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HHV-8-Related Lung Neoplastic and Nonneoplastic Diseases

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Viruses and the Lung

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Abstract

The emergence of Kaposi’s sarcoma (KS) among gay men in New York, Los Angeles, and San Francisco in 1981 heralded the beginning of the AIDS pandemic (Centers for Disease Control 1981; Hymes et al. 1981). Nearly 40 % of persons infected with HIV in the mid-1980s developed KS (Beral et al. 1990). It was the work of Chang et al. and Moore et al., using a technique based on the polymerase chain reaction (PCR), which identified two small fragments of DNA that were reproducibly present in AIDS-Kaposi’s sarcoma (KS) specimens and established that a novel human herpesvirus, human herpesvirus-8 (HHV-8), now known as Kaposi’s sarcoma-associated herpesvirus (KSHV), was responsible for the development of KS (Moore et al. 2001; Chang et al. 1994). The nucleotide sequences of these two fragments revealed homology to two known gamma- (lymphotropic) herpesviruses, indicating that these fragments were derived from a novel herpes viral genome. Human HHV-8 is causally related to KS, as well as the rarer primary effusion lymphoma (PEL) (Cesarman et al. 1995) and multicentric Castleman disease (MCD) (Soulier et al. 1995; Waterston and Bower 2004). In addition, associations between HHV-8 and other diseases have been suggested based on the finding of HHV-8 DNA by PCR in clinical specimens. These diseases include multiple myeloma (Beksac et al. 2001; Hsu et al. 2001; Rettig et al. 1997; Said et al. 1997), sarcoidosis (Di Alberti et al. 1997), primary pulmonary arterial hypertension (Bull et al. 2003; Cool et al. 2003), inflammatory myofibroblastic tumor (Gómez-Román et al. 2000), interstitial pneumonias, multiple sclerosis (Enbom 2001), and other diseases (see also Chaps. 6, 18, 21, and 23 in this volume).

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Authors and Affiliations

  1. Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Kotoku, Tokyo, 135-8550, Japan

    Osamu Matsubara M.D.

  2. Department of Diagnostic Pathology, Hiratsuka Kyosai Hospital, 9-11 Oiwake, Hiratsuka, 254-8502, Japan

    Osamu Matsubara M.D.

  3. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Boston, MA, 02114, USA

    Eugene J. Mark M.D.

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  1. Osamu Matsubara M.D.
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  2. Eugene J. Mark M.D.
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Correspondence to Osamu Matsubara M.D. .

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Editors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Armando E. Fraire

  2. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Bruce A. Woda

  3. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Raymond M. Welsh

  4. Massachusetts General Hospital, Boston, Massachusetts, USA

    Richard L. Kradin

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Matsubara, O., Mark, E.J. (2014). HHV-8-Related Lung Neoplastic and Nonneoplastic Diseases. In: Fraire, A., Woda, B., Welsh, R., Kradin, R. (eds) Viruses and the Lung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40605-8_20

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