Zusammenfassung
Die Elektrokonvulsionstherapie (EKT) ist ein nichtpharmakologisches biologisches Behandlungsverfahren, dessen ausgezeichnete Wirksamkeit v. a. bei depressiven Störungsbildern, aber auch bei Erkrankungen aus dem schizophrenen Formenkreis in einer Vielzahl an kontrollierten Untersuchungen gut belegt werden konnte. Dies gilt sowohl für Akutbehandlungen als auch für eine Erhaltungstherapie zur Rezidivprophylaxe. Sicherheit und Verträglichkeit der EKT sind durch umfangreiche Modifikationen der Stimulationstechnik sowie durch die umfassenden Fortschritte der Anästhesiologie stetig verbessert worden. Somit konnten v. a. in den letzten Jahren viele Kontraindikationen weitgehend relativiert werden, sodass heute auch Patienten mit erhöhten somatischen Risiken eine sichere Behandlung angeboten werden kann. Im vorliegenden Kapitel werden die historische Entwicklung der EKT, Untersuchungen zu Wirkmechanismen, die Indikationsstellung, Kontraindikationen und Risiken sowie die klinische Durchführung der Behandlung im Rahmen der Akutbehandlung sowie der Rezidivprophylaxe dargestellt. Die EKT ist demnach weiterhin eine wichtige Therapieoption, die v. a. schwer erkrankten Patienten, die durch andere Behandlungsformen wie z. B. eine intensive kombinierte Pharmako- und Psychotherapie keine ausreichende Besserung erfahren haben, nicht vorenthalten werden darf.
Literatur
Aarre TF, Bugge P (2002) ECT for patients taking lamotrigine. Eur Psychiat 17(Suppl 1):135
Abbasinazari M, Adib-Eshgh L, Rostami A, Beyraghi N, Dabir S, Jafari R (2015) Memantine in the prevention or alleviation of electroconvulsive therapy induces cognitive disorders: a placebo controlled trial. Asian J Psychiat 15:5–9
Abbott CC, Jones T, Lemke NT, Gallegos P, McClintock SM, Mayer AR, Bustillo J, Calhoun VD (2014) Hippocampal structural and functional changes associated with electroconvulsive therapy response. Transl Psychiatry 4, e483
Abrams R (1982) ECT and tricyclic antidepressants in the treatment of endogenous depression. Psychopharmacol Bull 18:73–75
Abrams R (1997a) Electroconvulsive therapy. Oxford University Press, New York/Oxford
Abrams R (1997b) The mortality rate with ECT. Convuls Ther 13:125–127
Abrams R (2002) Electroconvulsive therapy. Oxford University Press, New York/Oxford
Abrams R, Taylor MA (1974) Unipolar and bipolar depressive illness. Phenomenology and response to electroconvulsive therapy. Arch Gen Psychiatry 30:320–321
Abrams R, Swartz CM, Vedak C (1991) Antidepressant effects of high-dose right unilateral electroconvulsive therapy. Arch Gen Psychiatry 48:746–748
Adams DA, Kellner CH, Aloysi AS, Majeske MF, Liebman LS, Ahle GM, Bryson EO (2014) Case report: transient left bundle branch block associated with ECT. Int J Psychiatry Med 48:147–153
Agarkar S, Hurt S, Lisanby S, Young RC (2012) ECT use in unipolar and bipolar depression. J ECT 28:e39–e40
Agelink MW, Andrich J, Postert T, Wurzinger U, Zeit T, Klotz P, Przuntek H (2001) Relation between electroconvulsive therapy, cognitive side effects, neuron specific enolase, and protein S-100. J Neurol Neurosurg Psychiatry 71:394–396
Alpak G, Ercan S, Alici H, Bulbul F, Altunbas G, Alici D, Saricicek V, Davutoglu V (2014) Influence of recurrent electroconvulsive therapy on cardiac function. Med Princ Pract 23:225–228
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5). Washington, DC
American Psychiatric Association Committee on Electroconvulsive Therapy, Weiner RD, Coffey CE, Folk J, Fochtmann LJ, Greenberg RM, Isenberg KE, Kellner CH, Sackeim HA, Moench LM (2001) The practice of electroconvulsive therapy. American Psychiatric Association, Washington, DC
Anastasian ZH, Khan N, Heyer EJ, Berman MF, Ornstein E, Prudic J, Brady JE, Berman JA (2014) Effect of atropine dose on heart rate during electroconvulsive therapy. J ECT 30:298–302
Andrade C, Gangadhar BN, Channabasavanna SM (1987) Mania associated with electroconvulsive therapy. J Clin Psychiatry 48:303–304
Angst J, Angst K, Baruffol I, Meinherz-Surbeck R (1992) ECT-induced and drug-induced hypomania. Convuls Ther 8:179–185
Aten JJ, Oudega M, van EE, Stek ML, van Waarde JA (2015) Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study. Eur Arch Psychiatry Clin Neurosci 265:351–356
Atiku L, Gorst-Unsworth C, Khan BU, Huq F, Gordon J (2015) Improving relapse prevention after successful electroconvulsive therapy for patients with severe depression: completed audit cycle involving 102 full electroconvulsive therapy courses in West Sussex, United kingdom. J ECT 31:34–36
Avery D, Lubrano A (1979) Depression treated with imipramine and ECT: the DeCarolis study reconsidered. Am J Psychiatry 136:559–562
Ayhan Y, Akbulut BB, Karahan S, Gecmez G, Oz G, Gurel SC, Basar K (2015) Etomidate is associated with longer seizure duration, lower stimulus intensity, and lower number of failed trials in electroconvulsive therapy compared with thiopental. J ECT 31:26–30
Baghai TC, Möller HJ (2008) Electroconvulsive therapy and its different indications. Dialogues Clin Neurosci 10:105–117
Baghai TC, Frey R, Kasper S, Möller H-J (2004a) ElektrokonvulsionstherapieWien. Springer, New York
