autologous fat transplantation: a minimally invasive new approach. J Craniofac Surg. 2013;24(4):1361–4.

    Article  PubMed  Google Scholar 

  32. Cantarella G, Mazzola RF, Domenichini E, Arnone F, Maraschi B. Vocal fold augmentation by autologous fat injection with lipostructure procedure. Otolaryngol Head Neck Surg. 2005;132(2):239–43.

    Article  PubMed  Google Scholar 

  33. De Santis G, Nocini PF, Chiarini L, Bedogni A. Functional rehabilitation of the atrophic mandible and maxilla with fibula flaps and implant-supported prosthesis. Plast Reconstr Surg. 2004;113(1):88–98.

    Article  PubMed  Google Scholar 

  34. Coleman SR. Facial augmentation with structural fat grafting. Clin Plast Surg. 2006;33(4):567–77.

    Article  PubMed  Google Scholar 

  35. Condé-Green A, de Amorim NFG, Pitanguy I. Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study. J Plast Reconstr Aesthet Surg. 2010;63(8):1375–81.

    Article  PubMed  Google Scholar 

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Correspondence to Alberto Bedogni M.D. .

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Bedogni, A., Bettini, G., Fior, A., Saia, G. (2014). Secondary Correction of Facial Deformities Following Major Resection and Reconstruction: Fat Stem Cell for Restoration of Facial Asymmetries. In: Shiffman, M., Di Giuseppe, A., Bassetto, F. (eds) Stem Cells in Aesthetic Procedures. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45207-9_32

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  • DOI: https://doi.org/10.1007/978-3-642-45207-9_32

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  • Publisher Name: Springer, Berlin, Heidelberg

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