Skip to main content
SpringerLink
Log in

Keimzelltumoren

  • Chapter
Therapie der Krankheiten im Kindes- und Jugendalter

  • 304 Accesses

Zusammenfassung

Keimzelltumoren (GCT) sind hinsichtlich der Lokalisation und der Histologie sehr heterogen und treten entlang der Körpermittelinie auf; die Tumormanifestation wird stark durch das Alter modifiziert. Bei Jugendlichen und Erwachsenen finden sich über 90% der Keimzelltumoren in den Gonaden oder im Zentralnervensystem (ZNS), während im Kindesalter etwa 40% gonadal und 60% extragonadal, wie z. B. vom Steißbein ausgehend (sacrococcygeal), im ZNS oder im Mediastinum auftreten. Histologisch kommen gutartige (Teratome) und verschiedene bösartige Tumorentitäten vor, die sich in reiner Form oder als gemischte Tumoren manifestieren können. Diese Vielgestaltigkeit der Keimzelltumoren erfordert eine enge Zusammenarbeit zwischen Kinderonkologen, Chirurgen (entsprechend der Lokalisation), Pathologen und Radiotherapeuten (bei ZNS-Tumoren) sowie Endokrinologen und Neuropädiatern (Hirntumoren). Eine gute interdisziplinäre Koordination ist entscheidend für den Therapieerfolg.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 179.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Alapetite C, Brisse H, Patte C (2010) Patterns of relapse and outcome of non-metastatic germinoma treated with chemotheraspy and limited field irradiation: The SFOP experience. Neuro Oncol 12: 1318–1325

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bamberg M, Kortmann RD, Calaminus G et al. (1999) Radiation therapy for intracranial germinoma: results of the cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17: 2585–2592

    CAS  PubMed  Google Scholar 

  • Baranzelli MC, Kramar A, Bouffet E et al. (1999) Prognostic factors in children with localized malignant nonseminomatous germ cell tumours. J Clin Oncol 17: 1212–1219

    CAS  PubMed  Google Scholar 

  • Blohm ME, Vesterling-Horner D, Calaminus G et al. (1998) Alpha1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol 15: 135–142

    Article  CAS  PubMed  Google Scholar 

  • Buckner JC, Peethambraam PP, Smithon WA et al. (1999) Phase II, trial of primary chemotherapy followed by reduced –dose radiation for CNS germ cell tumors. J Clin Oncol 17: 933–940

    CAS  PubMed  Google Scholar 

  • Calaminus G, Schneider DT, Bökkerink JP et al. (2003)Prognostic value of tumour size, metastases, extension into bone, and increased tumour marker in children with malignant sacrococcygeal germ cell tumours: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumouren (MAKEI) 83/86 and MAKEI 89. J Clin Oncol 21: 781–786

    Article  CAS  PubMed  Google Scholar 

  • Calaminus G, Bamberg M, Jürgens et al (2004): Impact of surgery, chemotherapy and irradiation on long term outcome of intracranial malignant non-germinomatous germ cell tumors: results of the German Cooperative Trial MAKEI 89. Klin Padiatr 216: 141–149

    Google Scholar 

  • Calaminus G, Kortmann RD, Worch J et al (2013) SIOP CNS GCT 96; final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. Neuroncology 15: 788–796

    CAS  Google Scholar 

  • Cushing B, Giller R, Cullen JW et al. (2004) Pediatric Oncology Group 9049; Children’s Cancer Group 8882. Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study. J Clin Oncol 22: 2691–700

    Article  CAS  PubMed  Google Scholar 

  • De Giorgi U, Rosti G, Slavin S et al. (2005) European Group for Blood and Marrow Transplantation Solid Tumours and Paediatric Disease Working Parties. Salvage high-dose chemotherapy for children with extragonadal germ-cell tumours. Br J Cancer 93: 412–417

    Article  PubMed Central  PubMed  Google Scholar 

  • Ebele Ed JN, Sauter G, Epstein JI et al. (2004) Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs; (Eds) World Health Organization Classification of Tumours. IARC, Lyon