Baghai TC, Frey R, Kasper S, Möller H-J (2004b) Elektrokonvulsionstherapie – klinische und wissenschaftliche Aspekte. Springer, Wien
Baghai TC, Marcuse A, Moller HJ, Rupprecht R (2004c) Electroconvulsive therapy at the Department of Psychiatry and Psychotherapy, University of Munich Development during the years 1995–2002. Nervenarzt
Baghai TC, Eser D, Schüle C, Nothdurfter C, Möller H-J, Rupprecht R (2005) Elektrokonvulsionstherapie bei depressiven Störungen. J Neurol Neurochirurgie Psychiatr 4(2005):20–28
Baghai TC, Marcuse A, Brosch M, Schule C, Eser D, Nothdurfter C, Steng Y, Noack I, Pietschmann K, Moller HJ, Rupprecht R (2006) The influence of concomitant antidepressant medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry 7:82–90
Bailine SH, Rifkin A, Kayne E, Selzer JA, Vital-Herne J, Blieka M, Pollack S (2000) Comparison of bifrontal and bitemporal ECT for major depression. Am J Psychiatry 157:121–123
Bailine S, Fink M, Knapp R, Petrides G, Husain MM, Rasmussen K, Sampson S, Mueller M, McClintock SM, Tobias KG, Kellner CH (2010) Electroconvulsive therapy is equally effective in unipolar and bipolar depression. Acta Psychiatr Scand 121:431–436
Bannour S, Bouhlel S, Krir MW, Amamou B, Ben NS, El KY, Ben Hadj AB (2014) Combination of maintenance electroconvulsive therapy and clozapine in treating a patient with refractory schizophrenia. J ECT 30:e29–e30
Bica BE, Moro AL, Hax V, Nicol NA, Campos GS, Rivera LM, da Costa AF, Xavier RM, Monticielo OA (2015) Electroconvulsive therapy as a treatment for refractory neuropsychiatric lupus with catatonia: three case studies and literature review. Lupus 12:1327–31
Birkenhager TK, Pluijms EM, Lucius SA (2003) ECT response in delusional versus non-delusional depressed inpatients. J Affect Disord 74:191–195
Bjolseth TM, Engedal K, Benth JS, Dybedal GS, Gaarden TL, Tanum L (2015a) Baseline cognitive function does not predict the treatment outcome of electroconvulsive therapy (ECT) in late-life depression. J Affect Disord 185:67–75
Bjolseth TM, Engedal K, Benth JS, Dybedal GS, Gaarden TL, Tanum L (2015b) Clinical efficacy of formula-based bifrontal versus right unilateral electroconvulsive therapy (ECT) in the treatment of major depression among elderly patients: a pragmatic, randomized, assessor-blinded, controlled trial. J Affect Disord 175:8–17
Black DW, Winokur G, Nasrallah A (1986) ECT in unipolar and bipolar disorders: a naturalistic evaluation of 460 patients. Convuls Ther 2:231–237
Bolwig TG, Povlsen UJ (2004) Status epilepticus and ECT: a reply to Dr. Fink. J ECT 20:274–275
Brodaty H, Berle D, Hickie I, Mason C (2001) „Side effects“ of ECT are mainly depressive phenomena and are independent of age. J Affect Disord 66:237–245
Brown ED, Lee H, Scott D, Cummings GG (2014) Efficacy of continuation/maintenance electroconvulsive therapy for the prevention of recurrence of a major depressive episode in adults with unipolar depression: a systematic review. J ECT 30:195–202
Bryson EO, Kellner CH, Ahle GM, Liebman LS (2014) Asystole during electroconvulsive therapy. J ECT 30:259–260
Bryson EO, Popeo DM, Briggs MC, Pasculli RM, Kellner CH (2015) Automatic implantable cardioverter defibrillator in electroconvulsive therapy. J ECT 31, e22
Bulbul F, Copoglu US, Alpak G, Unal A, Demir B, Tastan MF, Savas HA (2013) Electroconvulsive therapy in pregnant patients. Gen Hosp Psychiatry 35:636–639
Bumb JM, Aksay SS, Janke C, Kranaster L, Geisel O, Gass P, Hellweg R, Sartorius A (2015) Focus on ECT seizure quality: serum BDNF as a peripheral biomarker in depressed patients. Eur Arch Psychiatry Clin Neurosci 265:227–232
Burakgazi E, Dalkilic A, Moghal U, Shah U, Carran M (2013) A case of atypical absence seizures after electroconvulsive treatment in a patient with treatment-resistant depression. Clin EEG Neurosci 44:62–69
Calev A, Nigal D, Shapira B, Tubi N, Chazan S, Ben Yehuda Y, Kugelmass S, Lerer B (1991) Early and long-term effects of electroconvulsive therapy and depression on memory and other cognitive functions. J Nerv Ment Dis 179:526–533
Calev A, Gaudino EA, Squires NK, Zervas IM, Fink M (1995) ECT and non-memory cognition: a review. Br J Clin Psychol 34(Pt 4):505–515
Canbek O, Ipekcioglu D, Menges OO, Atagun MI, Karamustafalioglu N, Cetinkaya OZ, Ilnem MC (2015) Comparison of propofol, etomidate, and thiopental in anesthesia for electroconvulsive therapy: a randomized, double-blind clinical trial. J ECT 31:91–97
Carney S, Sami MB, Clark V, Kuruvilla KK (2015) Electroconvulsive therapy: a life course approach for recurrent depressive disorder. BMJ Case reports 2015, published online 24.05.15
Caudill GB, Rosenquist P, McCall WV (2011) Could monoamine oxidase inhibitors promote asystole in electroconvulsive therapy patients? J ECT 27:264–265
Cerletti U, Bini L (2015) Un nuovo metodo di shocktherapie „L´elettroshock“. Boll Acad Med Roma 64:136–138
Chanpattana W, Kramer BA (2003) Acute and maintenance ECT with flupenthixol in refractory schizophrenia: sustained improvements in psychopathology, quality of life, and social outcomes. Schizophr Res 63:189–193
Chater SN, Simpson KH (1988) Effect of passive hyperventilation on seizure duration in patients undergoing electroconvulsive therapy. Br J Anaesth 60:70–73
Cheng YC, Liang CM, Liu HC (2015) Serotonin syndrome after electroconvulsive therapy in a patient on trazodone, bupropion, and quetiapine: a case report. Clin Neuropharmacol 38:112–113
Cline JS, Roos K (2007) Treatment of status epilepticus with electroconvulsive therapy. J ECT 23:30–32
Cohen D, Taieb O, Flament M, Benoit N, Chevret S, Corcos M, Fossati P, Jeammet P, Allilaire JF, Basquin M (2000) Absence of cognitive impairment at long-term follow-up in adolescents treated with ECT for severe mood disorder. Am J Psychiatry 157:460–462
Conca A, Hinterhuber H, Prapotnik M, Geretsegger C, Frey R, Hausmann A, Hofmann P, Kasper S, Lahousen T, König P, DiPauli J, Pramsohler B, Rittmannsberger H, Wagner W, Pycha R (2004) Die Elektrokrampftherapie: Theorie und Praxis (Offizielles EKT-Konsensuspapier der ÖGPP). Neuropsychiatr 18:1–17
Coughlin JM, Rodenbach K, Lee PH, Hayat MJ, Griffin MM, Mirski MA, Reti IM (2012) Asystole in ultrabrief pulse electroconvulsive therapy. J ECT 28:165–169
d’Elia G, Raotma H (1975) Is unilateral ECT less effective than bilateral ECT? Br J Psychiatry 126:83–89
Daly JJ, Prudic J, Devanand DP, Nobler MS, Lisanby SH, Peyser S, Roose SP, Sackeim HA (2001) ECT in bipolar and unipolar depression: differences in speed of response. Bipolar Disord 3:95–104
Davidson J, McLeod M, Law-Yone B, Linnoila M (1978) A comparison of electroconvulsive therapy and combined phenelzine-amitriptyline in refractory depression. Arch Gen Psychiatry 35:639–642
de Wolf MM, Olde Bijvank EG (2015) Takotsubo cardiomyopathy as a complication of electroconvulsive therapy. Tijdschr Psychiatr 57:361–366
DeCarolis V, Giberti F, Roccatagliata G, Rossi R (1964a) Catamnestic findings in imipramine and electro-convulsive therapy of depressions. Sist Nerv 16:43–52
DeCarolis V, Giberti F, Roccatagliata G, Rossi R, Venuti G (1964b) Imipramine and electroshok in the therapy of depressions: clinico-statistical analysis of the results in 437 cases. Sist Nerv 16:29–42
Dehning S, Feddersen B, Mehrkens JH, Muller N (2011) Long-term results of electroconvulsive therapy in severe Gilles de la Tourette syndrome. J ECT 27:145–147
Delva NJ, Brunet D, Hawken ER, Kesteven RM, Lawson JS, Lywood DW, Rodenburg M, Waldron JJ (2000) Electrical dose and seizure threshold: relations to clinical outcome and cognitive effects in bifrontal, bitemporal, and right unilateral ECT. J ECT 16:361–369
Dequardo JR, Tandon R (1988) Concurrent lithium therapy prevents ECT-induced switch to mania. J Clin Psychiatry 49:167–168
Dersch R, Zwernemann S, Voderholzer U (2011) Partial status epilepticus after electroconvulsive therapy and medical treatment with bupropion. Pharmacopsychiat 44:344–346
Devanand DP, Decina P, Sackeim HA, Prudic J (1988a) Status epilepticus following ECT in a patient receiving theophylline. J Clin Psychopharmacol 8:153
Devanand DP, Sackeim HA, Decina P, Prudic J (1988b) The development of mania and organic euphoria during ECT. J Clin Psychiatry 49:69–71
Devanand DP, Verma AK, Tirumalasetti F, Sackeim HA (1991) Absence of cognitive impairment after more than 100 lifetime ECT treatments. Am J Psychiatry 148:929–932
Devanand DP, Dwork AJ, Hutchinson ER, Bolwig TG, Sackeim HA (1994) Does ECT alter brain structure? Am J Psychiatry 151:957–970
Devanand DP, Fitzsimons L, Prudic J, Sackeim HA (1995) Subjective side effects during electroconvulsive therapy. Convuls Ther 11:232–240
Dierckx B, Heijnen WT, van den Broek WW, Birkenhager TK (2012) Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a meta-analysis. Bipolar Disord 14:146–150
Dietzfelbinger T, Möller HJ, Steinmeier EM, Fimmers R (1990) In: Möller HJ (Hrsg) Therapieresistenz unter Antidepressiva-Behandlung. Springer, Berlin/Heidelberg/New York, S 176–185
Dinan TG, Barry S (1989) A comparison of electroconvulsive therapy with a combined lithium and tricyclic combination among depressed tricyclic nonresponders. Acta Psychiatr Scand 80:97–100
Duthie AC, Perrin JS, Bennett DM, Currie J, Reid IC (2015) Anticonvulsant mechanisms of electroconvulsive therapy and relation to therapeutic efficacy. J ECT 31(3):173–8
Dybedal GS, Tanum L, Sundet K, Bjolseth TM (2015) The role of baseline cognitive function in the neurocognitive effects of electroconvulsive therapy in depressed elderly patients. Clin Neuropsychol 29:487–508
ECT review group (2003) Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 361:799–808
Edridge A, Ferguson AL (1952) Discussion on new muscle relaxants in electric convulsion therapy. Proc R Soc Med 45:869–877
Erdil F, Ozgul U, Colak C, Cumurcu B, Durmus M (2015) Effect of the addition of ketamine to sevoflurane anesthesia on seizure duration in electroconvulsive therapy. J ECT 31(2):182–5
Eschweiler GW, Vonthein R, Bode R, Huell M, Conca A, Peters O, Mende-Lechler S, Peters J, Klecha D, Prapotnik M, DiPauli J, Wild B, Plewnia C, Bartels M, Schlotter W (2007) Clinical efficacy and cognitive side effects of bifrontal versus right unilateral electroconvulsive therapy (ECT): a short-term randomised controlled trial in pharmaco-resistant major depression. J Affect Disord 101:149–157
Fazio C, Giberti F, Rossi R, DeCarolis V (1964) Imipramine and electroshock in the treatment of depressions. Ann Med Psychol (Paris) 122:731–741
Felkel WC, Wagner G, Kimball J, Rosenquist P, McCall WV, Arias L (2012) Tardive seizure with postictal aphasia: a case report. J ECT 28:180–182
Fink M (1990a) Clozapine and electroconvulsive therapy. Arch Gen Psychiatry 47:290–291
Fink M (1990b) Is catatonia a primary indication for ECT? Convuls Ther 6:1–4
Fink M (1998) ECT and clozapine in schizophrenia. J ECT 14:223–226
Fink M (2013) Rediscovering catatonia: the biography of a treatable syndrome. Acta Psychiatr Scand Suppl:1–47
Folkerts H (1995) Elektrokrampftherapie bei neurologischen Krankheiten. Nervenarzt 66:241–251
Folkerts HW, Michael N, Tolle R, Schonauer K, Mucke S, Schulze-Monking H (1997) Electroconvulsive therapy vs. paroxetine in treatment-resistant depression – a randomized study. Acta Psychiatr Scand 96:334–342
Fontenelle LF, Coutinho ES, Lins-Martins NM, Fitzgerald PB, Fujiwara H, Yucel M (2015) Electroconvulsive therapy for obsessive-compulsive disorder: a systematic review. J Clin Psych 76(7):949–57
Frey R, Heiden A, Scharfetter J, Schreinzer D, Blasbichler T, Tauscher J, Felleiter P, Kasper S (2001) Inverse relation between stimulus intensity and seizure duration: implications for ECT procedure. J ECT 17:102–108
Gabrielli A, Layon AJ, Cole P, Holbert R, Modell JH (2002) Prolonged cardiopulmonary resuscitation with preservation of cerebral function in an elderly patient with asystole after electroconvulsive therapy. J Clin Anesth 14:234–240
Gangadhar BN, Kapur RL, Kalyanasundaram S (1982) Comparison of electroconvulsive therapy with imipramine in endogenous depression: a double blind study. Br J Psychiatry 141:367–371
Genz A, Krause P, Koch RD, Knorr W (1985) Side effects of bilateral electroconvulsive therapy – comparative clinico-computer tomographic study. Psychiatr Neurol Med Psychol (Leipz) 37:197–204
Ghaziuddin N, Laughrin D, Giordani B (2000) Cognitive side effects of electroconvulsive therapy in adolescents. J Child Adolesc Psychopharmacol 10:269–276
Ghaziuddin N, Nassiri A, Miles JH (2015) Catatonia in down syndrome; a treatable cause of regression. Neuropsychiatr Dis Treat 11:941–949
Ghignone E, Rosenthal L, Lloyd RB, Mouli S, Dinwiddie S (2015) Electroconvulsive therapy in a patient with moyamoya syndrome. J ECT 31:e14–e16
Greenblatt M, Grosser GH, Wechsler HA (1964) Differential response of hospitalized depressed patients in somatic therapy. Am J Psychiatry 935–943
Grogan R, Wagner DR, Sullivan T, Labar D (1995) Generalized nonconvulsive status epilepticus after electroconvulsive therapy. Convuls Ther 11:51–56
Grover S, Hazari N, Chakrabarti S, Avasthi A (2015a) Augmentation of Clozapine with ECT: observations from India. Am J Psychiatry 172:487
Grover S, Hazari N, Kate N (2015b) Combined use of clozapine and ECT: a review. Acta Neuropsychiatr 27:131–142
Grözinger M, Conca A, Nickl-Jockschat T, Di Pietro A (2013) Elektrokonvulsionstherapie kompakt: Für Zuweiser und Anwende. Springer, Berlin/Heidelberg
Grozinger M, Smith ES, Conca A (2015) On the significance of elektroconvulsive therapy in the treatment of severe mental diseases. Wien Klin Wochenschr 127:297–302
Haskett RF (2014) Electroconvulsive therapy’s mechanism of action: neuroendocrine hypotheses. J ECT 30:107–110
Hill GE, Wong KC, Hodges MR (1976) Potentiation of succinylcholine neuromuscular blockade by lithium carbonate. Anesthesiology 44:439–442
Hill GE, Wong KC, Hodges MR (1977) Lithium carbonate and neuromuscular blocking agents. Anesthesiology 46:122–126
Höflich G, Kasper S, Hufnagel A, Ruhrmann S, Moller HJ (1993) Application of transcranial magnetic stimulation in treatment of drug-resistant major depression: a report of two cases. Psychopharmacology 8:361–365
Holak EJ, Scott JP, Pagel P (2007) Electroconvulsive therapy-induced asystole: occurrence after 39 previous uneventful treatments. Can J Anaesth 54:772–773
Hoyer C, Kranaster L, Janke C, Sartorius A (2014) Impact of the anesthetic agents ketamine, etomidate, thiopental, and propofol on seizure parameters and seizure quality in electroconvulsive therapy: a retrospective study. Eur Arch Psychiatry Clin Neurosci 264:255–261
Janicak PG, Davis JM, Gibbons RD, Ericksen S, Chang S, Gallagher P (1985) Efficacy of ECT: a meta-analysis. Am J Psychiatry 142:297–302
Janke C, Bumb JM, Aksay SS, Thiel M, Kranaster L, Sartorius A (2015) Ketamine as anesthetic agent in electroconvulsion therapy. Anaesthesist 64:357–364
Jarventausta K, Chrapek W, Kampman O, Tuohimaa K, Bjorkqvist M, Hakkinen H, Yli-Hankala A, Leinonen E (2013) Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study. J ECT 29:158–161
Jha AK, Stein GS, Fenwick P (1996) Negative interaction between lithium and electroconvulsive therapy – a case-control study. Br J Psychiatry 168:241–243
Jorgensen A, Magnusson P, Hanson LG, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen JD, Fink-Jensen A, Knudsen GM, Paulson OB, Bolwig TG, Jorgensen MB (2015) Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. Acta Psychiatr Scand
Joshi SH, Espinoza RT, Pirnia T, Shi J, Wang Y, Ayers B, Leaver A, Woods RP, Narr KL (2015) Structural plasticity of the hippocampus and amygdala induced by electroconvulsive therapy in major depression. Biol Psych 79(4):282–92
Kalogerakou S, Oulis P, Anyfandi E, Konstantakopoulos G, Papakosta VM, Kontis D, Theochari E, Angelopoulos E, Zervas IM, Mellon RC, Papageorgiou CC, Tsaltas E (2015) Episodic visual learning/memory and attentional flexibility in patients with major depressive disorder after clinically effective electroconvulsive therapy. J ECT 31(4): 246–52
Karadenizli D, Dilbaz N, Bayam G (2005) Gilles de la Tourette syndrome: response to electroconvulsive therapy. J ECT 21:246–248
Kellner CH (2012) Brain stimulation in psychiatry: ECT, DBS, TMS, and other modalities. Camebridge University Press, Camebridge
Kellner CH, Kellner DA (2015) Deep brain stimulation versus electroconvulsive therapy in Parkinson’s disease. J ECT 31, e23
Kellner CH, Knapp R, Husain MM, Rasmussen K, Sampson S, Cullum M, McClintock SM, Tobias KG, Martino C, Mueller M, Bailine SH, Fink M, Petrides G (2010a) Bifrontal, bitemporal and right unilateral electrode placement in ECT: randomised trial. Br J Psychiatry 196:226–234
Kellner CH, Tobias KG, Wiegand J (2010b) Electrode placement in electroconvulsive therapy (ECT): a review of the literature. J ECT 26:175–180
Kellner DB, Bryson EO, Liebman LS, Majeske MF, Aloysi AS, Ahle GM, Kellner CH (2014) Electroconvulsive therapy (ECT): protocols for variations in technique. J ECT 30:e41–e42
Kellner CH, Adams DA, Benferhat A (2015a) Further improving the cognitive effect profile of electroconvulsive therapy (ECT): the case for studying carbamylated erythropoietin. Med Hypotheses 84:258–261
Kellner CH, Kaicher DC, Banerjee H, Knapp RG, Shapiro RJ, Briggs MC, Pasculli RM, Popeo DM, Ahle GM, Liebman LS (2015b) Depression severity in electroconvulsive therapy (ECT) versus pharmacotherapy trials. J ECT 31:31–33
Kim SW, Grant JE, Rittberg BR, Simon JE, Vine CJ, Schulz SC (2007) Decreased memory loss associated with right unilateral ultra-brief pulse wave ECT. Minn Med 90:34–35
Kleimann A, Kotsiari A, Sperling W, Groschl M, Heberlein A, Kahl KG, Hillemacher T, Bleich S, Kornhuber J, Frieling H (2015) BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy. J Neural Transm 122:925–928
Kramer BA (1999) Use of ECT in California, revisited: 1984–1994. J ECT 15:245–251
Kranaster L, Kammerer-Ciernioch J, Hoyer C, Sartorius A (2011) Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study. Eur Arch Psychiatry Clin Neurosci 261:575–582
Kranaster L, Hoyer C, Janke C, Sartorius A (2012a) Preliminary evaluation of clinical outcome and safety of ketamine as an anesthetic for electroconvulsive therapy in schizophrenia. World Journal 15(3):242–50
Kranaster L, Janke C, Hausner L, Frolich L, Sartorius A (2012a) Venlafaxin-associated post-ictal asystole during electroconvulsive therapy. Pharmacopsychiatry 45:122–124
Kranaster L, Hoyer C, Janke C, Sartorius A (2014) Preliminary evaluation of clinical outcome and safety of ketamine as an anesthetic for electroconvulsive therapy in schizophrenia. World J Biol Psychiatry 15:242–250
Krause P, Genz A, Knorr W (1988) Prospective study of the late sequelae of electroconvulsive treatment. Psychiatr Neurol Med Psychol 40:532–536
Krystal AD, Coffey CE (1997) Neuropsychiatric considerations in the use of electroconvulsive therapy. J Neuropsych Clin Neurosci 9:283–292
Kuhs H (1995) Stages of treatment resistance in depressive disorders, defined after somatotherapeutic methods. Nervenarzt 66:561–567
Kupchik M, Spivak B, Mester R, Reznik I, Gonen N, Weizman A, Kotler M (2000) Combined electroconvulsive-clozapine therapy. Clin Neuropharmacol 23:14–16
Lambourn J, Gill D (1978) A controlled comparison of simulated and real ECT. Br J Psychiatry 133:514–519
Leiknes KA, Cooke MJ, Jarosch-von SL, Harboe I, Hoie B (2015) Electroconvulsive therapy during pregnancy: a systematic review of case studies. Arch Womens Ment Health 18:1–39
Letemendia FJ, Delva NJ, Rodenburg M, Lawson JS, Inglis J, Waldron JJ, Lywood DW (1993) Therapeutic advantage of bifrontal electrode placement in ECT. Psychol Med 23:349–360
Lewis DA, Nasrallah HA (1986) Mania associated with electroconvulsive therapy. J Clin Psychiatry 47:366–367
Lippmann SB, Tao CA (1993) Electroconvulsive therapy and lithium: safe and effective treatment. Convuls Ther 9:54–57
Lisanby SH, Maddox JH, Prudic J, Devanand DP, Sackeim HA (2000) The effects of electroconvulsive therapy on memory of autobiographical and public events. Arch Gen Psychiatry 57:581–590
Lisanby SH, Bazil CW, Resor SR, Nobler MS, Finck DA, Sackeim HA (2001) ECT in the treatment of status epilepticus. J ECT 17:210–215
Lubit EB, Fetterman TC, Ying P (2015) Recurrent aspiration in a patient with gastric band undergoing electroconvulsive therapy. J ECT 32(2):134–5
Luchini F, Medda P, Mariani MG, Mauri M, Toni C, Perugi G (2015) Electroconvulsive therapy in catatonic patients: efficacy and predictors of response. World J Psychiat 5:182–192
Lykouras E, Malliaras D, Christodoulou GN, Papakostas Y, Voulgari A, Tzonou A, Stefanis C (1986) Delusional depression: phenomenology and response to treatment. A prospective study. Acta Psychiatr Scand 73:324–329
Lynch AM, Pandurangi AK, Levenson JL (2008) Electroconvulsive therapy in a candidate for heart transplant with an implantable cardiovertor defibrillator and cardiac contractility modulator. Psychosomatics 49:341–344
Markowitz JS, Kellner CH, DeVane CL, Beale MD, Folk J, Burns C, Liston HL (2001) Intranasal sumatriptan in post-ECT headache: results of an open-label trial. J ECT 17:280–283
McCall WV (2001) Electroconvulsive therapy in the era of modern psychopharmacology. Int J Neuropsychopharmacol 4:315–324
McCall WV, Reboussin DM, Weiner RD, Sackeim HA (2000) Titrated moderately suprathreshold vs fixed high-dose right unilateral electroconvulsive therapy: acute antidepressant and cognitive effects. Arch Gen Psychiatry 57:438–444
McDonald IM, Perkins M, Marjerrison G, Podilsky M (1966) A controlled comparison of amitriptyline and electroconvulsive therapy in the treatment of depression. Am J Psychiatry 122:1427–1431
McGirr A, Berlim MT, Bond DJ, Neufeld NH, Chan PY, Yatham LN, Lam RW (2015) A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: efficacy and tolerability. J Psychiatr Res 62:23–30
Micallef-Trigona B, Spiteri J (2012) Maintenance electroconvulsive therapy in a patient with treatment-resistant paranoid schizophrenia and comorbid epilepsy. Case Rep Psychiat 2012:374752
Mirzakhani H, Welch CA, Eikermann M, Nozari A (2012) Neuromuscular blocking agents for electroconvulsive therapy: a systematic review. Acta Anaesthesiol Scand 56:3–16
Mohagheghi A, Arfaie A, Amiri S, Nouri M, Abdi S, Safikhanlou S (2015) Preventive effect of liothyronine on electroconvulsive therapy-induced memory deficit in patients with major depressive disorder: a double-blind controlled clinical trial. Biomed Res Int 2015:503918
Mollenberg O (1997) Electroconvulsive therapy – anesthesiological procedures. Anasthesiol Intensivmed Notfallmed Schmerzther 32:593–603
Möller H-J (1991) Therapieresistenz auf Antidepressiva: Risikofaktoren und Behandlungsmöglichkeiten. Nervenarzt 62:658–669
Nelson JP, Benjamin L (1989) Efficacy and safety of combined ECT and tricyclic antidepressant drugs in the treatment of depressed geriatric patients. Convuls Ther 5:321–329
Ng C, Schweitzer I, Alexopoulos P, Celi E, Wong L, Tuckwell V, Sergejew A, Tiller J (2000) Efficacy and cognitive effects of right unilateral electroconvulsive therapy. J ECT 16:370–379
Nobler MS, Sackeim HA, Moeller JR, Prudic J, Petkova E, Waternaux C (1997) Quantifying the speed of symptomatic improvement with electroconvulsive therapy: comparison of alternative statistical methods. Convuls Ther 13:208–221
Okamoto N, Nakai T, Sakamoto K, Nagafusa Y, Higuchi T, Nishikawa T (2010) Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia. J ECT 26:223–227
Ostroff R, Gonzales M, Sanacora G (2005) Antidepressant effect of ketamine during ECT. Am J Psychiatry 162:1385–1386
Pagnin D, de Q, V, Pini S, Cassano GB (2004) Efficacy of ECT in depression: a meta-analytic review. J ECT 20:13–20
Pearlman C, Obedian E (1995) ECT-valproic acid interaction. Gen Hosp Psychiatry 17:456–457
Pecenak J, Janik P, Vaseckova B, Trebulova K (2015) Electroconvulsive therapy treatment in a patient with neurosyphilis and psychotic disorder: case report and literature review. J ECT 31(4):268–70
Peng LY, Lee Y, Lin PY (2013) Electroconvulsive therapy for a patient with persistent tardive dyskinesia: a case report and literature review. J ECT 29:e52–e54
Petrides G, Malur C, Braga RJ, Bailine SH, Schooler NR, Malhotra AK, Kane JM, Sanghani S, Goldberg TE, John M, Mendelowitz A (2015) Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study. Am J Psychiatry 172:52–58
Pettinati HM, Bonner KM (1984) Cognitive functioning in depressed geriatric patients with a history of ECT. Am J Psychiatry 141:49–52
Pinkhasov A, Furer T, Augusto S (2015) Transient expressive aphasia after bitemporal electroconvulsive therapy: a rarely documented reversible phenomenon. J ECT 31:e20–e21
Pinna M, Manchia M, Pillai G, Salis P, Minnai GP (2015) Efficacy and safety of electroconvulsive therapy in the first trimester of pregnancy: a case of severe manic catatonia. Bipol Disord 17(5): 567–71
Pogarell O, Ehrentraut S, Ruther T, Mulert C, Hegerl U, Moller HJ, Henkel V (2005) Prolonged confusional state following electroconvulsive therapy – diagnostic clues from serial electroencephalography. Pharmacopsychiatry 38:316–320
Post T, Kemmler G, Krassnig T, Brugger A, Hausmann A (2015) Efficacy of continuation and maintenance electroconvulsive therapy (c/m ECT) in the treatment of patients with therapy-resistant affective disorders: a retrospective analysis. Neuropsychiatr 29(3):133–8
Povlsen UJ, Wildschiodtz G, Hogenhaven H, Bolwig TG (2003) Nonconvulsive status epilepticus after electroconvulsive therapy. J ECT 19:164–169
Prudic J, Sackeim HA, Devanand DP (1990) Medication resistance and clinical response to electroconvulsive therapy. Psychiatry Res 31:287–296
Prudic J, Haskett RF, Mulsant B, Malone KM, Pettinati HM, Stephens S, Greenberg R, Rifas SL, Sackeim HA (1996) Resistance to antidepressant medications and short-term clinical response to ECT. Am J Psychiatry 153:985–992
Quitkin FM (1985) The importance of dosage in prescribing antidepressants. Br J Psychiatry 147:593–597
Quitkin FM, Rabkin JG, Ross D, McGrath PJ (1984) Duration of antidepressant drug treatment. What is an adequate trial? Arch Gen Psychiatry 41:238–245
Quitkin FM, McGrath PJ, Stewart JW, Taylor BP, Klein DF (1996) Can the effects of antidepressants be observed in the first two weeks of treatment? Neuropsychopharmacology 15:390–394
Rabheru K (2012) Maintenance electroconvulsive therapy (M-ECT) after acute response: examining the evidence for who, what, when, and how? J ECT 28:39–47
Rabheru K, Persad E (1997) A review of continuation and maintenance electroconvulsive therapy. Can J Psychiatry 42:476–484
Rajashree VC, Manjiri CD, Ivan SN, Alka VP (2014) Gilles de la Tourette’s syndrome successfully treated with electroconvulsive therapy. Indian J Psychiat 56:407–408
Rao KM, Gangadhar BN, Janakiramaiah N (1993) Nonconvulsive status epilepticus after the ninth electroconvulsive therapy. Convuls Ther 9:128–129
Rasmussen KG (2015a) Do patients with personality disorders respond differentially to electroconvulsive therapy? A review of the literature and consideration of conceptual issues. J ECT 31:6–12
Rasmussen KG (2015b) Lithium for post-electroconvulsive therapy depressive relapse prevention: a consideration of the evidence. J ECT 31:87–90
Rasmussen KG, Zorumski CF (1993) Electroconvulsive therapy in patients taking theophylline. J Clin Psychiatry 54:427–431
Rasmussen KG, Kung S, Lapid MI, Oesterle TS, Geske JR, Nuttall GA, Oliver WC, Abenstein JP (2014) A randomized comparison of ketamine versus methohexital anesthesia in electroconvulsive therapy. Psychiatry Res 215:362–365
Reimherr FW, Hodges MR, Hill GE, Wong KC (1977) Prolongation of muscle relaxant effects by lithium carbonate. Am J Psychiat 134:205–206
Rifkin A (1988) ECT versus tricyclic antidepressants in depression: a review of the evidence. J Clin Psychiatry 49:3–7
Rubin EH, Kinscherf DA, Figiel GS, Zorumski CF (1993) The nature and time course of cognitive side effects during electroconvulsive therapy in the elderly. J Geriatr Psychiatry Neurol 6:78–83
Sackeim HA, Ross FR, Hopkins N, Calev L, Devanand DP (1987) Subjective side effects acutely following ECT: associations with treatment modality and clinical response. Convuls Ther 3:100–110
Sackeim HA, Prudic J, Devanand DP, Decina P, Kerr B, Malitz S (1990) The impact of medication resistance and continuation pharmacotherapy on relapse following response to electroconvulsive therapy in major depression. J Clin Psychopharmacol 10:96–104
Sackeim HA, Prudic J, Devanand DP, Kiersky JE, Fitzsimons L, Moody BJ, McElhiney MC, Coleman EA, Settembrino JM (1993) Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. N Engl J Med 328:839–846
Sackeim HA, Devanand DP, Nobler MS (1995) In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, S 1123–1141
Sackeim HA, Prudic J, Devanand DP, Nobler MS, Lisanby SH, Peyser S, Fitzsimons L, Moody BJ, Clark J (2000) A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities. Arch Gen Psychiatry 57:425–434
Sackeim HA, Haskett RF, Mulsant BH, Thase ME, Mann JJ, Pettinati HM, Greenberg RM, Crowe RR, Cooper TB, Prudic J (2001) Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial. JAMA 285:1299–1307
Sackeim HA, Dillingham EM, Prudic J, Cooper T, McCall WV, Rosenquist P, Isenberg K, Garcia K, Mulsant BH, Haskett RF (2009) Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: short-term efficacy and adverse effects. Arch Gen Psychiatry 66:729–737
Sakel M (1935) Neue Behandlungsmethode der Schizophrenie. Moritz Perles, Wien/Leipzig
Santos PL, Bouckaert F, Obbels J, Wampers M, Simons W, Wyckaert S, Sienaert P (2015) Maintenance electroconvulsive therapy in severe bipolar disorder: a retrospective chart review. J ECT 32(1):23–8
Sauer H, Lauter H (1987a) Elektrokrampftherapie I: Wirksamkeit und Nebenwirkungen der Elektrokrampftherapie. Nervenarzt 58:201–209
Sauer H, Lauter H (1987b) Electroconvulsive therapy. II. Indications, contraindications and therapeutic technics of electroconvulsive therapy. Nervenarzt 58:210–218
Scharfetter J, Frey R, Kasper S (2004a) In: Baghai TC, Frey R, Kasper S, Moeller HJ (Hrsg) Elektrokonvulsionstherapie – Klinische und wissenschaftliche Aspekte. Springer, Wien/New York, S 87–105
Scharfetter J, Frey R, Kasper S (2004b) In: Baghai TC, Frey R, Kasper S, Moeller HJ (Hrsg) Elektrokonvulsionstherapie – Klinische und wissenschaftliche Aspekte. Springer, Wien/New York, S 87–105
Schüle C, Kapfhammer HP (2004) In: Baghai TC, Frey R, Kasper S, Möller H-J (Hrsg) Elektrokonvulsionstherapie. Springer, Wien/New York, S 305–340
Scott AI, Riddle W (1989) Status epilepticus after electroconvulsive therapy. Br J Psychiatry 155:119–121
Shelef A, Mazeh D, Berger U, Baruch Y, Barak Y (2015) Acute electroconvulsive therapy followed by maintenance electroconvulsive therapy decreases hospital re-admission rates of older patients with severe mental illness. J ECT 31:125–128
Shimizu E, Imai M, Fujisaki M, Shinoda N, Handa S, Watanabe H, Nakazato M, Hashimoto K, Iyo M (2007) Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 31:571–573
Shiwach RS, Reid WH, Carmody TJ (2001) An analysis of reported deaths following electroconvulsive therapy in Texas, 1993–1998. Psychiatr Serv 52:1095–1097
Sienaert P, Vansteelandt K, Demyttenaere K, Peuskens J (2010a) Randomized comparison of ultra-brief bifrontal and unilateral electroconvulsive therapy for major depression: cognitive side-effects. J Affect Disord 122:60–67
Sienaert PA, Vansteelandt K, Demyttenaere K, Peuskens J (2010b) Predictors of patient satisfaction after ultrabrief bifrontal and unilateral electroconvulsive therapies for major depression. J ECT 26:55–59
Simpson KH, Halsall PJ, Carr CM, Stewart KG (1988) Propofol reduces seizure duration in patients having anaesthesia for electroconvulsive therapy. Br J Anaesth 61:343–344
Small JG, Kellams JJ, Milstein V, Small IF (1980) Complications with electroconvulsive treatment combined with lithium. Biol Psychiatry 15:103–112
Solomon RL, Rich CL, Darko DF (1990) Antidepressant treatment and the occurrence of mania in bipolar patients admitted for depression. J Affect Disord 18:253–257
Sonawalla SB, Fava M (2001) Severe depression: is there a best approach? CNS Drugs 15:765–776
Spodniakova B, Halmo M, Nosalova P (2014) Electroconvulsive therapy in pregnancy – a review. J Obstet Gynaecol 1–4
Squire LR, Zouzounis JA (1986) ECT and memory: brief pulse versus sine wave. Am J Psychiatry 143:596–601
Stewart PT, Loo CK, MacPherson R, Hadzi-Pavlovic D (2011) The effect of electrode placement and pulsewidth on asystole and bradycardia during the electroconvulsive therapy stimulus. Int J Neuropsychopharmacol 14:585–594
Strassnig M, Riedel M, Muller N (2004) Electroconvulsive therapy in a patient with Tourette’s syndrome and co-morbid obsessive compulsive disorder. World J Biol Psychiatry 5:164–166
Sutor B, Rasmussen KG (2015) Clinical challenges in maintenance electroconvulsive therapy for older patients with medical comorbidity. J ECT
Swartz CM, Nelson AI (2005) Rational electroconvulsive therapy electrode placement. Psychiatry (Edgmont) 2:37–43
Tauscher J, Neumeister A, Fischer P, Frey R, Kasper S (1997) Electroconvulsive therapy in clinical practice. Nervenarzt 68:410–416
Thase ME, Friedman ES, Howland RH (2000) Venlafaxine and treatment-resistant depression. Depress Anxiety 12(Suppl 1):55–62
Tor PC, Bautovich A, Wang MJ, Martin D, Harvey SB, Loo C (2015) A systematic review and meta-analysis of brief versus ultrabrief right unilateral electroconvulsive therapy for depression. J Clin Psychiatry
Trivedi HK, Mendelowitz AJ, Fink M (2003) Gilles de la Tourette form of catatonia: response to ECT. J ECT 19:115–117
van Waarde JA, Stek ML (2001) Electroconvulsive therapy effective and safe in 55 patients aged 56 years and older with mood disorders and physical comorbidity. Ned Tijdschr Geneeskd 145:1693–1697
Viswanath B, Narayanaswamy JC, Thirthalli J, Gangadhar BN (2011) Effectiveness of bifrontal ECT in practice: a comparison with bitemporal ECT. Indian J Psychol Med 33:66–70
von Meduna L (1937) Konvulsionstherapie bei Schizophrenie. Carl Marhold, Halle
Weaver LA Jr, Ives JO, Williams R, Nies A (1977) A comparison of standard alternating current and low-energy brief-pulse electrotherapy. Biol Psychiatry 12:525–543
Weiss AM, Hansen SM, Safranko I, Hughes P (2015) Effectiveness of left anterior right temporal electrode placement in electroconvulsive therapy: 3 case reports. J ECT 31:e1–e3
World Health Organization (1992)The ICD-10 Classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization, Geneva
World Health Organization (2005) WHO Resource book on mental health, human rights and legislation. WHO, Geneva
World Health Organization (2012) WHO QualityRights tool kit: assessing and improving quality and human rights in mental health and social care facilities. (3-8-2015): WHO
Yasui-Furukori N, Kikuchi A, Katagai H, Kaneko S (2014) The effects of electroconvulsive therapy on tardive dystonia or dyskinesia induced by psychotropic medication: a retrospective study. Neuropsychiatr Dis Treat 10:1209–1212
Yatham LN, Kusumakar V, Parikh SV, Haslam DR, Matte R, Sharma V, Kennedy S (1997) Bipolar depression: treatment options. Can J Psychiatry 42(Suppl 2):87S–91S
Ye L, Karlapati SK, Lippmann S (2013) Topiramate for post-electroconvulsive therapy headaches. J ECT 29, e49
Yoosefi A, Sepehri AS, Kargar M, Akhondzadeh S, Sadeghi M, Rafei A, Alimadadi A, Ghaeli P (2014) Comparing effects of ketamine and thiopental administration during electroconvulsive therapy in patients with major depressive disorder: a randomized, double-blind study. J ECT 30:15–21
Zarate CA Jr, Tohen M, Baraibar G (1997) Combined valproate or carbamazepine and electroconvulsive therapy. Ann Clin Psychiatry 9:19–25
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Baghai, T.C., Kasper, S. (2016). Hirnstimulationsverfahren, Elektrokonvulsionstherapie. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie, Psychosomatik, Psychotherapie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45028-0_32-1
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