Abstract
Spatially discordant T-wave alternans (TWA) has been shown to be linked to the genesis of ventricular fibrillation. Identification of discordant TWA through spatial characterization of TWA patterns in the heart has the potential to improve sudden cardiac death risk stratification. In this paper we present a method to solve a new variant of the inverse problem in electrocardiography that is tailored to estimate the TWA regions on the heart from non-invasive measurements on the body surface. We evaluate our method using both body surface potentials synthesized from heart surface potentials generated with ECGSIM and from potentials measured on a canine heart, and we show that this method detects the main regions in the heart undergoing TWA.
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Coll-Font, J., Erem, B., Karma, A., Brooks, D.H. (2013). An Inverse Spectral Method to Localize Discordant Alternans Regions on the Heart from Body Surface Measurements. In: Ourselin, S., Rueckert, D., Smith, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2013. Lecture Notes in Computer Science, vol 7945. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38899-6_29
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DOI: https://doi.org/10.1007/978-3-642-38899-6_29
Publisher Name: Springer, Berlin, Heidelberg
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