    Google Scholar 

  • Einhorn LH, Donohue JP (1977) Chemotherapy for disseminated testicular cancer. Urol Clin North Am 4: 407–426

    CAS  PubMed  Google Scholar 

  • Göbel U, Schneider DT, Calaminus G et al. (2000) Germ cell tumors in childhood and adolescence. Ann Oncol 11: 263–271

    Article  PubMed  Google Scholar 

  • Göbel U, von Kries R, Teske C et al. (2012) Brain metastases during follow-up of children and adolescents with extracranial malignant germ cell tumors: Risk adapted management decision tree analysis based on data of the MAHO/MAKEI-registry. Pediatr Blood Cancer 97: 3935–3943

    Google Scholar 

  • Harms D, Zahn S, Göbel U, Schneider DT (2006) Pathology and Molecular Biology of Teratomas in Childhood and Adolescence. Klin Pädiatr 218: 296–302

    Article  CAS  PubMed  Google Scholar 

  • Kleihues P, Louis DN, Scheithauer BW et al. (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215–225; discussion 226–229

    PubMed  Google Scholar 

  • Maghine M, Cosi GL, Genovese E et al. (2000) Central Diabetes Insipidus in children and young adults. N Engl J Med 343: 998–1007

    Article  Google Scholar 

  • Mann JR, Raafat F, Robinson K et al. (2000) The United Kingdom Children’s Cancer Study Group’s Second Germ Cell Tumour Study: Carboplatin, Etoposide, and Bleomycin are effective treatment for children with malignant extracranial germ cell tumours, with acceptable toxicity. J Clin Oncol 18: 3809–3818

    CAS  PubMed  Google Scholar 

  • Marina M, Chang KW, Malogolowkin M et al. (2005) Children’s Oncology Group. Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children’s Oncology Group study. Cancer 104: 841–847

    Article  CAS  PubMed  Google Scholar 

  • Palmer RD, Foster NA, Vowler SL et al. (2007) Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br J Cancer 96: 667–676

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schmoll HJ, Kollmannsberger C, Metzner B et al. (2003) German Testicular Cancer Study Group: Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group. J Clin Oncol 21: 4083–4091

    Article  CAS  PubMed  Google Scholar 

  • Schneider DT, Calaminus G, Koch S et al. (2004) Epidemiological analysis of 1442 children and adolescents registered in the German Germ Cell Tumor Protocols. Pediatr Blood Cancer 42: 169–175

    Article  PubMed  Google Scholar 

  • Simbre VC, Duffy SA, Dadlani GH, Miller TL, Lipshultz SE (2005) Cardiotoxicity of cancer chemotherapy: implications for children. Paediatr Drugs 7: 187–202

    Article  PubMed  Google Scholar 

  • Wessalowski R, Schneider DT, Mils O (2003) An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors. Klin Padiatr 215: 303–309

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Erhebungseinheit für seltene pädiatrische Erkrankungen in Deutschland, Heinrich-Heine Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    Gabriele Calaminus Dr. med.

Authors
  1. Gabriele Calaminus Dr. med.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ulrich Göbel Prof. (em.) Dr. med.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Klinikum der Universität München, Lindwurmstr. 4, 80337, München, Deutschland

    Dietrich Reinhardt Prof. Dr. med. Dr. h. c.  & Thomas Nicolai Prof. Dr. med.  & 

  2. Zentrum für Kinder- und Jugendmedizin, Abt. Allgem. Pädiatrie und Neonatologie, Universitätsklinikum Gießen und Marburg, Standort Gießen, Feulgenstr. 12, 35392, Gießen, Deutschland

    Klaus-Peter Zimmer Prof. Dr. med.

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Calaminus, G., Göbel, U. (2014). Keimzelltumoren. In: Reinhardt, D., Nicolai, T., Zimmer, KP. (eds) Therapie der Krankheiten im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41814-3_63

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-41814-3_63

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-41813-6

  • Online ISBN: 978-3-642-41814-3

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation